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Results for "

BP1

" in MedChemExpress (MCE) Product Catalog:

45

Inhibitors & Agonists

4

Peptides

2

Natural
Products

8

Recombinant Proteins

4

Isotope-Labeled Compounds

14

Antibodies

15

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-100493
    BP-1-102
    Maximum Cited Publications
    11 Publications Verification

    STAT Cancer
    BP-1-102 is an orally available, small-molecule inhibitor of transcription factor Stat3, with an IC50 of 6.8 μM.
    BP-1-102
  • HY-141898

    Fluorescent Dye Others
    Biotin-4-aminophenol is a biotin-phenol analog. Biotin-4-aminophenol generates free radicals and conjugates to tyrosine residues in proteins more efficiently and selectively than the previously reported BP1 [1].
    Biotin-4-aminophenol
  • HY-W412264

    Pim Cancer
    Pim-1/2 kinase inhibitor 1 is an orally active pim-1/2 kinase inhibitor. Pim-1/2 kinase inhibitor 1 blocks the ability of Pim kinases to phosphorylate peptides, and inhibits the pim protein kinase directed phosphorylation of 4E-BP1 and p27 Kip1. Pim-1/2 kinase inhibitor 1 can be used in study of cancer, especially prostate cancer [1].
    Pim-1/2 kinase inhibitor 1
  • HY-W348485

    mTOR Cancer
    WRX606 is an inhibitor for mTOR complex 1 (mTORC1). WRX606 inhibits the phosphorylation of mTORC1 substrate S6 kinase 1 S6K1 (IC50=10 nM), and the phosphorylation of the eukaryotic translation initiation factor 4E binding protein (p-4E-BP1) (IC50=0.27 μM) in MCF-7. WRX606 exhibits cytotoxicity to HepG2 with IC50 of 17 nM. WRX606 exhibits antitumor efficacy in mouse models [1].
    WRX606
  • HY-N6954
    Garcinone C
    2 Publications Verification

    ATM/ATR STAT CDK Hedgehog Inflammation/Immunology Cancer
    Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active [1] .
    Garcinone C
  • HY-134903

    mTOR Cancer
    (32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2) [1].
    (32-Carbonyl)-RMC-5552
  • HY-125151

    STAT Apoptosis Cancer
    BP-1-108 is a selective inhibitor of STAT5 (Ki=8.3 μM) with anticancer activity. BP-1-108 induces apoptosis of leukemia cells by inhibiting the phosphorylation of STAT5. BP-1-108 can be used in the study of acute myeloid leukemia and prostate cancer [1].
    BP-1-108
  • HY-115869

    mTOR Cancer
    RMC-4529 has an IC50 value of 1.0 nM against p-4E-BP1-(T37/46) in mTOR kinase cellular assay.
    RMC-4529
  • HY-111370

    mTOR Cancer
    mTOR inhibitor-2 is a highlt potent, selective and oral mTOR inhibitor with an IC50 of 7 nM. mTOR inhibitor-2 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates [1].
    mTOR inhibitor-2
  • HY-149292

    Casein Kinase Cancer
    SR-4133 is a potent and highly CK1ε selective inhibitor with an IC50 of 58 nM. SR-4133 binds to the ATP-binding site of CK1ε. SR-4133 displays nanomolar growth inhibition of bladder cancer cells, and inhibits the phosphorylation of 4E-BP1 [1].
    SR-4133
  • HY-124348

    3,5-Dimethyl PIT-1

    PI3K Cancer
    DM-PIT-1 is a PIP3/PH (phosphatidylinositol-3,4,5-triphosphate/Pleckstrin) interaction inhibitor. DM-PIT-1 decreases he expression of P-Akt, P-GSK-3-β, P-p70S6K, P-S6, P-4E-BP1. DM-PIT-1 induces apoptosis and shows anticancer activity. DM-PIT-1 has the potential for the research of ovarian cancer [1] .
    DM-PIT-1
  • HY-N6954R

    ATM/ATR STAT CDK Hedgehog Cancer
    Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active [1] .
    Garcinone C (Standard)
  • HY-156110

    Insulin Receptor Cancer
    IGF2BP1-IN-1 (Compound A11) is a IGF2BP1 inhibitor and inhibits downstream signaling. IGF2BP1-IN-1 binds to IGF2BP1 protein with a KD value of 2.88 nM. IGF2BP1-IN-1 inhibits cancer cells proliferation (IC50: 9 nM for A549 cell, 34 nM for HCT116). IGF2BP1-IN-1 induces cancer cell apoptosis. GF2BP1-IN-1 inhibits tumor growth in A549 xenograft mouse model [1].
    IGF2BP1-IN-1
  • HY-170873

    Ligands for Target Protein for PROTAC Cancer
    G3BP1/2-Targeting ligand-1 is the ligand for G3BP1/2 that can be used as target protein ligand for synthesis of G3BP1/2 PROTAC degrader PT-129 (HY-170872) [1].
    G3BP1/2-Targeting ligand-1
  • HY-RS14842

    Small Interfering RNA (siRNA) Others

    TNKS1BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TNKS1BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TNKS1BP1 Human Pre-designed siRNA Set A
    TNKS1BP1 Human Pre-designed siRNA Set A
  • HY-RS14915

    Small Interfering RNA (siRNA) Others

    TP53BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TP53BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TP53BP1 Human Pre-designed siRNA Set A
    TP53BP1 Human Pre-designed siRNA Set A
  • HY-RS06619

    Small Interfering RNA (siRNA) Others

    IGF2BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for IGF2BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    IGF2BP1 Human Pre-designed siRNA Set A
    IGF2BP1 Human Pre-designed siRNA Set A
  • HY-RS23290

    Small Interfering RNA (siRNA) Others
    Igf2bp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Igf2bp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Igf2bp1 Rat Pre-designed siRNA Set A
    Igf2bp1 Rat Pre-designed siRNA Set A
  • HY-RS16849

    Small Interfering RNA (siRNA)
    Igf2bp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Igf2bp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Igf2bp1 Mouse Pre-designed siRNA Set A
    Igf2bp1 Mouse Pre-designed siRNA Set A
  • HY-RS12830

    Small Interfering RNA (siRNA) Others

    SH3BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for SH3BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SH3BP1 Human Pre-designed siRNA Set A
    SH3BP1 Human Pre-designed siRNA Set A
  • HY-RS24378

    Small Interfering RNA (siRNA) Others
    G3bp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for G3bp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    G3bp1 Rat Pre-designed siRNA Set A
    G3bp1 Rat Pre-designed siRNA Set A
  • HY-RS22048

    Small Interfering RNA (siRNA) Others
    Tax1bp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tax1bp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Tax1bp1 Mouse Pre-designed siRNA Set A
    Tax1bp1 Mouse Pre-designed siRNA Set A
  • HY-RS08979

    Small Interfering RNA (siRNA) Others

    N4BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for N4BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    N4BP1 Human Pre-designed siRNA Set A
    N4BP1 Human Pre-designed siRNA Set A
  • HY-RS05189

    Small Interfering RNA (siRNA) Others

    G3BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for G3BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    G3BP1 Human Pre-designed siRNA Set A
    G3BP1 Human Pre-designed siRNA Set A
  • HY-RS17909

    Small Interfering RNA (siRNA)
    G3bp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for G3bp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    G3bp1 Mouse Pre-designed siRNA Set A
    G3bp1 Mouse Pre-designed siRNA Set A
  • HY-RS14227

    Small Interfering RNA (siRNA) Others

    TAX1BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TAX1BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TAX1BP1 Human Pre-designed siRNA Set A
    TAX1BP1 Human Pre-designed siRNA Set A
  • HY-RS06904

    Small Interfering RNA (siRNA) Others

    IRF2BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for IRF2BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    IRF2BP1 Human Pre-designed siRNA Set A
    IRF2BP1 Human Pre-designed siRNA Set A
  • HY-RS08464

    Small Interfering RNA (siRNA) Others

    MIS18BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for MIS18BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MIS18BP1 Human Pre-designed siRNA Set A
    MIS18BP1 Human Pre-designed siRNA Set A
  • HY-RS06964

    Small Interfering RNA (siRNA) Others

    ITGB1BP1 Human Pre-designed siRNA Set A contains three designed siRNAs for ITGB1BP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ITGB1BP1 Human Pre-designed siRNA Set A
    ITGB1BP1 Human Pre-designed siRNA Set A
  • HY-156906

    MDM-2/p53 Cancer
    UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1 TT, with a dissociation constant (Kd) of 1.0 ± 0.3 μM. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells [1].
    UNC3474
  • HY-162289
    FAZ-3780
    1 Publications Verification

    DNA/RNA Synthesis Cancer
    FAZ-3780 (compound G3Ib) is an inhibitor of binding to the NTF2L domain of G3BP1/2 that binds to G3BP1 with a Kd of 0.15 μM. FAZ-3780 targets the protein-protein interaction domain of G3BP1/2 and specifically inhibits co-condensation of G3BP1, caprin 1, and RNA in vitro [1].
    FAZ-3780
  • HY-162288
    FAZ-3532
    1 Publications Verification

    DNA/RNA Synthesis Cancer
    FAZ-3532 (compound G3Ia) is an inhibitor of binding to the NTF2L domain of G3BP1/2 that binds to G3BP1 with a Kd of 0.54 μM. FAZ-3532 targets the protein-protein interaction domain of G3BP1/2 and specifically inhibits co-condensation of G3BP1, caprin 1, and RNA in vitro [1].
    FAZ-3532
  • HY-144873

    Insulin Receptor Cancer
    AVJ16 is a cancer cell migration inhibitor that targets the insulin-like growth factor 2 mRNA binding protein IGF2BP1 to inhibit the migration of H1299 cells with high endogenous IGF2BP1 expression. AVJ16 interferes with IGF2BP1 binding target mRNA to regulate gene expression and translation [1].
    AVJ16
  • HY-156257

    DNA/RNA Synthesis Cancer
    UNC9512 is a potent methyl-lysine reader p53 binding protein 1 (53BP1) antagonist. UNC9512 can be used to study the role of 53BP1 in DNA repair, gene editing and tumorigenesis [1].
    UNC9512
  • HY-115531

    DNA/RNA Synthesis Cancer
    UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) [1].
    UNC-2170
  • HY-118897

    DNA/RNA Synthesis Cancer
    UNC-2170 maleate is the maleate salt form of UNC-2170 (HY-115531). UNC-2170 maleate is a selective inhibitor for the methyl-lysine binding protein 53BP1, with IC50 of 29 µM and Kd of 22 µM. UNC-2170 maleate shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) [1].
    UNC-2170 maleate
  • HY-170872

    PROTACs DNA/RNA Synthesis Cancer
    PT-129 is an RPOTAC degrader targeting the NTF2 domain (protein-RNA interaction site) of G3BP1/2, which mediates the disassembly of intracellular stress granules. PT-129 can inhibit the formation of stress granules in stressed cells and disassemble existing stress granules, and can disrupt the transmission of ATF4, thereby inhibiting the proliferation of cancer cells. Stress granules (SGs) are membrane-less cytoplasmic compartments formed under stress stimuli. SGs promote the transmission of ATF4 from fibroblasts to tumor cells through a migratory effect, mediating fibroblast-related tumor growth. And G3BP1/2 is a central protein of the SGs network, and the inhibition of G3BP1/2 may reduce the stress resistance of cancer cells in the tumor microenvironment. PT-129 is composed of a target protein ligand (red part) G3BP1/2-Targeting ligand-1 (HY-170873), an E3 ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547), and a PROTAC linker (black part) Amino-PEG3-C2-acid (HY-W040165); among them, the E3 ligase ligand + linker form a complex Thalidomide-NH-PEG3-propionic acid (HY-136166) [1].
    PT-129
  • HY-17401
    Ranolazine dihydrochloride
    4 Publications Verification

    CVT 303 dihydrochloride; RS 43285

    Calcium Channel Sodium Channel Autophagy Cardiovascular Disease Cancer
    Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor .
    Ranolazine dihydrochloride
  • HY-B0280
    Ranolazine
    4 Publications Verification

    CVT 303; RS 43285-003

    Sodium Channel Calcium Channel Cardiovascular Disease Cancer
    Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor . Antianginal agent.
    Ranolazine
  • HY-17401S

    CVT 303-dd8 dihydrochloride; RS 43285-d8

    Calcium Channel Sodium Channel Autophagy Cardiovascular Disease Cancer
    Ranolazine-d8 (dihydrochloride) is the deuterium labeled Ranolazine dihydrochloride. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor[3].
    Ranolazine-d8 dihydrochloride
  • HY-B0280S2

    Sodium Channel Calcium Channel Cardiovascular Disease Cancer
    Ranolazine-d3 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor[3]. Antianginal agent.
    Ranolazine-d3
  • HY-B0280S

    CVT 303-d5; RS 43285-003-d5

    Isotope-Labeled Compounds Sodium Channel Calcium Channel Cardiovascular Disease Cancer
    Ranolazine-d5 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor[3]. Antianginal agent.
    Ranolazine-d5
  • HY-B0280S1

    Isotope-Labeled Compounds Sodium Channel Calcium Channel Cardiovascular Disease Cancer
    Ranolazine-d8 is the deuterium labeled Ranolazine. Ranolazine (CVT 303) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[1][2]. Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor[3]. Antianginal agent.
    Ranolazine-d8
  • HY-B0280R

    Sodium Channel Calcium Channel Cardiovascular Disease Cancer
    Ranolazine (Standard) is the analytical standard of Ranolazine. This product is intended for research and analytical applications. Ranolazine (CVT 303) is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP) . Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor . Antianginal agent.
    Ranolazine (Standard)
  • HY-124072

    Cyclophilin LPL Receptor MDM-2/p53 Apoptosis Reactive Oxygen Species Cancer
    HL001 is an orally active small molecule inhibitor of Cyclophilin A (CypA) and a receptor antagonist of Lysophosphatidic acid 1 (LPA1). HL001 induces cell cycle arrest and apoptosis of tumor cells by p53. HL001 stabilizes p53 by down-regulating G3BP1, inducing reactive oxygen species and DNA damage. HL001 disrupts the interaction between MDM2 and p53-72R in a CypA dependent manner. HL001 has antitumor activity. HL001 can also be used to study pulmonary fibrosis [1] .
    HL001

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