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aminopeptidase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminopeptidase (39) MetAP (7) Angiotensin Receptor (1) Antibiotic (8) Apoptosis (2) Bacterial (10) Carboxypeptidase (1) Dipeptidyl Peptidase (5) Epoxide Hydrolase (1) Isotope-Labeled Compounds (1) Leukotriene Receptor (2) Lipase (1) MMP (1) Neprilysin (3) Opioid Receptor (1) Parasite (2) Prolyl Endopeptidase (PREP) (1) Proteasome (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (6) Infection (11) Inflammation/Immunology (8) Metabolic Disease (8) Neurological Disease (9)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Aminopeptidase MetAP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101932

TNP-470 1 Publications Verification AGM-1470	Aminopeptidase	Cardiovascular Disease Cancer
TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor.

HY-151518

Aminopeptidase-IN-1	Aminopeptidase	Neurological Disease
Aminopeptidase-IN-1 (compound 16o) is a potent *insulin-regulated aminopeptidase* (IRAP)** inhibitor with an K_i value of 7.7 μM. Aminopeptidase-IN-1 can be used tor research cognitive and memory impairments .

HY-P1044A

Spinorphin TFA LVV-hemorphin-4 TFA	Angiotensin Receptor	Neurological Disease
Spinorphin TFA is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect .

HY-129298

Amastatin	Aminopeptidase	Others
Amastatin is A slow, tightly bound, competitive inhibitor of aminopeptidase (AP) with an IC₅₀ of 0.54 μg/mL for AP-A .

HY-117238

Ketomethylenebestatin	Aminopeptidase	Others
Ketomethylenebestatin is an aminopeptidase (AP) inhibitor and an analog of the natural aminopeptidase inhibitor Bestatin (HY-B0134) with IC₅₀ of 56 μM, 752 μM and 0.39 μM for AP-B, AP-M and Leu-AP, respectively .

HY-158410

PSA-IN-1	Others	Neurological Disease
PSA-IN-1 (compound 19) is a *puromycin sensitive aminopeptidase* (PSA)** inhibitor with IC₅₀ at 7 nM. PSA-IN-1 has analgesic activity .

HY-125422

Matlystatin A	Aminopeptidase	Cancer
Matlystatin A is a potent *aminopeptidase* inhibitor, with IC₅₀ values of 0.3 μM and 0.56 μM against 92 kDa and 72 kDa type IV collagenases, respectively. Matlystatin A can be utilized in cancer research .

HY-136887

Arphamenine B hemisulfate	Bacterial	Others
Arphamenine B (hemisulfate) is a Zn ²⁺-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B (hemisulfate) Arphamenine B (hemisulfate) is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B (hemisulfate) enhances the immune response and is used to characterize novel proteases .

HY-115194

Amastatin hydrochloride	Aminopeptidase Bacterial	Infection
Amastatin hydrochloride is a slow, tight binding, competitive aminopeptidase (AP) inhibitor with K_i values of 0.26 nM, 30 nM, 52 nM for Aeromonas aminopeptidase, cytosolic leucine aminopeptidase, microsomal aminopeptidase .

HY-P1044

Spinorphin LVV-hemorphin-4	Carboxypeptidase	Neurological Disease
Spinorphin is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect .

HY-121483

Leucinal	Aminopeptidase	Others
Leucinal is a competitive inhibitor of brain aminopeptidase, inhibits brain soluble aminopeptidase activity (Ki = 22 microM), and can enhance the analgesia induced by leuprorelin, but has no effect on the analgesia induced by some other substances.

HY-13731

PPI-2458	MetAP	Inflammation/Immunology Cancer
PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 (MetAP-2). PPI-2458 can be used for arthritis and lymphoma research .

HY-W027340

ARM1 1 Publications Verification 4BSA	Aminopeptidase Epoxide Hydrolase	Cancer
ARM1 (4BSA) is a potent *aminopeptidase* and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC₅₀ 7.61 µM and epoxide hydrolase inhibitory activity with an IC₅₀ 12.4 µM .

HY-147401

Sitagliptin fenilalanil	Dipeptidyl Peptidase	Metabolic Disease
Sitagliptin fenilalanil is a *dipeptidyl aminopeptidase* 4 (DPP-4)** inhibitor .

HY-W015876

L-Leucinol (+)-Leucinol	Aminopeptidase	Others
L-Leucinol ((+)-Leucinol) is a competitive *aminopeptidase* inhibitor with K_i value of 17 μM .

HY-147401A

Sitagliptin fenilalanil hydrochloride	Dipeptidyl Peptidase	Metabolic Disease
Sitagliptin fenilalanil hydrochloride is a *dipeptidyl aminopeptidase* 4 (DPP-4)** inhibitor .

HY-133016A

(R)-M8891	MetAP	Others
(R)-M8891 (compound R-9) is a less active isomer of M8891. M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor .

HY-113952

Actinonin 5 Publications Verification (-)-Actinonin	Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Infection Cancer
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

HY-110259

HFI-142 1 Publications Verification	Aminopeptidase	Neurological Disease
HFI-142 is an *insulin-regulated aminopeptidase* (IRAP)** inhibitor with a K_i of 2.01 μM .

HY-118661

BDM14471	Aminopeptidase	Others
BDM14471 is a selective inhibitor of hydroxamate aminopeptidase M1 (PfAM1), with the IC₅₀ of 6 nM .

HY-B0134A

Bestatin hydrochloride 5+ Cited Publications Ubenimex hydrochloride	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin hydrochloride is an inhibitor of *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase**, used for cancer research.

HY-B0134B

Bestatin trifluoroacetate Ubenimex trifluoroacetate	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin trifluoroacetate is an inhibitor of *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase**, used for cancer research.

HY-120868

TP-004	MetAP	Metabolic Disease
TP-004 is a potent and reversible inhibitor of *methionine aminopeptidase* 2 (MetAP2), with an IC₅₀** of 6 nM .

HY-133016

M8891	MetAP	Cardiovascular Disease Cancer
M8891 is an orally active, reversible and brain penetrant *Methionine Aminopeptidase-2 (MetAP-2)* inhibitor with an IC₅₀ of 54 nM and a K_i of 4.33 nM. M8891 does not inhibit MetAP-1 (IC₅₀>10 µM) . M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity .

HY-137159

Bestatin methyl ester	Aminopeptidase	Cancer
Bestatin methyl ester is a cell permeable Zn2+-binding aminopeptidases inhibitor. Bestatin methyl ester inhibits spore cell differentiation .

HY-163714

IRAP-IN-1	Aminopeptidase	Metabolic Disease
IRAP-IN-1 (compound 3) is a potent and selective *insulin regulated aminopeptidase* (IRAP)** inhibitor with an IC₅₀ value of 157 nM .

HY-158690

DDD00057570	Parasite Antibiotic	Infection
DDD00057570 is a selective *M17 leucyl-aminopeptidase* (LAP)** inhibitor. DDD00057570 inhibits L. major and L. donovani intracellular amastigotes in vitro growth .

HY-160239

HFI-437	Aminopeptidase	Neurological Disease
HFI-437 is a potent non-peptidic *insulin-regulated aminopeptidase* (IRAP)** inhibitor with a K_i of 20 nM. HFI-437 is a cognitive enhancer .

HY-116306

Probestin	Aminopeptidase	Others
Probestin is a potent aminopeptidase N (APN) inhibitor produced by Streptomyces cyanogens MH663-2F6 .

HY-14807

Tosedostat 5+ Cited Publications CHR-2797	Aminopeptidase	Cancer
Tosedostat (CHR-2797) is an orally active *aminopeptidase* inhibitor. CHR-2797 exerts antiproliferative effects against a range of tumor cell lines .

HY-109188

Relzomostat	MetAP	Metabolic Disease
Relzomostat is a methionine aminopeptidase 2 (MetAP2) inhibitor.Relzomostat may be useful for the research of obesity, type 2 diabetes, and other obesity-associated conditions .

HY-B0134

Bestatin 5+ Cited Publications Ubenimex	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin is a natural, broad-spectrum, and competitive *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase** inhibitor. Bestatin has anticancer effects .

HY-B0134AS

Bestatin-d7 hydrochloride Ubenimex-d₇ hydrochloride	Isotope-Labeled Compounds Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin-d₇ (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

HY-128090

Apstatin	Aminopeptidase	Cardiovascular Disease
Apstatin is a potent aminopeptidase P (APP) inhibitor with K_i values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin shows cardioprotection .

HY-W012888

D-Leucinol (-)-Leucinol	Aminopeptidase	Others
D-Leucinol is the isomer of L-Leucinol (HY-W015876), and can be used as an experimental control. L-Leucinol ((+)-Leucinol) is a competitive *aminopeptidase* inhibitor with K_i value of 17 μM .

HY-143249

MtMetAP1-IN-1	Bacterial	Infection
MtMetAP1-IN-1 is an inhibitor of Mycobacterium tuberculosis (Mtb), targeting *methionine aminopeptidase* 1 (MetAP1**). MtMetAP1-IN-1 exerts antimycobacterial activity .

HY-162920

QGC583	Aminopeptidase	Cardiovascular Disease
QGC583 is an effective selective Aminopeptidase A (APA) inhibitor with oral activity and blood-brain barrier permeability, boasting an IC₅₀ value of 4 nM. QGC583 can inhibit APA activity in the brain, kidneys, and heart of rats .

HY-133125

ERAP1-IN-1 2 Publications Verification	Aminopeptidase	Inflammation/Immunology
ERAP1-IN-1 is an *endoplasmic reticulum aminopeptidase* 1 (ERAP1)** inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates .

HY-N9898

Sinocrassoside C1	Others	Others
Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .

HY-111173

Diprotin B	Dipeptidyl Peptidase	Others
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue .

HY-116126

Leuhistin	Aminopeptidase	Cancer
Leuhistin is an AP-M (aminopeptidase-M) inhibitor. AP-M is an inactivating enzyme of bioactive peptides in cerebral membranes. Leuhistin can be produced by Bacillus laterosporus BMI156-14F1 .

HY-158006

SDX-7539	MetAP	Cancer
SDX-7539 is a selective inhibitor for Methionine aminopeptidase type 2 (MetAP2). SDX-7539 inhibits proliferarion of HUVECs with an IC₅₀ of 120 μM. SDX-7539 exhibits antitumor activity in NSCLC xenograft athymic nude mice .

HY-116476

Risotilide	Neprilysin	Others
Risotilide is an inhibitor of enkephalinase B, which has the ability to inhibit enkephalinase B activity (IC₅₀ value is 0.35 microM), and can also effectively inhibit enkephalinase A (IC₅₀ = 0.02 microM) and aminopeptidase activity (IC₅₀ = 13 microM), and can be regarded as a complete inhibitor of enkephalin biodegradation.

HY-168181

ERAP1-IN-2	Aminopeptidase	Others
ERAP1-IN-2 (compound 3f) is an inhibitor of ERAP1 (endoplasmic reticulum aminopeptidase 1). ERAP1-IN-2 has an IC₅₀ value of 1.72 μM against hERAP1 .

HY-156960

JNJ-40929837	Aminopeptidase Leukotriene Receptor	Inflammation/Immunology
JNJ-40929837 is a selective and orally active LTA₄H (leukotriene A₄ hydrolase) inhibitor. JNJ-40929837 effectively inhibits *aminopeptidase* activity and causes serum accumulation of Pro-Gly-Pro. JNJ-40929837 can be used in asthma research .

HY-W717329

EC33	Aminopeptidase	Cardiovascular Disease
EC33 is a selective aminopeptidase A (APA) inhibitor. EC33 blocks the pressor response of exogenous Ang II. EC33 does not cross the blood-brain barrier. EC33 has the potential for salt-dependent model of hypertension research .

HY-B0134R

Bestatin (Standard)	Aminopeptidase Bacterial Antibiotic	Infection Cancer
Bestatin (Standard) is the analytical standard of Bestatin. This product is intended for research and analytical applications. Bestatin is a natural, broad-spectrum, and competitive *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase** inhibitor. Bestatin has anticancer effects .

HY-163727

MMV1557817	Parasite	Infection
MMV1557817 is an orally active and potent antimalarial compound. MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 and M17, leading to inhibition of end-stage hemoglobin digestion in asexual parasites .

HY-109058

Firibastat 1 Publications Verification QGC001; RB150	Aminopeptidase	Cardiovascular Disease
Firibastat (QGC001), an orally active brain penetrating proagent of EC33, is a first-in-class brain aminopeptidase A (APA) inhibitor (K_i=200 nM). Firibastat selectively and specifically inhibits conversion of brain angiotensin-II into angiotensin-III and decreases blood pressure in hypertensive rats .

HY-W009906

2-(2′-Pyridyl)benzimidazole	Aminopeptidase	Inflammation/Immunology
2-(2’-Pyridyl)benzimidazole is a potentially tridentate ligand that can form stable complexes with various transition metal ions. 2-(2’-Pyridyl)benzimidazole can be used as an anti-inflammatory agent and an inhibitor of Escherichia coli methionine *aminopeptidase* .

Cat. No.	Product Name	Target	Research Area

HY-P1044A

Spinorphin TFA LVV-hemorphin-4 TFA	Angiotensin Receptor	Neurological Disease
Spinorphin TFA is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect .

HY-111173

Diprotin B	Dipeptidyl Peptidase	Others
Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue .

HY-W345510

Opiorphin	Neprilysin	Neurological Disease
Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC₅₀ value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113952

Actinonin 5 Publications Verification (-)-Actinonin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities .

HY-B0134A

Bestatin hydrochloride Maximum Cited Publications 7 Publications Verification Ubenimex hydrochloride	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Aminopeptidase Bacterial Antibiotic
Bestatin hydrochloride is an inhibitor of *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase**, used for cancer research.

HY-B0134

Bestatin Maximum Cited Publications 7 Publications Verification Ubenimex	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Aminopeptidase Bacterial Antibiotic
Bestatin is a natural, broad-spectrum, and competitive *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase** inhibitor. Bestatin has anticancer effects .

HY-N9898

Sinocrassoside C1	Structural Classification Sinocrassula indica (Decne.) Berger Flavonoids Flavones Source classification Crassulaceae Plants Saccharides Monosaccharides	Others
Sinocrassoside C1 is a natural compound isolated from themethanolic extract of the whole plant ofSinocrassula indica (Crassulaceae) .

HY-125422

Matlystatin A	Structural Classification Natural Products Microorganisms Source classification	Aminopeptidase
Matlystatin A is a potent *aminopeptidase* inhibitor, with IC₅₀ values of 0.3 μM and 0.56 μM against 92 kDa and 72 kDa type IV collagenases, respectively. Matlystatin A can be utilized in cancer research .

HY-B0134B

Bestatin trifluoroacetate Ubenimex trifluoroacetate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Aminopeptidase Bacterial Antibiotic
Bestatin trifluoroacetate is an inhibitor of *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase**, used for cancer research.

HY-116306

Probestin	Structural Classification Natural Products Microorganisms Source classification	Aminopeptidase
Probestin is a potent aminopeptidase N (APN) inhibitor produced by Streptomyces cyanogens MH663-2F6 .

HY-116126

Leuhistin	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Aminopeptidase
Leuhistin is an AP-M (aminopeptidase-M) inhibitor. AP-M is an inactivating enzyme of bioactive peptides in cerebral membranes. Leuhistin can be produced by Bacillus laterosporus BMI156-14F1 .

HY-B0134R

Bestatin (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Aminopeptidase Bacterial Antibiotic
Bestatin (Standard) is the analytical standard of Bestatin. This product is intended for research and analytical applications. Bestatin is a natural, broad-spectrum, and competitive *CD13 (Aminopeptidase* N)/APN and leukotriene A4 hydrolase** inhibitor. Bestatin has anticancer effects .

HY-126564

Ebelactone A	Structural Classification Natural Products Microorganisms Source classification	Lipase MetAP
Ebelactone A is a mycolic acid β-lactone, which exhibits inhibitory activity for esterase, lipase, fMet aminopeptidase (fMet AP) and PNBase, with IC₅₀s of 56, 3, 8 and 7.5 μM, respectively . Ebelactone A inhibits cutinase, exhibits plants protective potency against Erysiphe graminis .

Cat. No.	Product Name	Chemical Structure

HY-B0134AS

Bestatin-d7 hydrochloride
Bestatin-d₇ (hydrochloride) is deuterium labeled Bestatin (hydrochloride). Bestatin hydrochloride is an inhibitor of CD13 (Aminopeptidase N)/APN and leukotriene A4 hydrolase, used for cancer research.

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aminopeptidase inhibitor

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