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Results for "

NQO1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (5) Caspase (1) DNA Alkylator/Crosslinker (1) Endogenous Metabolite (1) Keap1-Nrf2 (10) Microtubule/Tubulin (2) Mitochondrial Metabolism (1) NAMPT (1) PDHK (1) Pyroptosis (1) Reactive Oxygen Species (5) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (2) Inflammation/Immunology (8) Metabolic Disease (2) Neurological Disease (2)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114315

NQO1 substrate	Others	Cancer
NQO1 substrate acts as an efficient NQO1 substrate and may be a new option for the treatment of NQO1-overexpresssing drug-resistant NSCLC ^[1].

HY-100367

ES 936	Others	Cancer
ES 936 is a potent and specific *NQO1* inhibitor, effective at concentrations over 1000 times lower than the non-specific inhibitor Dicoumarol (HY-N0645). *NQO1* is generally considered a detoxification enzyme, capable of directly reducing quinones to hydroquinones, which in turn prevents the formation of reactive oxygen species arising from redox cycling. ES 936 can be utilized in cancer research ^[1].

HY-N7335

Dehydroglyasperin C	Others	Neurological Disease Inflammation/Immunology Cancer
Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities ^[1] .

HY-120371

CPUY192018 1 Publications Verification	Others	Inflammation/Immunology
CPUY192018 is a potent *Keap1-Nrf2-ARE* inhibitor with an IC₅₀ of 0.63 µM. CPUY192018 exhibits induction of Nrf2-dependent gene NQO1 at 100 µM ^[1].

HY-RS09523

NQO1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NQO1 Human Pre-designed siRNA Set A contains three designed siRNAs for NQO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NQO1 Human Pre-designed siRNA Set A NQO1 Human Pre-designed siRNA Set A

HY-147795

Nampt-IN-8	NAMPT Apoptosis Reactive Oxygen Species	Cancer
Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC₅₀ of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS ^[1].

HY-N10344

Glucoarabin	Others	Cancer
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity ^[1].

HY-123903

Tanshindiol B	Others	Cancer
Tanshindiol B, a naphthaquinone diterpene, inhibits GBM growth by induction of noptosis (NQO1-dependent necrosis) ^[1].

HY-107736

AI-3	Others	Inflammation/Immunology Cancer
AI-3 is a potent ARE (antioxidant response element) activator. AI-3 increases the NQO1 at the transcript levels and protein expression levels. AI-3 has the potential for the research of oxidative stress related diseases ^[1].

HY-118588

Diminutol	Microtubule/Tubulin	Others
Diminutol is an inhibitor for NADP-dependent quinone oxidoreductase (NQO1), that is involved in microtubule morphogenesis and cell devision ^[1].

HY-146048

Antitumor agent-57	Apoptosis Reactive Oxygen Species	Cancer
Antitumor agent-57 (Compound 3o) is an NQO1-directed antitumor agent. Antitumor agent-57 inhibits tumor cell growth, triggers ROS generation and induces cell apoptosis ^[1].

HY-125027

Isobutyl-deoxynyboquinone IB-DNQ	Others	Cancer
Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer ^[1].

HY-147548

Keap1-Nrf2-IN-10	Others	Others
Keap1-Nrf2-IN-10 (compound 15) is a potent *NQO1* inducer. Keap1-Nrf2-IN-10 inhibits oxidative stress by decreasing the levels of MDA, ROS, NQO1 in the liver for gamma-irradiated mice. Keap1-Nrf2-IN-10 improves the survival of gamma-irradiated mice ^[1].

HY-146114

Antitumor agent-67	Others	Cancer
Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity ^[1].

HY-N0645

Dicoumarol Maximum Cited Publications 8 Publications Verification Dicumarol	PDHK	Cancer
Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and *PDK1* with IC₅₀s of 0.37 and 19.42 μM, respectively.

HY-103667

2-HBA 3 Publications Verification	Caspase	Cancer
2-HBA is a potent inducer of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

HY-150971

ICy-Q	Pyroptosis	Cancer
ICy-Q is a quinone oxidoreductase 1 (NQO-1)-activated near-infrared (NIR) reagent which can react with NQO-1 to release the reduction product ICy-OH. ICy-OH selectively induces pancreatic cancer cell death through the pyroptosis pathway. ICy-Q can be used as an effective tool for rapid and accurate diagnosis of intraoperative pathological sections ^[1].

HY-13543

Tretazicar CB 1954	DNA Alkylator/Crosslinker	Cancer
Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) ^[1] .

HY-108992

Deoxynyboquinone	Apoptosis Reactive Oxygen Species	Cancer
Deoxynyboquinone, an excellent *NQO1* substrate, is a potent antineoplastic agent. Deoxynyboquinone induces apoptosis in cancer cell lines. Deoxynyboquinone kills cancer cells through oxidative stress and reactive oxygen species (ROS) formation ^[1] .

HY-168526

Keap1-Nrf2-IN-24	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-24 (compound 57) is a potent *Keap1-Nrf2* inhibitor with a K_i value of 13 nM. Keap1-Nrf2-IN-24 increases the protein expression of TRXR1 and NQO1. Keap1-Nrf2-IN-24 increases the AKR1B10 mRNA expression. Keap1-Nrf2-IN-24 shows good metabolic stability ^[1].

HY-167694

Antiproliferative agent-62	Others	Cancer
Antiproliferative agent-62 is a functionalized benzylidene-indolin-2-one with notable antiproliferative activity, particularly in inducing NQO1 expression in murine Hepa1c1c7 cells and demonstrating effectiveness against human cancer cell lines, including MCF-7 and HCT116.

HY-146578

Keap1-Nrf2-IN-8	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with IC₅₀s of 64.5 nM and 14.2 nM for FP and TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1 ^[1].

HY-30267

4-Hydroxyphenyl acetate 4-HPA; 4-Acetoxyphenol	Endogenous Metabolite	Others
4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor ^[1].

HY-149021

Tubulin polymerization-IN-28	Microtubule/Tubulin Apoptosis	Cancer
Tubulin polymerization-IN-28 (compound-4) is a microtubule protein polymerization inhibitor with highly selective anticancer activity. Tubulin polymerization-IN-28 can be activated by *NQO1* and effectively release combretastatin A-4 to kill tumor cells. Tubulin polymerization-IN-28 can induce cell apoptosis and be used in anti-cancer research ^[1].

HY-15673

KP372-1 2 Publications Verification	Akt Reactive Oxygen Species Apoptosis	Cancer
KP372-1 is an Akt inhibitor that inhibits proliferation and induces apoptosis and anoikis. KP372-1 is also an *NQO1* redox cycling agent that causes DNA damage (including DNA breakage) by generating ROS. KP372-1 can be used in cancer research (such as head and neck squamous cell carcinoma (HNSCC) and pancreatic cancer) ^[1] .

HY-163772

Fraxinellone analog 1	Keap1-Nrf2	Neurological Disease
Fraxinellone analog 1 (compound 2) is a potent and rapid activator of the Nrf2 mediated antioxidant defense system, which protects against glutamate-mediated excitotoxicity and induces the expression of antioxidant genes Gpx4, *Sod1, and Nqo1*. Fraxinellone analog 1 has neuroprotective effects and regulatory effects against oxidative stress and inflammation, and can be used in the study of neurodegenerative diseases ^[1].

HY-128895

KL1333 1 Publications Verification	Mitochondrial Metabolism	Metabolic Disease
KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures ^[1] .

HY-141439

TBE 31	Keap1-Nrf2	Inflammation/Immunology Cancer
TBE 31 is a potent and orally active *NQO1* inducer with an D_m value of 1.1 nM. TBE 31 also is a potent Nrf2 activator. TBE 31 reacts with cysteines of Keap1, impairing its ability to target nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) for degradation. TBE 31 shows cytoprotective effects ^[1] .

HY-N6802

Tigloylgomisin H	Others	Cancer
Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent ^[1].

HY-149245

Keap1-Nrf2-IN-15	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-15 (Compound 24a) is a potent Keap1-Nrf2 protein-protein interaction inhibitor with IC₅₀s of 77 nM and 2.5 nM in FP assay and TR-FRET assay, respectively ^[1].

HY-162096

Keap1-Nrf2-IN-17	Keap1-Nrf2	Cancer
Keap1-Nrf2-IN-17 (compound 18) is a potent inhibitor of *Keap1-Nrf2* protein-protein interaction ^[1].

HY-146577

Keap1-Nrf2-IN-7	Keap1-Nrf2	Inflammation/Immunology
Keap1-Nrf2-IN-7 (compound 7v) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC₅₀ of 0.45 µM ^[1].

HY-148480

Nrf2 activator-6	Keap1-Nrf2	Cardiovascular Disease
Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator. Nrf2 activator-6 has an IC₅₀ of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4) ^[1].

HY-110258

ML334 5+ Cited Publications LH601A	Keap1-Nrf2	Cancer
ML334 is a potent, cell permeable activator of NRF2 by inhibition of *Keap1-NRF2* protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K_d of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity ^[1] .

HY-122915

Zedoarondiol	Reactive Oxygen Species	Cardiovascular Disease
Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research ^[1] .

HY-121523

MIND4-17	Keap1-Nrf2	Metabolic Disease
MIND4-17 is a potent NRF2 activator that covalently modifies a C151 residue of Keap1. MIND4-17 disrupts Keap1-Nrf2 association, leading to Nrf2 protein stabilization and nuclear translocation. MIND4‐17 exerts potent antioxidant activity ^[1] .

HY-110258B

(R,S,R)-ML334 (R,S,R)-LH601A	Others	Cancer
(R,S,R)-ML334 is the isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of *Keap1-NRF2* protein-protein interaction. ML334 binds to Keap1 Kelch domain with a K_d of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity ^[1] .

Dehydroglyasperin C	Flavonoids Classification of Application Fields Neurological Disease Leguminosae Source classification Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Glycyrrhiza uralensis Fisch. Isoflavones	Others
Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities ^[1] .

Dicoumarol 5+ Cited Publications Dicumarol	Structural Classification Melilotus officinalis (L.) Pall. Classification of Application Fields Leguminosae Source classification Coumarins Phenylpropanoids Plants Disease Research Fields Biological Pesticide Research Cancer Agricultural Research	PDHK
Dicoumarol is an inhibitor of both NAD(P)H:quinone oxidoreductase 1 (NQO1) and *PDK1* with IC₅₀s of 0.37 and 19.42 μM, respectively.

4-Hydroxyphenyl acetate 4-HPA; 4-Acetoxyphenol	Structural Classification Monophenols Classification of Application Fields Source classification Other Diseases Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4-Hydroxyphenyl acetate (4-HPA) is a natural antioxidant and protects cells from oxidative stress-induced necrosis. 4-Hydroxyphenyl acetate blocks the increase of cellular ROS induced by oxidative stress, and up-regulates NQO1 and HO-1 genes by stabilizing and inducing the nuclear translocation of NRF2 transcription factor ^[1].

Zedoarondiol	Terpenoids Sesquiterpenes Source classification Plants Curcuma aromatica Salisb. Zingiberaceae	Reactive Oxygen Species
Zedoarondiol, a sesquiterpene lactone compound, with antioxidant and anti-inflammatory activity. Zedoarondiol can be used for atherosclerosis research ^[1] .

Glucoarabin	Structural Classification Natural Products Classification of Application Fields Source classification Camelina sativa (L.) Crantz Glucosinolates Plants Brassicaceae Disease Research Fields Cancer	Others
Glucoarabin is a bioactive glucosinolate. In Hepa1c1c7 cells, hydrolyzed Glucoarabin (hGSL 9) upregulates the phase II detoxification enzyme quinone reductase (NQO1), with no effect on cytochrome P450 (CYP) 1A1 activity ^[1].

Tanshindiol B	Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Others
Tanshindiol B, a naphthaquinone diterpene, inhibits GBM growth by induction of noptosis (NQO1-dependent necrosis) ^[1].

Tigloylgomisin H	Structural Classification Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer	Others
Tigloylgomisin H is a lignan isolated from the fruits of S. chinensis, can induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a monofunctional inducer that specifically upregulates phase II detoxification enzyme NQO1 through the NF-E2-related factor 2 (Nrf2)-ARE pathway, thus represents a potential liver cancer prevention agent ^[1].

Species:	Human (2) Mouse (1)
Tag:	His (2) Tag Free (1)
Source:	P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P74405A

	*Azoreductase/NQO1* Protein, Human** NQO1; DIA4; NAD(P)H dehydrogenase [quinone] 1; Azoreductase; DTD; QR1	Human	E. coli
	Azo reductase/NQO1 protein is a flavin-containing quinone reductase that uses NADH or NADPH to catalyze the two-electron reduction of quinone to hydroquinone. It regulates cellular redox status by detoxifying quinones and reducing plasma membrane redox components. Azoreductase/NQO1 Protein, Human is the recombinant human-derived Azoreductase/NQO1 protein, expressed by E. coli , with tag free. The total length of Azoreductase/NQO1 Protein, Human is 274 a.a., with molecular weight of ~33 kDa.

HY-P74405

	*Azoreductase/NQO1* Protein, Human (His)** NQO1; DIA4; NAD(P)H dehydrogenase [quinone] 1; Azoreductase; DTD; QR1	Human	E. coli
	Azo reductase/NQO1 protein is a flavin-containing quinone reductase that uses NADH or NADPH to catalyze the two-electron reduction of quinone to hydroquinone. It regulates cellular redox status by detoxifying quinones and reducing plasma membrane redox components. Azoreductase/NQO1 Protein, Human (His) is the recombinant human-derived Azoreductase/NQO1 protein, expressed by E. coli , with N-His labeled tag. The total length of Azoreductase/NQO1 Protein, Human (His) is 274 a.a., with molecular weight of ~33 kDa.

HY-P71831

	*Azoreductase/NQO1* Protein, Mouse (P.pastoris, His)** NQO1; Dia4; Nmo1; Nmor1; NAD(P)H dehydrogenase [quinone] 1; EC 1.6.5.2; Azoreductase; DT-diaphorase; DTD; Phylloquinone reductase; Quinone reductase 1; QR1	Mouse	P. pastoris
	The azoreductase/NQO1 protein reduces quinones to hydroquinone using NADH or NADPH as an electron donor.Azoreductase/NQO1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Azoreductase/NQO1 protein, expressed by P.pastoris , with N-6*His labeled tag.

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HY-P80250

	NQO1 Antibody (YA697)	WB, IHC-P	Human, Rat
	NQO1 Antibody (YA697) is a non-conjugated and Mouse origined monoclonal antibody about 31 kDa, targeting to NQO1. It can be used for WB,IHC-P assays with tag free, in the background of Human, Rat.

HY-P80251

	NQO1 Antibody (YA261)	WB, ICC/IF, IP, FC	Human, Mouse
	NQO1 Antibody (YA261) is a non-conjugated and Rabbit origined monoclonal antibody about 31 kDa, targeting to NQO1. It can be used for WB,ICC/IF,IP,FC assays with tag free, in the background of Human, Mouse.

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