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Results for "

ROCK2 inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (6) Calcium Channel (6) HIV (4) JNK (1) LIM Kinase (LIMK) (2) MMP (1) PKA (9) PKC (9) ROCK (52) SGK (2) STAT (1)
By Research Areas:	Cancer (21) Cardiovascular Disease (15) Endocrinology (2) Inflammation/Immunology (14) Metabolic Disease (2) Neurological Disease (10)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15687

SAR407899 hydrochloride 2 Publications Verification	ROCK	Metabolic Disease
SAR407899 hydrochloride is a selective, potent and ATP-competitive *ROCK* inhibitor, with an IC₅₀ of 135 nM for *ROCK-2, and K_is of 36 nM and 41 nM for human and rat ROCK-2*, respectively.

HY-156592A

ROCK2-IN-6 hydrochloride	ROCK	Inflammation/Immunology
ROCK2-IN-6 hydrochloride (Comp A) is a selective ROCK2 inhibitor, can be used for ROCK mediated diseases, autoimmune diseases and inflammation research .

HY-149266

THK01	ROCK	Cancer
THK01 is a potent *ROCK2* inhibitor with IC₅₀ values of 5.7 and 923 nM for ROCK2 and ROCK1, respectively. THK01 inhibits breast cancer metastasis through the ROCK2-STAT3 signaling pathway. THK01 can be used in research of breast cancer .

HY-103620

ROCK2-IN-2	ROCK	Inflammation/Immunology
ROCK2-IN-2 is a selective *ROCK2* inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC₅₀ of <1 μM.

HY-15687A

SAR407899 2 Publications Verification	ROCK	Metabolic Disease
SAR407899 is a selective, potent and ATP-competitive *ROCK* inhibitor, with an IC₅₀ of 135 nM for *ROCK-2, and K_is of 36 nM and 41 nM for human and rat ROCK-2*, respectively. SAR407899 shows stable inhibition of migrasome formation.

HY-149700

ROCK2-IN-7	ROCK MMP STAT	Others
ROCK2-IN-7 is a kinase inhibitor targeting to *ROCK2. ROCK2-IN-7 inhibits* ROCK2/pSTAT3 Signaling. ROCK2-IN-7 suppresses systemic immunity activation and attenuates inflammation in psoriasis model .

HY-162798

ROCK2-IN-9	ROCK	Cancer
ROCK2-IN-9 (compound 7u) is a selective *ROCK2* inhibitor (IC₅₀=36.8 nM) with anticancer activity. ROCK2-IN-9 inhibits cancer cell migration and invasion by regulating multiple cellular activities of the actin cytoskeleton. ROCK2-IN-9 can be used in breast cancer research .

HY-116420

ROCK2-IN-8	ROCK	Neurological Disease
ROCK2-IN-8 (Compound 1) is an orally active *ROCK2* inhibitor, with an IC₅₀ of 7.2 nM. ROCK2-IN-8 can be used for the research of aqueous humor outflow in porcine eyes and myosin light chain phosphorylation .

HY-156592

ROCK2-IN-6	ROCK	Inflammation/Immunology
ROCK2-IN-6 (Comp A) is a selective ROCK2 inhibitor, can be used for ROCK mediated diseases, autoimmune diseases and inflammation research .

HY-145294

ROCK2-IN-5	ROCK	Neurological Disease
ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation .

HY-15307

Belumosudil 20+ Cited Publications KD025; SLx-2119	ROCK	Inflammation/Immunology Cancer
Belumosudil (KD025) is a selective inhibitor of *ROCK2* with IC₅₀s of 105 nM and 24 μM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties .

HY-15307A

Belumosudil mesylate 20+ Cited Publications KD025 mesylate; SLx-2119 mesylate	ROCK	Inflammation/Immunology
Belumosudil mesylate (KD025 mesylate) is a selective inhibitor of *ROCK2* with IC₅₀s of 105 nM and 24 µM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties .

HY-U00351

ROCK-IN-1 1 Publications Verification	ROCK	Cardiovascular Disease Inflammation/Immunology
ROCK-IN-1 is a potent inhibitor of *ROCK, with an IC₅₀* of 1.2 nM for ROCK2.

HY-15720A

H-1152 dihydrochloride 2 Publications Verification	ROCK	Neurological Disease
H-1152 dihydrochloride is a membrane-permeable and selective *ROCK* inhibitor, with a K_i value of 1.6 nM, and an IC₅₀ value of 12 nM for *ROCK2*.

HY-13911

Hydroxyfasudil 3 Publications Verification HA-1100	ROCK	Cardiovascular Disease Inflammation/Immunology Cancer
Hydroxyfasudil is a *ROCK* inhibitor, with IC₅₀s of 0.73 and 0.72 μM for *ROCK1* and *ROCK2*, respectively.

HY-13911A

Hydroxyfasudil hydrochloride 3 Publications Verification HA-1100 hydrochloride; HA 1100 hydrochloride; HA1100 hydrochloride	ROCK	Cardiovascular Disease Inflammation/Immunology Cancer
Hydroxyfasudil hydrochloride is a *ROCK* inhibitor, with IC₅₀s of 0.73 and 0.72 μM for *ROCK1* and *ROCK2*, respectively.

HY-15720

H-1152 2 Publications Verification	ROCK	Neurological Disease
H-1152 is a membrane-permeable and selective *ROCK* inhibitor, with a K_i value of 1.6 nM, and an IC₅₀ value of 12 nM for *ROCK2*.

HY-15685

Ripasudil 5+ Cited Publications K-115	ROCK	Cardiovascular Disease Neurological Disease
Ripasudil (K-115) is a specific inhibitor of *ROCK, with IC₅₀s of 19 and 51 nM for ROCK2* and *ROCK1*, respectively.

HY-15755

RKI-1447 3 Publications Verification	ROCK	Cancer
RKI-1447 is a potent small molecule inhibitor of *ROCK1* and *ROCK2* with IC₅₀ values of 14.5 nM and 6.2 nM, respectively.

HY-10319

BAY-549 2 Publications Verification ROCK-IN-2; Azaindole 1; TC-S 7001	ROCK	Cardiovascular Disease
BAY-549 (Azaindole 1) is an orally active and ATP-competitive *ROCK* inhibitor with IC₅₀s of 0.6 and 1.1 nM for human *ROCK-1* and *ROCK-2*, respectively .

HY-15685A

Ripasudil free base K-115 free base	ROCK	Neurological Disease
Ripasudil free base (K-115 free base) is a specific inhibitor of *ROCK, with IC₅₀s of 19 and 51 nM for ROCK2* and *ROCK1*, respectively.

HY-113641

ROCK-IN-32	ROCK	Cardiovascular Disease Inflammation/Immunology Cancer
ROCK-IN-32 is a *ROCK* inhibitor, with an IC₅₀ value of 11 nM for *ROCK2. ROCK*-IN-32 can be used in research of cardiovascular disease, cancer and inflammation .

HY-12437

BDP5290	ROCK	Cancer
BDP5290 is a potent inhibitor of both *ROCK* and MRCK with IC₅₀s of 5 nM, 50 nM, 10 nM and 100 nM for *ROCK1, ROCK2, MRCKα* and MRCKβ, respectively.

HY-162596

NRL-1049 BA-1049	ROCK	Neurological Disease
NRL-1049 (BA-1049) is a *ROCK2* selective inhibitor (IC₅₀: 0.59 µM and 26 µM for ROCK2 and ROCK1 respectively). NRL-1049 reduces Lysophosphatidic acid induced ROCK activation in endothelial cells. NRL-1049 reduces lesion volume and hemorrhagic transformation in a mouse model of cavernous angiomas. NRL-1049 also preserves the BBB and suppresses seizures after brain injury, and inhibits hemorrhagic transformation after ischemic stroke in mice .

HY-108518

SB-772077B dihydrochloride	ROCK	Cardiovascular Disease
SB-772077B dihydrochloride is an aminofurazan-based Rho kinase (ROCK) inhibitor with IC₅₀s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively .

HY-100460

BIPM	ROCK	Cancer
BIPM is a potent *ROCK2* inhibitor. BIPM leads to significant changes in neurite length, cell migration and actin stress fibers. BIPM plays an important role in anti-cancer metastasis .

HY-119937

ROCK inhibitor-2 2 Publications Verification	ROCK	Cardiovascular Disease Inflammation/Immunology
ROCK inhibitor-2 (compound 6) is a selective dual inhibitor of ROCK1 and ROCK2, with IC₅₀ values of 160 nM and 21 nM, respectively. ROCK inhibitor-2 inhibits pMYPT1 with IC₅₀ of 75 nM .

HY-15556

GSK269962A 3 Publications Verification GSK 269962	ROCK	Cardiovascular Disease Inflammation/Immunology
GSK269962A (GSK 269962) is a potent *ROCK* inhibitor with IC₅₀s of 1.6 and 4 nM for recombinant human *ROCK1* and *ROCK2* respectively. GSK269962A has anti-inflammatory and vasodilatory activities .

HY-100270

Rho-Kinase-IN-1	ROCK	Cancer
Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (K_i values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008 .

HY-15556A

GSK269962A hydrochloride GSK 269962 hydrochloride	ROCK	Cardiovascular Disease Inflammation/Immunology
GSK269962A hydrochloride (GSK 269962 hydrochloride) is a potent *ROCK* inhibitor with IC₅₀s of 1.6 and 4 nM for recombinant human *ROCK1* and *ROCK2* respectively. GSK269962A hydrochloride has anti-inflammatory and vasodilatory activities .

HY-110339

RKI-1447 dihydrochloride 3 Publications Verification	ROCK Apoptosis	Cancer
RKI 1447 dihydrochloride is a potent and selective *ROCK* inhibitor with IC₅₀s of 14.5 and 6.2 nM for *ROCK1* and *ROCK2, respectively . RKI 1447 dihydrochloride suppresses colorectal carcinoma cell growth and promotes apoptosis* .

HY-10833

ROCK-IN-10	ROCK	Cardiovascular Disease
ROCK-IN-10 (compound 50) is a potent *ROCK* inhibitor with IC₅₀ values of 6 nM and 4 nM for ROCK1 and ROCK2, respectively. ROCK-IN-10 shows >100-fold selectivity against other kinases .

HY-122011

PF-4950834	ROCK SGK PKA PKC	Inflammation/Immunology
PF-4950834 is a potent, selective, orally bioavailable, ATP-competitive rho kinase inhibitor with IC₅₀ values of 8.35 nM and 33.12 nM against ROCK2 and ROCK1, respectively. PF-4950834 inhibits neutrophil migration .

HY-103045A

CMPD101 hydrochloride	PKC ROCK	Cardiovascular Disease
CMPD101 hydrochloride is a novel membrane-permeable, small-molecule inhibitor of both GRK2 and GRK3 with IC₅₀s of 18 nM and 5.4 nM, respectively. CMPD101 hydrochloride also inhibits Rho-associated kinase 2 (ROCK-2) and PKCα (IC₅₀s =1.4 μM and 8.1 μM, respectively) .

HY-126275

HSD1590	ROCK	Cancer
HSD1590 is potent *ROCK* inhibitor, with IC₅₀s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (K_ds<2 nM). HSD1590 displays low cytotoxicity .

HY-16758

Verosudil AR-12286	ROCK	Neurological Disease
Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with K_is of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork .

HY-150640

Rho-Kinase-IN-2	ROCK	Neurological Disease
Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC₅₀=3 nM). Rho-Kinase-IN-2 can be used in Huntington’s research .

HY-16758A

Verosudil hydrochloride AR-12286 hydrochloride	ROCK	Others
Verosudil hydrochloride (AR-12286 hydrochloride) is the hydrochloride form of Verosudil (HY-16758). Verosudil hydrochloride is an inhibitor for Rho-kinase (ROCK) with K_is of 2 and 2 nM for ROCK1 and ROCK2, respectively. Verosudil hydrochloride lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork .

HY-15392

Chroman 1 Maximum Cited Publications 25 Publications Verification	ROCK	Cardiovascular Disease
Chroman 1 is a highly potent and selective *ROCK* inhibitor. Chroman 1 is more potent against ROCK2 (IC₅₀=1 pM) than ROCK1 (IC₅₀=52 pM). Chroman 1 also has inhibitory activity against MRCK, with an IC₅₀ of 150 nM .

HY-15392A

Chroman 1 dihydrochloride Maximum Cited Publications 25 Publications Verification	ROCK	Cardiovascular Disease
Chroman 1 dihydrochloride is a highly potent and selective *ROCK* inhibitor. Chroman 1 dihydrochloride is more potent against ROCK2 (IC₅₀=1 pM) than ROCK1 (IC₅₀=52 pM). Chroman 1 dihydrochloride also has inhibitory activity against MRCK, with an IC₅₀ of 150 nM .

HY-103045

CMPD101 4 Publications Verification	PKC ROCK	Cardiovascular Disease
CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of GRK2/3 with IC₅₀ of 18 nM and 5.4 nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC₅₀s of 3.1 μM , 2.3 μM, 1.4 μM and 8.1 μM, respectively. CMPD101 can be used for the study of heart failure .

HY-10341

Fasudil Hydrochloride 15+ Cited Publications HA-1077 Hydrochloride; AT-877 Hydrochloride	ROCK Calcium Channel Autophagy PKA PKC HIV	Cancer
Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific *RhoA/ROCK* inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for *ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2* and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca ²⁺ channel antagonist and vasodilator .

HY-10341A

Fasudil HA-1077; AT877	ROCK Calcium Channel Autophagy PKA PKC	Cancer
Fasudil (HA-1077; AT877) is a nonspecific *RhoA/ROCK* inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for *ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2* and PKA, PKC, PKG, respectively. Fasudil is also a potent Ca ²⁺ channel antagonist and vasodilator .

HY-10341C

Fasudil dihydrochloride HA-1077 dihydrochloride; AT-877 dihydrochloride	Calcium Channel ROCK PKA PKC Autophagy HIV	Cancer
Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific *RhoA/ROCK* inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for *ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2* and PKA, PKC, PKG, respectively. Fasudil dihydrochloride is also a potent Ca ²⁺ channel antagonist and vasodilator .

HY-12659

LX7101 2 Publications Verification	LIM Kinase (LIMK) ROCK PKA	Endocrinology
LX7101 is a potent LIM-kinase, *ROCK* and PKA inhibitor with IC₅₀s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 proves significantly selective for LIMK2 with IC₅₀ values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 has the potential for ocular hypertension and associated glaucoma research .

HY-10341B

Fasudil hydrochloride semihydrate HA-1077 hydrochloride semihydrate; AT877 hydrochloride semihydrate	ROCK Calcium Channel Autophagy HIV PKA PKC	Cancer
Fasudil (HA-1077; AT877) hydrochloride semihydrate is a nonspecific *RhoA/ROCK* inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for *ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2* and PKA, PKC, PKG, respectively. Fasudil hydrochloride semihydrate is also a potent Ca ²⁺ channel antagonist and vasodilator .

HY-10341D

Fasudil mesylate HA-1077 mesylate; AT-877 mesylate	ROCK Calcium Channel Autophagy PKA PKC	Cancer
Fasudil (HA-1077; AT877) mesylate is a nonspecific and orally active *RhoA/ROCK* inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for *ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2* and PKA, PKC, PKG, respectively. Fasudil mesylate is also a potent Ca ²⁺ channel antagonist and vasodilator .

HY-12659B

LX7101 monohydrochloride	LIM Kinase (LIMK) ROCK PKA	Endocrinology
LX7101 monohydrochloride is a potent LIM-kinase, *ROCK* and PKA inhibitor with IC₅₀s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC₅₀ values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research .

HY-10341R

Fasudil Hydrochloride (Standard)	ROCK Calcium Channel Autophagy PKA PKC HIV	Cancer
Fasudil (Hydrochloride) (Standard) is the analytical standard of Fasudil (Hydrochloride). This product is intended for research and analytical applications. Fasudil (HA-1077; AT877) Hydrochloride is a nonspecific *RhoA/ROCK* inhibitor and also has inhibitory effect on protein kinases, with an K_i of 0.33 μM for *ROCK1, IC₅₀s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2* and PKA, PKC, PKG, respectively. Fasudil Hydrochloride is also a potent Ca ²⁺ channel antagonist and vasodilator .

HY-148808

Zelasudil RXC007	ROCK	Cancer
Zelasudil (RXC007) is an orally active, highly selective small molecule Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor with anti-fibrotic efficacy. Zelasudil elicits positive immunomodulatory effects in metastatic pancreatic tumors with increase of CD8+ and CD4+ T cell infiltrate into the tumor cortex and reduction in immunosuppressive FOXP3+ regulatory T cells at the tumor border. Zelasudil is promising for research of pancreatic ductal adenocarcinoma .

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ROCK2 inhibitor

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