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Results for "

Chondrocytes

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Autophagy (5) Bacterial (1) Caspase (1) CDK (1) CFTR (1) Endogenous Metabolite (4) FGFR (4) Fluorescent Dye (2) Fungal (1) Glucocorticoid Receptor (1) GSK-3 (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (4) IGF-1R (1) JNK (1) MDM-2/p53 (1) MMP (2) NF-κB (3) p38 MAPK (1) Parasite (1) Ras (1) Reactive Oxygen Species (5) Salt-inducible Kinase (SIK) (2) TGF-beta/Smad (1) Wnt (2)
By Research Areas:	Cancer (11) Endocrinology (1) Infection (1) Inflammation/Immunology (15) Neurological Disease (5)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1570

Pterosin B	Salt-inducible Kinase (SIK)	Inflammation/Immunology
Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 .

HY-136651

BNTA	Reactive Oxygen Species	Inflammation/Immunology
BNTA, a potent extracellular matrix (ECM) modulator, facilitates cartilage structural molecule synthesis on chondrocytes by activating superoxide dismutase 3 (SOD3). BNTA shows a promising potential for osteoarthritis alleviation by modulating cartilage generation .

HY-B0636

Triamcinolone acetonide 4 Publications Verification	Glucocorticoid Receptor FGFR	Inflammation/Immunology Endocrinology Cancer
Triamcinolone acetonide inhibits basic fibroblast growth factor (bFGF) induced proliferation of retinal endothelial cells. Triamcinolone acetonide reduces chondrocyte viability and leads to cartilage destruction. Triamcinolone acetonide activates macrophage with anti-inflammatory characteristics. Triamcinolone acetonide can be used in the study of diseases such as atopic dermatitis .

HY-139254

Indirubin-3′-oxime IDR3O; I3O	CDK GSK-3 JNK	Neurological Disease
Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC₅₀s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes .

HY-D0220A

Toluidine Blue (purity 36%) Toluidine Blue O (purity 36%)	Fluorescent Dye	Others Cancer
Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .

HY-18306

SB 242235 2 Publications Verification	p38 MAPK Autophagy	Cancer
SB-242235 is a potent and selective p38 MAP kinase inhibitor, with an IC₅₀ of 1.0　μM in primary human chondrocytes .

HY-P3503A

Vosoritide acetate BMN 111 acetate	FGFR	Others
Vosoritide (BMN 111) acetate is a natriuretic peptide receptor 2 (NPR2) agonist that acts on the proliferation and differentiation of chondrocytes to promote bone growth .

HY-19981A

Derazantinib Racemate ARQ-087 Racemate	FGFR	Cancer
Derazantinib Racemate (ARQ-087 Racemate) is the racemate of Derazantinib. Derazantinib is an orally bioavailable, ATP competitive tyrosine kinase inhibitor; exhibits potent activity against FGFR1-3 chondrocytes with IC₅₀s of 4.5, 1.8, and 4.5 nM, respectively.

HY-N1570R

Pterosin B (Standard)	Salt-inducible Kinase (SIK)	Inflammation/Immunology
Pterosin B (Standard) is the analytical standard of Pterosin B. This product is intended for research and analytical applications. Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 .

HY-P3503

Vosoritide BMN 111	FGFR	Others
Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research .

HY-P2374

Ac-DMQD-CHO	Caspase Apoptosis	Neurological Disease
Ac-DMQD-CHO is a selective inhibitor for caspase 3, with IC₅₀ of 39 nM. Ac-DMQD-CHO reduces apoptosis, and exhibits neuroprotective efficacy .

HY-B1125

Glucosamine 3 Publications Verification D-Glucosamine; Chitosamine	CFTR Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy	Inflammation/Immunology Cancer
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .

HY-N0733

Glucosamine hydrochloride 3 Publications Verification D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride	Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy	Inflammation/Immunology Cancer
Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .

HY-N0487

Glucosamine sulfate 3 Publications Verification D-Glucosamine sulfate	Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy	Inflammation/Immunology Cancer
Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .

HY-126849

3-Morpholinosydnonimine SIN-1; Linsidomine	MDM-2/p53	Cancer
3-Morpholinosydnonimine (SIN-1; Linsidomine) is a spontaneous ROS/RNS generator and a peroxynitrite donor. 3-Morpholinosydnonimine inhibits hypertrophic chondrocytes activity and induces necrosis. 3-Morpholinosydnonimine induces p53-dependent apoptosis, induces p53 accumulation and activates MAPK phosphorylation .

HY-N0733R

Glucosamine hydrochloride (Standard)	Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy	Inflammation/Immunology Cancer
Glucosamine (hydrochloride) (Standard) is the analytical standard of Glucosamine (hydrochloride). This product is intended for research and analytical applications. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .

HY-N0665

Specnuezhenide 1 Publications Verification (8E)-Nuezhenide	NF-κB Wnt	Inflammation/Immunology
Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of?Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) .

HY-110135

NBI-31772	IGF-1R	Neurological Disease Inflammation/Immunology
NBI-31772 is a non-selective IGFBP inhibitor (K_i=47 nM). NBI-31772 has neuroprotective effects and reduces infarct volume during cerebral ischemia. NBI-31772 can also restore or enhance proteoglycan synthesis in osteoarticular chondrocytes. In addition, NBI-31772 also increases the effect of IGF3 on zebrafish oocyte maturation .

HY-D0220

Toluidine Blue Toluidine Blue O	Fluorescent Dye	Cancer
Toluidine Blue (Toluidine Blue O) is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue can stain different components of plant tissues and cells in different colours. Toluidine Blue is also used as a diagnostic aid to identify malignant lesions, such as cancer .

HY-16268

Kartogenin Maximum Cited Publications 23 Publications Verification KGN	TGF-beta/Smad	Inflammation/Immunology
Kartogenin (KGN) is an inducer of chondrogenic tissue formation (EC₅₀: 100 nM). Kartogenin induces chondrogenesis by binding to fibrin A, disrupting its interaction with the transcription factor core binding factor beta subunit (CBFβ), and by modulating the CBFβ-RUNX1 transcriptional program. Kartogenin also promotes tendon-bone junction (TBJ) wound healing by stimulating collagen synthesis. Kartogenin is widely used in cell-free therapy in the field of regeneration for cartilage regeneration and protection, tendon-bone healing, wound healing and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research .

HY-N0665R

Specnuezhenide (Standard)	NF-κB Wnt	Inflammation/Immunology
Specnuezhenide (Standard) is the analytical standard of Specnuezhenide. This product is intended for research and analytical applications. Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of?Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) .

HY-N2503

Ginsenoside F4	Apoptosis MMP	Inflammation/Immunology
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis . Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .

HY-N7030

5,7,3',4'-Tetramethoxyflavone	Fungal Parasite Bacterial	Infection
5,7,3',4'-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3',4'-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling .

HY-120793

CMC2.24 TRB-N0224	Ras Apoptosis MMP	Inflammation/Immunology Cancer
CMC2.24 (TRB-N0224), an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC₅₀s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis .

HY-P10462

SAP15 Synthetic anti-inflammatory peptide 15	HDAC NF-κB	Inflammation/Immunology
SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation. In addition, SAP15 treatment increased the expression of aggrecan and type II collagen and decreased the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials .

Cat. No.	Product Name	Type

HY-D0220A

Toluidine Blue (purity 36%) Toluidine Blue O (purity 36%)	Dyes
Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .

Toluidine Blue (purity 36%)

Toluidine Blue O (purity 36%)

Dyes

Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .

Cat. No.	Product Name	Target	Research Area

HY-P3503A

Vosoritide acetate BMN 111 acetate	FGFR	Others
Vosoritide (BMN 111) acetate is a natriuretic peptide receptor 2 (NPR2) agonist that acts on the proliferation and differentiation of chondrocytes to promote bone growth .

HY-P2632A

RAD16-I hydrochloride	Peptides	Neurological Disease
RAD16-I hydrochloride, a soft nanofibrous self-assembling peptide, is a suitable microenvironment for human mesenchymal stem cells’ (hMSC) proliferation and differentiation into chondrocytes . RAD16-I is a well-studied ionic complementary peptide was used as a model to check potential amyloid-like staining properties of SAPNFs .

HY-P3503

Vosoritide BMN 111	FGFR	Others
Vosoritide (BMN 111) is a modified recombinant CNP (C-type natriuretic peptide) analogue, binds to NPR-B (natriuretic peptide receptor type B) and reduces the activity of FGFR3 (fibroblast growth factor receptor 3). Vosoritide can be used in achondroplasia and dwarfism research .

HY-P2374

Ac-DMQD-CHO	Caspase Apoptosis	Neurological Disease
Ac-DMQD-CHO is a selective inhibitor for caspase 3, with IC₅₀ of 39 nM. Ac-DMQD-CHO reduces apoptosis, and exhibits neuroprotective efficacy .

HY-P2632

RAD16-I	Peptides	Neurological Disease
RAD16-I, a soft nanofibrous self-assembling peptide, is a suitable microenvironment for human mesenchymal stem cells’ (hMSC) proliferation and differentiation into chondrocytes . RAD16-I is a well-studied ionic complementary peptide was used as a model to check potential amyloid-like staining properties of SAPNFs .

HY-P6022

G4RGDSP, integrin-binding peptide	Peptides	Others
G4RGDSP, Integrin-binding peptide is a cell integrin-binding peptide that targets integrin receptors. G4RGDSP, integrin-binding peptide is coupled to alginate to increase the viability of cells in the scaffold. G4RGDSP, integrin-binding peptide can be used as an extrudable carrier for chondrocyte delivery for the study of 3D printing technology

HY-P10462

SAP15 Synthetic anti-inflammatory peptide 15	HDAC NF-κB	Inflammation/Immunology
SAP15 (Synthetic anti-inflammatory peptide 15) is a synthetic anti-inflammatory peptide consisting of 15 amino acids designed from human beta-defensin 3. SAP15 has the ability to penetrate cells and is able to induce downregulation of intracellular inflammation. SAP15 inhibits inflammation by inhibiting the phosphorylation of HDAC5 and thereby reducing the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 inhibits HDAC5 and NF-κB p65 phosphorylation. In addition, SAP15 treatment increased the expression of aggrecan and type II collagen and decreased the expression of osteocalcin in LPS-induced chondrocytes. SAP15 can be used in the study of inflammation regulation and anti-inflammatory therapy of biomaterials .

Pterosin B	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Pteridium aquilinum Inflammation/Immunology Disease Research Fields Pteridiaceae	Salt-inducible Kinase (SIK)
Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 .

Toluidine Blue (purity 36%) Toluidine Blue O (purity 36%)	Classification of Application Fields Disease Research Fields Cancer	Fluorescent Dye
Toluidine Blue (Toluidine Blue O) purity 36% is an alkaline quinonimine dye (vivo dye) with high affinity for acidic tissue components, staining nuclei blue and polysaccharides purple. Toluidine Blue purity 36% shows heterostaining properties for mast cells, mucins and chondrocytes. Toluidine Blue purity 36% can stain different components of plant tissues and cells in different colours. Toluidine Blue purity 36% is also used as a diagnostic aid to identify malignant lesions, such as cancer .

Glucosamine 3 Publications Verification D-Glucosamine; Chitosamine	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Anti-aging Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides Monosaccharides Cancer	CFTR Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy
Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .

Glucosamine hydrochloride 3 Publications Verification D-(+)-Glucosamine hydrochloride; Chitosamine hydrochloride	Structural Classification Microorganisms Animals Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Cancer	Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy
Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .

Glucosamine sulfate 3 Publications Verification D-Glucosamine sulfate	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Saccharides Cancer	Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy
Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .

Specnuezhenide 1 Publications Verification (8E)-Nuezhenide	Structural Classification Monophenols Iridoids Oleaceae Classification of Application Fields Ligustrum lucidum Ait. Terpenoids Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	NF-κB Wnt
Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of?Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) .

Pterosin B (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Source classification Plants Pteridium aquilinum Pteridiaceae	Salt-inducible Kinase (SIK)
Pterosin B (Standard) is the analytical standard of Pterosin B. This product is intended for research and analytical applications. Pterosin B, a indanone found in bracken fern (Pteridium aquilinum), is an inhibitor of salt-inducible kinase 3 (Sik3) signaling. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 .

Glucosamine hydrochloride (Standard)	Structural Classification Microorganisms Animals Source classification Endogenous metabolite Saccharides	Endogenous Metabolite Reactive Oxygen Species HIF/HIF Prolyl-Hydroxylase Autophagy
Glucosamine (hydrochloride) (Standard) is the analytical standard of Glucosamine (hydrochloride). This product is intended for research and analytical applications. Glucosamine hydrochloride (D-Glucosamine hydrochloride) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine hydrochloride also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes .

Specnuezhenide (Standard)	Structural Classification Monophenols Iridoids Oleaceae Ligustrum lucidum Ait. Terpenoids Source classification Phenols Plants	NF-κB Wnt
Specnuezhenide (Standard) is the analytical standard of Specnuezhenide. This product is intended for research and analytical applications. Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of?Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA) .

Ginsenoside F4	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	Apoptosis MMP
Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis . Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .

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