Search Result

Results for "

antitumour activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Deaminase (1) Akt (1) AMPK (2) Antibiotic (2) Antifolate (1) Apoptosis (8) ATP Synthase (1) Autophagy (2) Bacterial (4) Biochemical Assay Reagents (1) BRK (1) CDK (1) Cholinesterase (ChE) (3) DNA Alkylator/Crosslinker (3) DNA/RNA Synthesis (2) Drug Metabolite (2) EBV (1) EGFR (6) Endogenous Metabolite (5) FGFR (1) Fungal (2) GSK-3 (1) HDAC (1) Histamine Receptor (1) Histone Acetyltransferase (1) HIV (1) Influenza Virus (1) Isotope-Labeled Compounds (3) LAG-3 (1) Ligands for E3 Ligase (1) LRRK2 (1) MAP4K (1) Mitochondrial Metabolism (1) Molecular Glues (1) Monoamine Oxidase (1) NAMPT (1) Nucleoside Antimetabolite/Analog (1) Oxidative Phosphorylation (1) Parasite (1) PD-1/PD-L1 (2) Phosphodiesterase (PDE) (1) PKC (1) Ras (1) Reactive Oxygen Species (2) TGF-β Receptor (1) Topoisomerase (1) VEGFR (1) Virus Protease (1)
By Research Areas:	Cancer (50) Cardiovascular Disease (5) Infection (11) Inflammation/Immunology (6) Metabolic Disease (5) Neurological Disease (5)

By Targets:

Adenosine Deaminase (1)

Akt (1)

AMPK (2)

Antibiotic (2)

Antifolate (1)

Apoptosis (8)

ATP Synthase (1)

Autophagy (2)

Bacterial (4)

Biochemical Assay Reagents (1)

BRK (1)

CDK (1)

Cholinesterase (ChE) (3)

DNA Alkylator/Crosslinker (3)

DNA/RNA Synthesis (2)

Drug Metabolite (2)

EBV (1)

EGFR (6)

Endogenous Metabolite (5)

FGFR (1)

Fungal (2)

GSK-3 (1)

HDAC (1)

Histamine Receptor (1)

Histone Acetyltransferase (1)

HIV (1)

Influenza Virus (1)

Isotope-Labeled Compounds (3)

LAG-3 (1)

Ligands for E3 Ligase (1)

LRRK2 (1)

MAP4K (1)

Mitochondrial Metabolism (1)

Molecular Glues (1)

Monoamine Oxidase (1)

NAMPT (1)

Nucleoside Antimetabolite/Analog (1)

Oxidative Phosphorylation (1)

Parasite (1)

PD-1/PD-L1 (2)

Phosphodiesterase (PDE) (1)

PKC (1)

Ras (1)

Reactive Oxygen Species (2)

TGF-β Receptor (1)

Topoisomerase (1)

VEGFR (1)

Virus Protease (1)

By Research Areas:

Cancer (50)

Cardiovascular Disease (5)

Infection (11)

Inflammation/Immunology (6)

Metabolic Disease (5)

Neurological Disease (5)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111651

Gboxin 3 Publications Verification	Oxidative Phosphorylation ATP Synthase Mitochondrial Metabolism	Cancer
Gboxin is an oxidative phosphorylation (OXPHOS) inhibitor that targets glioblastoma. Gboxin inhibits the activity of F₀F₁ ATP synthase. Antitumour activity .

HY-111652

S-Gboxin 1 Publications Verification	Others	Cancer
S-Gboxin, a functional analogue of Gboxin, inhibits growth of mouse and human glioblastoma (GBM) with an IC₅₀ of 470 nM . Antitumour activity .

HY-W000427

Ethyl Orsellinate	Bacterial	Infection Cancer
Ethyl orsellinate is a lichen metabolite and a derivative of lecanoric acid with antiproliferative and antitumour activities . Ethyl Orsellinate is against A. salina for the cytotoxic activity with an LC₅₀ of 495 μM .

HY-N1214

Squalene Super Squalene; trans-Squalene; AddaVax	Endogenous Metabolite Reactive Oxygen Species Fungal	Infection Cardiovascular Disease
Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-P99617

Fianlimab REGN3767	LAG-3	Cancer
Fianlimab (REGN3767) is a human monoclonal antibody that targets the immune checkpoint receptor LAG-3 on T cells and has anti-tumour activity .

HY-23120

1-Hydroxyguanidine sulfate	Antibiotic Virus Protease	Infection Cancer
1-Hydroxyguanidine sulfate is an antitumor agent that inhibits mast cell P815, leukaemia P388, leukaemia L1210 and carcinosarcoma Walker 256 cells growth. 1-Hydroxyguanidine sulfate also has antiviral activity .

HY-N10793

RA-XI	Others	Cancer
RA-XI is a bicyclic hexapeptide isolated from Rubia cordifolia with antitumour activity .

HY-113743

Ecomustine CY233; NSC-609224	Others	Cancer
Ecomustine (CY233) is a nitrosoureido sugar derived from acosamine. Ecomustine shows antitumour activity .

HY-W145584

D-Iditol	Endogenous Metabolite	Metabolic Disease Cancer
D-Iditol is a fungal metabolite, a sugar alcohol that accumulates in galactokinase deficiency. D-Iditol may have potential antitumour activity .

HY-N9318

4'-Demethyldehydropodophyllotoxin	Others	Cancer
4'-Demethyldehydropodophyllotoxin is an aryltetralin lignan that can be isolated from leaves of Podophyllum hexandrum. 4'-Demethyldehydropodophyllotoxin exhibits some cytotoxic and antitumour activity .

HY-101488

CC-885 10+ Cited Publications	Molecular Glues Ligands for E3 Ligase	Cancer
CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. CC-885 is also a known degrader of GSPT1, inhibiting protein translation.

HY-N0793A

Protopine hydrochloride Corydinine hydrochloride	Cholinesterase (ChE)	Infection Neurological Disease Inflammation/Immunology Cancer
Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-N0793

Protopine Corydinine	Cholinesterase (ChE)	Infection Neurological Disease Inflammation/Immunology Cancer
Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-P99380

Zanidatamab ZW 25	EGFR	Cancer
Zanidatamab (ZW25) is a humanised, bispecific monoclonal antibody targeting 2 distinct HER2 epitopes (ECD2 and ECD4). Zanidatamab has anti-tumour activity .

HY-N8459

α-Cembrenediol α-CBD	EBV	Cancer
α-Cembrenediol is a potent inhibitor of EBV.α-Cembrenediol inhibits the early antigen of the Epstein-Bar virus. α-Cembrenediol also has anti-tumour activity .

HY-103019

(+)-Enitociclib 2 Publications Verification (+)-BAY-1251152; (+)-VIP152; (S)-Enitociclib	CDK	Cancer
(+)-Enitociclib ((+)-BAY-1251152) is an enanthiomer of BAY-1251152 with rotation (+). Enitociclib is a potent and selective CDK9 inhibitor with an IC₅₀ of 3 nM. Enitociclib has anti-tumour activity .

HY-W145584S

D-Iditol-13C	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Cancer
D-Iditol- ¹³C is the ¹³C labeled D-Iditol. D-Iditol is a fungal metabolite, a sugar alcohol that accumulates in galactokinase deficiency. D-Iditol may have potential antitumour activity[1][2][3].

HY-121401A

(−)-Myrtenal (1R)-(−)-Myrtenal; (−)-(1R,5S)-Myrtenal	Akt	Metabolic Disease Cancer
(?)-Myrtenal ((1R)-(?)-Myrtenal) is an orally active terpene with antitumour activity. (?)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats .

HY-W074006

Tris(2-cyanoethyl)phosphine	Biochemical Assay Reagents	Others
Tris(2-cyanoethyl)phosphine is a protein crosslinker. Tris(2-cyanoethyl)phosphine can be used to synthesis copper(I) complexes which shows antitumour activity .

HY-16293

Lurbinectedin 4 Publications Verification PM01183; LY-01017	DNA Alkylator/Crosslinker DNA/RNA Synthesis	Cancer
Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC₅₀ values of 1.25 and 1.16 nM, respectively.

HY-N2575

Hypocrellin A 1 Publications Verification	PKC Bacterial Parasite	Infection Cancer
Hypocrellin A, a naturally occurring PKC inhibitor, has many biological and pharmacological properties, such as antitumour, antiviral, antibacterial, and antileishmanial activities. Hypocrellin A is a promising photosensitizer for anticancer photodynamic therapy (PDT) .

HY-119995

Chloropyramine	Apoptosis Histamine Receptor	Cardiovascular Disease Cancer
Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma .

HY-N3845

Ergosterol peroxide	Bacterial	Inflammation/Immunology Cancer
Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities .

HY-108345

Bleomycin	Antibiotic	Cancer
Bleomycin is a glycopeptide antibiotic. Bleomycin has potent antitumour activities against a range of lymphomas, head and neck cancers and germ-cell tumours. Bleomycin can be used for the research of cancer and chemotherapy .

HY-N1214S

Squalene-d6 Super Squalene-d₆; trans-Squalene-d₆; AddaVax-d₆	Isotope-Labeled Compounds	Others
Squalene-d6 is a deuterium labeled Squalene. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-110244

Tilfrinib	BRK	Cancer
Tilfrinib (compound 4f) is a potent and selective Brk/PTK6 inhibitor with an IC₅₀ value of 3.15 nM for Brk. Tilfrinib shows good anti-proliferative activity and has potential of anti-tumour .

HY-13611

Diflomotecan BN 80915	Topoisomerase	Cancer
Diflomotecan (BN 80915) is a potent and orally active inhibitor of topoisomerase I. Diflomotecan (BN 80915) causes enhanced plasma stability and has the superior preclinical anti-tumour activity compared with other established compounds .

HY-P99895

Rulonilimab	PD-1/PD-L1	Inflammation/Immunology Cancer
Rulonilimab is a human IgG1 monoclonal antibody against PD-1 that targets, binds and inhibits PD-1 and its downstream signalling pathways with potential immune checkpoint inhibition and anti-tumour activity .

HY-N3797A

Echitamine chloride Ditaine chloride	Apoptosis	Cancer
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC₅₀ of 10.92 μM .

HY-N1214R

Squalene (Standard)	Endogenous Metabolite Reactive Oxygen Species Fungal	Infection Cardiovascular Disease
Squalene (Standard) is the analytical standard of Squalene. This product is intended for research and analytical applications. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-125098

Illudin S	DNA Alkylator/Crosslinker Apoptosis	Infection Cancer
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .

HY-N7557

(E)-2'-Hydroxy-3,4-dimethoxychalcone	Others	Cancer
(E)-2'-Hydroxy-3,4-dimethoxychalcone (compound 7) is a Chalcone derivative with orally active. (E)-2'-Hydroxy-3,4-dimethoxychalcone has anti-tumour activities .

HY-N0793R

Protopine (Standard)	Cholinesterase (ChE)	Infection Neurological Disease Inflammation/Immunology Cancer
Protopine (Standard) is the analytical standard of Protopine. This product is intended for research and analytical applications. Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-14375

CB 300919	NAMPT	Cancer
CB 300919 is a quinazoline-based antitumour agent with high activity in the CH1 human ovarian tumour xenograft. CB 300919 has a continuous exposure (96 h) growth inhibition IC₅₀ value of 2 nM in human CH1 ovarian tumor xenograft .

HY-121370

a-D-Galactose	HIV Endogenous Metabolite	Others
α-D-Galactose is a non-starch polysaccharide isolated from the bulb tissues of Lilium davidii var. unicolor Salisb. α-D-Galactose has anti-oxidation properties, anti-tumour activities, immunomodulatory effects and anti-HIV functions .

HY-103396

Trimetrexate glucuronate CI-898 glucuronate	Antifolate Bacterial	Infection Cancer
Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia .

HY-16293S

Lurbinectedin-d3 PM01183-d₃; LY-01017-d₃	DNA Alkylator/Crosslinker DNA/RNA Synthesis	Cancer
Lurbinectedin-d₃ is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively[1].

HY-147895

PCAF-IN-2	Histone Acetyltransferase Apoptosis	Cancer
PCAF-IN-2 (compound 17) is a potent PCAF inhibitor with an IC₅₀ value of 5.31 µM. PCAF-IN-2 shows anti-tumour activity. CAF-IN-2 induces apoptosis and arrest the cell cycle at the G2/M phase .

HY-152257

HPK1-IN-31	MAP4K	Inflammation/Immunology Cancer
HPK1-IN-31 (compound 5i) is an orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC₅₀ value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunoresearch .

HY-113604

Pentabromopseudilin	TGF-β Receptor	Cancer
Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer .

HY-50895A

Gefitinib hydrochloride Maximum Cited Publications 124 Publications Verification ZD-1839 hydrochloride	EGFR	Cancer
Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib hydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib hydrochloride also induces autophagy. Gefitinib hydrochloride has antitumour activity .

HY-15228

RX-3117 1 Publications Verification TV-1360; Fluorocyclopentenylcytosine	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis .

HY-50895S1

Gefitinib-d6 ZD1839-d₆	EGFR Autophagy	Cancer
Gefitinib-d₆ is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

HY-40294

Indazole	Monoamine Oxidase GSK-3 LRRK2	Cardiovascular Disease Neurological Disease Cancer
Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases .

HY-119367

ODM-203	FGFR VEGFR	Cancer
ODM-203 is an orally active and selective FGFR/VEGFR inhibitor with IC₅₀ values of 6, 11, 16, 5, 9, 26 and 35 nM for FGFR3/1/2 and VEGFR3/2/1/4, respectively. ODM-203 has strong anti-tumour activity and activates immune responses in the tumour microenvironment .

HY-131257

Gefitinib impurity 1	Drug Metabolite	Others
Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity .

HY-133779

Gefitinib impurity 5	Drug Metabolite	Others
Gefitinib impurity 5 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity .

HY-50895S2

Gefitinib-d3	Isotope-Labeled Compounds EGFR Autophagy	Cancer
Gefitinib-d₃ (ZD1839-d3) is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

HY-100663

Gefitinib impurity 2	EGFR	Others
Gefitinib impurity 2 is the impurity of Gefitinib. Gefitinib (ZD1839; HY-50895) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC₅₀ of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC₅₀ of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity .

HY-148278

BI-0474	Ras	Cancer
BI-0474 is a potent KRAS ^G12C inhibitor with an IC₅₀ value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models .

Cat. No.	Product Name	Target	Research Area

HY-P99617

Fianlimab REGN3767	LAG-3	Cancer
Fianlimab (REGN3767) is a human monoclonal antibody that targets the immune checkpoint receptor LAG-3 on T cells and has anti-tumour activity .

HY-P99380

Zanidatamab ZW 25	EGFR	Cancer
Zanidatamab (ZW25) is a humanised, bispecific monoclonal antibody targeting 2 distinct HER2 epitopes (ECD2 and ECD4). Zanidatamab has anti-tumour activity .

HY-P99895

Rulonilimab	PD-1/PD-L1	Inflammation/Immunology Cancer
Rulonilimab is a human IgG1 monoclonal antibody against PD-1 that targets, binds and inhibits PD-1 and its downstream signalling pathways with potential immune checkpoint inhibition and anti-tumour activity .

HY-P99189

Cixutumumab IMC-A12; NSC742460	Inhibitory Antibodies	Cancer
Cixutumumab (IMC-A12) is a human anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W000427

Ethyl Orsellinate	Infection Classification of Application Fields Usnea diffracta Vain. Source classification Phenols Polyphenols Plants Disease Research Fields Usneaceae	Bacterial
Ethyl orsellinate is a lichen metabolite and a derivative of lecanoric acid with antiproliferative and antitumour activities . Ethyl Orsellinate is against A. salina for the cytotoxic activity with an LC₅₀ of 495 μM .

HY-N1214

Squalene Super Squalene; trans-Squalene; AddaVax	Cardiovascular Disease Triterpenes Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Microorganisms other families Animals Terpenoids Disease Research Fields	Endogenous Metabolite Reactive Oxygen Species Fungal
Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-P99617

Fianlimab REGN3767	Classification of Application Fields Disease Research Fields Cancer	LAG-3
Fianlimab (REGN3767) is a human monoclonal antibody that targets the immune checkpoint receptor LAG-3 on T cells and has anti-tumour activity .

HY-N0793

Protopine Corydinine	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Cancer	Cholinesterase (ChE)
Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-P99380

Zanidatamab ZW 25	Classification of Application Fields Disease Research Fields Cancer	EGFR
Zanidatamab (ZW25) is a humanised, bispecific monoclonal antibody targeting 2 distinct HER2 epitopes (ECD2 and ECD4). Zanidatamab has anti-tumour activity .

HY-N10793

RA-XI	Structural Classification Cyclopeptides Source classification Rubiaceae Plants Rubia cordifolia L.	Others
RA-XI is a bicyclic hexapeptide isolated from Rubia cordifolia with antitumour activity .

HY-W145584

D-Iditol	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Saccharides Monosaccharides Cancer	Endogenous Metabolite
D-Iditol is a fungal metabolite, a sugar alcohol that accumulates in galactokinase deficiency. D-Iditol may have potential antitumour activity .

HY-N9318

4'-Demethyldehydropodophyllotoxin	Classification of Application Fields Sinopodophyllum hexandrum (Royle) Ying Source classification Lignans Phenols Polyphenols Phenylpropanoids Plants Berberidaceae Disease Research Fields Cancer	Others
4'-Demethyldehydropodophyllotoxin is an aryltetralin lignan that can be isolated from leaves of Podophyllum hexandrum. 4'-Demethyldehydropodophyllotoxin exhibits some cytotoxic and antitumour activity .

HY-N0793A

Protopine hydrochloride Corydinine hydrochloride	Structural Classification Alkaloids Other Alkaloids Source classification Rosaceae Pseudocydonia sinensis (Thouin) C. K. Schneid. Plants	Cholinesterase (ChE)
Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-N8459

α-Cembrenediol α-CBD	Structural Classification Natural Products Nicotiana tabacum L. Source classification Plants Solanaceae	EBV
α-Cembrenediol is a potent inhibitor of EBV.α-Cembrenediol inhibits the early antigen of the Epstein-Bar virus. α-Cembrenediol also has anti-tumour activity .

HY-121401A

(−)-Myrtenal (1R)-(−)-Myrtenal; (−)-(1R,5S)-Myrtenal	Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Labiatae Source classification Erythrina poeppigiana Metabolic Disease Plants Disease Research Fields	Akt
(?)-Myrtenal ((1R)-(?)-Myrtenal) is an orally active terpene with antitumour activity. (?)-Myrtenal ameliorates hyperglycemia by enhancing GLUT2 through Akt in the skeletal muscle and liver of diabetic rats .

HY-N2575

Hypocrellin A 1 Publications Verification	Infection Natural Products other families Microorganisms Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields	PKC Bacterial Parasite
Hypocrellin A, a naturally occurring PKC inhibitor, has many biological and pharmacological properties, such as antitumour, antiviral, antibacterial, and antileishmanial activities. Hypocrellin A is a promising photosensitizer for anticancer photodynamic therapy (PDT) .

HY-N3845

Ergosterol peroxide	Natural Products Classification of Application Fields Orchidaceae Source classification Plants Disease Research Fields Inflammation/Immunology Anoectochilus elwesii	Bacterial
Ergosterol peroxide is a steroid derivative and can be isolated from a variety of fungi, yeast, lichens or sponges. Ergosterol peroxide has anti-tumour, proapoptotic, anti-inflammatory, anti-mycobacterial, and anti-proliferative activities .

HY-N3797A

Echitamine chloride Ditaine chloride	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Alstonia scholaris (L.) R. Br. Plants Disease Research Fields Indole Alkaloids Cancer	Apoptosis
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC₅₀ of 10.92 μM .

HY-N1214R

Squalene (Standard)	Triterpenes Structural Classification Human Gut Microbiota Metabolites Microorganisms other families Animals Terpenoids Source classification Plants Endogenous metabolite	Endogenous Metabolite Reactive Oxygen Species Fungal
Squalene (Standard) is the analytical standard of Squalene. This product is intended for research and analytical applications. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-125098

Illudin S	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	DNA Alkylator/Crosslinker Apoptosis
Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .

HY-N0793R

Protopine (Standard)	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Cholinesterase (ChE)
Protopine (Standard) is the analytical standard of Protopine. This product is intended for research and analytical applications. Protopine (Corydinine), an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity .

HY-121370

a-D-Galactose	Structural Classification Human Gut Microbiota Metabolites Microorganisms Liliaceae Source classification Plants Endogenous metabolite Lilium davidii Duchartre ex Elwes Saccharides Monosaccharides	HIV Endogenous Metabolite
α-D-Galactose is a non-starch polysaccharide isolated from the bulb tissues of Lilium davidii var. unicolor Salisb. α-D-Galactose has anti-oxidation properties, anti-tumour activities, immunomodulatory effects and anti-HIV functions .

HY-113604

Pentabromopseudilin	Structural Classification Natural Products Source classification Marine natural products Marine microorganism	TGF-β Receptor
Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer .

HY-P99189

Cixutumumab IMC-A12; NSC742460	Classification of Application Fields Disease Research Fields Cancer	Others
Cixutumumab (IMC-A12) is a human anti-IGF-1R monoclonal antibody with high affinity that inhibits ligand-dependent receptor activation and downstream signaling. Cixutumumab also mediates the internalization and degradation of IGF-IR. Cixutumumab shows broad-spectrum anti-tumour activity and can be used in studies of cancers such as lung cancer, malignancies, leukaemia, non-small cell lung cancer and prostate cancer .

HY-N2447

Amarogentin 2 Publications Verification	Structural Classification Gentiana scabra Bunge Iridoids Classification of Application Fields Terpenoids Source classification Gentianaceae Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	AMPK Apoptosis
Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK .

HY-N2447R

Amarogentin (Standard)	Structural Classification Gentiana scabra Bunge Iridoids Terpenoids Source classification Gentianaceae Phenols Polyphenols Plants	AMPK Apoptosis
Amarogentin (Standard) is the analytical standard of Amarogentin. This product is intended for research and analytical applications. Amarogentin is a secoiridoid glycoside that is mainly extracted from Swertia and Gentiana roots. Amarogentin exhibits many biological effects, including anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin exerts hepatoprotective and immunomodulatory effects. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways. Amarogentin exerts beneficial vasculo-metabolic effect by activating AMPK .

Cat. No.	Product Name	Chemical Structure

HY-N1214S

Squalene-d6
Squalene-d6 is a deuterium labeled Squalene. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .

HY-50895S1

Gefitinib-d6
Gefitinib-d₆ is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

HY-W145584S

D-Iditol-13C
D-Iditol- ¹³C is the ¹³C labeled D-Iditol. D-Iditol is a fungal metabolite, a sugar alcohol that accumulates in galactokinase deficiency. D-Iditol may have potential antitumour activity[1][2][3].

HY-16293S

Lurbinectedin-d3
Lurbinectedin-d₃ is deuterium labeled Lurbinectedin. Lurbinectedin (PM01183) is a DNA minor groove covalent binder with potent anti-tumour activity; inhibits RMG1 and RMG2 cell growth with IC50 values of 1.25 and 1.16 nM, respectively[1].

HY-50895S2

Gefitinib-d3

Gefitinib-d₃ (ZD1839-d3) is the deuterium labeled Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity[1][2].

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antitumour activity

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