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Isoforms Recommended: Akt1 Akt1
Results for "

AKT1

" in MedChemExpress (MCE) Product Catalog:

94

Inhibitors & Agonists

1

Screening Libraries

3

Peptides

8

Natural
Products

3

Recombinant Proteins

8

Antibodies

1

Click Chemistry

4

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-146459

    Akt Cancer
    Akt1-IN-1 (compound 5b) is a potent and selective Akt1 inhibitor with an IC50 value of 18.79 nM in MIA Paca-2 cells. Akt1-IN-1 does not exhibit obvious teratogenicity, hepatotoxicity and cardiotoxicity (No Observed Adverse Effect Level > 100 µM). Akt1-IN-1 can be used for researching anticancer [1].
    Akt1-IN-1
  • HY-RS00544

    Small Interfering RNA (siRNA) Akt Others

    Akt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Akt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Akt1 Rat Pre-designed siRNA Set A
    Akt1 Rat Pre-designed siRNA Set A
  • HY-RS00542

    Small Interfering RNA (siRNA) Akt Others

    AKT1 Human Pre-designed siRNA Set A contains three designed siRNAs for AKT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AKT1 Human Pre-designed siRNA Set A
    AKT1 Human Pre-designed siRNA Set A
  • HY-RS00543

    Small Interfering RNA (siRNA) Akt Others

    Akt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Akt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Akt1 Mouse Pre-designed siRNA Set A
    Akt1 Mouse Pre-designed siRNA Set A
  • HY-173155

    Akt Cancer
    AKT1-IN-9 (4) is a selective mutant AKT1(E17K) inhibitor, with EC50 values of 9 nM and 995 nM in LAPC4-CR and SkBr3 cells, respectively [1].
    AKT1-IN-9
  • HY-161438

    Akt Cancer
    Akt1-IN-3 (Compd 7) is an inhibitor of AKT1. Akt1-IN-3 inhibits AKT1- E17K with IC50 < 15 nM [1].
    Akt1-IN-3
  • HY-163577

    Akt Cancer
    Akt1-IN-5 (Compound 115) is an Akt1 inhibitor (IC50: <15 nM) [1]
    Akt1-IN-5
  • HY-163579

    Akt Cancer
    Akt1-IN-7 (Compound 370) is an Akt1 inhibitor (IC50: <15 nM) [1].
    Akt1-IN-7
  • HY-163578

    Akt Cancer
    Akt1-IN-6 (Compound 273) is an Akt1 inhibitor (IC50: <15 nM) [1]
    Akt1-IN-6
  • HY-161439

    Akt Cancer
    Akt1-IN-4 (Compound 62) is an AKT1-E17K inhibitor with an IC50 value of less than 15 nM [1].
    Akt1-IN-4
  • HY-148868A

    Akt CDK Cancer
    Akt1&PKA-IN-2 ((R)-29) is an inhibitor of PKB/AKT with cyclin-dependent kinase 2 (CDK2) selectivity. Akt1&PKA-IN-2 inhibits AKT1, PKAa and CDK2 a with IC50 values of 0.007 µM, 0.01 µM and 0.69 µM, respectively [1].
    Akt1&PKA-IN-2
  • HY-129119

    Akt Caspase Cancer
    Akt1/Akt2-IN-2 (compound 7) is an allosteric dual Akt1 and Akt2 inhibitor (IC50=138 nM and 212 nM, respectively). Akt1/Akt2-IN-2 increases activity of caspase-3, and inhibits viability of a number of tumor cells [1].
    Akt1/Akt2-IN-2
  • HY-50862
    Akt1/Akt2-IN-1
    1 Publications Verification

    Akt Cancer
    Akt1/Akt2-IN-1 (Compound 17) is an allosteric inhibitor of Akt1 (IC50=3.5 nM) and Akt2 (IC50=42 nM), with potent and balanced activity [1].
    Akt1/Akt2-IN-1
  • HY-148868

    Akt PKA CDK Others
    Akt1&PKA-IN-1 is a potent dual Akt/PKA inhibitor with IC50 values of 0.03 , 0.11 μM, and 9.8 μM for PKAa, Akt, and CDK2, respectively. Akt1&PKA-IN-1 is selective for cyclin-dependent kinase 2 (CDK2) [1].
    Akt1&PKA-IN-1
  • HY-16032

    Akt Cancer
    AKT-I-1 is a selective inhibitor of Akt1, with an IC50 of 4.6 µM [1].
    Akt1-IN-2
  • HY-RS00545

    Small Interfering RNA (siRNA) Others

    AKT1S1 Human Pre-designed siRNA Set A contains three designed siRNAs for AKT1S1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    AKT1S1 Human Pre-designed siRNA Set A
    AKT1S1 Human Pre-designed siRNA Set A
  • HY-154960

    Akt Apoptosis Microtubule/Tubulin Cancer
    Tubulin/AKT1-IN-1 (Compound D1-1) is an inhibitor of tubulin polymerization and AKT pathway activation. Tubulin/AKT1-IN-1 significantly inhibits the proliferation and metastasis of H1975 cells and slightly induced their apoptosis and can be used for non-small-cell lung cancer (NSCLC) research [1].
    Tubulin/AKT1-IN-1
  • HY-169960

    mTOR Cancer
    2DII is a potent and selective mTORC2 inhibitor. 2DII selectively binds mSin1 PH domain and decreases the expression of AKT1 phosphorylation [1].
    2DII
  • HY-19982

    Akt Cancer
    AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1).
    AKT-IN-6
  • HY-W750451

    Akt Cancer
    Reptoside, an iridoid glucoside, is a DNA damaging active agent. Reptoside has strong interactions with Trp352 and Tyr335 in AKT1 [1].
    Reptoside
  • HY-19719
    Miransertib
    10+ Cited Publications

    ARQ-092

    Akt Parasite Infection Cancer
    Miransertib (ARQ-092) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. Miransertib is also a potent the AKT1-E17K mutant protein inhibitor and has the potential for PI3K/AKT-driven tumors and Proteus syndrome research [1]. Miransertib is effective against Leishmania .
    Miransertib
  • HY-19719A
    Miransertib hydrochloride
    10+ Cited Publications

    ARQ-092 hydrochloride

    Akt Parasite Infection Cancer
    Miransertib hydrochloride (ARQ-092 hydrochloride) is a potent, orally active, selective and allosteric Akt inhibitor with IC50s of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively. Miransertib hydrochloride is also a potent the AKT1-E17K mutant protein inhibitor and has the potential for PI3K/AKT-driven tumors and Proteus syndrome research [1]. Miransertib hydrochloride is effective against Leishmania .
    Miransertib hydrochloride
  • HY-153640

    Akt Cancer
    AKT-IN-14 (Example 2) is a potent AKTinhibitor with the IC50 values of <0.01 nM, 1.06 nM and 0.66 nM for AKT1, AKT2, AKT3, respectively. AKT-IN-14 can be used in cancer research [1].
    AKT-IN-14
  • HY-143611

    Akt Cancer
    AKT-IN-8 is a potent AKT inhibitor with IC50s of 4.46, 2.44, and 9.47 nM for AKT1, AKT2, and AKT3, respectively [1].
    AKT-IN-8
  • HY-153640A

    Akt Cancer
    AKT-IN-14 (Example 2) free baseis a potent AKTinhibitor with the IC50 values of <0.01 nM, 1.06 nM and 0.66 nM for AKT1, AKT2, AKT3, respectively. AKT-IN-14 free basecan be used in cancer research [1].
    AKT-IN-14 free base
  • HY-137458A

    ARQ 751 trihydrochloride

    Akt Cancer
    Vevorisertib (ARQ 751) trihydrochloride is a selective, allosteric, pan-AKT and AKT1-E17K mutant inhibitors. Vevorisertib trihydrochloride potently inhibit phosphorylation of AKT. Vevorisertib trihydrochloride has Kd values of 1.2 nM and 8.6 nM for AKT1 and AKT1-E17K, respectively. Vevorisertib trihydrochloride has IC50 values of 0.55, 0.81, and 1.3 nM for AKT1, AKT2, and AKT3, respectively. Vevorisertib trihydrochloride can be used for the research of cancer [1].
    Vevorisertib trihydrochloride
  • HY-100018
    BAY1125976
    1 Publications Verification

    Akt Cancer
    BAY1125976 is a selective allosteric Akt1/Akt2 inhibitor; inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively.
    BAY1125976
  • HY-123390

    Bcr-Abl Akt Cancer
    DB07107 is a potent agent resistant T315I mutant Bcr-Abl tyrosine kinase inhibitor. DB07107 is also a potent Akt1 inhibitor with an IC50 value of 360 nM [1] .
    DB07107
  • HY-W013816

    AMPK Akt Metabolic Disease
    Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant [1].
    Dipentyl phthalate
  • HY-13254A
    A-674563 hydrochloride
    4 Publications Verification

    Akt Cancer
    A-674563 hydrochloride is a potent and selective Akt1 inhibitor with Ki of 11 nM.
    A-674563 hydrochloride
  • HY-13254
    A-674563
    4 Publications Verification

    Akt Cancer
    A-674563 is an orally active Akt1 inhibitor with a Ki of 11 nM.
    A-674563
  • HY-16666
    3CAI
    3 Publications Verification

    Akt Cancer
    3CAI is a potent and specific AKT1 and AKT2 inhibitor.
    3CAI
  • HY-145281

    PROTACs Akt Cancer
    MS98 is a potent and selective PROTAC AKT degrader. MS98 depletes cellular total AKT (T-AKT) with the DC50 value of 78 nM. MS98 binds to AKT1, AKT2, and AKT3 with Kds of 4 nM, 140 nM, and 8.1 nM, respectively [1].
    MS98
  • HY-145282
    MS170
    1 Publications Verification

    PROTACs Akt Cancer
    MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with Kds of 1.3 nM, 77 nM, and 6.5 nM, respectively [1].
    MS170
  • HY-162285

    Akt Cancer
    Anticancer agent 189 (compound 4) is an anticancer agent that antagonizes CRC effects by targeting AKT1 [1].
    Anticancer agent 189
  • HY-112148

    Akt Cancer
    AKT-IN-2 is a potent, selective and orally bioavailable AKT inhibitor with an IC50 of 5 nM for AKT1 [1].
    AKT-IN-2
  • HY-W013816R

    AMPK Akt Metabolic Disease
    Dipentyl phthalate (Standard) is the analytical standard of Dipentyl phthalate. This product is intended for research and analytical applications. Dipentyl phthalate is an endocrine-disrupting phthalate plasticizer. Dipentyl phthalate increases AMPK phosphorylation and decreases AKT1 phosphorylation and SIRT1 levels. Dipentyl phthalate reduces adrenocorticotropic hormone levels. Dipentyl phthalate is a testicular toxicant [1].
    Dipentyl phthalate (Standard)
  • HY-138767

    Akt Cancer
    AKT-IN-5 (Example 8) is a Akt inhibitor with IC50 values of 450 nM and 400 nM for Akt1 and Akt2, respectively [1].
    AKT-IN-5
  • HY-15431
    Capivasertib
    60+ Cited Publications

    AZD5363

    Akt Autophagy Cancer
    Capivasertib (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.
    Capivasertib
  • HY-15965A

    GSK2141795 hydrochloride

    Akt Cancer
    Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.
    Uprosertib hydrochloride
  • HY-15965
    Uprosertib
    15+ Cited Publications

    GSK2141795

    Akt Cancer
    Uprosertib (GSK2141795) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.
    Uprosertib
  • HY-18271
    CaMKII-IN-1
    5 Publications Verification

    CaMK Autophagy Inflammation/Immunology
    CaMKII-IN-1 is a potent and highly selective CaMKII inhibitor with IC50 of 63 nM; significantly high selectivity against CaMKIV, MLCK, p38a, Akt1, and PKC.
    CaMKII-IN-1
  • HY-151613

    PROTACs Akt Cancer
    MS15 is a potent and selective AKT PROTAC degrader. MS15 inhibits the AKT1, -2, and -3 activities, with IC50 values of 798 nM, 90 nM, and 544 nM, respectively [1].
    MS15
  • HY-10425
    A-443654
    10+ Cited Publications

    Akt Cancer
    A-443654 is a pan-Akt inhibitor and has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM) [1].
    A-443654
  • HY-15186A
    Ipatasertib dihydrochloride
    40+ Cited Publications

    GDC-0068 dihydrochloride; RG-7440 dihydrochloride

    Organoid Akt Cancer
    Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective and ATP-competitive pan-Akt inhibitor with IC50s of 5, 18 and 8 nM for Akt1, Akt2 and Akt3, respectively.
    Ipatasertib dihydrochloride
  • HY-151613A

    PROTACs Akt Cancer
    MS15 TFA is a potent and selective AKT PROTAC degrader. MS15 TFA inhibits the AKT1, -2, and -3 activities, with IC50 values of 798 nM, 90 nM, and 544 nM, respectively [1].
    MS15 TFA
  • HY-15727
    Afuresertib
    10+ Cited Publications

    GSK2110183; LAE002

    Akt PKC ROCK Cancer
    Afuresertib (GSK2110183) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3, respectively [1] .
    Afuresertib
  • HY-15727A
    Afuresertib hydrochloride
    10+ Cited Publications

    GSK2110183 hydrochloride; LAE002 hydrochloride

    Akt PKC ROCK Cancer
    Afuresertib hydrochloride (GSK 2110183 hydrochloride) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively [1] .
    Afuresertib hydrochloride
  • HY-133120
    INY-03-041
    1 Publications Verification

    PROTACs Akt Cancer
    INY-03-041 is a potent, highly selective and PROTAC-based pan-AKT degrader consisting of the ATP-competitive AKT inhibitor Ipatasertib (HY-15186) conjugated to Lenalidomide (HY-A0003, Cereblon ligand). INY-03-041 inhibits AKT1, AKT2 and AKT3 with IC50s of 2.0, 6.8 and 3.5 nM, respectively [1].
    INY-03-041
  • HY-N10336

    VEGFR STAT Akt Ras Others
    Notoginsenoside R4 is a ginsenoside that can be isolated from ginseng roots. In the molecular docking results, Notoginsenoside R4 can target STAT3, AKT1, HRAS, VEGFA and CASP3 [1] .
    Notoginsenoside R4

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