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Results for "

Trypanosoma brucei

" in MedChemExpress (MCE) Product Catalog:

43

Inhibitors & Agonists

7

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-155655
    JC-229

    		Parasite Infection
    JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .
    JC-229
  • HY-103056
    DDD85646

    IMP-366

    		 DNA/RNA Synthesis Parasite Infection
    DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis .
    DDD85646
  • HY-136637
    NPD-001

    		Phosphodiesterase (PDE) Parasite Infection
    NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC50 of 80 nM .
    NPD-001
  • HY-136200
    Antitrypanosomal agent 2

    		Parasite Infection
    Antitrypanosomal agent 2 is a potent and selective trypanosoma brucei inhibitor .
    Antitrypanosomal agent 2
  • HY-128170
    Ebsulfur

    		Parasite Infection
    Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase (TryR) of Trypanosoma brucei, with IC50 values of 61-293 nM for Trypanosoma brucei. Ebsulfur can be used for the research of African trypanosomiasis .
    Ebsulfur
  • HY-125632
    Ro 19-9638

    		Parasite Infection
    Ro 19-9638 is the major metabolite of Ro 15-0216. Ro 19-9638 exhibits antiparasitic efficacy against Trypanosoma brucei rhodesiense with an IC50 of 0.0341 µg/mL .
    Ro 19-9638
  • HY-147933
    Antitrypanosomal agent 8

    		Parasite Infection
    Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against Trypanosoma brucei with an IC50 value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC50=80.95 μM) .
    Antitrypanosomal agent 8
  • HY-147940
    TbPTR1 inhibitor 1

    		Parasite Infection
    TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an IC50<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC50=0.66 μM) .
    TbPTR1 inhibitor 1
  • HY-162656
    DHFR-IN-19

    		Dihydrofolate reductase (DHFR) Infection
    DHFR-IN-19 (Compound 2g) is a selective inhibitor for TbDHFR with Ki of 9 nM. DHFR-IN-19 exhibits antiparasitic activity against Trypanosoma brucei with an EC50 of 14.5 μM .
    DHFR-IN-19
  • HY-16121
    CAA-0225

    		Cathepsin Others
    CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC50 value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites [1][2][3].
    CAA-0225
  • HY-119938
    Tuberculosis inhibitor 1

    		Bacterial Infection
    Tuberculosis inhibitor 1 is a potent and non-cytotoxic trypanosoma brucei growth inhibitor with an EC50 of 5 nM .
    Tuberculosis inhibitor 1
  • HY-N3247
    Monomethyl kolavate

    		Parasite Others
    Monomethyl kolavate is a Trypanosoma brucei GAPDH enzyme (TbGAPDH) inhibitor with theIC50 value of 2 µM .
    Monomethyl kolavate
  • HY-146049
    Antitrypanosomal agent 4

    		Parasite Infection
    Antitrypanosomal agent 4 (compound 19) is a potent and blood-brain barrier permeable antitrypanosomal agent. Antitrypanosomal agent 4 has good activity against Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei brucei (T. b. brucei) with IC50s of 1.2 μM and 70 nM, respectively . Antitrypanosomal agent 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Antitrypanosomal agent 4
  • HY-157028
    Antiparasitic agent-19

    		Others Infection
    Antiparasitic agent-19 (compound 40) is a compound with broad-spectrum antiparasitic activity. Antiparasitic agent-19 has minimal toxicity against Trypanosoma brucei, Leishmania Infantum, and Trypanosoma cruzi .
    Antiparasitic agent-19
  • HY-142021
    Z-Leu-Arg-AMC

    		Parasite Infection
    Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (Amc) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC is the active site of cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei .
    Z-Leu-Arg-AMC
  • HY-155207
    Antileishmanial agent-23

    		Parasite Infection
    Antileishmanial agent-23 (compound G1/9) is a potent and selective trypanothione reductase (TR) inhibitor, with an IC50 of 2.24 ± 0.52 μM. Antileishmanial agent-23 inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei .
    Antileishmanial agent-23
  • HY-118580
    RO-09-4609

    		Fungal Parasite Infection
    RO-09-4609 exhibits antimicrobial activity, that inhibits Candida albicans, Trypanosoma brucei and Plasmodium vivax through inhibition of N-myristoyl transferase .
    RO-09-4609
  • HY-125731
    Glycodeoxycholic Acid

    		Endogenous Metabolite STAT Autophagy Inflammation/Immunology Cancer
    Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .
    Glycodeoxycholic Acid
  • HY-116045
    PDEB1-IN-1

    		Parasite Cancer
    PDEB1-IN-1 (Compound 12b) is the derivative of Cilomilast (HY-10790), and serves as an inhibitor for TryPanosoma Brucei PDEB1 (TbrPDEB1) with an IC50 of 0.95 μM. PDEB1-IN-1 inhibits the proliferation of T. Brucei with an EC50 of 26 μM .
    PDEB1-IN-1
  • HY-N7266
    Obtusifoliol

    		Cytochrome P450 Parasite Infection Cancer
    Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with Kd values of 1.2 μM and 1.4 μM for Trypanosoma brucei (TB) and human CYP51, respectively .
    Obtusifoliol
  • HY-101015A
    OBAA

    		Phospholipase Apoptosis Inflammation/Immunology
    OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC50 of 70 nM. OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei with an IC50 of 0.4 μM .
    OBAA
  • HY-144296
    Purine phosphoribosyltransferase-IN-2

    		Parasite Infection
    Purine phosphoribosyltransferase-IN-2 is a potent inhibitor of the Plasmodium falciparum ((Pf)), Plasmodium vivax ((Pv)) and Trypanosoma brucei ((Tbr)) 6-oxopurine phosphoribosyltransferase (PRT), with Kis of 30, 20 and 2 nM, respectively .
    Purine phosphoribosyltransferase-IN-2
  • HY-147550
    Antitrypanosomal agent 7

    		Parasite Infection
    Antitrypanosomal agent 7 (compound 18c) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 7 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.71 μM. Antitrypanosomal agent 7 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .
    Antitrypanosomal agent 7
  • HY-147549
    Antitrypanosomal agent 6

    		Parasite Infection
    Antitrypanosomal agent 6 (compound 18a) is a potent and antitrypanosomal agent with favorable ADME properties. Antitrypanosomal agent 6 is > 2-fold more potent against Trypanosoma brucei (T. brucei) than Nifurtimox, with an IC50 value of 0.47 μM. Antitrypanosomal agent 6 has strong interaction to DNA and can bind with high selectivity to AT-rich DNA .
    Antitrypanosomal agent 6
  • HY-12054
    Hesperadin
    Maximum Cited Publications
    8 Publications Verification

    		 Aurora Kinase Autophagy Influenza Virus Parasite Cancer
    Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC50 of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral .
    Hesperadin
  • HY-125731R
    Glycodeoxycholic Acid (Standard)

    		Endogenous Metabolite STAT Autophagy Inflammation/Immunology Cancer
    Glycodeoxycholic Acid (Standard) is the analytical standard of Glycodeoxycholic Acid. This product is intended for research and analytical applications. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis .
    Glycodeoxycholic Acid (Standard)
  • HY-125084
    NEU617

    		Parasite Infection
    NEU617 is an anti-parasite agent. NEU617 inhibits the proliferation for the HAT (human African trypanosomiasis) pathogen (EC50: 42 nM for Trypanosoma brucei, 1.8 μM for T. cruzi). NEU617 is a derivative of Lapatinib (HY-50898) .
    NEU617
  • HY-108938
    SDZ285428

    		Cytochrome P450 Fungal Parasite Infection
    SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h) .
    SDZ285428
  • HY-144294
    Purine phosphoribosyltransferase-IN-1

    		Parasite Infection
    Purine phosphoribosyltransferase-IN-1 (Compound (S,R)-48) is a potent inhibitor of the Plasmodium falciparum (Pf), P. vivax (Pv) and Trypanosoma brucei (Tbr) 6-oxopurine purine phosphoribosyltransferases (PRTs), with Ki values of 50, 20, and 2 nM, respectively .
    Purine phosphoribosyltransferase-IN-1
  • HY-126250
    NPD-1335

    		Phosphodiesterase (PDE) Parasite Infection Inflammation/Immunology
    NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death . NPD-1335 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    NPD-1335
  • HY-118996A
    Isometamidium chloride

    		Parasite Infection
    Isometamidium chloride is an antiprotozoal agent, that exhibits activity against trypanosome. Isometamidium chloride can be used in research of african sleeping sickness .
    Isometamidium chloride
  • HY-111759
    Jaspamycin
    1 Publications Verification

    7-CN-7-C-Ino

    		 PKA Parasite Infection
    Jaspamycin (7-CN-7-C-Ino) is a potent activator of PKA, binding to the R site (PKAR), with an EC50 of 6.5 nM and Kd of 8 nM in Trypanosoma brucei. Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα. Anti-parasite activity .
    Jaspamycin
  • HY-101015
    (2E)-OBAA

    		Phospholipase Apoptosis Inflammation/Immunology
    (2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM .
    (2E)-OBAA
  • HY-N0389
    Columbin
    1 Publications Verification

    		 COX Parasite Inflammation/Immunology
    Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) .
    Columbin
  • HY-129288
    GW837016X

    NEU-391

    		 EGFR Paraptosis Infection
    GW837016X (NEU-391) is an orally active ErbB-2 kinase covalent inhibitor. GW837016X also is a potent antitrypanosome agent. GW837016X inhibits mitosis and cytokinesis .
    GW837016X
  • HY-N0389R
    Columbin (Standard)

    		COX Parasite Inflammation/Immunology
    Columbin (Standard) is the analytical standard of Columbin. This product is intended for research and analytical applications. Columbin is an orally active diterpenoid furanolactone from Calumbae radix, has anti-inflammatory and anti-trypanosomal effects. Columbin selectively inhibits COX-2 (EC50=53.1 μM) over COX-1 (EC50=327 μM) .
    Columbin (Standard)
  • HY-126417
    Methylenetanshinquinone

    		Parasite Infection
    Methylenetanshinquinone is a natural compound with antiplasmodial, antitrypanosomal and antioxidative activities. Methylenetanshinquinone can be used for the research of parasite infection .
    Methylenetanshinquinone
  • HY-W391625
    (Rac)-Dehydrocostus Lactone

    (Rac)-Epiligulyl oxide

    		 Others Cancer
    (Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index .
    (Rac)-Dehydrocostus Lactone
  • HY-147766
    Antileishmanial agent-10

    		Parasite Infection
    Antileishmanial agent-10 (Compound 7h) is an antiprotozoal agent .
    Antileishmanial agent-10
  • HY-147765
    Anti-Trypanosoma cruzi agent-3

    		Parasite Infection
    Anti-Trypanosoma cruzi agent-3 (Compound 7c) is an antiprotozoal agent .
    Anti-Trypanosoma cruzi agent-3
  • HY-14932
    Pafuramidine
    1 Publications Verification

    DB289

    		 Parasite Antibiotic Infection
    Pafuramidine (DB289) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria .
    Pafuramidine
  • HY-14932A
    Pafuramidine maleate

    DB289 maleate

    		 Parasite Antibiotic Infection
    Pafuramidine (maleate) (DB289 (maleate)) is an orally active proagent of Furamidine (HY-110137A). Pafuramidine (maleate) (DB289 (maleate)) is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria .
    Pafuramidine maleate
  • HY-119480
    Megazol

    		Bacterial Infection
    Megazol is an orally active antibacterial agent. Megazol has effective inhibitory against T. b. brueei with an EC50 of 0.01 μg/mL. Megazol can be used for the research of protozoan infections .
    Megazol

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