Search Result

Isoforms Recommended:	Tie2

Results for "

TIE2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (1) Apoptosis (6) Autophagy (2) Bcr-Abl (2) BRK (1) c-Fms (1) c-Kit (3) c-Met/HGFR (6) Discoidin Domain Receptor (1) EGFR (1) ERK (1) FGFR (3) FLT3 (5) Insulin Receptor (1) MEK (1) p38 MAPK (1) PDGFR (1) Phosphatase (1) Raf (1) Ras (1) Src (3) TAM Receptor (4) Tie (17) Trk Receptor (2) VEGFR (17)
By Research Areas:	Cancer (29) Cardiovascular Disease (8) Infection (1) Inflammation/Immunology (5) Metabolic Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100556

Tie2 kinase inhibitor 1 1 Publications Verification	Tie	Cancer
Tie2 kinase inhibitor 1 (compound 5) is a potent, selective Tie2 kinase inhibitor with an IC₅₀ of 250 nM . Tie2 kinase inhibitor 1 has anti-cancer activity ^[2].

HY-112294

TIE-2/VEGFR-2 kinase-IN-1	Tie VEGFR	Cardiovascular Disease Inflammation/Immunology Cancer
TIE-2/VEGFR-2 kinase-IN-1 is used for the synthesis of TIE-2 and/or VEGFR-2 inhibitors, extracted from patent WO2003022852, example 14. TIE-2/VEGFR-2 kinase-IN-1 is used for the study of diseases associated with inappropriate angiogenesis .

HY-12572

TIE-2/VEGFR-2 kinase-IN-2	Tie VEGFR	Cancer
TIE-2/VEGFR-2 kinase-IN-2 is a potent dual *VEGFR2* and *Tie-2* inhibitor with pIC₅₀ values of 8.61 and 8.56, respectively . TIE-2/VEGFR-2 kinase-IN-2 is an anti-angiogenic agent and can be used for cancer research ^[2].

HY-13023

*AMG-Tie2-1*	VEGFR	Cancer
AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) with an IC₅₀ of 1 nM. AMG-Tie2-1 is a VEGFR2 inhibitor with an IC₅₀ of 3 nM .

HY-16782

Pexmetinib 1 Publications Verification ARRY-614	p38 MAPK Autophagy	Cancer
Pexmetinib is a potent *Tie-2* and p38 MAPK dual inhibitor, with IC₅₀s of 1 nM, 35 nM and 26 nM for Tie-2, p38α and p38β, respectively, and can be used in the research of acute myeloid leukemia.

HY-113571

Tie2 kinase inhibitor 2	Tie	Cardiovascular Disease
Tie2 kinase inhibitor 2 (compound 7) is a selective Tie2 kinase inhibitor with an IC₅₀ value of 1 μM. Tie2 kinase inhibitor 2 inhibits endothelial cell tube formation, and can be used for Tie2-mediated angiogenic disorders research .

HY-160708

Tie2 kinase inhibitor 3	Tie	Cancer
Tie2 kinase inhibitor 3 (compound 63) is a potent *Tie-2* kinase inhibitor with good oral activity (IC₅₀=30 nM). Tie2 kinase inhibitor 3 inhibits phosphorylation and signaling of *Tie-2* by competing with the ATP binding site of *Tie-2* kinase. This inhibition affects the stability and maturity of blood vessels, which has an impact on tumor angiogenesis. Tie2 kinase inhibitor 3 can be used to restrict tumor growth and regulate angiogenesis .

HY-156635

TIE-2/VEGFR-2 kinase-IN-3	Tie VEGFR	Cardiovascular Disease
TIE-2/VEGFR-2 kinase-IN-3, benzimidazole, is a potent *TIE-2* and *VEGFR-2* tyrosine kinase receptors inhibitors with IC₅₀ values of 6.9 nM and 3.5 nM, respectively. TIE-2/VEGFR-2 kinase-IN-3 can be used for the research of angiogenesis .

HY-156637

TIE-2/VEGFR-2 kinase-IN-4	Tie VEGFR	Cardiovascular Disease
TIE-2/VEGFR-2 kinase-IN-4, benzimidazole, is a potent *TIE-2* and *VEGFR-2* tyrosine kinase receptors inhibitors with IC₅₀ values of 5.2 nM and 5.1 nM, respectively. TIE-2/VEGFR-2 kinase-IN-4 can be used for the research of angiogenesis .

HY-156638

TIE-2/VEGFR-2 kinase-IN-5	Tie VEGFR	Cardiovascular Disease
TIE-2/VEGFR-2 kinase-IN-5 is an anti-angiogenic agent. TIE-2/VEGFR-2 kinase-IN-5 also is a potent *TIE-2* and *VEGFR-2* tyrosine kinase inhibitor with pIC₅₀ values of 7.78 nM and 8.11 nM, respectively. TIE-2/VEGFR-2 kinase-IN-5 can be used for the research of angiogenesis .

HY-100756

BAY-826	Discoidin Domain Receptor Tie	Cancer
BAY-826 is a selective and potent *TIE-2* inhibitor with a K_d of 1.6 nM, respectively.

HY-16135A

CEP-11981 tosylate ESK981 tosylate; BOL 303213X tosylate	VEGFR FGFR	Others Cancer
CEP-11981 (tosylate) (ESK981 (tosylate), BOL 303213X (tosylate)) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects .

HY-13561

AZM475271 M475271	Src	Cancer
AZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM; no inhibitory activity on Flt3, KDR, Tie-2.

HY-N2666

5α-Hydroxycostic acid	VEGFR	Cancer
5α-Hydroxycostic acid, a eudesmane-type sesquiterpene, is isolated from the herb Laggera alata. 5α-Hydroxycostic acid inhibits angiogenesis and suppresses breast cancer cell migration through regulating *VEGF/VEGFR2* and *Ang2/Tie2* pathways .

HY-16135

CEP-11981 ESK981; BOL 303213X	VEGFR FGFR	Cancer
CEP-11981(ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects .

HY-16025

EOC317 1 Publications Verification ACTB-1003	FGFR VEGFR	Cancer
EOC317 (ACTB-1003) is an oral kinase inhibitor with IC₅₀s of 6, 2 and 4 nM for FGFR1, *VEGFR2* and *Tie-2*.

HY-12014

SU11274 5+ Cited Publications PKI-SU11274	c-Met/HGFR Autophagy Apoptosis	Cancer
SU11274 is a selective Met inhibitor with IC₅₀ of 10 nM, but has no effects on PGDFRβ, EGFR or Tie2.

HY-P10580

Vasculotide	Tie	Infection Metabolic Disease Inflammation/Immunology Cancer
Vasculotide, an angiopoietin-1 mimetic, is a *Tie-2* activator and induces Tie-2 phosphorylation. Vasculotide has anti-inflammatiory effect and anti-permeability. Vasculotide ameliorates endotoxin-induced endothelial barrier dysfunction. Vasculotide promotes angiogenesis in a mouse model of diabetic ulcer. Vasculotide protects mice from vascular leakage and reduces mortality in murine abdominal sepsis. Vasculotide decreases microvascular leakage and improves microcirculatory perfusion in a rat model of hemorrhagic shock ^[2] .

HY-108333

SB-633825 2 Publications Verification	Tie BRK	Cardiovascular Disease Cancer
SB-633825 is a potent and ATP-competitive inhibitor of *TIE2, LOK (STK10)* and BRK with IC₅₀s of 3.5 nM, 66 nM, 150 nM, respectively. SB-633825 can inhibit cancer cell growth and angiogenesis .

HY-109041

Razuprotafib 1 Publications Verification AKB-9778	Phosphatase Tie	Inflammation/Immunology
Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC₅₀of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC₅₀ of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC₅₀=36 pM) and HPTPγ (100 pM) .

HY-112423

CE-245677	Trk Receptor Tie	Cardiovascular Disease Cancer
CE-245677 is a potent reversible inhibitor of *Tie2* and TrkA/B kinases with a cellular IC₅₀s of 4.7 and 1 nM.

HY-125741

GW768505A free base	Tie VEGFR	Cancer
GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and *Tie-2*, with a pIC₅₀ of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity 。

HY-100824

PP2 Analog	Src	Cancer
PP2 Analog (compound 3) is a ATP-competitive Src family kinases inhibitor with the IC₅₀ values of 0.22, 0.15, 2.68, and 7 aganist of lck (64-509), src , kdr, and tie-2 .

HY-13024

Rebastinib 5+ Cited Publications DCC-2036	Bcr-Abl FLT3 Src Apoptosis	Cancer
Rebastinib (DCC-2036) is an orally active, non-ATP-competitive Bcr-Abl inhibitor for Abl1 ^WT and Abl1 ^T315I with IC₅₀s of 0.8 nM and 4 nM, respectively. Rebastinib also inhibits SRC, KDR, FLT3, and Tie-2, and has low activity to seen towards c-Kit.

HY-14243

CEP-14083	Anaplastic lymphoma kinase (ALK) Insulin Receptor VEGFR Tie	Cancer
CEP-14083 is a ATP-competitive ALK kinase inhibitor with an IC₅₀ value in enzymatic assays of 2 nM. CEP-14083 also inhibits other kinases, such as insulin receptor (IR), vascular endothelial growth factor receptor 2 (VEGFR2), angiopoietin-1 receptor (TIE2) and dual leucine zipper kinase (DLK). CEP-14083 suppresses CD274 mRNA expression and the NPM/ALK function in the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells. CEP-14083 is promising for research of lymphoma ^[2].

HY-B0791

Altiratinib 1 Publications Verification DCC-2701	VEGFR c-Met/HGFR FLT3 Trk Receptor	Cancer
Altiratinib (DCC-2701) is a multi-targeted kinase inhibitor with IC₅₀s of 2.7, 8, 9.2, 9.3, 0.85, 4.6, 0.83 nM for MET, *TIE2, VEGFR2, FLT3, Trk1, Trk2, and Trk3* respectively.

HY-18307

SYN1143	c-Met/HGFR	Cancer
SYN1143 is a potent, selective and orally active dual inhibitor of c-Met/RON, with IC₅₀s of 4 and 9 nM, respectively. SYN1143 has weak inhibitory activity on Lck, *Tie2, Src, and BTK* with IC₅₀s ranging from 160 to 710 nM. SYN1143 can be used for the research of cancers that RON and c-Met are activated .

HY-N3634

Corylifol C	EGFR TAM Receptor Tie	Cancer
Corylifol C is a potent protein kinase inhibitor with IC₅₀ valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively .

HY-13016A

Cabozantinib hydrochloride XL184 hydrochloride; BMS-907351 hydrochloride	VEGFR c-Met/HGFR c-Kit TAM Receptor FLT3 Apoptosis	Cancer
Cabozantinib hydrochloride is a potent and orally active inhibitor of *VEGFR2* and MET, with IC₅₀ values of 0.035 and 1.3 nM, respectively. Cabozantinib hydrochloride displays strong inhibition of KIT, RET, AXL, *TIE2, and FLT3* (IC₅₀=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib hydrochloride shows antiangiogenic activity. Cabozantinib hydrochloride disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis .

HY-13016

Cabozantinib Maximum Cited Publications 40 Publications Verification XL184; BMS-907351	VEGFR c-Met/HGFR c-Kit TAM Receptor FLT3 Apoptosis	Cancer
Cabozantinib is a potent and orally active inhibitor of *VEGFR2* and MET, with IC₅₀ values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, *TIE2, and FLT3* (IC₅₀=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis ^[2].

HY-13016R

Cabozantinib (Standard)	VEGFR c-Met/HGFR c-Kit TAM Receptor FLT3 Apoptosis	Cancer
Cabozantinib (Standard) is the analytical standard of Cabozantinib. This product is intended for research and analytical applications. Cabozantinib is a potent and orally active inhibitor of *VEGFR2* and MET, with IC₅₀ values of 0.035, and 1.3 nM, respectively. Cabozantinib displays strong inhibition of KIT, RET, AXL, *TIE2, and FLT3* (IC₅₀=4.6, 5.2, 7, 14.3, and 11.3 nM, respectively). Cabozantinib shows antiangiogenic activity. Cabozantinib disrupts tumor vasculature and promotes tumor and endothelial cell apoptosis ^[2].

HY-164529

SJ-C1044	Raf Ras MEK ERK VEGFR Tie c-Fms	Cancer
SJ-C1044 is an orally available pan-RAF inhibitor with immunomodulatory and anti-tumor activities. SJ-C1044 inhibits wild-type BRAF, wild-type CRAF, and BRAF (V600E) with IC₅₀ values ??of 331, 257, and 187 nM, respectively. SJ-C1044 inhibits tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. In addition, SJ-C1044 also has a certain inhibitory effect on *VEGFR2, TIE2, and CSF1R, with IC₅₀* values ??of 100, 23, and 235 nM, respectively. SJ-C1044 improves the tumor immune microenvironment by inhibiting angiogenesis and regulating macrophage function. SJ-C1044 can be used in the study of colorectal cancer .

HY-123450

S116836	Bcr-Abl Apoptosis PDGFR	Cancer
S116836, a potent, orally active BCR-ABL tyrosine kinase inhibitor, blocks both wild-type as well as T315I Bcr-Abl. S116836 arrests the cells in the G0/G1 phase of cell cycle, induces apoptosis, increases ROS production, and decreases GSH production in BaF3/WT and BaF3/T315I cells. S116836 also inhibits SRC, LYN, HCK, LCK and BLK, and receptor tyrosine kinases such as FLT3, TIE2, KIT, PDGFR-β. Antitumor activies ^[2] . S116836 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Target	Research Area

HY-P5438

Srctide	Peptides	Others
Srctide is a biological active peptide. (This is a peptide substrate for many protein kinases, such as Blk, BTK, cKit, EPHA1, EPHB2, EPHB3, ERBB4, FAK, Flt3, IGF-1R, ITK, Lck, MET, MUSK, Ret, Src, TIE2, TrkB, VEGF-R1 (Flt-1) and VEGF-R2 (KDR).)

HY-P10580

Vasculotide	Tie	Infection Metabolic Disease Inflammation/Immunology Cancer
Vasculotide, an angiopoietin-1 mimetic, is a *Tie-2* activator and induces Tie-2 phosphorylation. Vasculotide has anti-inflammatiory effect and anti-permeability. Vasculotide ameliorates endotoxin-induced endothelial barrier dysfunction. Vasculotide promotes angiogenesis in a mouse model of diabetic ulcer. Vasculotide protects mice from vascular leakage and reduces mortality in murine abdominal sepsis. Vasculotide decreases microvascular leakage and improves microcirculatory perfusion in a rat model of hemorrhagic shock ^[2] .

HY-P5527F

FAM-CSKtide	Peptides	Others
FAM-CSKtide is a biological active peptide. (This is a FAM labeled peptide substrate (Abs/Em = 494/521 nm) for C-terminal Src kinase (Csk) and many other kinases such as Axl, cKit, ERBB4, Fes, Flt3, IGF-1 R, MET, MUSK, PYK2, Ret, TIE2, TrkA, VEGF-R1 and VEGF-R2.)

Nesvacumab	Inhibitory Antibodies	Cardiovascular Disease Inflammation/Immunology Cancer
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand *Angiopoietin-2* (Ang2) with high affinity, but shows no binding to Ang1 .

Nesvacumab	Classification of Application Fields Disease Research Fields Cancer	Others
Nesvacumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody that specifically binds and inactivates the Tie2 receptor ligand *Angiopoietin-2* (Ang2) with high affinity, but shows no binding to Ang1 .

5α-Hydroxycostic acid	Other Terpenoids Classification of Application Fields Terpenoids Source classification Erythrina burttii Baker f. Plants Compositae Disease Research Fields Cancer	VEGFR
5α-Hydroxycostic acid, a eudesmane-type sesquiterpene, is isolated from the herb Laggera alata. 5α-Hydroxycostic acid inhibits angiogenesis and suppresses breast cancer cell migration through regulating *VEGF/VEGFR2* and *Ang2/Tie2* pathways .

CEP-11981 tosylate ESK981 tosylate; BOL 303213X tosylate	Classification of Application Fields Disease Research Fields Cancer	VEGFR FGFR
CEP-11981 (tosylate) (ESK981 (tosylate), BOL 303213X (tosylate)) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects .

Corylifol C	Structural Classification Leguminosae Source classification Phenols Polyphenols Psoralea corylifolia L. Plants	EGFR TAM Receptor Tie
Corylifol C is a potent protein kinase inhibitor with IC₅₀ valueS of 8.7, 3.0, 2.1, 6.4, 4.5, 6.2, 2.3, 1.2, 5.1 μg/ml for ARK5, Aurora-A, Aurora-B, AXL, B-RAF-VE, CDK4/CycD1, TIE2, EGF-R, EPHB4, respectively .

Recombinant Proteins Recommended:

TIE-2
TIE-2

Species:	Human (7) Rhesus Macaque (2) Mouse (4) Rat (1) Cynomolgus (2) Dog (1)
Tag:	His (11) Tag Free (1) Avi (3) GST (2) Fc (6)
Source:	HEK293 (14) Sf9 insect cells (2) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72450

	TIE-2 Protein, Human (HEK293, His) Angiopoietin-1 receptor; CD202b antigen; CD202b; hTIE2; p140 TEK; TEK; TIE2; TIE-2; VMCM; VMCM1	Human	HEK293
	TIE-2 is a tyrosine protein kinase that serves as a cell surface receptor for ANGPT1, ANGPT2, and ANGPT4 and is critical for angiogenesis, endothelial cell processes, and vascular stability. In addition to embryonic vasculogenesis, TIE-2 also affects postnatal hematopoiesis, regulating angiogenesis depending on the situation. TIE-2 Protein, Human (HEK293, His) is the recombinant human-derived TIE-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIE-2 Protein, Human (HEK293, His) is 723 a.a., with molecular weight of 100-120 kDa.

HY-P73438

	TIE-2 Protein, Rat (HEK293, Fc) Angiopoietin-1 receptor; CD202b; hTIE2; p140 TEK; TIE2; VMCM	Rat	HEK293
	TIE-2 protein has growth factor binding activity and is involved in ossification, cAMP response, and estrogen response. It is predicted to be present in a variety of cellular components, as a component of the plasma membrane, and as part of receptor complexes. TIE-2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived TIE-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIE-2 Protein, Rat (HEK293, Fc) is 721 a.a., with molecular weight of 120-130 kDa.

HY-P73610

	TIE-2 Protein, Mouse (HEK293, His) Angiopoietin-1 receptor; CD202b; hTIE2; p140 TEK; TIE2; VMCM	Mouse	HEK293
	TIE-2 Protein, Mouse (HEK293, His) belongs to the receptor tyrosine kinase family and functions as a receptor for Angiopoietin-1 (Ang1). Ang1 bridges TIE-2 at cell-cell contacts, resulting in trans-association of TIE-2 in the presence of cell-cell contacts. TIE-2 activation promotes vessel assembly and maturation by mediating survival signals for EC and regulating the recruitment of pericytes. TIE-2 maintains the vascular integrity of mature vessels by enhancing endothelial barrier function and inhibiting apoptosis of endothelial cells. TIE-2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TIE-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of TIE-2 Protein, Mouse (HEK293, His) is 722 a.a., with molecular weight of 95-120 kDa.

HY-P78568

	TIE-2 Protein, Cynomolgus (HEK293, His) TIE2; TIE-2; TEK; VMCM; VMCM1; CD202b; Angiopoietin-1 receptor	Cynomolgus	HEK293
	TIE-2 is a tyrosine protein kinase that serves as a cell surface receptor for ANGPT1, ANGPT2, and ANGPT4 and is critical for angiogenesis, endothelial cell processes, and vascular stability. In addition to embryonic vasculogenesis, TIE-2 also affects postnatal hematopoiesis, regulating angiogenesis depending on the situation. TIE-2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TIE-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of TIE-2 Protein, Cynomolgus (HEK293, His) is 723 a.a., with molecular weight of 95-130 kDa.

HY-P73437

	TIE-2 Protein, Mouse (HEK293, Fc) Angiopoietin-1 receptor; CD202b; hTIE2; p140 TEK; TIE2; VMCM	Mouse	HEK293
	TIE-2 is a tyrosine protein kinase that serves as a cell surface receptor for ANGPT1, ANGPT2, and ANGPT4 and is critical for angiogenesis, endothelial cell processes, and vascular stability. In addition to embryonic vasculogenesis, TIE-2 also affects postnatal hematopoiesis, regulating angiogenesis depending on the situation. TIE-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TIE-2 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P73434

	TIE-2 Protein, Human (HEK293, His-Fc) Angiopoietin-1 receptor; CD202b; hTIE2; p140 TEK; TIE2; VMCM	Human	HEK293
	TIE2 Protein is a cell surface receptor for ANGPT1, ANGPT2, and ANGPT4, belonging to the protein tyrosine kinase Tie2 family. TIE2 Protein is an angiogenic factor that regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion, cell spreading, and actin cytoskeleton reorganization, and has anti-inflammatory effects. TIE2 Protein consists of 1124 amino acids (M1-A1124), with two immunoglobulin-like domains, three N-terminal fibronectin type III domains (447-541 a.a, 545-636 a.a, 641-735 a.a), and three epidermal growth factor (EGF)-like domains (210-252 a.a, 254-299 a.a, 301-341 a.a). TIE-2 Protein, Human (HEK293, His-Fc) is the recombinant human-derived TIE-2 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of TIE-2 Protein, Human (HEK293, His-Fc) is 723 a.a., with molecular weight of ~130.7 kDa.

HY-P73435

	TIE-2 Protein, Human (sf9, His-GST) Angiopoietin-1 receptor; CD202b; hTIE2; p140 TEK; TIE2; VMCM	Human	Sf9 insect cells
	TIE-2 is a tyrosine protein kinase that serves as a cell surface receptor for ANGPT1, ANGPT2, and ANGPT4 and exerts a global control over angiogenesis and vascular stability. It regulates endothelial cell survival, proliferation, migration, adhesion, and actin cytoskeletal reorganization. TIE-2 Protein, Human (sf9, His-GST) is the recombinant human-derived TIE-2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of TIE-2 Protein, Human (sf9, His-GST) is 354 a.a., with molecular weight of ~64 kDa.

HY-P73436

	TIE-2 Protein, Mouse (sf9, His-GST) Angiopoietin-1 receptor; CD202b; hTIE2; p140 TEK; TIE2; VMCM	Mouse	Sf9 insect cells
	TIE-2 is a tyrosine protein kinase that serves as a cell surface receptor for ANGPT1, ANGPT2, and ANGPT4 and is critical for angiogenesis, endothelial cell processes, and vascular stability.In addition to embryonic vasculogenesis, TIE-2 also affects postnatal hematopoiesis, regulating angiogenesis depending on the situation.TIE-2 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived TIE-2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P77542

	TIE-2 Protein, Human (Biotinylated, HEK293, His) Angiopoietin-1 receptor; CD202b; hTIE2; p140 TEK; TIE2; VMCM	Human	HEK293
	TIE-2 is a tyrosine protein kinase that serves as a cell surface receptor for ANGPT1, ANGPT2, and ANGPT4 and exerts a global control over angiogenesis and vascular stability. It regulates endothelial cell survival, proliferation, migration, adhesion, and actin cytoskeletal reorganization. TIE-2 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived TIE-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of TIE-2 Protein, Human (Biotinylated, HEK293, His) is 723 a.a., with molecular weight of ~99.9 kDa.

HY-P702705

	TIE-2 Protein, Human (Biotinylated, sf9, Avi) TEK; TEK tyrosine kinase, endothelial; venous malformations, multiple cutaneous and mucosal , VMCM; angiopoietin-1 receptor; CD202b; TIE 2; TIE2; VMCM1; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; endothelial tyrosine kinase; tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase; tyrosine-protein kinase receptor TIE-2; tyrosine kinase with Ig and EGF homology domains-2; VMCM; TIE-2; CD202B	Human	Sf9 insect cells
	TIE-2 is a tyrosine protein kinase that serves as a cell surface receptor for ANGPT1, ANGPT2, and ANGPT4 and exerts a global control over angiogenesis and vascular stability. It regulates endothelial cell survival, proliferation, migration, adhesion, and actin cytoskeletal reorganization. TIE-2 Protein, Human (Biotinylated, sf9, Avi) is the recombinant human-derived TIE-2, expressed by Sf9 insect cells , with Avi labeled tag. ,

HY-P76673

	TIE-2 Protein, Cynomolgus (HEK293, Fc) Angiopoietin-1 receptor; CD202b antigen; CD202b; hTIE2; p140 TEK; TEK; TIE-2; VMCM; VMCM1	Cynomolgus	HEK293
	TIE-2 belongs to the RTPK family of proteins and is a type I transmembrane protein. TIE-2 can serve as a receptor for growth factors, differentiation factors, and metabolic response stimulators. TIE-2 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived TIE-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIE-2 Protein, Cynomolgus (HEK293, Fc) is 723 a.a., with molecular weight of ~130 kDa.

HY-P77232

	TIE-2 Protein, Rhesus Macaque (HEK293, His) Angiopoietin-1 receptor; CD202b antigen; CD202b; hTIE2; p140 TEK; TEK; TIE-2; VMCM; VMCM1	Rhesus Macaque	HEK293
	TIE-2 Protein, a tyrosine-protein kinase, acts as a cell-surface receptor for ANGPT1, ANGPT2, and ANGPT4, exerting comprehensive control over angiogenesis, endothelial cell behavior, and vascular stability. It regulates diverse processes, including endothelial cell survival, proliferation, migration, adhesion, and actin cytoskeleton reorganization, while also playing a crucial role in maintaining vascular quiescence and preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. TIE-2 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived TIE-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of TIE-2 Protein, Rhesus Macaque (HEK293, His) is 723 a.a., with molecular weight of ~84.2 KDa.

HY-P700396

	ANGPT2/Angiopoietin-2, Dog (HEK293, His) angiopoietin 2; angiopoietin-2; Ang2; ANG-2; TIE2-ligand; angiopoietin-2B; angiopoietin-2a; ANG2; AGPT2	Dog	HEK293
	ANGPT2/Angiopoietin-2, Dog, intricately modulates angiogenesis by binding to TEK/TIE2, competitively impacting ANGPT1 signaling. It induces TEK/TIE2 phosphorylation independently and, in the absence of VEGF, may lead to endothelial apoptosis, contributing to vascular regression. Collaborating with VEGF, ANGPT2 facilitates angiogenesis, promoting endothelial cell migration and proliferation. Additionally, ANGPT2 regulates lymphangiogenesis, emphasizing its comprehensive role in vascular dynamics within dog biology. Its interactions with TEK/TIE2 and ITGA5 highlight its multifaceted contribution to angiogenesis and vascular regulation. ANGPT2/Angiopoietin-2, Dog (HEK293, His) is the recombinant dog-derived ANGPT2/Angiopoietin-2, Dog, expressed by HEK293, with C-6*His labeled tag. The total length of ANGPT2/Angiopoietin-2, Dog (HEK293, His) is 477 a.a., with molecular weight of 57.2 kDa.

HY-P78381

	Angiopoietin-2 Protein, Human (HEK293, His-Avi) AGPT2; ANG2; ANG-2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; TIE2-ligand	Human	HEK293
	Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of Angiopoietin-2 Protein, Human (HEK293, His-Avi) is 222 a.a., with molecular weight of 30-40 kDa.

HY-P78061

	Angiopoietin-2 Protein, Human (Biotinylated, HEK293, His-Avi) AGPT2; ANG2; ANG-2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; TIE2-ligand	Human	HEK293
	Angiopoietin-2 (ANGPT2) protein competes with ANGPT1 for TEK/TIE2 binding, modulates ANGPT1 signaling and induces TEK/TIE2 phosphorylation even in the absence of ANGPT1. In the absence of angiogenic stimulation, ANGPT2 disrupts cell-matrix contacts, potentially triggering endothelial cell apoptosis and vessel regression. Angiopoietin-2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Angiopoietin-2 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of Angiopoietin-2 Protein, Human (Biotinylated, HEK293, His-Avi) is 222 a.a., with molecular weight of 32-37 kDa.

HY-P70123

	Angiopoietin-2 Protein, Rhesus macaque (HEK293, Fc) rRhANG2, Fc; AGPT2; ANG2; ANG-2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; TIE2-ligand	Rhesus Macaque	HEK293
	ANGPT2 is a secreted factor on the angiopoietin/Tie (tyrosine kinase with Ig and EGF homology domains) signaling pathway and is involved in tumor angiogenesis. In the presence of ANGPT1, ANGPT2 antagonizes ANGPT1-mediated Tie2 phosphorylation, leading to vessel sprouting or degeneration depending on the level of VEGF-A. Overexpression or inhibition of ANGPT2 increases or decreases angiogenic capacity, respectively. Angiopoietin-2 Protein, Rhesus macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Angiopoietin-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Angiopoietin-2 Protein, Rhesus macaque (HEK293, Fc) is 477 a.a., with molecular weight of 90-120 kDa.

HY-P7844

	Angiopoietin-2 Protein, Mouse (HEK293, Fc) rMuAngiopoietin-2/ANG2, Fc ; AGPT2; ANG2; ANG-2; angiopoietin 2; Angiopoietin-2; angiopoietin-2a; angiopoietin-2B; angiopoitin 2; ANGPT2; TIE2-ligand	Mouse	HEK293
	Angiopoietin 2 protein (ANGPT2) binds to TEK/TIE2, competes with ANGPT1, and modulates its signaling. Even in the absence of ANGPT1, ANGPT2 induces TEK/TIE2 phosphorylation. Angiopoietin-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Angiopoietin-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Angiopoietin-2 Protein, Mouse (HEK293, Fc) is 478 a.a., with molecular weight of 90-120 kDa.

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