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Results for "

LTA

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (15) Autophagy (1) Bacterial (6) Calcium Channel (1) Cathepsin (1) Endogenous Metabolite (1) HDAC (2) Leukotriene Receptor (2) NO Synthase (1) p38 MAPK (1) Raf (1) Small Interfering RNA (siRNA) (4)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (5) Inflammation/Immunology (21) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (4) siRNAs (4)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-137298

LYS006 LTA4H-IN-1	Aminopeptidase	Inflammation/Immunology
LTA4H-IN-1 is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC₅₀ of 2 nM. LTA4H-IN-1 can be used for the research of inflammatory and autoimmune disorders .

HY-161349

LTA4H-IN-4	Aminopeptidase	Inflammation/Immunology
LTA4H-IN-4 (compound 3) is an orally active *LTA4H* inhibitor. The IC₅₀ value of LTA4H-IN-4 for hERG is 156 μM. LTA4H-IN-4 can be used in inflammation related studies .

HY-160646

LTA4H-IN-3	Aminopeptidase	Inflammation/Immunology
LTA4H-IN-3 (compound 9) is a *LTA4H* inhibitor with the IC₅₀ of 28 nM .

HY-162710

LTA4H-IN-5	Aminopeptidase	Inflammation/Immunology
LTA4H-IN-5 (Compound H122) is an orally active inhibitor for leukotriene A4 hydrolase (LTA4H), that inhibits the LTA4H aminopeptidase and LTA4H hydrolase with IC₅₀ of 0.38 nM and 16.93 nM. LTA4H-IN-5 exhibits good pharmacokinetic characteristics in C57 mice and ameliorates the DNBS-induced ulcerative enteritis in rat models .

HY-162015

LTA4H-IN-2	Aminopeptidase	Inflammation/Immunology
LTA4H-IN-2 (compound (S)-2 ) is an orally active inhibitor of Leukotriene A4 Hydrolase, with an IC₅₀ of <3 nM .

HY-112621

Leukotriene A4 methyl ester LTA4 methyl ester	Others	Inflammation/Immunology
Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively.2 LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells.3 Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis.2 LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

HY-156416

LtaS-IN-2	Bacterial	Infection
LtaS-IN-2 (compound 13) is a inhibitor of LTA synthesis, and shows antibacterial activity against S. aureus and S. epidermidis, with the MIC₉₀ of 0.5 μg/mL and 1 μg/mL, respectively. LtaS-IN-2 is a derivative of LtaS-IN-1 (HY-135813) .

HY-RS07868

LTA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LTA Human Pre-designed siRNA Set A contains three designed siRNAs for LTA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LTA Human Pre-designed siRNA Set A LTA Human Pre-designed siRNA Set A

HY-RS07869

Lta Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lta Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lta gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lta Mouse Pre-designed siRNA Set A Lta Mouse Pre-designed siRNA Set A

HY-RS07870

LTA Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LTA Rat Pre-designed siRNA Set A contains three designed siRNAs for LTA gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

LTA Rat Pre-designed siRNA Set A LTA Rat Pre-designed siRNA Set A

HY-RS07871

LTA4H Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LTA4H Human Pre-designed siRNA Set A contains three designed siRNAs for LTA4H gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LTA4H Human Pre-designed siRNA Set A LTA4H Human Pre-designed siRNA Set A

HY-135813

LtaS-IN-1 1 Publications Verification	Bacterial	Infection
LtaS-IN-1 (compound 1771) is a potent small-molecule inhibitor of *Lipoteichoic acid (LTA) synthesis* in multidrug-resistant (MDR) E. faecium and by altering the cell wall morphology. LtaS-IN-1 alone inhibits Enterococcus.spp 28 strains with varying MIC values ranging from 0.5 μg/mL to 64 μg/mL. LtaS-IN-1 combination with antibiotics abolishs multidrug-resistant E. faecium growth almost completely .

HY-163336

14,15-Leukotriene A4 methyl ester 14,15-LTA4 methyl ester	Others	Inflammation/Immunology
14,15-Leukotriene A4 methyl ester (14,15-LTA4 methyl ester) is the methyl esterified form of Leukotriene A4, which can be used for the study of biological effects of leukotrienes .

HY-129461

Dibenzyl trisulfide DTS	Cathepsin	Cancer
Dibenzyl trisulfide (DTS) is an active ingredient that can be isolated from Petiveria alliacea L.. Dibenzyl trisulfide inhibits cell proliferation and migration. Dibenzyl trisulfide decreased the mRNA and protein expression of BAK-1 and LTA. Dibenzyl trisulfide induces lysosomal membrane permeabilization and cathepsin B release .

HY-130441

Leukotriene B3	Others	Inflammation/Immunology
Leukotriene B3 is a LTA hydrolase metabolite of LTA3 in the leukotriene biosynthesis pathway. Leukotriene B3 has proinflammatory activity .

HY-103226

SC-57461A 1 Publications Verification	Aminopeptidase	Inflammation/Immunology
SC-57461A is a potent, orally active, nonpeptide, and selective inhibitor of *Leukotriene A4 (LTA4) hydrolase* with IC₅₀s of 2.5 nM, 3 nM, and 23 nM for recombinant human, mouse, and rat LTA4 hydrolase, respectively .

HY-W004291

Methyl arachidate Methyl icosanoate	Aminopeptidase	Inflammation/Immunology
Methyl arachidate (Methyl eicosanoate), a natural compound, is a leukotriene A4 hydrolase (LTA4H) inhibitor .

HY-118795

SC-22716	Aminopeptidase	Inflammation/Immunology
SC-22716 is a potent, competitive, reversible inhibitor of *human LTA₄* hydrolase, with an IC₅₀** of 0.20 µM. SC-22716 has potential for the research of inflammatory bowel disease (IBD) and psoriasis .

HY-N8760

Batatasin IV	Aminopeptidase	Inflammation/Immunology
Batatasin IV is an *LTA4H* inhibitor with anti-inflammatory activity. Batatasin IV is also a natural product that can be obtained from Dioscorea batatus. Batatasin IV can be used in research in the area of inflammation .

HY-W004291R

Methyl arachidate (Standard) Methyl icosanoate (Standard)	Aminopeptidase	Inflammation/Immunology
Methyl arachidate (Standard) is the analytical standard of Methyl arachidate. This product is intended for research and analytical applications. Methyl arachidate (Methyl eicosanoate), a natural compound, is a leukotriene A4 hydrolase (LTA4H) inhibitor .

HY-125770

5(S)-HPETE 1 Publications Verification	Endogenous Metabolite	Inflammation/Immunology
5(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 5-LO on arachidonic acid. 5(S)-HpETE is metabolized to leukotriene A4 (LTA4), a key intermediate in the formation of LTs.

HY-B0494

Bufexamac 1 Publications Verification Bufexamic acid	HDAC Aminopeptidase	Inflammation/Immunology Cancer
Bufexamac is a selective Ⅱb HDAC (HDAC6, HDAC10) and *LTA4H* dual inhibitor, with K_ds of 0.53 µM and 0.22 µM for HDAC6 and HDAC10. Bufexamac is a nonsteroida anti-inflammatory drug .

HY-156960

JNJ-40929837	Aminopeptidase Leukotriene Receptor	Inflammation/Immunology
JNJ-40929837 is a selective and orally active *LTA₄H* (leukotriene A₄ hydrolase) inhibitor. JNJ-40929837 effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 can be used in asthma research .

HY-156960A

JNJ-40929837 succinate	Aminopeptidase Leukotriene Receptor	Inflammation/Immunology
JNJ-40929837 succinate is a selective and orally active *LTA₄H* (leukotriene A₄ hydrolase) inhibitor. JNJ-40929837 succinate effectively inhibits aminopeptidase activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 succinate can be used in asthma research .

HY-10826

DG051 free acid	Aminopeptidase	Cardiovascular Disease Neurological Disease
DG051 (free acid) is an effective inhibitor of leukotriene A4 hydrolase (LTA4H), with a K_d of 26 nM. It has high water solubility (greater than 30 mg/mL) and high oral bioavailability (over 80% across different species). DG051 (free acid) can be used in research related to myocardial infarction and stroke .

HY-P99309

Pagibaximab BSYX-A 110; Anti-S. Epidermidis LTA Recombinant Antibody	Bacterial	Infection
Pagibaximab is a chimeric IgG1 antibody recognizing the surface component lipoteichoic acid of S. aureus and S. epidermidis. Pagibaximab can be used to prevent staphylococcal sepsis .

HY-B0494R

Bufexamac (Standard)	HDAC Aminopeptidase	Inflammation/Immunology Cancer
Bufexamac (Standard) is the analytical standard of Bufexamac. This product is intended for research and analytical applications. Bufexamac is a selective Ⅱb HDAC (HDAC6, HDAC10) and LTA4H dual inhibitor, with Kds of 0.53 μM and 0.22 μM for HDAC6 and HDAC10. Bufexamac is a nonsteroida anti-inflammatory drug .

HY-164051

1650-M15	Bacterial	Infection
1650-M15 is an inhibitor of lipoteichoic acid synthase (LtaS). It has inhibitory activity against Gram-positive bacteria but has no significant inhibitory effect against Gram-negative bacteria. The IC₅₀s of 1650-M15 against MRSA and MSSA are 62.44 μM and 66.42 μM, respectively, and the MICs are both 200 μM .

HY-W074890

Palmitoylglycine N-palmitoyl glycine	Calcium Channel NO Synthase	Neurological Disease Inflammation/Immunology
Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA .

HY-146811

HSGN-94	Bacterial	Inflammation/Immunology
HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model .

HY-10320A

Doramapimod hydrochloride BIRB 796 hydrochloride	Autophagy Raf p38 MAPK	Inflammation/Immunology
Doramapimod hydrochloride (BIRB 796 hydrochloride) is an anti-inflammatory compound with biological activity through inhibition of p38 MAPK. Doramapimod hydrochloride can significantly inhibit the activities of TNF-α and IL-1β induced by LPS, LTA and PGN. Doramapimod hydrochloride showed a stronger inhibitory effect on inflammation induced by all three bacterial toxins, which was more significant compared with the effects of other compounds. Doramapimod hydrochloride can be used in the research of autoimmune diseases .

HY-149801A

Antibacterial agent 140 chloride	Bacterial	Infection
Antibacterial agent 140 chloride is a promising antibacterial agent. Antibacterial agent 140 chloride is also the first Ru-based AIEgen photosensitizer for simultaneous dual applications of Gram-positive bacteria (G+) detection and treatment. Antibacterial agent 140 chloride uniquely selective discriminates and efficient exterminates Gram-positive bacteria (G+) from other bacteria due to its interaction with lipoteichoic acids (LTA). Antibacterial agent 140 chloride also possessed robust antibacterial activity for G+ under light irradiation .

Cat. No.	Product Name	Target	Research Area

HY-P99309

Pagibaximab BSYX-A 110; Anti-S. Epidermidis LTA Recombinant Antibody	Bacterial	Infection
Pagibaximab is a chimeric IgG1 antibody recognizing the surface component lipoteichoic acid of S. aureus and S. epidermidis. Pagibaximab can be used to prevent staphylococcal sepsis .

Methyl arachidate Methyl icosanoate	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Aminopeptidase
Methyl arachidate (Methyl eicosanoate), a natural compound, is a leukotriene A4 hydrolase (LTA4H) inhibitor .

5(S)-HPETE 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
5(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of 5-LO on arachidonic acid. 5(S)-HpETE is metabolized to leukotriene A4 (LTA4), a key intermediate in the formation of LTs.

Palmitoylglycine N-palmitoyl glycine	Human Gut Microbiota Metabolites Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Calcium Channel NO Synthase
Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA .

Dibenzyl trisulfide DTS	Structural Classification Natural Products Petiveriaceae Source classification Plants Petiveria alliacea	Cathepsin
Dibenzyl trisulfide (DTS) is an active ingredient that can be isolated from Petiveria alliacea L.. Dibenzyl trisulfide inhibits cell proliferation and migration. Dibenzyl trisulfide decreased the mRNA and protein expression of BAK-1 and LTA. Dibenzyl trisulfide induces lysosomal membrane permeabilization and cathepsin B release .

Leukotriene B3	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Others
Leukotriene B3 is a LTA hydrolase metabolite of LTA3 in the leukotriene biosynthesis pathway. Leukotriene B3 has proinflammatory activity .

Batatasin IV	Structural Classification Leguminosae Source classification Phenols Polyphenols Plants Bauhinia purpurea L.	Aminopeptidase
Batatasin IV is an *LTA4H* inhibitor with anti-inflammatory activity. Batatasin IV is also a natural product that can be obtained from Dioscorea batatus. Batatasin IV can be used in research in the area of inflammation .

Methyl arachidate (Standard) Methyl icosanoate (Standard)	Structural Classification Natural Products other families Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Aminopeptidase
Methyl arachidate (Standard) is the analytical standard of Methyl arachidate. This product is intended for research and analytical applications. Methyl arachidate (Methyl eicosanoate), a natural compound, is a leukotriene A4 hydrolase (LTA4H) inhibitor .

Species:	Human (6) Mouse (1)
Tag:	His (6) Tag Free (1) Avi (1)
Source:	HEK293 (3) Sf9 insect cells (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P70277

	*Leukotriene A4 Hydrolase/LTA4H Protein, Human (HEK293, His)* rHuLeukotriene A-4 hydrolase/LTA4H, His; Leukotriene A-4 hydrolase; LTA-4 hydrolase; Leukotriene A(4) hydrolase; LTA4; LTA4H	Human	HEK293
	The leukotriene A4 hydrolase/LTA4H protein is a bifunctional zinc metalloenzyme that functions as an epoxide hydrolase to convert LTA4 to the proinflammatory mediator LTB4 and exhibits aminopeptidase activity targeting the N-terminal arginine. In addition to its pro-inflammatory effects, LTA4H also combats inflammation by inactivating the neutrophil attractant Pro-Gly-Pro. Leukotriene A4 Hydrolase/LTA4H Protein, Human (HEK293, His) is the recombinant human-derived Leukotriene A4 Hydrolase/LTA4H protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P7304

	TNF-beta/TNFSF1 Protein, Human rHuTNF-β; TNF-β; TNFSF1; Lymphotoxin-alpha	Human	E. coli
	TNF-β (tumor necrosis factor β) also called lymphotoxin-α (LT-α), a member of the tumor necrosis factor superfamily, is a cytokine produced by lymphocytes. TNF-β activates the NF-κB signaling pathway, inducing cancer cell proliferation, invasion. TNF-β up-regulates genes connected with metastasis, promotes epithelial-to-mesenchymal-transition, stimulates its own expression. TNF-β mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. TNF-beta/TNFSF1 Protein, Human is a recombinant protein consisting of 158 amino acids (L35-L205) and is produced in E. coli.

HY-P700154AF

	Animal-Free TNF-beta/TNFSF1 Protein, Human (His) Lymphotoxin-Alpha; LT-Alpha; TNF-beta; Tumor Necrosis Factor Ligand Superfamily Member 1; LTA; TNFB; TNFSF1	Human	E. coli
	TNF-β protein acts as a homotrimeric cytokine that binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR, and TNFRSF14/HVEM. Animal-Free TNF-beta/TNFSF1 Protein, Human (His) is the recombinant human-derived animal-FreeTNF-beta/TNFSF1 protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free TNF-beta/TNFSF1 Protein, Human (His) is 171 a.a., with molecular weight of ~18.65 kDa.

HY-P700419

	TNF-beta/TNFSF1 Protein, Human (HEK293, His) LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; TNF-beta; LT-alpha	Human	HEK293
	TNF-β protein acts as a homotrimeric cytokine that binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR, and TNFRSF14/HVEM. TNF-beta/TNFSF1 Protein, Human (HEK293, His) is the recombinant human-derived TNF-beta/TNFSF1 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of TNF-beta/TNFSF1 Protein, Human (HEK293, His) is 171 a.a., with molecular weight of 20.8 kDa.

HY-P73275

	*Leukotriene A4 Hydrolase/LTA4H Protein, Human (sf9, His)* Leukemia inhibitory factor; Leukotriene A-4 hydrolase; LTA-4 hydrolase; LTA4H	Human	Sf9 insect cells
	The leukotriene A4 hydrolase/LTA4H protein is a bifunctional zinc metalloenzyme that functions as an epoxide hydrolase to convert LTA4 to the proinflammatory mediator LTB4 and exhibits aminopeptidase activity targeting the N-terminal arginine. In addition to its pro-inflammatory effects, LTA4H also combats inflammation by inactivating the neutrophil attractant Pro-Gly-Pro. Leukotriene A4 Hydrolase/LTA4H Protein, Human (sf9, His) is the recombinant human-derived Leukotriene A4 Hydrolase/LTA4H protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P74776

	*Leukotriene A4 Hydrolase/LTA4H Protein, Mouse (sf9, His)* Leukemia inhibitory factor; Leukotriene A-4 hydrolase; LTA-4 hydrolase; LTA4H	Mouse	Sf9 insect cells
	The LTA4H protein is a bifunctional zinc metalloenzyme that acts as an epoxide hydrolase to convert leukotriene A4 (LTA4) into proinflammatory leukotriene B4 (LTB4).It also acts as an aminopeptidase, cleaving N-terminal arginine and fighting inflammation, particularly through Pro-Gly-Pro (PGP) cleavage.Leukotriene A4 Hydrolase/LTA4H Protein, Mouse (sf9, His) is the recombinant mouse-derived Leukotriene A4 Hydrolase/LTA4H protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P700612

	TNF-beta/TNFSF1 Protein, Human (HEK293, His-Avi) LTA; lymphotoxin alpha (TNF superfamily, member 1); LT; TNFB; TNFSF1; lymphotoxin alpha; OTTHUMP00000165897; tumor necrosis factor beta; Tumor necrosis factor ligand superfamily member 1; TNF-beta; LT-alpha	Human	HEK293
	TNF-β protein acts as a homotrimeric cytokine that binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR, and TNFRSF14/HVEM. TNF-beta/TNFSF1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived TNF-beta/TNFSF1 protein, expressed by HEK293 , with N-Avi, N-6*His labeled tag. The total length of TNF-beta/TNFSF1 Protein, Human (HEK293, His-Avi) is 171 a.a., with molecular weight of 22.7 kDa.

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HY-P82655

	Leukotriene A4 Hydrolase Antibody (YA2400) LTA4; LTA4 hydrolase; LTA4H	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Leukotriene A4 Hydrolase Antibody (YA2400) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2400), targeting Leukotriene A4 Hydrolase, with a predicted molecular weight of 69 kDa (observed band size: 69 kDa). Leukotriene A4 Hydrolase Antibody (YA2400) can be used for WB, IHC-P, ICC/IF, FC experiment in human, mouse, rat background.

HY-P83589

	Lymphotoxin alpha Antibody (YA3334) LTAlpha; DIF; LT alpha; LTA; Lymphotoxin alpha; TNF B; TNF superfamily member 1; TNF-beta; TNFB; TNFbeta; TNFSF1; TNLG1E	WB	Human
	Lymphotoxin alpha Antibody (YA3334) is a biotin-conjugated non-conjugated IgG antibody, targeting Lymphotoxin alpha, with a predicted molecular weight of 22 kDa (observed band size: 18 kDa). Lymphotoxin alpha Antibody (YA3334) can be used for WB experiment in human background.

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