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Results for "

Human Kallikrein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Kallikrein (5) Biochemical Assay Reagents (1) Bradykinin Receptor (1) CD3 (1) Protease Activated Receptor (PAR) (1) Ser/Thr Protease (2)
By Research Areas:	Cardiovascular Disease (6) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Targets Recommended: Kallikrein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145568

Feniralstat KVD-824	Kallikrein	Cardiovascular Disease Metabolic Disease
Feniralstat (compound 30), a pyrazole derivative, is a potent *kallikrein* inhibitor with an IC₅₀ of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC₅₀>40 μM).

HY-153115

Plasma kallikrein-IN-4	Kallikrein	Cardiovascular Disease Inflammation/Immunology
Plasma kallikrein-IN-4 (Example 153) is a plasma kallikrein inhibitor with an IC₅₀ of 0.016 μM against human plasma kallikrein .

HY-P990608

Alpitatug IMC 3C5; JNJ-69086420 antibody; Anti-KLK2 Antibody (h11B6)	CD3	Inflammation/Immunology
Alpitatug (IMC 3C5) is a CHO-expressed human antibody that targets KLK2/Kallikrein 2. Alpitatug has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.3 kDa. The isotype control for Alpitatug can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99110

Lanadelumab SHP643; DX-2930	Kallikrein	Inflammation/Immunology
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against *plasma kallikrein* (pKal) with an K_i** value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema .

HY-E70389

**Human Kallikrein**	Ser/Thr Protease	Cardiovascular Disease Inflammation/Immunology
Human Kallikrein is a serine protease that can be found in plasma and tissue. Human Kallikrein has the potential for the research of blood pressure, complement activation, and mediation and maintenance of inflammatory responses .

HY-P990459

Anti-KLK5/Kallikrein 5 Antibody	Kallikrein	Inflammation/Immunology
Anti-KLK5/Kallikrein 5 Antibody is a CHO-expressed human antibody that targets KLK5/Kallikrein 5. The Anti-KLK5/Kallikrein 5 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-KLK5/Kallikrein 5 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-E70546

Human Factor XII	Biochemical Assay Reagents	Cardiovascular Disease
Human Factor XII is a naturally occurring coagulation factor in human plasma. Human Factor XII is a single-chain polypeptide that, upon activation (primarily by kallikrein), is converted to factor α XIIa .

HY-129047D

Trypsin, Human Pancreas	Ser/Thr Protease Kallikrein Protease Activated Receptor (PAR)	Cardiovascular Disease Inflammation/Immunology
Trypsin, Human Pancreas is a serine protease that hydrolyses proteins into peptides and amino acids, and is an improtant enzyme for digestive system. Trypsin, Human Pancreas activates *kallikrein* and regulates the blood pressure. Trypsin, Human Pancreas is an activator for PAR, thereby regulating cellular inflammatory and immune responses .

HY-103293B

Lys-Bradykinin tetraacetate Kallidin (380-389) (Human, porcine, bovine) tetraacetate	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin (Kallidin (380-389) (human, porcine, bovine)) tetraacetate, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin tetraacetate, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin tetraacetate involves in vascular regulation, inflammation and pain sensation .

Cat. No.	Product Name	Target	Research Area

HY-P2618

Pro-Phe-Arg-AMC acetate	Peptides	Others
Pro-Phe-Arg-AMC acetate is a peptide that can be used as the substrate of human glandular kallikrein 2 (hK2) .

HY-103293B

Lys-Bradykinin tetraacetate Kallidin (380-389) (Human, porcine, bovine) tetraacetate	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin (Kallidin (380-389) (human, porcine, bovine)) tetraacetate, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin tetraacetate, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin tetraacetate involves in vascular regulation, inflammation and pain sensation .

Cat. No.	Product Name	Target	Research Area

HY-P990608

Alpitatug IMC 3C5; JNJ-69086420 antibody; Anti-KLK2 Antibody (h11B6)	CD3	Inflammation/Immunology
Alpitatug (IMC 3C5) is a CHO-expressed human antibody that targets KLK2/Kallikrein 2. Alpitatug has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.3 kDa. The isotype control for Alpitatug can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99110

Lanadelumab SHP643; DX-2930	Kallikrein	Inflammation/Immunology
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against *plasma kallikrein* (pKal) with an K_i** value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema .

HY-P990459

Anti-KLK5/Kallikrein 5 Antibody	Kallikrein	Inflammation/Immunology
Anti-KLK5/Kallikrein 5 Antibody is a CHO-expressed human antibody that targets KLK5/Kallikrein 5. The Anti-KLK5/Kallikrein 5 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-KLK5/Kallikrein 5 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Species:	Human (23)
Tag:	His (21) Tag Free (1) Fc (1)
Source:	HEK293 (22) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70317

	Kallikrein-2 Protein, Human (HEK293, His) rHuKallikrein 2/KLK2, His; Kallikrein-2; Glandular Kallikrein-1; hGK-1; Tissue Kallikrein-2; KLK2	Human	HEK293
	The Kallikrein-2 protein is a member of the glandular kallikrein family and is critical in the enzymatic process as it selectively cleaves the Met-Lys and Arg-Ser bonds in kininogen, thereby releasing Lys-bradykinin . This proteolytic activity contributes to the production of bradykinin, a bioactive peptide with multiple roles in regulating blood pressure, inflammation, and vascular permeability. Kallikrein-2 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-2 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73262

	Kallikrein-1 Protein, Human (240a.a, HEK293, His) Kallikrein 1; Kidney/pancreas/salivary gland Kallikrein; KLK1; Klk6; KLKR	Human	HEK293
	Kallikrein-1 protein cleaves bonds in kininogen to release Lys-bradykinin. It also cleaves Neisseria meningitidis NHBA in saliva during microbial infection. Kallikrein-1 Protein, Human (240a.a, HEK293, His) is the recombinant human-derived Kallikrein-1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70144

	Kallikrein-1 Protein, Human (244a.a, HEK293, His, solution) rHuKallikrein-1/KLK1, His; Kallikrein-1; Kidney/Pancreas/Salivary Gland Kallikrein; Tissue Kallikrein; KLK1	Human	HEK293
	Kallikrein-1 protein cleaves bonds in kininogen to release Lys-bradykinin. It also cleaves Neisseria meningitidis NHBA in saliva during microbial infection.Kallikrein-1 Protein, Human (244a.a, HEK293, His, solution) is the recombinant human-derived Kallikrein-1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70934

	Kallikrein-13 Protein, Human (HEK293, His) Kallikrein-13; Kallikrein-Like Protein 4; KLK-L4; KLK13; KLKL4	Human	HEK293
	Kallikrein-13 (KLK13) is a member of KLK family and is a secreted serine protease expressed in endocrine tissues, including the prostate, testis, breast, and ovary.Expression of KLK13 is regulated by steroid hormones and may be useful as a marker for breast cancer.KLK13 is also required for the human coronavirus HKU1 infection of human respiratory epithelial cells as a priming protease.Kallikrein-13 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-13 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70939

	Kallikrein-5 Protein, Human (HEK293, His) Kallikrein-5; Kallikrein-Like Protein 2; KLK-L2; Stratum Corneum Tryptic Enzyme; KLK5; SCTE	Human	HEK293
	The Kallikrein-5 protein may be involved in desquamation, suggesting a role in the process of skin shedding and exfoliation.Its association with desquamation suggests that it plays a role in regulating the removal of dead skin cells, which is critical for skin homeostasis.Kallikrein-5 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-5 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P77048

	Kallikrein-15 Protein, Human (HEK293, His) ACO protease; KLK15; Kallikrein-related peptidase 15	Human	HEK293
	Kallikrein-15 is a kallikrein (KLK) with trypsin-like activity that may promote cancer metastasis. The study found that Kallikrein-15 is only strongly expressed in mature sperm cells and not in immature germ cells. KLK15 may be able to cleave many extracellular matrix (ECM) components, interact with the extracellular matrix (ECM) receptor group, and be associated with tumorigenesis. Kallikrein-15 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-15 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70249

	*Plasma kallikrein/KLKB1 Protein, Human* (HEK293, His, solution)** rHuPlasma Kallikrein/KLKB1, His; Plasma Kallikrein; Fletcher factor; Kininogenin; Plasma preKallikrein; KLKB1; KLK3	Human	HEK293
	Plasma kallikrein (KLKB1) serves as an enzyme, cleaving Lys-Arg and Arg-Ser bonds to release bradykinin from HMW kininogen. It plays a crucial role in the reciprocal activation of factor XII, especially upon binding to a negatively charged surface. Besides its role in the kinin system, KLKB1 may contribute to the renin-angiotensin system by converting prorenin into renin. Plasma kallikrein/KLKB1 Protein, Human (HEK293, His, solution) is the recombinant human-derived Plasma kallikrein/KLKB1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70939A

	Kallikrein-5 Protein, Human (HEK293, C-His) Kallikrein-5; Kallikrein-Like Protein 2; KLK-L2; Stratum Corneum Tryptic Enzyme; KLK5; SCTE	Human	HEK293
	The Kallikrein-5 protein may be involved in desquamation, suggesting a role in the process of skin shedding and exfoliation. Its association with desquamation suggests that it plays a role in regulating the removal of dead skin cells, which is critical for skin homeostasis. Kallikrein-5 Protein, Human (HEK293,C-His) is the recombinant human-derived Kallikrein-5 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73265

	Kallikrein-8 Protein, Human (HEK293, His) Kallikrein-8; hK8; Neuropsin; Ovasin; TADG-14; NRPN; PRSS19	Human	HEK293
	Kallikrein-8 protein is a serine protease that degrades proteins such as casein, fibrinogen, kininogen, fibronectin, and type IV collagen. It cleaves L1CAM in response to neural activity, promoting neurite growth in hippocampal neurons. Kallikrein-8 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-8 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77047

	Kallikrein-15 Protein, Human (HEK293, Fc) ACO protease; KLK15; Kallikrein-related peptidase 15	Human	HEK293
	Kallikrein-15 is a kallikrein (KLK) with trypsin-like activity that may promote cancer metastasis. The study found that Kallikrein-15 is only strongly expressed in mature sperm cells and not in immature germ cells. KLK15 may be able to cleave many extracellular matrix (ECM) components, interact with the extracellular matrix (ECM) receptor group, and be associated with tumorigenesis. Kallikrein-15 Protein, Human (HEK293, Fc) is the recombinant human-derived Kallikrein-15 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P77048A

	Kallikrein-15 Protein, Human (HEK293, C-His) ACO protease; KLK15; Kallikrein-related peptidase 15	Human	HEK293
	Kallikrein-15 is a kallikrein (KLK) with trypsin-like activity that may promote cancer metastasis. The study found that Kallikrein-15 is only strongly expressed in mature sperm cells and not in immature germ cells. KLK15 may be able to cleave many extracellular matrix (ECM) components, interact with the extracellular matrix (ECM) receptor group, and be associated with tumorigenesis. Kallikrein-15 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-15 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70249A

	*Plasma kallikrein/KLKB1 Protein, Human* (HEK293, His)** Plasma Kallikrein; PKK; KLK3; KLKB1; Fletcher factor; Kininogenin	Human	HEK293
	Plasma kallikrein (KLKB1) serves as an enzyme, cleaving Lys-Arg and Arg-Ser bonds to release bradykinin from HMW kininogen. It plays a crucial role in the reciprocal activation of factor XII, especially upon binding to a negatively charged surface. Besides its role in the kinin system, KLKB1 may contribute to the renin-angiotensin system by converting prorenin into renin. Plasma kallikrein/KLKB1 Protein, Human (HEK293, His) is the recombinant human-derived Plasma kallikrein/KLKB1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P76466

	Kallikrein-7 Protein, Human (HEK293, His) Kallikrein-7; Serine protease 6; hSCCE; KLK7; PRSS6; SCCE	Human	HEK293
	Kallikrein-7 is a serine protease with chymotrypsin-like activity that plays a role in intercellular proteolysis, leading to epidermal exfoliation. It is involved in cancer invasion and metastasis, and elevated expression is associated with poor prognosis and cancer progression. Kallikrein-7 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-7 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P73263

	Kallikrein-11 Protein, Human (HEK293, His) Kallikrein-11; TLSP; hK11; Hippostasin; Trypsin-like protease; Serine protease 20	Human	HEK293
	Kallikrein-11 protein is suggested to be a multifunctional protease, efficiently cleaving the substrate 'bz-Phe-Arg-4-methylcoumaryl-7-amide' and showing weak cleavage activity toward other kallikrein and trypsin substrates. It predominantly cleaves synthetic peptides after arginine residues rather than lysine residues. Kallikrein-11 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-11 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77431

	Kallikrein-4 Protein, Human (HEK293, His) Kallikrein-4; Enamel matrix serine proteinase 1; KLK-L1; Prostase; EMSP1; PRSS17; PSTS	Human	HEK293
	Kallikrein-4 Protein is crucial in enamel formation, particularly during tooth maturation, playing a significant role in clearing enamel proteins and contributing to the structural patterning of the crystalline matrix. Its involvement underscores its importance in intricate tooth development processes, emphasizing its role in proper dental structure and function. Kallikrein-4 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70606

	Kallikrein-3/PSA Protein, Human (237a.a, HEK293, His) Prostate-specific antigen; PSA; Gamma-seminoprotein; Kallikrein-3; P-30 antigen; Semenogelase; KLK3; APS	Human	HEK293
	Kallikrein-3 (PSA) protein, pivotal in the male reproductive system, hydrolyzes semenogelin-1, a seminal vesicle protein. This enzymatic activity initiates seminal coagulum liquefaction, crucial for sperm mobility and fertility. PSA's cleavage of semenogelin-1 highlights its importance in the complex processes of semen physiology and male reproductive function. Kallikrein-3/PSA Protein, Human (237a.a, HEK293, His) is the recombinant human-derived Kallikrein-3/PSA protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70947

	Kallikrein-4 Protein, Human (H197Q, HEK293, His) Kallikrein-4; Enamel Matrix Serine Proteinase 1; Kallikrein-Like Protein 1; KLK-L1; Prostase; Serine Protease 17; KLK4; EMSP1; PRSS17; PSTS	Human	HEK293
	Kallikrein-4 Protein is crucial in enamel formation, particularly during tooth maturation, playing a significant role in clearing enamel proteins and contributing to the structural patterning of the crystalline matrix. Its involvement underscores its importance in intricate tooth development processes, emphasizing its role in proper dental structure and function. Kallikrein-4 Protein, Human (H197Q, HEK293, His) is the recombinant human-derived Kallikrein-4 protein, expressed by HEK293 , with C-6*His labeled tag and H197Q mutation.

HY-P70887

	Kallikrein-6 Protein, Human (HEK293, His) Kallikrein-6; Neurosin; Protease M; SP59; Serine Protease 18; Serine Protease 9; Zyme; KLK6; PRSS18; PRSS9	Human	HEK293
	Kallikrein-6 is a serine protease that exhibits substrate preference and activity against different substrates. It degrades alpha-synuclein, plays a role in synucleinopathies, and may regulate axonal growth after spinal cord injury. Kallikrein-6 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-6 protein, expressed by HEK 293 , with C-6*His labeled tag.

HY-P70163

	Kallikrein-7 Protein, Human (HEK293, His, solution) rHuKallikrein 7/KLK7, His ; Kallikrein-7; hK7; Serine Protease 6; Stratum Corneum Chymotryptic Enzyme; hSCCE; KLK7; PRSS6; SCCE	Human	HEK293
	Kallikrein-7 Protein (KLK7), a member of the tissue kallikrein family, is a first protease target of vaspin inhibited by classical serpin mechanism with high specificity in vitro. KLK7 cleaves human insulin in the A- and B-chain. KLK7 a serine protease with chymotrypsin-like activity which was involved in the regulated desquamation of terminally differentiated keratinocytes. KLK7 mediates the disruption of corneodesmosomes, the cell–cell adhesion junctions of corneocyites, by hydrolyzing the two mayor cadherins (corneodesmosin and desmocollin 1) in the extracellular region of these junctions. KLK7 overexpression and/or increased activity result in over-desquamation. Kallikrein-7 Protein, Human (HEK293, His, solution) is the recombinant human-derived Kallikrein-7 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70266

	Kallikrein-3/PSA Protein, Human (244a.a, HEK293, His) 1 Publications Verification rHuProstate-specific antigen/KLK3, His; Prostate-Specific Antigen; PSA; Gamma-Seminoprotein; Seminin; Kallikrein-3; P-30 Antigen; Semenogelase; KLK3; APS	Human	HEK293
	Kallikrein-3 (PSA) protein, pivotal in the male reproductive system, hydrolyzes semenogelin-1, a seminal vesicle protein. This enzymatic activity initiates seminal coagulum liquefaction, crucial for sperm mobility and fertility. PSA's cleavage of semenogelin-1 highlights its importance in the complex processes of semen physiology and male reproductive function. Kallikrein-3/PSA Protein, Human (244a.a, HEK293, His) is the recombinant human-derived Kallikrein-3/PSA protein, expressed by HEK293 , with C-His labeled tag.

HY-P70143

	Kallikrein-10 Protein, Human (HEK293, His) rHuKallikrein-10/KLK10, His ; Kallikrein-10; Normal Epithelial Cell-Specific 1; Protease Serine-Like 1; KLK10; NES1; PRSSL1	Human	HEK293
	Kallikrein-10 protein has a tumor suppressive effect, especially in breast and prostate cancer, by inhibiting NES1. This emphasizes its importance in mitigating tumorigenesis in these specific types of cancer. Kallikrein-10 Protein, Human (HEK293, His) is the recombinant human-derived Kallikrein-10 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7381

	Kallikrein-11 Protein, Human (Sf9) rHuKallikrein-11; TLSP; hK11; Hippostasin; Trypsin-like protease; Serine protease 20	Human	Sf9 insect cells
	Kallikrein 11 Protein, Human (Sf9) is a possible multifunctional protease and efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin.

HY-P71143

	Serpin A4 Protein, Human (HEK293, His) Kallistatin; Kallikrein Inhibitor; Peptidase Inhibitor 4; PI-4; Serpin A4; SERPINA4; KST; PI4	Human	HEK293
	Serpin A4 Protein inhibits tissue kallikrein's amidolytic and kininogenase activities by forming a heat- and SDS-stable equimolar complex with the enzyme. Tissue kallikrein concurrently cleaves the reactive site of Serpin A4, producing a small C-terminal fragment. The protein, existing as a monomer and occasionally forming homodimers, demonstrates its regulatory role in modulating tissue kallikrein-mediated enzymatic activities. Serpin A4 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A4 protein, expressed by HEK293 , with C-6*His labeled tag.

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