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Isoforms Recommended:	IL-15

Results for "

IL15

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) HIV (1) Interleukin Related (7) JAK (1) Small Interfering RNA (siRNA) (4) STAT (1)
By Research Areas:	Cancer (4) Infection (1) Inflammation/Immunology (8)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Pre-designed siRNA Sets (4) siRNAs (4)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-102049

IL-15-IN-1	Interleukin Related	Inflammation/Immunology
IL-15-IN-1 (compound 76) is a potent and selective Interleukin 15 (IL-15) inhibitor, inhibiting the proliferation of IL-15-dependent cells with an IC₅₀ of 0.8 μM .

HY-P99661

Inbakicept	Interleukin Related	Cancer
Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an *IL-15* superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells .

HY-P99410

Ordesekimab AMG 714; PRV-015	Interleukin Related	Inflammation/Immunology
Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD) .

HY-Y0493

HODHBt HOOBt	STAT HIV	Infection Cancer
HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer .

HY-153050

JAK-IN-24	JAK	Inflammation/Immunology Cancer
JAK-IN-24 is a JAK inhibitor, with IC₅₀s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24 also inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC₅₀ of 86.171 nM . JAK-IN-24 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15898

Y-320 3 Publications Verification	Interleukin Related Apoptosis	Inflammation/Immunology Cancer
Y-320 is a potent, orally active phenylpyrazoleanilide immunomodulator. Y-320 inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC₅₀ values of 20 to 60 nM. Y-320 enhances TP53, DMD, and COL17A1 PTC readthrough by G418 and increases cellular protein levels and protein synthesis. Y-320 concomitants use of with a low dose of Paclitaxel (HY-B0015) significantly sensitized multidrug resistance (MDR) tumors by inducing G2/M phase arrest and apoptosis. Y-320 can be used for research of rheumatoid arthritis (RA) and cancer .

HY-RS06690

IL15 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL15 Human Pre-designed siRNA Set A contains three designed siRNAs for IL15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL15 Human Pre-designed siRNA Set A IL15 Human Pre-designed siRNA Set A

HY-RS06691

Il15 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il15 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il15 Mouse Pre-designed siRNA Set A Il15 Mouse Pre-designed siRNA Set A

HY-RS06692

Il15 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il15 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il15 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il15 Rat Pre-designed siRNA Set A Il15 Rat Pre-designed siRNA Set A

HY-RS06693

IL15RA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL15RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL15RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL15RA Human Pre-designed siRNA Set A IL15RA Human Pre-designed siRNA Set A

HY-P991005

Larnefpendekin alfa	Interleukin Related	Inflammation/Immunology
HY-P991005 is an *IL-15RA*-targeting Fusion Protein .

HY-P990719

Efbalropendekin alfa	Interleukin Related	Inflammation/Immunology
Efbalropendekin alfa is an anti-IL15RA monoclonal antibody .

HY-P99850

Depemokimab GSK-3511294	Interleukin Related	Inflammation/Immunology
Depemokimab (GSK-3511294) is a long-acting anti-IL-15 monoclonal antibody. Depemokimab can be used for research of asthma .

Cat. No.	Product Name	Target	Research Area

HY-P99661

Inbakicept	Interleukin Related	Cancer
Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an *IL-15* superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells .

HY-P99410

Ordesekimab AMG 714; PRV-015	Interleukin Related	Inflammation/Immunology
Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD) .

HY-P99850

Depemokimab GSK-3511294	Interleukin Related	Inflammation/Immunology
Depemokimab (GSK-3511294) is a long-acting anti-IL-15 monoclonal antibody. Depemokimab can be used for research of asthma .

HY-P990223

*Anti-Mouse IL-15* Antibody (AIO.3)**	Inhibitory Antibodies	Others
Anti-Mouse IL-15 Antibody (AIO.3) is a rat-derived IgG2a, λ type antibody inhibitor, targeting to mouse IL-15.

HY-P990446

*Anti-IL-15* Antibody (DISC0280)** DISC0280	Inhibitory Antibodies	Inflammation/Immunology
The Anti-IL-15 Antibody (DISC0280) is a CHO-expressed human antibody that targets *IL-15. The Anti-IL-15* Antibody (DISC0280) has a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-IL-15 Antibody (DISC0280) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991005

Larnefpendekin alfa	Interleukin Related	Inflammation/Immunology
HY-P991005 is an *IL-15RA*-targeting Fusion Protein .

HY-P990719

Efbalropendekin alfa	Interleukin Related	Inflammation/Immunology
Efbalropendekin alfa is an anti-IL15RA monoclonal antibody .

Recombinant Proteins Recommended:

IL-15

Species:	Human (15) Rhesus Macaque (1) Mouse (3) Cynomolgus (1) Pig (1)
Tag:	His (12) Tag Free (2) Avi (4) Fc (7)
Source:	HEK293 (14) P. pastoris (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P71745

	IL-15 Protein, Rhesus macaque (P.pastoris, His) IL15; Interleukin-15; IL-15	Rhesus Macaque	P. pastoris
	The IL-15 protein is a cytokine that plays a key role in inflammatory and protective immune responses by regulating innate and adaptive immune cells. It stimulates the proliferation of natural killer cells, T cells and B cells, and promotes the secretion of cytokines. IL-15 Protein, Rhesus macaque (P.pastoris, His) is the recombinant Rhesus Macaque-derived IL-15 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of IL-15 Protein, Rhesus macaque (P.pastoris, His) is 114 a.a., with molecular weight of ~16 kDa.

HY-P70655

	IL-15R alpha & IL-15 Protein, Human (HEK293, Fc) IL15RA& IL15; Interleukin-15; IL-15; IL15; IL-15 receptor subunit alpha; IL-15RA; IL-15R-alpha; interleukin-15 receptor subunit alpha	Human	HEK293
	IL-15R alpha is a high affinity receptor for IL-15 (K_d: 100 pM). IL-15 is essential for the development and function natural killer (NK) cell, NKT cell and memory (m) CD8+ T cell. IL-15R alpha maintains memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha/IL-15 complex can activate the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha & IL-15 Protein, Human (HEK293, Fc) is a recombinant human IL-15R alpha (I31-D96) & IL-15 (N49-S162) fusion protein with a C-Terminal hFc tag, which is produced in HEK293 cells.

HY-P7034

	IL-15 Protein, Human rHuIL-15; IL15	Human	E. coli
	IL-15 Protein, Human is a pleiotropic cytokine, including T, B and NK cell-stimulatory activities.

HY-P7371

	IL-15 Protein, Human (His) rHuIL-15, His; IL15	Human	E. coli
	IL-15 Protein, Human (His) is a cytokine for immune cell stimulation, increases the proliferation and persistence of natural killer (NK) and T cells.

HY-P77699

	IL-15R alpha & IL-15 Protein, Human (HEK293, His) 2 Publications Verification IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha1; Interleukin-15; IL-15; IL15	Human	HEK293
	IL-15R alpha is a high affinity receptor for IL-15 (K_d: 100 pM). IL-15 is essential for the development and function natural killer (NK) cell, NKT cell and memory (m) CD8+ T cell. IL-15R alpha maintains memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha/IL-15 complex can activate the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha & IL-15 Protein, Human (HEK293, His) is a recombinant human IL-15R alpha (I31-S108) & IL-15 (N49-S162) fusion protein with a C-Terminal His tag, which is produced in HEK293 cells.

HY-P78558

	IL-15R alpha & IL-15 Protein, Mouse (HEK293, His) IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha1; Interleukin-15; IL-15; IL15	Mouse	HEK293
	IL-15R alpha Protein, the high-affinity receptor for interleukin-15, crucially signals in cis and trans, presenting IL-15 to neighboring IL2RG-expressing cells. In neutrophils, it activates SYK kinase, essential for IL-15-induced phagocytosis in a SYK-dependent manner. IL-15R alpha forms a heterotrimer with IL2RB and IL2RG, capable of self-association. Interactions with SYK underscore its intricate involvement in cellular signaling pathways. IL-15R alpha & IL-15 Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived IL-15R alpha & IL-15 protein, expressed by HEK293 , with C-His labeled tag. IL-15R alpha & IL-15 Protein, Mouse (HEK293, His), has molecular weight of ~36 kDa.

HY-P78860

	IL-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) IL-15; Interleukin-15; MGC9721	Human	HEK293
	IL-15 protein regulates immune cells, stimulates the proliferation of NK cells, T cells, and B cells, and promotes cytokine secretion. IL-15 Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived IL-15 protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P78154

	IL-15R alpha Protein, Human (Biotinylated, HEK293, His-Avi) IL-15 R alpha; CD215; IL-15RA; MGC104179	Human	HEK293
	IL-15R alpha is a high affinity receptor for IL-15 (K_d: 100 pM). IL-15R alpha binds IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha plays an important role in memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is a biotinylated recombinant human extracellular region of IL-15R alpha (I31-T205) with a C-Terminal His-Avi tag, which is produced in HEK293 cells.

HY-P77700

	IL-15R alpha & IL-15 Protein, Human (Biotinylated, HEK293, His) IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha1; Interleukin-15; IL-15; IL15	Human	HEK293
	IL-15R alpha is a high affinity receptor for IL-15 (K_d: 100 pM). IL-15 is essential for the development and function natural killer (NK) cell, NKT cell and memory (m) CD8+ T cell. IL-15R alpha maintains memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha/IL-15 complex can activate the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha & IL-15 Protein, Human (Biotinylated, HEK293, His) is a recombinant biotinylated human IL-15R alpha (I31-S108) & IL-15 (N49-S162) fusion protein with a C-Terminal His tag, which is produced in HEK293 cells.

HY-P78468

	IL-15R alpha Protein, Human (HEK293, His-Avi) IL-15 R alpha; CD215; IL-15RA; MGC104179	Human	HEK293
	IL-15R alpha is a high affinity receptor for IL-15 (K_d: 100 pM). IL-15R alpha binds IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha plays an important role in memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha Protein, Human (HEK293, His-Avi) is a recombinant human extracellular region of IL-15R alpha (I31-T205) with a C-Terminal His-Avi tag, which is produced in HEK293 cells.

HY-P71978

	IL-15R alpha Protein, Mouse (HEK293, hFc) IL15ra; Interleukin-15 receptor subunit alpha; IL-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; CD antigen CD215; Soluble interleukin-15 receptor subunit alpha; sIL-15 receptor subunit alpha; sIL-15R-alpha; sIL-15RA;	Mouse	HEK293
	IL-15R alpha is a high affinity receptor for IL-15 (K_d: 100 pM). IL-15R alpha binds IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha plays an important role in memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha Protein, Mouse (HEK293, hFc) is a recombinant mouse extracellular region of IL-15R alpha (G33-K205) with a C-Terminal hFc tag, which is produced in HEK293 cells.

HY-P72592

	IL-15R alpha Protein, Human (142a.a, HEK293, Fc) Interleukin-15 receptor subunit alpha; IL-15R-alpha; IL-15RA; CD215; sIL-15R-alpha; sIL-15RA	Human	HEK293
	IL-15R alpha is a high affinity receptor for IL-15 (K_d: 100 pM). IL-15R alpha binds IL-15 and thereby activating the antitumor functions of NK cells and CD8+ T cells. IL-15R alpha plays an important role in memory CD8+ T cell homeostasis and lymphocyte development. IL-15R alpha Protein, Human (142a.a, HEK293, Fc) is a recombinant human extracellular region of IL-15R alpha (I31-T172) with a C-Terminal Fc tag, which is produced in HEK293 cells.

HY-P70776G

	*GMP IL-15* Protein, Human** Interleukin-15; IL-15; IL15	Human	E. coli
	IL-15 protein regulates immune cells, stimulates the proliferation of NK cells, T cells, and B cells, and promotes cytokine secretion. GMP IL-15 Protein, Human is the recombinant human-derived IL-15 protein, expressed by E. coli , with tag free.

HY-P7371AF

	*Animal-Free IL-15* Protein, Human (His)** Interleukin-15; IL-15; IL15	Human	E. coli
	IL-15 protein regulates immune cells, stimulates the proliferation of NK cells, T cells, and B cells, and promotes cytokine secretion. Animal-Free IL-15 Protein, Human (His) is the recombinant human-derived animal-FreeIL-15 protein, expressed by E. coli , with N-His, N-His labeled tag.

HY-P700193AF

	*Animal-Free IL-15* Protein, Mouse (His)** Interleukin-15; IL-15; IL15	Mouse	E. coli
	The IL-15 protein is a cytokine that crucially shapes inflammatory and protective immune responses by regulating innate and adaptive immune cells. It stimulates the proliferation and activation of natural killer cells, T cells and B cells, and promotes the secretion of cytokines. Animal-Free IL-15 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-15 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free IL-15 Protein, Mouse (His) is 114 a.a., with molecular weight of ~14.06 kDa.

HY-P700245AF

	*Animal-Free IL-15* Protein, Pig (His)** Interleukin-15; IL-15; IL15	Pig	E. coli
	The IL-15 protein is a key cytokine that promotes inflammatory and protective immune responses against invaders by regulating immune cells in the innate and adaptive systems. It stimulates natural killer cells, T cells and B cells, and promotes the secretion of various cytokines. Animal-Free IL-15 Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-15 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free IL-15 Protein, Pig (His) is 114 a.a., with molecular weight of ~14.1 kDa.

HY-P701298

	*FITC-Labeled IL-15R alpha Protein, Human (HEK293, Fc)* IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha	Human	HEK293
	IL-15R alpha Protein, a proven high-affinity receptor for interleukin-15, signals in both cis and trans. In neutrophils, it activates SYK kinase, crucial for IL-15-induced phagocytosis in a SYK-dependent manner. Different isoforms may introduce variations in signal transduction. Notably, IL-15R alpha Protein, while having high affinity, does not directly bind to IL15. FITC-Labeled IL-15R alpha Protein, Human (HEK293, Fc) is the recombinant human-derived FITC-Labeled IL-15R alpha protein, expressed by HEK293 , with Fc labeled tag.

HY-P701299

	*PE-Labeled IL-15R alpha Protein, Human (HEK293, Fc)* IL-15 R alpha; CD215; IL15RA; IL-15RA; IL-15R-alpha	Human	HEK293
	IL-15R alpha Protein, a proven high-affinity receptor for interleukin-15, signals in both cis and trans. In neutrophils, it activates SYK kinase, crucial for IL-15-induced phagocytosis in a SYK-dependent manner. Different isoforms may introduce variations in signal transduction. Notably, IL-15R alpha Protein, while having high affinity, does not directly bind to IL15. PE-Labeled IL-15R alpha Protein, Human (HEK293, Fc) is the recombinant human-derived PE-Labeled IL-15R alpha protein, expressed by HEK293 , with Fc labeled tag.

HY-P77883

	IL-2R beta/CD122 Protein, Cynomolgus (HEK293, His) CD122; IL-15 R beta; IL-2 R beta; IL-2R subunit beta; IL2RB; P70-75; p75; RP5-1170K4.6	Cynomolgus	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Cynomolgus (HEK293, His) is a recombinant cynomolgus IL-2R beta (A27-D239) with a C-Terminal His tag, which is produced in HEK 293.

HY-P77594

	IL-2R beta/CD122 Protein, Human (HEK293, His-Avi) CD122; IL-15 R beta; IL-2 R beta; IL-2R subunit beta; IL2RB; P70-75; p75; RP5-1170K4.6	Human	HEK293
	IL-2R beta (CD122), a type Ⅰ cytokine receptor expressed on T lymphocytes, is a receptor for IL-2 (K_d: 1 nM approximately). IL-2R beta mediates T cell immune responses, such as stimulating T cell proliferation and activating lymphokine-activated killer cells. IL-2R beta/CD122 Protein, Human (HEK293, His-Avi) is a recombinant human extracellular region of IL-2R beta (A27-D239) with a C-Terminal His-Avi tag, which is produced in HEK293 cells.

HY-P77715

	IL-2R beta & IL-2R gamma Heterodimer Protein, Human (HEK293, Fc) IL-2RB&IL-2RG; IL-2RG; IL-2R subunit gamma; IL-2R subunit beta; IL-2RB; IL15RB; IL-2 R beta&IL-2 R gamma	Human	HEK293
	IL-2R beta (CD122) and IL-2Rγ (CD132), type Ⅰ cytokine receptors expressed on T lymphocytes, are receptors for IL-2 (K_d: 1 nM for IL-2R beta approximately). IL-2R beta mediates T cell immune responses. IL-2Rγ mediates inflammatory response IL-2Rβ and IL-2Rγ heterodimer binds to IL-2 with intermediate affinity. IL-2R beta & IL-2R gamma Heterodimer Protein, Human (HEK293, Fc) is a recombinant human IL-2R beta (A27-D239) and IL-2R gamma (L23-A262) heterodimer complex, with a C-Terminal hFc tag, which is produced in HEK293 cells.

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HY-153050

JAK-IN-24		Alkynes
JAK-IN-24 is a JAK inhibitor, with IC₅₀s of 0.534 and 24 nM at the presence of 4 μM or 1mM ATP, respectively. JAK-IN-24 also inhibits PBMC IL-15 induced STAT5 phosphorylation with an IC₅₀ of 86.171 nM . JAK-IN-24 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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