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Native Proteins

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Antibiotic (3) Apolipoprotein (1) Apoptosis (6) Autophagy (1) Bacterial (8) Biochemical Assay Reagents (141) Casein Kinase (1) Caspase (1) CDK (1) Collagen (1) Complement System (8) Discoidin Domain Receptor (1) DNA/RNA Synthesis (1) Endogenous Metabolite (6) Endonuclease (1) Estrogen Receptor/ERR (1) Ferroportin (1) FGFR (1) Fluorescent Dye (118) Fungal (1) Heme Oxygenase (HO) (1) Hippo (MST) (1) HSV (1) Integrin (3) Interleukin Related (1) Isotope-Labeled Compounds (2) LDLR (2) Liposome (1) Mitosis (1) MMP (24) Molecular Glues (1) NF-κB (4) NO Synthase (3) Nucleoside Antimetabolite/Analog (1) PDI (1) Phosphatase (1) Phosphodiesterase (PDE) (1) Reactive Oxygen Species (ROS) (1) Sirtuin (1) SOD (1) Src (2) Toll-like Receptor (TLR) (1) Transferrin Receptor (2)
By Research Areas:	Cancer (35) Cardiovascular Disease (9) Endocrinology (4) Infection (12) Inflammation/Immunology (80) Metabolic Disease (16) Neurological Disease (11)
Oligonucleotides:	Cholesterol (1)

334

Inhibitors & Agonists

Fluorescent Dye

331

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Slit Proteins Synaptic Vesicle Proteins HSP YTHDF

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-NP010

Collagen, rat tail	MMP	Others
Collagen, rat tail is a kind of collagen extracted from rat tail tendon tissue. Collagen, rat tail stimulates cell growth. Collagen, rat tail is often used as an attachment substrate for cell culture .

HY-NP001

Cationic Bovine Serum Albumin 1 Publications Verification CBSA	Biochemical Assay Reagents	Neurological Disease
Cationic Bovine Serum Albumin is a bovine serum albumin (BSA) modified with excess ethylenediamine, which has enhanced immunogenicity compared to native BSA. Positively charged primary amines block all negatively charged carboxyl groups, making Cationic Bovine Serum Albumin a cationic protein. Cationic Bovine Serum Albumin has remarkable neuroprotective effects on ischemic stroke when in combination with Tanshinone IIA (HY-N0135) .

HY-NP020

E.coli DH-5 alpha Bacterial protein E.coli DH-5 alpha protein	Bacterial	Others
E.coli DH-5 alpha Bacterial protein is a purified native protein from E.coli DH-5 alpha bacterial .

HY-NP025

E.coli Bacterial protein EPEC	Bacterial	Infection
E.coli Bacterial protein is a native protein that can be isolated from E.coli .

HY-NP016

Brucella bacterial protein	Bacterial Biochemical Assay Reagents	Others
Brucella bacterial protein is native protein that purified from Brucella for life science related research .

HY-176347S

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2	Isotope-Labeled Compounds	Cancer
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

HY-158882

FLAC6	Biochemical Assay Reagents Adenosine Receptor	Others
FLAC6 is a potent fluorinated detergent that can be used to solubilize membrane proteins (the native adenosine receptor A_2AR, a *G protein-coupled receptor, and two native* transporters AcrB and BmrA). FLAC6 can maintain the structural and functional integrity of different membrane proteins .

HY-P5428

Cdc2 kinase substrate	CDK	Others
Cdc2 kinase substrate is a biological active peptide. (The native peptide HATPPKKKRK is a substrate for cyclin-dependent protein kinase 1 (CDC2; CDK1).)

HY-D0167

NHS-5(6)Carboxyrhodamine	Fluorescent Dye	Others
NHS-5(6)Carboxyrhodamine is a dye used for fluorescence labeling applications, where accurate dye/protein ratios can be obtained under native conditions .

HY-W615327

Bis-sulfone NHS ester	Biochemical Assay Reagents	Others
Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.

HY-W190952

Bis-sulfone-PEG4-NHS ester	Biochemical Assay Reagents	Others
Bis-sulfone-PEG4-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.

HY-W800627

Bis-sulfone-PEG8-NHS ester	Biochemical Assay Reagents	Others
Bis-sulfone-PEG8-NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact. The hydrophilic PEG spacer increases solubility in aqueous media.

HY-P99930

Efruxifermin 1 Publications Verification	FGFR	Metabolic Disease
Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis .

HY-112641

AkaLumine	Fluorescent Dye	Cancer
AkaLumine is a D-luciferin (HY-12591A) analogue with a K_m of 2.06 μM for recombinant firefly luciferase (Fluc) protein. AkaLumine emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc. AkaLumine has high tissue-penetration and increases detection sensitivity from deep-tissue targets .

HY-112641A

AkaLumine hydrochloride 4 Publications Verification	Fluorescent Dye	Cancer
AkaLumine hydrochloride is a D-luciferin (HY-12591A) analogue with a K_m of 2.06 μM for recombinant firefly luciferase (Fluc) protein. AkaLumine hydrochloride emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc. AkaLumine hydrochloride has high tissue-penetration and increases detection sensitivity from deep-tissue targets .

HY-112096

eCF506 4 Publications Verification NXP900	Src	Cancer
eCF506 (NXP900) is a highly potent and orally active YES1/SRC kinase inhibitor with an IC₅₀ of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer .

HY-N10264

Avrainvillamide (+)-Avrainvillamide; CJ-17,665	Antibiotic	Infection Cancer
Avrainvillamide ((+)-Avrainvillamide) is a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Avrainvillamide affects cell biology both by directly binding NPM1 and Crm1 as well as by inhibiting the association of these proteins with certain native cellular partners. Avrainvillamide, an antibiotic, inhibits growth of multi-agent resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 μg/ml, respectively .

HY-P991677

Efmirenpase alfa	Phosphodiesterase (PDE)	Cardiovascular Disease Endocrinology
Efmirenpase alfa is an Fc-ENPP1 fusion protein (human IgG1 Fc domain linked to a modified human ENPP1). Efmirenpase alfa has prolonged half-life and enhanced receptor affinity compared with native human ENPP1. Efmirenpase alfa can be used as an enzyme replacement therapy for ENPP1 deficiency such as arterial calcification and hypophosphatemic rickets research .

HY-W414390

2-Cyclohexylethyl-4-O-(α-D-glucopyranosyl)-β-D-glucopyranoside, 98% 2-Cyclohexylethyl-4-O-(alpha-D-glucopyranosyl)-beta-D-glucopyranoside, 98%	Biochemical Assay Reagents	Others
2-Cyclohexylethyl-4-O-(α-D-glucopyranosyl)-β-D-glucopyranoside, 98% (2-Cyclohexylethyl-4-O-(alpha-D-glucopyranosyl)-beta-D-glucopyranoside, 98%) is a detergent that can be used for the purification and crystallization of membrane-bound proteins in their native structure. It can self-assemble into micelles and vesicles in aqueous solution and can be used for the study of biomembrane models.

HY-42984

BHQ-2 NHS	Biochemical Assay Reagents	Others
BHQ-2 NHS is a dark quencher with no native emission due to the polyaromatic-azo backbone and a terminal NHS ester. UBHQ-2 NHS has a wide and intense quenching range from 560-670 nm, which makes it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with orange to far-red emitting dyes. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

HY-E70565

O-Glycoprotease	Endonuclease	Inflammation/Immunology
O-Glycoprotease is an O-glycoprotein-specific endoprotease that catalyzes the hydrolysis of peptide bonds directly adjacent to the O-polymer in native mucin-type O-glycosylated proteins. O-Glycoprotease sequence is from Akkermansia muciniphila, recombinantly expressed in E.coli, with a 6×His tag at the C-terminus. The enzyme maintains high activity between pH 5.5-7.5 and is resistant to 1M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn ²⁺.

HY-W1005067

EN171	Molecular Glues Hippo (MST) Estrogen Receptor/ERR	Others
EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol .

HY-112096S

eCF506-d5 NXP900-d₅	Src Isotope-Labeled Compounds	Cancer
eCF506-d₅ (NXP900-d₅) is deuterated labeled eCF506 (HY-112096). eCF506 is a highly potent and orally active YES1/SRC kinase inhibitor with an IC₅₀ of 0.47 nM. eCF506 locks its target into its native “closed” conformation, thereby inhibiting both kinase activity and complex formation with protein partners. eCF506 can be used for the study of esophageal squamous cancer and breast cancer .

HY-116748

(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane	PDI Phosphatase
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane is a small-molecule dithiol catalyst with a low thiol pK_a value (8.3) and high reduction potential (-0.24 V), capable of mimicking PDI activity. It catalyzes the activation of scrambled ribonuclease A (scrambled ribonuclease A) and promotes the formation of native disulfide bonds, thereby significantly enhancing protein folding efficiency. Adding (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane to the culture medium of Saccharomyces cerevisiae can increase the secretion of exogenously expressed Schizosaccharomyces pombe acid phosphatase by more than threefold. (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane holds great potential for applications in protein production and secretion research .

HY-NP185

Chicken Tenascin,suitable for cell culture	Biochemical Assay Reagents	Others
Chicken Tenascin,suitable for cell culture 是一种糖蛋白，可形成二硫键连接的六聚体。Chicken Tenascin,suitable for cell culture 由重复的结构域组成，包括 EGF 样重复序列、纤连蛋白 III 型重复序列和与纤维蛋白原同源的区域。Chicken Tenascin,suitable for cell culture 可用于细胞培养。

HY-NP202

C2 Protein (human)	Complement System	Inflammation/Immunology
C2 Protein (human) is a naturally glycosylated peptide with a 20 amino acid signal sequence. Complement component C2 functions as a key regulator in the early activation phase of the classical pathway and participates in the formation of the classical pathway C3 convertase C4b2a .

HY-P3160

Fibronectin 5+ Cited Publications	Integrin	Cardiovascular Disease Inflammation/Immunology
Fibronectin, a glycoprotein present in blood as well as in cells, is a biomarker of tissue injury. Fibronectin binds to membrane-spanning receptor proteins called integrins. Fibronectin also binds to other extracellular matrix proteins such as collagen, fibrin, and heparan sulfate proteoglycans .

HY-NP126

Highly purified Type XI collagen, from porcine articular cartilage Porcine Type XI collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type XI collagen, from porcine articular cartilage (Porcine Type XI collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP058

Ovalbumin-AF594 OVA-AF594	Biochemical Assay Reagents	Others
Ovalbumin-AF594 is a biochemical reagent conjugated to fluorescein AF594 (Ex=590 nm; Em=617 nm). Ovalbumin-AF594 can be used to label or detect specific antigens, molecules or cellular structures .

HY-NP071

Lycopersicon esculentum (Tomato) Lectin LEL	Biochemical Assay Reagents	Others
Lycopersicon esculentum (Tomato) Lectin (LEL) specifically recognizes and binds to sugar structures, that combines with fluorescein for fluorescent labeling and imaging of cells and tissues. Lycopersicon esculentum (Tomato) Lectin is used to visualizes the vasculature within transplanted tissues by labeling with fluorescein .

HY-NP106

Highly purified Type XI collagen, from bovine articular cartilage Bovine Type XI collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type XI collagen, from bovine articular cartilage (Bovine Type XI collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-P2352

Fetuin, Fetal Bovine Serum 4 Publications Verification	Biochemical Assay Reagents	Metabolic Disease
Fetuin, Fetal Bovine Serum is a liver-secreted 64 kDa plasma glycoprotein isolated from fetal bovine serum. Fetuin, Fetal Bovine Serum inhibits trypsin activity and promote cellular attachment, growth, and differentiation .

HY-NP0168

Ulex Europaeus Agglutinin I (Agarose) UEA I (Agarose)	Fluorescent Dye	Others
Ulex Europaeus Agglutinin I (UEA I) Agarose is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ulex Europaeus Agglutinin I (UEA I) Agarose is a biological material or organic compound that can be used in life science research .

HY-NP041

Bovine Serum Albumin-PE BSA-PE	Biochemical Assay Reagents	Others
Bovine Sermu Albumin-PE is a biochemical reagent conjugated to fluorescein PE (Ex=565 nm; Em=578 nm). Bovine Sermu Albumin-PE can be used to label or detect specific antigens, molecules or cellular structures .

HY-NP108

Highly purified type II collagen, from rat sternal cartilage Rat Type II collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified type II collagen, from rat sternal cartilage (Rat Type II collagen, immunization grade) is an immune grade collagen derived from rat sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP127

Highly purified Type I collagen, from canine skin Canine Type I collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type I collagen, from canine skin (Canine Type I collagen, immunization grade) is an immune grade collagen derived from canine skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP0195

Sheep immunoglobulin G Sheep IgG		Inflammation/Immunology
Sheep Immunoglobulin G (Sheep IgG) is a sheep serum immunoglobulin that can be used in immunolabeling and coating protein in a variety of immunoassays including ELISA .

HY-NP078A

Pisum Sativum Agglutinin (FITC) PSA (FITC)	Fluorescent Dye Biochemical Assay Reagents	Others
Pisum Sativum Agglutinin (FITC) (PSA (FITC)) is a tetrameric glycoprotein with a molecular weight of approximately 48 kDa, labeled with FITC (HY-66019). Pisum Sativum Agglutinin (FITC) is specific for alpha-D-glucose (HY-128417) and alpha-D-mannose .

HY-NP055

Ovalbumin-Cy5 OVA-Cy5	Fluorescent Dye	Cancer
Ovalbumin-Cy5 is Cy5-labeled Ovalbumin (OVA) .

HY-W355779

Gliadins Tyrosylprolylglutaminylprolylglutamine	Biochemical Assay Reagents	Inflammation/Immunology
Gliadins (Tyrosylprolylglutaminylprolylglutamine) comprise a family of glutamine- and proline-rich monomeric proteins that plays an role in autoimmune disease, such as celiac disease .

HY-NP0190

Ulex Europaeus Agglutinin I (Biotinylated) UEA I (Biotinylated)	Fluorescent Dye	Others
Ulex Europaeus Agglutinin I (UEA I) Biotinylated is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Ulex Europaeus Agglutinin I (UEA I) Biotinylated is a biological material or organic compound that can be used in life science research .

HY-NP158A

Type II Collagen, T Cell Grade, from Chick	Biochemical Assay Reagents	Others
Type II Collagen, T Cell Grade, from Chick is a T-cell dependent antigen with unique immunological features. Type II Collagen, T Cell Chick, from Bovine can be used as a stimulating antigen for T-cells in in vitro culture systems .

HY-P2232

Conalbumin Ovotransferrin	Fungal	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Conalbumin (Ovotransferrin), also known as ovotransferrin, is a monomeric glycoprotein consisting of 686 amino acids, encoded by the avian transferrin gene in the oviduct, and a prominent component of chicken egg white. Exhibiting a unique glycosylation pattern that differentiates it from serum transferrin, Conalbumin is a potent iron binder that plays a crucial role in iron transport to developing embryos. Additionally, it possesses a range of biological activities, including antimicrobial, antifungal, antiviral, anticancer, antioxidative, antihypertensive, and immunoregulatory properties, making it valuable in numerous applications such as infant formula ingredients, food additives, and agents for enhancing animal health.

HY-NP164

Concanavalin A-HRP Con A-HRP	Fluorescent Dye	Cancer
Concanavalin A-HRP (Con A-HRP) is a HRP-labled Concanavalin A (HY-P2149). Concanavalin A is a Ca ²⁺/Mn ²⁺-dependent and mannose/glucose-binding plant lectin. Concanavalin A binds the N- and O-glycosylated proteins of head and neck carcinoma cells glycoproteins .

HY-P3443

Peanut agglutinin PNA	Fluorescent Dye	Others
Peanut agglutinin (PNA) is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Peanut agglutinin (PNA) is a biological material or organic compound that can be used in life science research .

HY-P3267A

Apo-Bovine Transferrin	Ferroportin Transferrin Receptor	Neurological Disease
Apo-Bovine Transferrin refers to iron free Transferrin (HY-P3267), serves as Transferrin receptor ligand and mediates iron release from endothelial cells. Apo-Transferrin can directly bind to hephaestin, which can convert Fe ²⁺ to Fe ³⁺. Apo-Transferrin mediates iron efflux most likely in cooperation with ferroportin 1. Apo-Bovine Transferrin can be used in neuroretinal research .

HY-NP0152

Wheat Germ Agglutinin (Peroxidase) WGA (Peroxidase)	Fluorescent Dye	Others
Wheat Germ Agglutinin (WGA) Peroxidase is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Wheat Germ Agglutinin (WGA) Peroxidase is a biological material or organic compound that can be used in life science research .

HY-NP166

Fibrinogen from human plasma	Biochemical Assay Reagents	Others
Fibrinogen from human plasma can be used to prepare production factor solutions .

HY-NP113

Highly purified Type II collagen, from chick sternal cartilage Chick Type II collagen, immunization grade	MMP	Inflammation/Immunology
Highly purified Type II collagen, from chick sternal cartilage (Chick Type II collagen, immunization grade) is an immune grade collagen derived from chick sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs .

HY-NP0180

Lens Culinaris Agglutinin (Biotinylated) LCA (Biotinylated)	Fluorescent Dye	Others
Lens Culinaris Agglutinin (LCA) Biotinylated is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.).Lens Culinaris Agglutinin (LCA) Biotinylated is a biological material or organic compound that can be used in life science research .

Cat. No.	Product Name	Type

HY-112641A

AkaLumine hydrochloride 4 Publications Verification	Chromogenic Substrates
AkaLumine hydrochloride is a D-luciferin (HY-12591A) analogue with a K_m of 2.06 μM for recombinant firefly luciferase (Fluc) protein. AkaLumine hydrochloride emits near-infrared (NIR) light (λmax=677 nm) in reactions with native Fluc. AkaLumine hydrochloride has high tissue-penetration and increases detection sensitivity from deep-tissue targets .

HY-42984

BHQ-2 NHS

Fluorescent Dyes/Probes

BHQ-2 NHS is a dark quencher with no native emission due to the polyaromatic-azo backbone and a terminal NHS ester. UBHQ-2 NHS has a wide and intense quenching range from 560-670 nm, which makes it useful as an acceptor in fluorescence resonance energy transfer (FRET) applications in conjunction with orange to far-red emitting dyes. The NHS ester can be applied to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.