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Results for "

5-HT1B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (91) Adrenergic Receptor (4) Autophagy (1) Dopamine Receptor (4) Drug Metabolite (1) Endogenous Metabolite (2) iGluR (1) Isotope-Labeled Compounds (8) P2X Receptor (1) Serotonin Transporter (6)
By Research Areas:	Cancer (10) Cardiovascular Disease (5) Inflammation/Immunology (6) Neurological Disease (85)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103156

NAS-181 dimesylate 2 Publications Verification	5-HT Receptor	Neurological Disease
NAS181 is a potent and selective antagonist of rat 5-HT_1B receptor, with a K_i of 47 nM. NAS181 shows 13-fold selectivity for r5-HT_1B over bovine 5-HT_1B receptor (K_i=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT_1B autoreceptors .

HY-101100

Anpirtoline hydrochloride D-16949 hydrochloride	5-HT Receptor	Neurological Disease
Anpirtoline (D-16949) hydrochloride is a centrally acting 5-HT_1B receptor agonist, with K_is of 28 nM (5-HT_1B), 150 nM (5-HT_1A) and 1.49 μM (5-HT2). Anpirtoline hydrochloride has serotonergic, antinociceptive, antidepressant-like effects .

HY-101367A

GR 55562 dihydrochloride	5-HT Receptor	Neurological Disease
GR 55562 dihydrochloride is a selective 5-HT_1B receptor antagonist. GR 55562 dihydrochloride can be used for the research of nerve disease .

HY-W010869

GR 55562 hydrochloride	5-HT Receptor	Neurological Disease
GR 55562 hydrochloride is a selective 5-HT_1B receptor antagonist. GR 55562 hydrochloride can be used for the research of nerve disease .

HY-101698B

Alniditan dihydrochloride Alnitidan dihydrochloride	5-HT Receptor	Neurological Disease Inflammation/Immunology
Alniditan (Alnitidan) dihydrochloride is a potent *5-HT_1B* and 5-HT_1D receptors agonist, with IC₅₀s of 1.7 nM and 1.3 nM for *h5-HT_1B* and h5-HT_1D receptors in HEK?293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects .

HY-19578B

Isamoltane hemifumarate (±)-Isamoltane hemifumarate	5-HT Receptor Adrenergic Receptor	Neurological Disease
Isamoltane hemifumarate is a selective antagonist of 5-HT_1B receptor, with an IC₅₀ of 39 nM for inhibits the binding of [ ¹²⁵I]ICYP to 5-HT_1B recognition sites in rat brain membranes. Isamoltane hemifumarate is also a β-adrenoceptor ligand, with an IC₅₀ of 8.4 nM. Isamoltane hemifumarate shows anxiolytic activity .

HY-135507A

NAS-181 free base	5-HT Receptor	Neurological Disease
NAS181 free base is a potent and selective antagonist of rat 5-HT_1B receptor, with a K_i of 47 nM. NAS181 free base shows 13-fold selectivity for r5-HT_1B over bovine 5-HT_1B receptor (K_i=630 nM). NAS181 free base increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT_1B autoreceptors .

HY-103199

Carpindolol SDZ21009	5-HT Receptor	Neurological Disease
Carpindolol (SDZ21009) is a 5-HT1B receptor antagonist (pK_d of 8.53 and pK_B of 8.0) and a 5-HT1D receptor agonist (pEC₅₀ of 5.91 and pK_d of 6.37) .

HY-101698

Alniditan Alnitidan	5-HT Receptor	Neurological Disease Inflammation/Immunology
Alniditan (Alnitidan) is a potent *5-HT_1B* and 5-HT_1D receptors agonist, with IC₅₀s of 1.7 nM and 1.3 nM for *h5-HT_1B* and h5-HT_1D receptors in HEK 293 cells, respectively. Alniditan has migraine-preventive effects .

HY-B1658

Frovatriptan (R)-Frovatriptan; SB 209509; VML 251	5-HT Receptor	Neurological Disease
Frovatriptan is a potent *5-HT_1B//D* receptor agonist and has the highest 5-HT_1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura .

HY-16688

RU 24969 1 Publications Verification	5-HT Receptor	Neurological Disease
RU 24969 is a preferential *5-HT_1B* agonist, with a K_i of 0.38 nM, but also displays appreciable affinity for the 5-HT_1A receptor (K_i=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion .

HY-B1517B

Alprenolol benzoate	5-HT Receptor	Cardiovascular Disease Cancer
Alprenolol benzoate is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and *5-HT1B* receptors. Alprenolol benzoate is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent .

HY-16688B

RU 24969 hemisuccinate	5-HT Receptor	Neurological Disease
RU 24969 hemisuccinate is a preferential *5-HT_1B* agonist, with a K_i of 0.38 nM, but also displays appreciable affinity for the 5-HT_1A receptor (K_i=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 hemisuccinate could decrease fluid consumption and increase forward locomotion .

HY-B1517

Alprenolol 5+ Cited Publications (RS)-Alprenolol; dl-Alprenolol	5-HT Receptor	Cancer
Alprenolol ((RS)-Alprenolol; dl-Alprenolol) is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and *5-HT1B* receptors. Alprenolol is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent .

HY-B1517A

Alprenolol hydrochloride 5+ Cited Publications (RS)-Alprenolol hydrochloride; dl-Alprenolol hydrochloride	5-HT Receptor	Cancer
Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and *5-HT1B* receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent .

HY-103089

LY393558	5-HT Receptor	Neurological Disease
LY393558 is a potent and orally active inhibitor of the 5-HT transporter and an antagonist of *5-HT1B* and 5-HT1D receptors. LY393558 increase the extracellular levels of 5-HT in mice model frontal cortex. LY393558 can be used for researching depression .

HY-100794

GR127935 hydrochloride	5-HT Receptor	Neurological Disease
GR127935 hydrochloride is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 hydrochloride can be used in neurological disease research .

HY-107018

AR-A 2 AR-A 000002	5-HT Receptor	Neurological Disease
AR-A 2 is a selective 5-HT_1B receptor antagonist, with high affinity to guinea pig cortex *5HT_1B/1D* and recombinant guinea pig 5-HT_1B receptors (K_i=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT_1D receptor (K_i, 5 nM), and shows an EC₅₀ of 4.5 nM for the guinea pig 5-HT_1B receptor; AR-A 2 can be used in the research of depression and anxiety.

HY-100942

5-Carboxamidotryptamine maleate 5-CT maleate	5-HT Receptor	Neurological Disease
5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT_1A, *5-HT_1B, 5-HT_1D, 5-HT₅* and 5-HT₇ receptors agonist .

HY-A0039

Eletriptan UK-116044	5-HT Receptor	Neurological Disease Inflammation/Immunology
Eletriptan (UK-116044) is a highly selective and orally active serotonin *5-HT_1B* and 5-HT_1D receptor agonist, with pK_i values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine .

HY-B1658A

Frovatriptan succinate hydrate (R)-Frovatriptan succinate hydrate; SB 209509 succinate hydrate; VML 251 succinate hydrate	5-HT Receptor	Neurological Disease
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate) is a potent, high affinity, selective and orally active *5-HT_1B* (pK₅₀ of 8.2) and 5-HT_1D receptor agonist. Frovatriptan succinate hydrate exhibits >10-fold selectivity for *5-HT_1B* and 5-HT_1D over 5-HT_1A, 5-HT_1F, and 5-HT₇ and >1000-fold selectivity over other 5-HT, dopamine, histamine H₁, and α1-adrenoceptor. Frovatriptan succinate hydrate has the potential for migraine research .

HY-B1658B

Frovatriptan succinate (R)-Frovatriptan succinate; SB 209509 succinate; VML 251 succinate	5-HT Receptor	Neurological Disease
Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active *5-HT_1B* (pK₅₀ of 8.2) and 5-HT_1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for *5-HT_1B* and 5-HT_1D over 5-HT_1A, 5-HT_1F, and 5-HT₇ and >1000-fold selectivity over other 5-HT, dopamine, histamine H₁, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research .

HY-101105A

SB-224289 hydrochloride 2 Publications Verification SB-224289A	5-HT Receptor	Neurological Disease
SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect.

HY-101105

SB-224289	5-HT Receptor	Neurological Disease
SB-224289 is a selective 5-HT1B receptor antagonist, with anxiolytic effect .

HY-B1658AR

Frovatriptan succinate hydrate (Standard)	5-HT Receptor	Neurological Disease
Frovatriptan (succinate hydrate) (Standard) is the analytical standard of Frovatriptan (succinate hydrate). This product is intended for research and analytical applications. Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate hydrate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate hydrate has the potential for migraine research .

HY-101049

CGS 12066 dimaleate	5-HT Receptor	Neurological Disease
CGS 12066 (dimaleate) dimaleate is a selective 5-HT_1B receptor agonist with an IC₅₀ of 51 nM .

HY-101100A

Anpirtoline D-16949	5-HT Receptor	Neurological Disease
Anpirtoline (D-16949) is a centrally acting 5-HT_1B receptor agonist, with K_is of 28 nM (5-HT_1B), 150 nM (5-HT_1A) and 1.49 μM (5-HT2). Anpirtoline has serotonergic, antinociceptive, antidepressant-like effects .

HY-19477

SB-616234-A	5-HT Receptor	Neurological Disease
SB-616234-A is a selective and orally bioavailable 5-HT1B receptor antagonist, with anxiolytic and antidepressant activity.

HY-123704

CGS-12066 maleate	5-HT Receptor	Neurological Disease
CGS-12066 (maleate) is a 5-HT receptor agonist. CGS-12066 has agonist effect for 5-HT_1A, 5-HT_1B ,5-HT_1C and 5-HT_1D with pEC₅₀ values of 6.41, 7.56, 4.05 and 7.11, respectively. CGS-12066 can be used for the research of neurological disease .

HY-101357

CP 93129	5-HT Receptor	Neurological Disease
CP 93129 is a potent and selective *5-HT_1B* agonist. CP 93129 has the potential for the research of Parkinson's disease .

HY-W740014

N-Desmethyl Zolmitriptan 183C91; DZT	5-HT Receptor	Neurological Disease
N-Desmethyl Zolmitriptan (183C91; DZT) is the active metabolite of the serotonin (5-HT) receptor subtype 5-HT1B and 5-HT1D agonist Zolmitriptan (HY-B0229). N-Desmethyl Zolmitriptan (183C91; DZT) is an agonist of 5-HT1B receptors and induces constriction in isolated human cerebral arteries (EC50=100 nM).

HY-116908

SB-272183	5-HT Receptor	Neurological Disease
SB-272183 is a selective 5-HT_1A, *5-HT_1B* and 5-HT_1D receptor antagonist. In addition, SB-272183 is also a potent and selective ligand for 5-HT_1A, *5-HT_1B* and 5-HT_1D receptors in human recombinant and native tissues with pK_i values ??of 8.0, 8.1 and 8.7, respectively. SB-272183 can be used in antidepressant research .

HY-101357A

CP 93129 dihydrochloride	5-HT Receptor	Neurological Disease
CP 93129 dihydrochloride is a potent 5HT_1B receptor agonist. CP 93129 dihydrochloride has the potential for parkinson's disease research .

HY-A0010

Eletriptan hydrobromide Eletriptan HBr; UK-116044 hydrobromide	5-HT Receptor	Neurological Disease
Eletriptan hydrobromide (Eletriptan HBr) is a *5-HT_1B* and 5-HT_1D receptor agonist with antimigraine activity, with K_i of 0.92 nM and 3.14 nM, respectively .

HY-103151A

CP94253	5-HT Receptor	Others
CP94253 is a selective, orally active agonist for serotonin receptor 1B (5-HT1B), through competitive binding with iodocyanopindolol (ICP) to the 5-HT1 receptor. CP94253 binds to the 5-HT1B, 5-HT1A, 5-HT1D, 5-HT1C and 5-HT2 receptors, with K_is of 2, 89, 49, 860 and 1600 nM. CP94253 causes satiety, anorexia, weight loss and hyperlocomotion in rats model .

HY-A0039S

Eletriptan-d3 UK-116044-d₃	5-HT Receptor	Neurological Disease
Eletriptan-d₃ is the deuterium labeled Eletriptan hydrobromide. Eletriptan hydrobromide is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively[1][2].

HY-B0229

Zolmitriptan BW-311C90; 311C90	5-HT Receptor Endogenous Metabolite	Neurological Disease
Zolmitriptan (BW-311C90; 311C90) is a 5-HT1B/1D receptor partial agonist with K_is of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, 5-HT1F receptor, respectively. Zolmitriptan can be used for the research of migraine .

HY-B1658S

Frovatriptan-d3 hydrochloride (R)-Frovatriptan-d₃ hydrochloride; SB 209509-d₃ hydrochloride; VML 251-d₃ hydrochloride	5-HT Receptor	Neurological Disease
Frovatriptan-d₃ (hydrochloride) is the deuterium labeled Frovatriptan[1]. Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura[2].

HY-10847

SB-277011 SB-277011A	Dopamine Receptor	Neurological Disease
SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant.

HY-117575

WAY-100135	Others	Neurological Disease
WAY-100135 is a serotonergic compound belonging to the phenylpiperazine family, utilized in scientific research for its role as a strong antagonist of the 5-HT1A receptor and a partial agonist of the 5-HT1D receptor, with minimal activity at the 5-HT1B receptor.

HY-B0229S

Zolmitriptan-d6	Isotope-Labeled Compounds 5-HT Receptor Endogenous Metabolite	Neurological Disease
Zolmitriptan-d₆ is deuterium labeled Zolmitriptan. Zolmitriptan (BW-311C90; 311C90) is a 5-HT1B/1D receptor partial agonist with Kis of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, 5-HT1F receptor, respectively. Zolmitriptan can be used for the research of migraine[1][2].

HY-A0010R

Eletriptan (hydrobromide) (Standard)	5-HT Receptor	Neurological Disease
Eletriptan hydrobromide (Standard) is an analytical standard for Eletriptan hydrobromide. This product is intended for research and analytical applications. Eletriptan hydrobromide (Eletriptan HBr) is a *5-HT_1B* and 5-HT_1D receptor agonist with antimigraine activity, with K_i of 0.92 nM and 3.14 nM, respectively .

HY-W795507

Cyanopindolol	Adrenergic Receptor 5-HT Receptor	Neurological Disease
Cyanopindolol is an β3-adrenoceptor antagonist. Cyanopindolol is a potent and selective antagonist at the presynaptic serotonin autoreceptor in the rat brain cortex. Cyanopindolol has binding affinity for 5-HT1A and *5-HT1B* receptor (K_i: 2.1 and 3 nM respectively) .

HY-B1658BS

Frovatriptan-d3 succinate (R)-Frovatriptan-d₃ succinate; SB 209509-d₃ succinate; VML 251-d₃ succinate	Isotope-Labeled Compounds 5-HT Receptor	Neurological Disease
Frovatriptan-d₃ (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research[1][2].

HY-15414

Vortioxetine Maximum Cited Publications 9 Publications Verification Lu AA 21004	5-HT Receptor Serotonin Transporter	Neurological Disease Cancer
Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a *5-HT_1A agonist and a partial agonist of 5-HT_1B* (K_i: 15 nM, 33 nM) .**

HY-10847A

SB-277011 dihydrochloride SB-277011A dihydrochloride	Dopamine Receptor	Neurological Disease
SB-277011 dihydrochloride (SB-277011A dihydrochloride) is a potent, selective, orally bioavailable and brain penetrate dopamine D₃ receptor antagonist, with pK_is of 8.0, 6.0, <5.2 and 5.9 for D₃, D₂, 5-HT_1B, and 5-HT_1D receptors, respectively.

HY-16688A

RU 24969 succinate 1 Publications Verification	5-HT Receptor	Neurological Disease
RU 24969 succinate is a 5-HT receptor agonist with K_i values of 0.38 and 2.5 nM for 5-HT_1B and 5-HT_1A, respectively. RU 24969 decreases fluid consumption and increases forward locomotion. RU 24969 succinate can be used for the research of neurological disease .

HY-112061

8-OH-DPAT 2 Publications Verification 8-Hydroxy-DPAT	5-HT Receptor	Neurological Disease
8-OH-DPAT is a potent and selective 5-HT agonist, with a pIC₅₀ of 8.19 for 5-HT1A and a K_i of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC₅₀, 5.42), 5-HT (pIC₅₀ <5).

HY-103131

PNU-142633	5-HT Receptor	Neurological Disease
PNU-142633 is a high affinity, selective and orally active 5-HT_1D receptor agonist with K_is of 6 nM and > 18 000 nM for human 5-HT_1D receptor and human 5-HT_1B receptor, respectively. PNU-142633 has anti-migraine efficacy .

HY-15414A

Vortioxetine hydrobromide Maximum Cited Publications 9 Publications Verification Lu AA21004 hydrobromide	5-HT Receptor Serotonin Transporter	Neurological Disease Cancer
Vortioxetine (Lu AA 21004) hydrobromide is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0229

Zolmitriptan BW-311C90; 311C90	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Indole Alkaloids	5-HT Receptor Endogenous Metabolite
Zolmitriptan (BW-311C90; 311C90) is a 5-HT1B/1D receptor partial agonist with K_is of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, 5-HT1F receptor, respectively. Zolmitriptan can be used for the research of migraine .

Cat. No.	Product Name	Chemical Structure

HY-B0121BS

Sumatriptan-d6 succinate
Sumatriptan-d6 succinate is the deuterium labeled Sumatriptan succinate. Sumatriptan succinate is an orally active 5-HT1 receptor agonist with K_is of 17 nM, 27 nM and 100 nM for 5-HT1D, *5-HT1B* and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for migraine headache research .

HY-A0039S

Eletriptan-d3
Eletriptan-d₃ is the deuterium labeled Eletriptan hydrobromide. Eletriptan hydrobromide is a selective 5-HT1B and 5-HT1D receptor agonist with Ki of 0.92 nM and 3.14 nM, respectively[1][2].

HY-B1658S

Frovatriptan-d3 hydrochloride
Frovatriptan-d₃ (hydrochloride) is the deuterium labeled Frovatriptan[1]. Frovatriptan is a potent 5-HT1B//D receptor agonist and has the highest 5-HT1B potency in the triptan class. Frovatriptan is apparently cerebroselective. Frovatriptan is efficacious and even superior in some endpoints also when taken during the headache phase in migraine attacks with aura[2].

HY-B0229S

Zolmitriptan-d6
Zolmitriptan-d₆ is deuterium labeled Zolmitriptan. Zolmitriptan (BW-311C90; 311C90) is a 5-HT1B/1D receptor partial agonist with Kis of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, 5-HT1F receptor, respectively. Zolmitriptan can be used for the research of migraine[1][2].

HY-B1658BS

Frovatriptan-d3 succinate

Frovatriptan-d₃ (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research[1][2].

HY-A0039S1

Eletriptan-d5
Eletriptan-d₅ is the deuterium labeled Eletriptan[1]. Eletriptan (UK-116044) is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan can be used for researching migraine[2].

HY-A0039S2

Eletriptan-d5 hydrochloride

Eletriptan-d₅ (hydrochloride) is the deuterium labeled Eletriptan hydrochloride[1]. Eletriptan (UK-116044) hydrochloride is a highly selective and orally active serotonin 5-HT1B and 5-HT1D receptor agonist, with pKi values of 8.0 and 8.9, respectively. Eletriptan hydrochloride has inhibitory effects on markers of neurogenic inflammation in rats. Eletriptan hydrochloride can be used for researching migraine[2].

HY-15414AS

Vortioxetine-d8 hydrobromide
Vortioxetine-d₈ (Lu AA 21004-d₈) hydrobromide is the deuterated form of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a *5-HT_1A agonist and a partial 5-HT_1B* agonist (K_i: 15 nM, 33 nM) .**

HY-15414S

Vortioxetine-d8
Vortioxetine-d₈ (Lu AA 21004-d₈) is a deuterated version of Vortioxetine. Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of 5-hydroxytryptamine transporter (SERT) (K_i: 1.6 nM), as well as a 5-HT_1A agonist and a partial 5-HT_1B agonist (K_i: 15 nM, 33 nM) .

HY-15414S1

Vortioxetine-d6
Vortioxetine-d6 (Lu AA 21004-d6) is the deuterium labeled Vortioxetine (HY-B1490A). Vortioxetine (Lu AA 21004) is an antagonist of 5-HT_3A and 5-HT₇ receptors (K_i: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (K_i: 1.6 nM), as well as a *5-HT_1A agonist and a partial agonist of 5-HT_1B* (K_i: 15 nM, 33 nM) .**

HY-B0121BS2

Sumatriptan-d5
Sumatriptan-d₅ is deuterated labeled Sumatriptan (HY-B0121B). Sumatriptan (GR 43175) is an orally active 5-HT1 receptor agonist with IC₅₀s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT_1D, 5-HT_1B and 5-HT_1F receptors, respectively. Sumatriptan can be used for migraine headache research .

HY-B0383AS2

Almotriptan-d3 benzoate
Almotriptan-d₃ benzoate is deuterated labeled Almotriptan (HY-B0383A). Almotriptan is a selective agonist of 5-HT 1B/1D Receptor. Almotriptan can used in study of migraine attacks .

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