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Results for "

Secretase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Beta-secretase (24) γ-secretase (73) Amyloid-β (20) Apoptosis (10) Autophagy (1) Calcium Channel (2) Caspase (1) Cholinesterase (ChE) (8) COX (1) Drug Metabolite (2) EGFR (2) ERK (2) Fluorescent Dye (2) GABA Receptor (1) Isotope-Labeled Compounds (1) NF-κB (1) Notch (13) Organoid (2) Phosphatase (1) Phosphodiesterase (PDE) (1) Proteasome (2) Reactive Oxygen Species (2) Sodium Channel (2)
By Research Areas:	Cancer (24) Inflammation/Immunology (6) Metabolic Disease (5) Neurological Disease (93)
Click Chemistry:	Azide (1)

116

Inhibitors & Agonists

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*gamma-secretase* modulator 1**	γ-secretase	Neurological Disease
γ-secretase inhibitior-1 is a gamma-secretase modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease.

*gamma-secretase* modulator 1 hydrochloride**	γ-secretase	Neurological Disease
gamma-secretase inhibitior-1 is a *gamma-secretase* modulator, γ-secretase inhibitior-1 is useful for Alzheimer's disease .

*gamma-secretase* modulator 3**	γ-secretase	Neurological Disease
gamma-secretase modulator 3 is a gamma-secretase modulator.

*gamma-secretase* modulator 2**	γ-secretase	Neurological Disease
gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's disease IC50 value: Target: γ-secretase γ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain.

*β-Secretase* Inhibitor I**	Beta-secretase	Neurological Disease
β-Secretase Inhibitor I is an extremely potent *β-secretase* inhibitor with reduced cardiovascular and liver toxicity.

*γ-secretase-IN-2*	γ-secretase	Neurological Disease
γ-secretase-IN-2 (Compound 36) is an inhibitor for *γ-secretase, with an IC₅₀* of 0.07 nM .

*β-Secretase* Inhibitor II**	Beta-secretase	Neurological Disease
β-Secretase Inhibitor II is a *β-Secretase* inhibitor. β-Secretase Inhibitor II is a simple tripeptide aldehyde (IC₅₀=700 nM for inhibition of total Aβ and IC₅₀=2.5 μM for Aβ_1–42). β-Secretase Inhibitor II can be used for the research of Alzheimer's disease .

*γ-Secretase* modulator 10**	γ-secretase	Neurological Disease
γ-Secretase modulator 10 is a novel *γ-secretase* modulator.

*α-Secretase* Substrate II, Fluorogenic**	Fluorescent Dye	Others
α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm

*γ-Secretase* modulator 14**	γ-secretase	Neurological Disease
γ-Secretase modulator 14 is a *γ-secretase* modulator. γ-Secretase modulator 14 has the potenial for Alzheimer's disease (AD) research (WO2013010904A1; compound 42) .

*δ-Secretase* inhibitor 11** 1 Publications Verification	Caspase Amyloid-β	Neurological Disease
δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific *δ-secretase* inhibitor, with an IC₅₀ of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research .

*γ-Secretase* modulator 11 hydrochloride**	γ-secretase	Neurological Disease
γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active *γ-secretase* modulator with an IC₅₀ of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease .

*γ-Secretase* modulator 13**	Amyloid-β	Neurological Disease
γ-Secretase modulator 13 (compound 4) is a gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC₅₀ value of 163 nM. γ-Secretase modulator 13 can be used in the study of Alzheimer's disease .

*gamma-Secretase* Modulators** Amyloid-β production inhibitor; γ-Secretase Modulators	Amyloid-β	Neurological Disease
gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor.

*γ-Secretase* modulator 12**	γ-secretase Amyloid-β	Neurological Disease
γ-Secretase modulator 12 (Compound 1a) is a *γ-secretase* modulator that can selectively decrease amyloid-β42 (Aβ42) levels (IC₅₀ of 0.39 µM). γ-Secretase modulator 12 can be used for Alzheimer’s disease research. γ-Secretase modulator 12 has a good brain/plasma ratio (Kp, brain = 0.72) in mice .

*gamma-secretase* modulator 5**	Amyloid-β	Neurological Disease
gamma-secretase modulator 5 (compound 22d) is a brain-penetrant gamma-secretase modulator (GSMs) that inhibits the production of the aggregated amyloid β-peptide Aβ42 with an IC₅₀ value of 60 nM. gamma-secretase modulator 5 can be used in the study of Alzheimer's disease .

*β-Secretase* Inhibitor III**	Beta-secretase	Neurological Disease
β-Secretase Inhibitor III is an extremely selective BACE1 inhibitor (K_i = 0.13 nM).

*γ-Secretase* modulator 16**	Others	Others
γ-Secretase modulator 16 is an active compound.

*γ-Secretase* modulator 4**	γ-secretase	Neurological Disease
γ-Secretase modulator 4 is a potent *γ-secretase* modulator, reduces the Aβ42 level with IC₅₀s of 0.014 μM and 0.017 μM in human and mouse, respectively .

Compound E 5+ Cited Publications γ-Secretase-IN-1	γ-secretase	Cancer
Compound E is a *γ-secretase* inhibitor. Compound E bloks β-amyloid(40), β-amyloid(42), and Notch γ-secretase cleavage with IC₅₀s of 0.24, 0.37, 0.32 nM, respectively.

*β-Secretase* inhibitor** [Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)	Beta-secretase	Neurological Disease
β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a *β-secretase* and BACE1 inhibitor (IC₅₀: 25 nM for β-secretase) .

*β-Secretase* Inhibitor IV**	Beta-secretase	Neurological Disease
β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC₅₀s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.

GSI-18	γ-secretase Notch	Cancer
GSI-18 is a γ-secretase inhibitor with anticancer activity. GSI-18 attenuates anchorage-independent growth in pancreatic cancer cells by inhibiting Notch signaling .

Z-Ile-Leu-aldehyde 2 Publications Verification Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII	Notch γ-secretase Apoptosis	Cancer
Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of *γ-secretase* and notch .

Sulindac sulfide 1 Publications Verification cis-Sulindac sulfide	Drug Metabolite γ-secretase	Neurological Disease
Sulindac sulfide is a noncompetitive *γ-secretase* inhibitor, with an IC₅₀ of 20.2 μM for γ₄₂-secretase activity.

Sulindac sulfide (Standard)	Drug Metabolite γ-secretase	Neurological Disease
Sulindac sulfide (Standard) is the analytical standard of Sulindac sulfide. This product is intended for research and analytical applications. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.

Nivegacetor	γ-secretase	Neurological Disease
Nivegacetor is a potent *γ-secretase* modulator .

Dihydroergocristine mesylate DHEC mesylate	Amyloid-β	Neurological Disease
Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (K_d) of 25.7 nM and 9.8 μM, respectively .

RO7185876	γ-secretase	Neurological Disease
RO7185876 is a potent and selective gamma secretase modulator as a potential research for Alzheimer's disease.

*γ-Secretase* modulator 11**	γ-secretase	Neurological Disease
5-{8-[(3,4'- difluoro [1,1'- biphenyl]-4-yl) methoxy] - 2-methylimidazo [1,2-a] pyridin-3-yl}-n-methylpyridin-2-formamide (1o) showed high potency in vitro and brain exposure, inducing brain a β 42 levels were significantly reduced and showed undetectable inhibition of cytochrome P450 enzymes. In addition, compound 1o showed excellent anti cognitive deficit effect in AD model mice.

FRM-024	γ-secretase	Neurological Disease
FRM-024 is a potent CNS-penetrant gamma secretase modulator for familial Alzheimer’s disease.

Dihydroergocristine mesylate (Standard) DHEC mesylate (Standard)	Amyloid-β	Neurological Disease
Dihydroergocristine (mesylate) (Standard) is the analytical standard of Dihydroergocristine (mesylate). This product is intended for research and analytical applications. Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (K_d) of 25.7 nM and 9.8 μM, respectively .

LY-411575 isomer 1	γ-secretase	Neurological Disease
LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor.

BMS 433796	γ-secretase	Neurological Disease
BMS 433796 is a *γ-secretase* inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.

LY-411575 (isomer 2)	γ-secretase	Neurological Disease
LY-411575 isomer 2 is an isomer of LY411575, which is a potent γ-secretase inhibitor.

LY-411575 (isomer 3)	γ-secretase	Neurological Disease
LY-411575 isomer 3 is an isomer of LY411575, which is a potent γ-secretase inhibitor.

Eslicarbazepine acetate BIA 2-093	Beta-secretase Sodium Channel	Neurological Disease
Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of *β-Secretase* and voltage-gated sodium channel.

NGP555	γ-secretase	Neurological Disease
NGP555 is a *γ-secretase* modulator. NGP555 Lowers the Amyloid Biomarker Aβ42 .

BI-1408	γ-secretase	Neurological Disease
BI-1408 is a potent γ secretase modulator with an IC₅₀ of 0.04 μM for Aβ₄₂ .

Glabrolide	Beta-secretase	Neurological Disease
Glabrolide, derived from Glycyrrhiza uralensis Fisch., is a β-secretase 1 (BACE-1) inhibitor[1].

L-685458 4 Publications Verification L-685,458	γ-secretase Apoptosis	Neurological Disease Cancer
L-685458 is a potent transition state analog (TSA) *γ-secretase* inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC₅₀ of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC₅₀s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers .

M-2420	Fluorescent Dye	Neurological Disease
M-2420 is a fluorogenic substrate containing β-secretase site of the Swedish mutation of amyloid precursor protein (APP) .

GL189	Beta-secretase	Neurological Disease
GL189 is a *β-secretase* inhibitor. GL189 has neuroprotective effect, and can be used for research of neurodegenerative diseases .

ELN318463	γ-secretase	Neurological Disease
ELN318463 is an amyloid precursor protein (APP) selective *γ-secretase* inhibitor. ELN318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC₅₀s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN318463 is 51-fold more selective for PS1 .

BMS-906024 2 Publications Verification	γ-secretase Notch	Cancer
BMS-906024 is an orally active and selective γ-secretase (gamma secretase) inhibitor. BMS-906024 is a potent pan-Notch receptors inhibitor with IC₅₀s of 1.6 nM, 0.7 nM, 3.4 nM, and 2.9 nM for Notch1, -2, -3, and -4 receptors, respectively. BMS-906024 demonstrates broad-spectrum antineoplastic activity .

Cat. No.	Product Name

HY-L013

Neuronal Signaling Compound Library

2,803 compounds

Neuronal Signaling is involved in the regulation of the mechanisms of the central nervous system (CNS) such as its structure, function, genetics and physiology as well as how this can be applied to understand diseases of the nervous system. Every information processing system in the CNS is composed of neurons and glia, neurons have evolved unique capabilities for intracellular signaling (communication within the cell) and intercellular signaling (communication between cells). G protein-coupled receptors (GPCRs), including 5-HT receptor, histamine receptor, opioid receptor, etc. are the largest class of sensory proteins and are important therapeutic targets in Neuronal Signaling. Besides, Notch signaling, such as β- and γ-secretase, also plays multiple roles in the development of the CNS including regulating neural stem cell (NSC) proliferation, survival, self-renewal and differentiation. GPCR dysfunction caused by receptor mutations and environmental challenges contributes to many neurological diseases. Notch signaling in neurons, glia, and NSCs is also involved in pathological changes that occur in disorders such as stroke, Alzheimer's disease and CNS tumors. Thus, targeting Neuronal Signaling, such as notch signaling and GPCRs, can be used as therapeutic interventions for several different CNS disorders.

MCE designs a unique collection of 2,803 Neuronal Signaling-related compounds that act as a useful tool for the research of neuronal regulation and neuronal diseases.

HY-L017

Stem Cell Signaling Compound Library

1,915 compounds

Adult stem cells are important for tissue homeostasis and regeneration due to their ability to self-renew and generate multiple types of differentiated daughters. Self-renewal is reflected by their capacity to undergo multiple/limitless divisions. Several signaling pathways are involved in self-renewal of stem cells, that is, Notch, Wnt, and Hedgehog pathways or Polycomb family proteins. Recent studies mainly focus on cancer stem cell (CSCs), induced pluripotent stem cell (iPSCs), neural stem cell and maintenance of embryonic stem cell pluripotency. Among them, CSCs have been believed to be responsible for tumor initiation, growth, and recurrence that have implications for cancer therapy.

MCE owns a unique collection of 1,915 compounds that can be used for stem cell regulatory and signaling pathway research.

Cat. No.	Product Name	Type

HY-13027G

DAPT (GMP) GSI-IX (GMP)	Fluorescent Dye
DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active *γ-secretase* inhibitor .

HY-13526G

YO-01027 (GMP) Dibenzazepine (GMP); DBZ (GMP)	Fluorescent Dye
YO-01027 (Dibenzazepine) (GMP) is YO-01027 (HY-13526) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potent *γ-secretase* inhibitor .

Cat. No.	Product Name	Type

HY-13027G

DAPT (GMP) GSI-IX (GMP)	Biochemical Assay Reagents
DAPT (GSI-IX) (GMP) is DAPT (HY-13027) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DAPT is a potent and orally active *γ-secretase* inhibitor .

HY-13526G

YO-01027 (GMP) Dibenzazepine (GMP); DBZ (GMP)	Biochemical Assay Reagents
YO-01027 (Dibenzazepine) (GMP) is YO-01027 (HY-13526) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. YO-01027 is a potent *γ-secretase* inhibitor .

Cat. No.	Product Name	Target	Research Area

HY-P10189

*α-Secretase* Substrate, Fluorogenic**	Peptides	Others
α-Secretase Substrate, Fluorogenic is α-secretase fluorogenic substrate that can be used to test α-secretase activity .

HY-P10191

*β-Secretase* Substrate-1, Fluorogenic**	Peptides	Others
β-Secretase Substrate-1, Fluorogenic is a fluorogenic substrate of β-Secretase that can be used to test β-Secretase activity .

HY-P10163

*α-Secretase* Substrate II, Fluorogenic**	Fluorescent Dye	Others
α-Secretase Substrate II, Fluorogenic is an internally quenched fluorogenic peptide substrate for α-Secretase that contains the α-secretase cleavage site of β-Amyloid precursor protein (APP) .Ex/Em = 340/490 nm

HY-P1962

*β-Secretase* inhibitor** [Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)	Beta-secretase	Neurological Disease
β-Secretase inhibitor ([Asn670, Sta671, Val672]-Amyloid β Peptide (662-675)) is a *β-secretase* and BACE1 inhibitor (IC₅₀: 25 nM for β-secretase) .

HY-P10197

DABCYL-VNLDAE-EDANS	Peptides	Others
DABCYL-VNLDAE-EDANS is a substrate of b-secretase. DABCYL-VNLDAE-EDANS can be used in BACE enzyme assays .

HY-P1729

M-2420	Fluorescent Dye	Neurological Disease
M-2420 is a fluorogenic substrate containing β-secretase site of the Swedish mutation of amyloid precursor protein (APP) .

HY-P4428

Z-Val-Lys-Met-AMC	Peptides	Others
Z-Val-Lys-Met-AMC is a fluorescent substrate that can be used to detect the β-secretase activity of cathepsin B .

HY-P10077

GL189	Beta-secretase	Neurological Disease
GL189 is a *β-secretase* inhibitor. GL189 has neuroprotective effect, and can be used for research of neurodegenerative diseases .

HY-P4919

Mca-SEVNLDAEFK(Dnp)	Beta-secretase	Others
Mca-SEVNLDAEFK(Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK(Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.

HY-P4926

Mca-SEVKMDAEFRK(Dnp)RR-NH2	Peptides	Neurological Disease
Mca-SEVKMDAEFRK(Dnp)RR-NH2, containing the wild-type amyloid precursor protein (APP) beta-secretase cleavage site, is the substrate of thimet oligopeptidase (TOP). It is used for Alzheimer's disease research .

HY-120234

Z-LLNle-CHO Z-Leu-Leu-Nle-CHO; GSII	γ-secretase Proteasome Apoptosis	Cancer
Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a *γ-secretase* inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia .

HY-P3779

Amyloid 17-42 Aβ(17-42)	Apoptosis	Neurological Disease
Amyloid 17-42 (Aβ(17-42)) is a major constituent of diffuse plaques in Alzheimer's disease and cerebellar pre-amyloid in Down's syndrome, derived by alpha- and gamma-secretase cleavage of the amyloid precursor protein (APP). Amyloid 17-42 can induce neuronal apoptosis via a Fas-like/caspase-8 activation pathway .

HY-P1845

PACAP-38 (31-38), human, mouse, rat	ERK EGFR Reactive Oxygen Species Calcium Channel	Neurological Disease
PACAP-38 (31-38), human, mouse, rat is a PAC₁ receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat can be used for neurotrophic and neuroprotective research .

HY-P1845A

PACAP-38 (31-38), human, mouse, rat TFA	ERK EGFR Reactive Oxygen Species Calcium Channel	Neurological Disease
PACAP-38 (31-38), human, mouse, rat TFA is a PAC₁ receptor activator and increases the α-secretase activity. PACAP-38 (31-38), human, mouse, rat TFA elevates cytosolic Ca ²⁺, increases proliferation and increases phosphorylation of extracellular regulates kinase (ERK) and the epidermal growth factor receptor (EGFR). PACAP-38 (31-38), human, mouse, rat TFA demonstrates potent, efficacious, and sustained stimulatory effects on sympathetic neuronal NPY and catecholamine production. PACAP-38 (31-38), human, mouse, rat TFA can be used for neurotrophic and neuroprotective research .

Species:	Human (6) Mouse (2)
Tag:	His (6) SUMO (1) Tag Free (1) Fc (1)
Source:	HEK293 (6) E. coli Cell-free (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72840

	BACE1 Protein, Human (HEK293) Beta-Secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149	Human	HEK293
	The BACE1 protein is an important member of the aspartic protease family and is critical in Alzheimer's disease pathology.Alternative splicing generates multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to produce the mature protease.BACE1 Protein, Human (HEK293) is the recombinant human-derived BACE1 protein, expressed by HEK293 , with tag free.

HY-P72843

	BACE1 Protein, Mouse (HEK293, His) Beta-Secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149	Mouse	HEK293
	BACE1 protein is an important member of the peptidase A1 family and is involved in the pathogenesis of Alzheimer's disease.They produce mature proteases through proteolytic processing of preprotein, which catalyze the initial steps in the formation of amyloid beta peptide from the amyloid precursor protein.BACE1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived BACE1 protein, expressed by HEK293 , with C-His labeled tag.

HY-P700606

	BACE1 Protein, Human (HEK293, N-His) Beta-Secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149	Human	HEK293
	BACE1 protein is crucial in proteolytic processing of amyloid precursor protein (APP), initiating cleavage at the N-terminus of the A-beta peptide sequence. This process results in the extracellular release of beta-cleaved soluble APP and a cell-associated C-terminal fragment. BACE1's cleavage activity extends to CHL1, demonstrating its versatility in substrate processing. BACE1 Protein, Human (HEK293, N-His) is the recombinant human-derived BACE1 protein, expressed by HEK293 , with N-6*His labeled tag.

HY-P75588

	BACE2 Protein, Mouse (HEK293, His) Beta-Secretase 2; Aspartyl protease 1; ASP1; Memapsin-1; Bace2	Mouse	HEK293
	The BACE2 protein is critically involved in the proteolytic processing of amyloid precursor protein (APP), producing beta-cleaved soluble APP and a cell-associated C-terminal fragment. It cleaves APP at residues 690-691 and 671-672. BACE2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived BACE2 protein, expressed by HEK293 , with C-His labeled tag. The total length of BACE2 Protein, Mouse (HEK293, His) is 443 a.a., with molecular weight of ~55 kDa.

HY-P70830

	Cathepsin B Protein, Human (His) Cathepsin B; APP Secretase; APPS; Cathepsin B1; CTSB; CPSB	Human	E. coli
	Cathepsin B Protein, a thiol protease, is crucial for intracellular protein degradation, cleaving matrix extracellular phosphoglycoprotein MEPE. It's implicated in solubilizing cross-linked TG/thyroglobulin in the thyroid follicle lumen. Associated with tumor invasion and metastasis, Cathepsin B signifies potential relevance in cancer-related pathways. Cathepsin B Protein, Human (His) is the recombinant human-derived Cathepsin B protein, expressed by E. coli , with C-6*His labeled tag. The total length of Cathepsin B Protein, Human (His) is 322 a.a., with molecular weight of 34 & 38-50 kDa, respectively.

HY-P702211

	APH1A Protein, Human (Cell-Free, His, SUMO) Gamma-Secretase subunit APH-1A; Aph-1alpha; Presenilin-stabilization factor	Human	E. coli Cell-free
	The APH1A protein is a noncatalytic subunit of the γ-secretase complex and is essential for the assembly of this endoprotease. The γ-secretase complex, including presenilin homodimer, nicastrin, APH1A, and PSENEN/PEN2, catalyzes the cleavage of intramembrane proteins such as Notch and APP. APH1A Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived APH1A protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of APH1A Protein, Human (Cell-Free, His, SUMO) is 247 a.a., with molecular weight of 42.9 kDa.

HY-P72842

	BACE1 Protein, Human (HEK293, His) Beta-Secretase 1; ASP2; Memapsin-2; BACE1; BACE; KIAA1149	Human	HEK293
	The BACE1 protein is an important member of the aspartic protease family and is critical in Alzheimer's disease pathology. Alternative splicing generates multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to produce the mature protease. BACE1 Protein, Human (HEK293, His) is the recombinant human-derived BACE1 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P77569

	BACE1 Protein, Human (HEK293, Fc) Beta-Secretase 1; ASP2; Asp 2; BACE1; BACE; FLJ90568; HSPC104; KIAA1149; Memapsin-2; BACE-1; EC 3.4.23; EC 3.4.23.46	Human	HEK293
	BACE1 protein is crucial in proteolytic processing of amyloid precursor protein (APP), initiating cleavage at the N-terminus of the A-beta peptide sequence.This process results in the extracellular release of beta-cleaved soluble APP and a cell-associated C-terminal fragment.BACE1's cleavage activity extends to CHL1, demonstrating its versatility in substrate processing.BACE1 Protein, Human (HEK293, Fc) is the recombinant human-derived BACE1 protein, expressed by HEK293 , with C-hFc labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B1786S

Sulindac sulfide-d3
Sulindac sulfide-d₃ is deuterium labeled Sulindac sulfide. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.

HY-B0703S

Eslicarbazepine acetate-d4
Eslicarbazepine acetate-d₄ is deuterated labeled Eslicarbazepine acetate (HY-B0703). Eslicarbazepine acetate (BIA 2-093), an antiepileptic agent, is a dual a dual Inhibitor of *β-Secretase* and voltage-gated sodium channel.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82169

	BACE1 Antibody (YA1914) BACE1; BACE; KIAA1149; Beta-Secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2	WB, IP	Human, Mouse, Rat
	BACE1 Antibody (YA1914) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1914), targeting BACE1, with a predicted molecular weight of 56 kDa (observed band size: 68 kDa). BACE1 Antibody (YA1914) can be used for WB, IP experiment in human, mouse, rat background.