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Results for "

Sodium

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Na+/K+ ATPase (1) SGLT (2) Sodium Channel (83) Amyloid-β (1) Apolipoprotein (1) Apoptosis (3) ATTECs (1) Autophagy (1) Bacterial (3) Biochemical Assay Reagents (10) Calcium Channel (10) Caspase (1) Complement System (1) Cytochrome P450 (1) Dopamine Receptor (3) ERK (1) Fluorescent Dye (1) Glucocorticoid Receptor (1) Guanylate Cyclase (1) HCV (1) iGluR (2) Isotope-Labeled Compounds (1) MicroRNA (1) Monoamine Transporter (2) NF-κB (1) NOD-like Receptor (NLR) (2) Opioid Receptor (1) p38 MAPK (1) Parasite (1) Phosphodiesterase (PDE) (1) Potassium Channel (4) Proton Pump (1) SARS-CoV (3) Small Interfering RNA (siRNA) (2) Transthyretin (TTR) (1) TRP Channel (2) TSH Receptor (1) VEGFR (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (20) Endocrinology (2) Infection (5) Inflammation/Immunology (11) Metabolic Disease (13) Neurological Disease (77)
Oligonucleotides:	saRNAs (1) Aptamers (2) Antisense Oligonucleotides (3) siRNAs (2)

130

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Sodium Citrate Buffer, 0.5M, pH 5.0	Biochemical Assay Reagents	Others
Sodium citrate buffer, 0.5M, pH 5.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 5.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 5.0 is the preferred solution for most antibodies . Sodium citrate buffer, 0.5M, pH 5.0 is used as solution for captisol in animal tumor models .

Sodium Citrate Buffer, 0.1M, pH 4.0 1 Publications Verification	Biochemical Assay Reagents	Others
Sodium citrate buffer, 0.1M, pH 4.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.1M, pH 4.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.1M, pH 4.0 is the preferred solution for most antibodies . Sodium citrate buffer, 0.1M, pH 4.0 is used in the hydration of liposome film .

Sodium hippurate, 98% N-Benzoylglycine Sodium, 98%	Biochemical Assay Reagents	Others
Sodium hippurate, 98% (N-Benzoylglycine sodium, 98%) can be used for bacterial culture, such as group B streptococci in beta-hemolytic streptococci, which can hydrolyze sodium hippurate into benzoic acid. Sodium hippurate, 98% is a biomaterial or organic compound that can be used as a life science research-related material .

Patisiran sodium	Small Interfering RNA (siRNA) Transthyretin (TTR)	Neurological Disease
Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis .

Mipomersen sodium ISIS 301012	Apolipoprotein HCV	Metabolic Disease
Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH) .

Sodium metaborate tetrahydrate, 99%	Biochemical Assay Reagents	Others
Sodium metaborate tetrahydrate, 99% is a derivative of the borax compound. Sodium metaborate tetrahydrate, 99% can be used as a source of boron in the production of sodium borohydride (NaBH4) .

Sodium acetate trihydrate, United States Pharmacopeia (USP) Reference Standard Sodium acetate trihydrate (Pharmaceutical primary standard, USP)	Biochemical Assay Reagents	Others
Sodium acetate trihydrate, United States Pharmacopeia (USP) Reference Standard is an inorganic salt that can be used for life science related research .

Sodium Citrate Buffer, 0.5M, pH 5.5	Biochemical Assay Reagents	Others
Sodium citrate buffer, 0.5M, pH 5.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer 0.5M pH 5.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer 0.5M pH 5.5 is the preferred solution for most antibodies. .

Sodium Citrate Buffer, 0.5M, pH 6.0	Biochemical Assay Reagents	Others
Sodium citrate buffer, 0.5M, pH 6.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.0 is used for RNA isolation and antigens detection in fixed tissue .

Sodium Citrate Buffer, 0.5M, pH 6.5	Biochemical Assay Reagents	Others
Sodium citrate buffer, 0.5M, pH 6.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 6.5 is the preferred solution for most antibodies .

Pegaptanib sodium EYE001; NX1838	VEGFR	Metabolic Disease Inflammation/Immunology
Pegaptanib sodium is an RNA aptamer directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .

Lumasiran sodium	Small Interfering RNA (siRNA)	Metabolic Disease
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .

Avacincaptad pegol sodium ARC1905	Complement System	Others
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system. Avacincaptad pegol sodium treats Geographic atrophy (GA) mice .

Jingzhaotoxin-II	Sodium Channel	Neurological Disease
Jingzhaotoxin-II, a 32 amino acid residues including two acidic and two basic residues, is a neurotoxin. Jingzhaotoxin-II inhibits voltage-gated sodium channels (VGSC) that significantly slows rapid inactivation of TTX-resistant (TTX-R) VGSC on cardiac myocytes with the IC₅₀ of 0.26 μM .

Propoxycaine hydrochloride 1 Publications Verification	Sodium Channel	Neurological Disease
Propoxycaine hydrochloride inhibits voltage-gated sodium channels, and thereby inhibits the ionic flux required for the initiation and conduction of impulses. Propoxycaine hydrochloride application can lead to a loss of sensation.

Pterinotoxin-2	Sodium Channel	Inflammation/Immunology
Pterinotoxin-2 is a sodium channel inhibitor peptide toxin .

Pterinotoxin-1	Sodium Channel	Neurological Disease
Pterinotoxin-1 is a sodium channel inhibitor peptide toxin .

Mifamurtide sodium hydrate MTP-PE Sodium hydrate; L-MTP-PE Sodium hydrate; CGP 19835 Sodium hydrate	Others	Inflammation/Immunology Cancer
Mifamurtide (sodium hydrate) (MTP-PE (sodium hydrate); L-MTP-PE (sodium hydrate); CGP 19835 (sodium hydrate)) is the sodium hydrate of mifamurtide. Mifamurtide is a nonspecific immunomodulator that acts by stimulating immune responses by activating macrophages and monocytes. Mifamurtide is a specific ligand for NOD2 and is used as an insulin sensitizer and may also be used in osteosarcoma research .

NaV1.7 blocker-801	Sodium Channel	Neurological Disease
NaV1.7 blocker-801 is a NaV1.7 channel blocker that can be used in the study of neurological diseases .

D-(-)-Lactic acid-13C-2 sodium (R)-2-Hydroxypropionic acid-¹³C-2 Sodium; D-Lactic acid-¹³C-2 Sodium	Isotope-Labeled Compounds	Others
D-(-)-Lactic acid-13C-2 (sodium) is a sodium. D-(-)-Lactic acid-13C-2 (sodium) can be used for a variety of biochemical studies.

XPC-5462	Sodium Channel	Neurological Disease
XPC-5462 is a NaV1.6 and NaV1.2 inhibitor with the IC₅₀s of 10.9 nM and 10.3 nM, respectively. XPC-5462 suppresses epileptiform activity in an ex vivo brain slice seizure model .

Nav1.8-IN-13	Sodium Channel	Cardiovascular Disease
Nav1.8-IN-13 (compound 16) is a Nav1.8 inhibitor (pIC₅₀=7.9) .

Ralitoline	Sodium Channel	Neurological Disease
Ralitoline is a sodium channel blocker with IC₅₀ of 2 μM. Ralitoline has anticonvulsant activity .

QX-314 bromide 1 Publications Verification	Sodium Channel	Neurological Disease
QX-314 bromide is a membrane-impermeable permanently charged sodium channel blocker .

QX-314 chloride 1 Publications Verification	Sodium Channel	Neurological Disease
QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker .

Remacemide hydrochloride FPL 12924AA	iGluR Sodium Channel	Neurological Disease
Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na ⁺ channel, is a weak uncompetitive NMDA receptor antagonist with IC₅₀s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively . Remacemide hydrochloride is an anticonvulsant agent .

Bliretrigine	Sodium Channel	Neurological Disease
Bliretrigine is a sodium channel blocker. Bliretrigine has the effect of relieving pain .

Tocainide	Sodium Channel	Cardiovascular Disease
Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus .

Aneratrigine	Sodium Channel	Neurological Disease
Aneratrigine is a sodium channel protein type 9 subunit alpha blocker. Aneratrigine can be used for neuropathic pain diseases research .

Aneratrigine hydrochloride	Sodium Channel	Neurological Disease
Aneratrigine (hydrochloride) is a sodium channel protein type 9 subunit alpha blocker. Aneratrigine (hydrochloride) can be used for neuropathic pain diseases research .

Hainantoxin-III	Sodium Channel	Neurological Disease
Jingzhaotoxin-V is a peptide that inhibits potassium currents in Xenopus laevis oocytes with an IC₅₀ value of 604.2 nM. Jingzhaotoxin-V also inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC₅₀ values of 27.6 and 30.2 nM, respectively .

Dezinamide AHR11748; AN051; ADD94057	Sodium Channel	Neurological Disease
Dezinamide (ADD94057) is an antiepileptic agent. Dezinamide binds to the voltage-sensitive sodium channel .

Benzo-15-crown-5-ether B15C5	Biochemical Assay Reagents	Others
Benzo-15-crown-5-ether can be used as a chelating agent for sodium and potassium .

BTG 502	Parasite Sodium Channel	Neurological Disease
BTG 502 is an alkylamide insecticide. BTG 502 can reduce sodium current and antagonize the effect of bat toxin (BTX) on cockroach sodium channels .

PD 122860	Sodium Channel Calcium Channel	Cardiovascular Disease
PD 122860 is a calcium channel blocker. PD 122860 also can stimulate sodium channel. PD 122860 can be used for the research of cardiovascular and cerebrovascular diseases .

E-0747	Sodium Channel	Neurological Disease
E-0747 is an antiarrhythmic drug that inhibits arrhythmias by inhibiting Na ^[+] channels in cardiomyocytes .

(R)-Duloxetine (R)-LY248686	Sodium Channel	Neurological Disease
(R)-Duloxetine is a form of Duloxetine (HY-B0161) that causes tonic and usage-dependent impairment of neuronal Na ⁺ channels. (R)-Duloxetine can be used in pain research .

Idrevloride P-1037	Sodium Channel	Others
Idrevloride, an epithelial sodium channel (ENaC) inhibitor (WO2016133967), can be used for the research of skin disorders .

SBFI tetraammonium	Fluorescent Dye	Others
SBFI (tetraammonium), the tetraammonium salt of SBFI, is a sodium fluorescence indicator. SBFI (tetraammonium) is sodium-sensitive dye. The excitation wavelength is set 333 nm, and the emission wavelength is 539 nm for SBFI .

DDMS Dibromo-dodecenyl-methylsulfimide	Cytochrome P450	Cardiovascular Disease
DDMS (Dibromo-dodecenyl-methylsulfimide) is a selective 20-HETE production inhibitor. DDMS attenuates the vasodilatory response to sodium nitroprusside (SNP) .

Jingzhaotoxin-34	Sodium Channel	Neurological Disease
Jingzhaotoxin-34, a 35-residue polypeptide, is a neurotoxin. Jingzhaotoxin-34 inhibits tetrodotoxin-sensitive (TTX-S) sodium currents (IC₅₀ of ~85 nM) while having no significant effects on tetrodotoxin-resistant (TTX-R) sodium currents on rat dorsal root ganglion neurons .

Sulcardine	Calcium Channel Sodium Channel	Cardiovascular Disease
Sulcardine is a multi-ion channel blocker that can reduce I_Na and I_Ca with IC₅₀ values of 26.9 µM and 69.2 µM, respectively. Sulcardine is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine has anti-arrhythmic effects .

Nav1.8-IN-14	Sodium Channel	Neurological Disease
Nav1.8-IN-14 (compound 20) is a potent and selective Nav1.8 inhibitor. Nav1.8-IN-14 can be used in the study of pain-related diseases .

RO-76	Opioid Receptor	Neurological Disease
RO-76 is a mu opioid receptor (μOR) selective partial agonist. RO-76 binds to μOR-G-protein complex with an EC₅₀ value of 454 nM. RO-76 reduces β-Arrestin-1/2 recruitment. RO-76 shows antinociception activity .

Lubeluzole dihydrochloride	Sodium Channel	Neurological Disease
Lubeluzole (dihydrochloride) is a neuroprotective agent which blockades neuronal voltage-gated sodium channels. Lubeluzole (dihydrochloride) also produces both tonic and block of cardiac sodium channels. Lubeluzole (dihydrochloride) is promising for research of antiarrhythmic agents .

Sulcardine hydrochloride	Calcium Channel Sodium Channel	Cardiovascular Disease
Sulcardine hydrochloride is a multi-ion channel blocker that can reduce I_Na and I_Ca with IC₅₀ values of 26.9 µM and 69.2 µM, respectively. Sulcardine hydrochloride is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine hydrochloride has anti-arrhythmic effects .

Cat. No.	Product Name	Type

HY-103311

Ruthenium red 5+ Cited Publications Ammoniated ruthenium oxychloride	Dyes
Ruthenium red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids and binds to acidic mucopolysaccharides. Ruthenium red is a L-type calcium current (I_Ca) blocker .

HY-D1442

SBFI tetraammonium	Fluorescent Dyes/Probes
SBFI (tetraammonium), the tetraammonium salt of SBFI, is a sodium fluorescence indicator. SBFI (tetraammonium) is sodium-sensitive dye. The excitation wavelength is set 333 nm, and the emission wavelength is 539 nm for SBFI .

Cat. No.	Product Name	Type

HY-Y1325H

Sodium acetate trihydrate, meets analytical specification of Ph. Eur. BP USP FCC E262, ≤0.00002% Al	Buffer Reagents
Sodium acetate trihydrate, meets analytical specification of Ph. Eur. BP USP FCC E262, ≤0.00002% Al is an inorganic salt that can be used for life science related research .

HY-B1610J

Sodium Citrate Buffer, 0.5M, pH 5.0

Buffer Reagents

Sodium citrate buffer, 0.5M, pH 5.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 5.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 5.0 is the preferred solution for most antibodies . Sodium citrate buffer, 0.5M, pH 5.0 is used as solution for captisol in animal tumor models .

HY-W094708D

Sodium phosphate dibasic dihydrate, meets analytical specification of Ph. Eur. BP DiSodium hydrogen phosphate dihydrate, meets analytical specification of Ph. Eur. BP	Buffer Reagents
Sodium phosphate dibasic dihydrate, meets analytical specification of Ph. Eur. BP is an inorganic salt that can be used for life science related research .

HY-Y0344H

Sodium chloride, United States Pharmacopeia (USP) Reference Standard Halite (Pharmaceutical primary standard, USP)	Buffer Reagents
Sodium chloride, United States Pharmacopeia (USP) Reference Standard is an inorganic salt that can be used for life science related research .

HY-W133954

Sodium metaborate tetrahydrate, 99%	Buffer Reagents
Sodium metaborate tetrahydrate, 99% is a derivative of the borax compound. Sodium metaborate tetrahydrate, 99% can be used as a source of boron in the production of sodium borohydride (NaBH4) .

HY-Y0308H

Sodium phosphate dibasic, for molecular biology DiSodium hydrogen phosphate, for molecular biology	Buffer Reagents
Sodium phosphate dibasic, for molecular biology is an inorganic salt that can be used for life science related research .

HY-Y1325E

Sodium acetate trihydrate, United States Pharmacopeia (USP) Reference Standard Sodium acetate trihydrate (Pharmaceutical primary standard, USP)	Buffer Reagents
Sodium acetate trihydrate, United States Pharmacopeia (USP) Reference Standard is an inorganic salt that can be used for life science related research .

HY-B1610K

Sodium Citrate Buffer, 0.5M, pH 5.5

Buffer Reagents

Sodium citrate buffer, 0.5M, pH 5.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer 0.5M pH 5.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer 0.5M pH 5.5 is the preferred solution for most antibodies. .

HY-B1610L

Sodium Citrate Buffer, 0.5M, pH 6.0	Buffer Reagents
Sodium citrate buffer, 0.5M, pH 6.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.0 is used for RNA isolation and antigens detection in fixed tissue .

HY-B1610M

Sodium Citrate Buffer, 0.5M, pH 6.5

Buffer Reagents

Sodium citrate buffer, 0.5M, pH 6.5, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.5M, pH 6.5 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.5M, pH 6.5 is the preferred solution for most antibodies .

HY-B1610N

Sodium Citrate Buffer, 0.1M, pH 4.0

1 Publications Verification

Buffer Reagents

Sodium citrate buffer, 0.1M, pH 4.0, is a commonly used buffer with main components are citric acid and sodium hydrogen phosphate. Sodium citrate buffer, 0.1M, pH 4.0 is used in heat induced epitope retrieval (HIER) methods to reverse the loss of antigenicity that occurs with some epitopes in formalin-fixed paraffin embedded tissues. Sodium citrate buffer, 0.1M, pH 4.0 is the preferred solution for most antibodies . Sodium citrate buffer, 0.1M, pH 4.0 is used in the hydration of liposome film .

HY-B2243D

Anhydrous sodium dihydrogen phosphate, for cell culture Sodium phosphate monobasic, for cell culture; MonoSodium dihydrogen orthophosphate, for cell culture; MonoSodium phosphate, for cell culture	Buffer Reagents
Anhydrous sodium dihydrogen phosphate, for cell culture is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for cell culture can be used in cell culture .

HY-B2243B

Anhydrous sodium dihydrogen phosphate, for molecular biology Sodium phosphate monobasic for molecular biology; MonoSodium dihydrogen orthophosphate for molecular biology; MonoSodium phosphate for molecular biology	Buffer Reagents
Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .

HY-160113

Sodium phosphate buffer (pH 6.9 0.02 mol/l)	Biochemical Assay Reagents
Sodium phosphate buffer (pH 6.9 0.02 mol/l) is a water-based salt solution. Sodium phosphate buffer (pH 6.9 0.02 mol/l) can be used in a variety of biochemical studies.

HY-W014841

Sodium hippurate, 98% N-Benzoylglycine Sodium, 98%	Microbial Culture
Sodium hippurate, 98% (N-Benzoylglycine sodium, 98%) can be used for bacterial culture, such as group B streptococci in beta-hemolytic streptococci, which can hydrolyze sodium hippurate into benzoic acid. Sodium hippurate, 98% is a biomaterial or organic compound that can be used as a life science research-related material .

HY-111157

Dezinamide AHR11748; AN051; ADD94057	Cell Assay Reagents
Dezinamide (ADD94057) is an antiepileptic agent. Dezinamide binds to the voltage-sensitive sodium channel .

HY-W008585

Benzo-15-crown-5-ether B15C5	Chelators
Benzo-15-crown-5-ether can be used as a chelating agent for sodium and potassium .

HY-B2243BR

Anhydrous sodium dihydrogen phosphate, for molecular biology (Standard)

Buffer Reagents

Anhydrous sodium dihydrogen phosphate, for molecular biology (Standard) is the analytical standard of Anhydrous sodium dihydrogen phosphate, for molecular biology. This product is intended for research and analytical applications. Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .

Cat. No.	Product Name	Target	Research Area

HY-P5772

Jingzhaotoxin-II	Sodium Channel	Neurological Disease
Jingzhaotoxin-II, a 32 amino acid residues including two acidic and two basic residues, is a neurotoxin. Jingzhaotoxin-II inhibits voltage-gated sodium channels (VGSC) that significantly slows rapid inactivation of TTX-resistant (TTX-R) VGSC on cardiac myocytes with the IC₅₀ of 0.26 μM .

HY-P5942

Pterinotoxin-2	Sodium Channel	Inflammation/Immunology
Pterinotoxin-2 is a sodium channel inhibitor peptide toxin .

HY-P5943

Pterinotoxin-1	Sodium Channel	Neurological Disease
Pterinotoxin-1 is a sodium channel inhibitor peptide toxin .

HY-P5180

Hainantoxin-III	Sodium Channel	Neurological Disease
Jingzhaotoxin-V is a peptide that inhibits potassium currents in Xenopus laevis oocytes with an IC₅₀ value of 604.2 nM. Jingzhaotoxin-V also inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC₅₀ values of 27.6 and 30.2 nM, respectively .

HY-P5773

Jingzhaotoxin-34	Sodium Channel	Neurological Disease
Jingzhaotoxin-34, a 35-residue polypeptide, is a neurotoxin. Jingzhaotoxin-34 inhibits tetrodotoxin-sensitive (TTX-S) sodium currents (IC₅₀ of ~85 nM) while having no significant effects on tetrodotoxin-resistant (TTX-R) sodium currents on rat dorsal root ganglion neurons .

HY-P1219

Jingzhaotoxin-III β-TRTX-Cj1α	Sodium Channel	Neurological Disease
Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC₅₀ of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype .

HY-P5770

Jingzhaotoxin-V	Sodium Channel	Neurological Disease
Jingzhaotoxin-V, a 29-residue polypeptide, is derived from the venom of the spider Chilobrachys jingzhao. Jingzhaotoxin-V inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC₅₀ values of 27.6 nM and 30.2 nM, respectively. Jingzhaotoxin-V also inhibits Kv4.2 potassium currents expressed in Xenpus Laevis oocytes (IC₅₀ of 604.2 nM) .

HY-P5771

Jingzhaotoxin-IX	Sodium Channel	Neurological Disease
Jingzhaotoxin-IX, a C-terminally amidated peptide composed of 35 amino acid residues, is a neurotoxin. Jingzhaotoxin-IX inhibits voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel. Jingzhaotoxin-IX has no effect on delayed rectifier potassium channel Kv1.1, 1.2 and 1.3 .

HY-P5807

Cn2 toxin β-Mammal toxin Cn2	Peptides	Neurological Disease
Cn2 toxin is aβ- toxoins. Cn2 toxin can bind to the voltage sensing domain of voltage gated sodium channels (Na_v) .

HY-P5179

Huwentoxin I HWTX-I	Calcium Channel Sodium Channel	Neurological Disease
Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC₅₀ values of 66.1 and 4.80 nM, respectively .

HY-P5177

GsAF-II	Sodium Channel Potassium Channel	Neurological Disease
GsAF-II is a peptide toxin that blocks hERG1 subtype potassium channels in a voltage-dependent manner. GsAF-II blocks Nav1.x subtype sodium channels .

HY-P10236

Ac-WEHD-pNA	Caspase	Others
Ac-WEHD-pNA is a colorimetric substrate for caspase 1, 4, 5 and 14, which is utilized to measure the caspase activity .

HY-P5868

mHuwentoxin-IV	Sodium Channel	Neurological Disease
mHuwentoxin-IV is a naturally modified Huwentoxin-IV (HY-P1220). mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC₅₀ of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages .

HY-P5184

Hainantoxin-IV HNTX-IV	Sodium Channel	Neurological Disease
Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif .

HY-P3777

β-Bag cell peptide	Potassium Channel	Neurological Disease
β-Bag cell peptide is a neuroactive peptide. β-Bag cell peptide elevates cyclic AMP levels in the bag cell neurons. β-Bag cell peptide decreases the amplitudes of the voltage-dependent potassium currents .

HY-P1218A

Phrixotoxin 3 TFA	Sodium Channel	Neurological Disease
Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .

HY-P1218

Phrixotoxin 3	Sodium Channel	Neurological Disease
Phrixotoxin 3 is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .

HY-P5164

GrTx1	Sodium Channel	Neurological Disease
GrTx1 is a peptide toxin originally isolated from the venom of the spider Grammostola rosea. GrTx1 blocks sodium channel， with IC₅₀s of 0.63 µM, 0.23 µM, 0.77 µM, 1.29 µM, 0.63 µM and 0.37 µM for Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7, repectively .GrTx1 can be used for neurological disease research .

HY-P1218B

Phrixotoxin 3-NH2 TFA	Sodium Channel	Neurological Disease
Phrixotoxin 3-NH2 TFA is a derivative of Phrixotoxin 3 TFA (HY-P1218A). Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC₅₀s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current .

HY-P1220

Huwentoxin-IV	Sodium Channel	Neurological Disease
Huwentoxin-IV is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV has analgesic effects on animal models of inflammatory and neuropathic pain .

HY-P1220A

Huwentoxin-IV TFA	Sodium Channel	Neurological Disease
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibits neuronal Nav1.7, Nav1.2, Nav1.3 and Nav1.4 with IC₅₀s of 26, 150, 338 and 400 nM, respectively. Huwentoxin-IV TFA preferentially blocks peripheral nerve subtype Nav1.7 by binding neurotoxin receptor site 4. Huwentoxin-IV TFA has analgesic effects on animal models of inflammatory and neuropathic pain .

HY-P5152

Scorpion toxin Tf2	Sodium Channel	Neurological Disease
Scorpion toxin Tf2 is a β-scorpion toxin, which is firstly identified in the venom of the Brazilian scorpion Tityus fasciolatus. Scorpion toxin Tf2 is a Nav1.3 activator, which is a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Scorpion toxin Tf2 enhances hNav1.3 activation voltage and opens the channel at resting membrane potentials .

Cat. No.	Product Name		Classification

HY-132609

Patisiran sodium		siRNAs
Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis .

HY-108764

Mipomersen sodium ISIS 301012		Antisense Oligonucleotides
Mipomersen sodium (ISIS 301012) is an antisense oligonucleotide inhibitor of apolipoprotein B (apoB). Mipomersen has anti-HCV effect and reduces the infectivity of the HCV. Mipomersen sodium can be used for the research of homozygous familial hypercholesterolemia (HoFH) .

HY-145725

Baliforsen sodium IONIS 598769 Sodium; ISIS 598769 Sodium		Antisense Oligonucleotides
Baliforsen (sodium) is an antisense oligonucleotide (16 nucleotides) designed to target myotonic dystrophy protein kinase (DMPK) mRNA and research myotonic dystrophy.

HY-109561

Pegaptanib sodium EYE001; NX1838		Aptamers
Pegaptanib sodium is an RNA aptamer directed against vascular endothelial growth factor (VEGF)-165. Pegaptanib could be used for the study of neovascular age-related macular degeneration (AMD) .

HY-132613

Lumasiran sodium		siRNAs
Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, reduces hepatic oxalate production by targeting glycolate oxidase. Lumasiran sodium reduces urinary oxalate excretion, the cause of progressive kidney failure in primary hyperoxaluria type 1 (PH1) .

HY-147080

Avacincaptad pegol sodium ARC1905		Aptamers
Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system. Avacincaptad pegol sodium treats Geographic atrophy (GA) mice .

HY-132607A

MTL-CEBPA sodium CEBPA-51 Sodium		saRNAs
MTL-CEBPA (sodium) is the sodium form of MTL-CEBPA (HY-132607). MTL-CEBPA (sodium) is a small activating RNA targeting for upregulation of C/EBPα. MTL-CEBPA (sodium) has anti-inflammatory and anti-cancer activity .

HY-B2243B

Anhydrous sodium dihydrogen phosphate, for molecular biology Sodium phosphate monobasic for molecular biology; MonoSodium dihydrogen orthophosphate for molecular biology; MonoSodium phosphate for molecular biology		Others
Anhydrous sodium dihydrogen phosphate, for molecular biology is an inorganic salt compound that can be used as a buffer and nutritional supplement. Anhydrous sodium dihydrogen phosphate, for molecular biology can be used in molecular biology experiments .

HY-148410C

Zorevunensen negative control STK-001 negative control		Antisense Oligonucleotides
Zorevunensen negative control is the negative control form of Zorevunensen (HY-148410). Zorevunensen (STK-001) is an antisense oligonucleotide that is intended to increase the level of productive SCN1A mRNA and consequently increase the expression of the sodium channel Nav_1.1 protein. Zorevunersen is used for the study of Dravet syndrome .

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