Search Result

Results for "

blood vessels

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Adenylate Cyclase (2) Adrenergic Receptor (21) Akt (1) Angiotensin Receptor (7) Apoptosis (13) Autophagy (9) Bacterial (2) Biochemical Assay Reagents (4) Bradykinin Receptor (3) Calcium Channel (5) Endogenous Metabolite (10) Fluorescent Dye (3) Fungal (1) HIF/HIF Prolyl-Hydroxylase (1) HSP (2) Integrin (1) Isotope-Labeled Compounds (10) Mitochondrial Metabolism (1) MMP (5) mTOR (1) NO Synthase (1) Organoid (1) Parasite (1) PDGFR (3) Phosphodiesterase (PDE) (1) Potassium Channel (1) Prostaglandin Receptor (5) SGLT (1) SOD (2) Tie (1) Trk Receptor (1) VEGFR (1) YAP (2)
By Research Areas:	Cancer (25) Cardiovascular Disease (42) Endocrinology (20) Infection (5) Inflammation/Immunology (12) Metabolic Disease (10) Neurological Disease (12)
Oligonucleotides:	Aptamers (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W005288

4-Vinylphenol	Apoptosis Endogenous Metabolite	Cancer
4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo .

HY-B1815

Xanthinol Nicotinate Xanthinol Niacinate	Others	Cardiovascular Disease
Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance .

HY-B0202

Irbesartan 5 Publications Verification SR-47436; BMS-186295	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology
Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0475

Xylometazoline hydrochloride	Adrenergic Receptor	Inflammation/Immunology
Xylometazoline hydrochloride is an α-adrenergic receptor agonist (K_i=0.05-1.7 μM). Xylometazoline hydrochloride can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research .

HY-147299

Povafonidine PGE-6201204	Adrenergic Receptor	Cardiovascular Disease
Povafonidine (PGE-6201204) is a potent α₂ adrenoreceptor agonist. Povafonidine can constrict blood vessels and reduce mucosal congestion. Povafonidine can be used for nasal congestion research .

HY-W127505S

trans-2-Undecenal-d5	Biochemical Assay Reagents Isotope-Labeled Compounds	Others
trans-2-Undecenal-d₅ is deuterated labeled 4-Vinylphenol (HY-W005288). 4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo .

HY-B0202A

Irbesartan hydrochloride SR-47436 hydrochloride; BMS-186295 hydrochloride	Angiotensin Receptor Apoptosis	Neurological Disease Metabolic Disease
Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0475A

Xylometazoline	Adrenergic Receptor	Inflammation/Immunology
Xylometazoline is an α-adrenergic receptor agonist (K_i=0.05-1.7 μM). Xylometazoline can constrict nasal blood vessels and increase nasal airflow. Xylometazoline can be used in nose stuffiness and runny nose research .

HY-B0202S3

Irbesartan-d7 SR-47436-d₇; BMS-186295-d₇	Apoptosis Angiotensin Receptor Isotope-Labeled Compounds	Cardiovascular Disease Endocrinology
Irbesartan-d₇ is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0202AS

Irbesartan-d7 hydrochloride SR-47436-d₇ hydrochloride; BMS-186295-d₇ hydrochloride	Apoptosis Angiotensin Receptor Isotope-Labeled Compounds	Neurological Disease Metabolic Disease
Irbesartan-d₇ hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0642

Isosorbide mononitrate 4 Publications Verification Isosorbide-5-mononitrate	Autophagy Endogenous Metabolite Apoptosis	Cardiovascular Disease Cancer
Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease .

HY-B0475S

Xylometazoline-d4 hydrochloride	Adrenergic Receptor Isotope-Labeled Compounds	Inflammation/Immunology
Xylometazoline-d₄ hydrochloride is deuterated labeled Xylometazoline hydrochloride (HY-B0475). Xylometazoline hydrochloride is an α-adrenergic receptor agonist (K_i=0.05-1.7 μM). Xylometazoline hydrochloride can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research .

HY-N0293

Paeoniflorin 15+ Cited Publications Peoniflorin	HSP	Infection Neurological Disease Cancer
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .

HY-103190

MRS1220	Adenosine Receptor	Neurological Disease Cancer
MRS1220, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a K_i of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system . MRS1220 reduces glioblastoma tumor size and blood vessel formation in vivo .

HY-B0362A

Phentolamine mesylate 3 Publications Verification Phentolamine methanesulfonate	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction .

HY-N0293R

Paeoniflorin (Standard)	HSP	Infection Neurological Disease Cancer
Paeoniflorin (Standard) is the analytical standard of Paeoniflorin. This product is intended for research and analytical applications. Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .

HY-B0362AR

Phentolamine mesylate (Standard)	Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Phentolamine (mesylate) (Standard) is the analytical standard of Phentolamine (mesylate). This product is intended for research and analytical applications. Phentolamine mesylate (Phentolamine methanesulfonate) is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine mesylate can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction .

HY-U00147

Nicotinoyl cyclandelate RV 12128	Others	Cardiovascular Disease
Nicotinoyl cyclandelate can be used to lower the perfusion pressure of cerebral blood vessels and the blood pressure of femoral artery.

HY-N0766

Isorhynchophylline	SOD	Cardiovascular Disease Others
Isorhynchophylline is an alkaloid compound isolated from Uncaria. It can lower blood pressure, relax blood vessels, and protect nerves from damage caused by local ischemia.

HY-153528

DMAA	Biochemical Assay Reagents	Cardiovascular Disease Neurological Disease
DMAA is an indirect sympathomimetic amine. DMAA constricts blood vessels and raises blood pressure. DMAA can be used for neurological and cardiovascular disease research .

HY-B0266

Gadodiamide hydrate 1 Publications Verification	Biochemical Assay Reagents	Others
Gadodiamide hydrate is a gadolinium-based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels.

HY-B1435

Moxisylyte hydrochloride Thymoxamine hydrochloride	Adrenergic Receptor	Cardiovascular Disease Endocrinology
Moxisylyte (hydrochloride) is (alpha 1-blocker) antagonist, it can vasodilates cerebral vessels without reducing blood pressure.

HY-119544

Ripisartan UP-2696	Angiotensin Receptor	Cardiovascular Disease
Ripisartan (UP-2696) is an angiotensin II receptor antagonist. Ripisartan is orally available. Ripisartan binds to angiotensin II receptors, dilates blood vessels, and lowers blood pressure .

HY-101952

Prostaglandin E2 25+ Cited Publications PGE2; Dinoprostone	Organoid Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

HY-130429

14,15-Leukotriene C4 Eoxin C4	Endogenous Metabolite	Inflammation/Immunology
14,15-Leukotriene C4 (Eoxin C4) is a Leukotriene compound produced by the enzymatic reaction of arachidonic acid. 14,15-Leukotriene C4 has the activity of promoting inflammatory response. 14,15-Leukotriene C4 can increase the permeability of blood vessels, causing fluid and white blood cells to leak out of the blood vessels, which increases the number of inflammatory cells in the tissue. 14,15-Leukotriene C4 can be used in studies of asthma and other inflammatory diseases .

HY-B0642R

Isosorbide mononitrate (Standard)	Autophagy Endogenous Metabolite	Cardiovascular Disease Cancer
Isosorbide mononitrate (Standard) is the analytical standard of Isosorbide mononitrate. This product is intended for research and analytical applications. Isosorbide mononitrate (Isosorbide-5-mononitrate) is a nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure.

HY-N0766R

Isorhynchophylline (Standard)	SOD	Others
Isorhynchophylline (Standard) is the analytical standard of Isorhynchophylline. This product is intended for research and analytical applications. Isorhynchophylline is an alkaloid compound isolated from Uncaria. It can lower blood pressure, relax blood vessels, and protect nerves from damage caused by local ischemia.

HY-163129

BPU	Apoptosis MMP	Cancer
BPU arrests cell cycle progression in the sub-G1 phase. BPU is an anticancer agent through inhibiting blood vessel formation in tumor tissues .

HY-14464

PF-00489791 PF-489791	Phosphodiesterase (PDE)	Metabolic Disease
PF-00489791 (PF-489791) is a potent inhibitor of phosphodiesterase 5A with IC₅₀ of 1.5 nM. PF-00489791 can enhance the relaxation of blood vessels within the kidney and so reduce blood pressure, improving renal function .

HY-139421

(Z)-16-(Ethylcarbamoylamino)hexadec-11-enoic acid	Others	Cardiovascular Disease
(Z)-16-(Ethylcarbamoylamino)hexadec-11-enoic acid (Compound 21) is a vasorelaxant (EC₅₀=5.7 μM) that can be used in cardiovascular disease research .

HY-106586A

Ioxaglate sodium P-286 sodium	Biochemical Assay Reagents	Cardiovascular Disease Cancer
Ioxaglate sodium (P-286 sodium) is an ionic, dimeric diagnostic contrast agent whose activity is mainly reflected in its ability to provide sufficient X-ray absorption to enhance visualization of blood vessels and other structures during imaging. Ioxaglate sodium is used to study the anatomical structure and functional status of cardiac vessels, especially in the diagnosis of coronary artery disease .

HY-108011

Naftazone	Others	Cardiovascular Disease
Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation .

HY-A0167

Gadopentetate dimeglumine 2 Publications Verification SH-L-451A; Gadopentetic acid dimeglumine salt	Others	Cancer
Gadopentetate dimeglumine (SH-L-451A) is used in combination with magnetic resonance imaging (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI.

HY-B0309

Felodipine 1 Publications Verification	Calcium Channel Autophagy	Cardiovascular Disease
Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier .

HY-B0371

Terazosin	Adrenergic Receptor	Metabolic Disease Endocrinology
Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment .

HY-B0371F

Terazosin hydrochloride 5 Publications Verification	Adrenergic Receptor	Metabolic Disease Endocrinology
Terazosin hydrochloride is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment .

HY-B0202R

Irbesartan (Standard) SR-47436 (Standard); BMS-186295 (Standard)	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology
Irbesartan (Standard) is the analytical standard of Irbesartan. This product is intended for research and analytical applications. Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-105672

Cafaminol	Adrenergic Receptor	Cancer
Cafaminol (Methylcoffanolamine) is a vasoconstrictor and anticatarrhal that selectively binds to alpha-1 receptors, causing blood vessels to constrict. Cafaminol is an xanthine derivative which can be utilized in decongestant and antitumor research .

HY-B0202S2

Irbesartan-d6-1	Apoptosis Angiotensin Receptor	Cardiovascular Disease
Irbesartan-d₆-1 is the deuterium labeled Irbesartan[1]. Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[2].

HY-B0371A

Terazosin hydrochloride dihydrate 5 Publications Verification	Adrenergic Receptor	Metabolic Disease Endocrinology
Terazosin hydrochloride dihydrate is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin hydrochloride dihydrate works by relaxing blood vessels and the opening of the bladder. Terazosin hydrochloride dihydrate has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment .

HY-B1538A

Bamethan hemisulfate DL-Bamethane hemisulfate	Others	Cardiovascular Disease
Bamethan (DL-Bamethane) hemisulfate is a vasodilator that exhibits significant activity in enhancing blood flow and reducing vascular resistance. Bamethan hemisulfate plays a crucial role in the treatment of cardiovascular conditions by improving oxygen delivery to tissues. Bamethan hemisulfate also aids in the management of hypertension through its relaxing effects on blood vessels.

HY-101952R

Prostaglandin E2 (Standard) 25+ Cited Publications PGE2(Standard); Dinoprostone (Standard)	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E2 (Standard) is the analytical standard of Prostaglandin E2. This product is intended for research and analytical applications. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

HY-E70303

Fucosyltransferase 6 FUT6	Endogenous Metabolite	Cancer
Fucosyltransferase 6 is a fucosyltransferase that mediates the expression of the tetrasaccharide Sialyl-Lewis x (sLex, CD15s) on the surface of leukocytes. sLex participates in E-selectin-mediated leukocyte rolling and is related to the migration of leukocytes out of blood vessels .

HY-B0309S2

Felodipine-d3	Calcium Channel Autophagy	Cardiovascular Disease
Felodipine-d₃ is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

HY-101952S

Prostaglandin E2-d4 PGE2-d₄; Dinoprostone-d₄	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E2-d₄ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-101952S1

Prostaglandin E2-d9 PGE2-d₉; Dinoprostone-d₉	Isotope-Labeled Compounds Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E2-d₉ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-B0309S1

Felodipine-d5	Isotope-Labeled Compounds Calcium Channel Autophagy	Cardiovascular Disease
Felodipine-d₅ is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

HY-B0371S

Terazosin-d8	Isotope-Labeled Compounds Adrenergic Receptor	Metabolic Disease Endocrinology
Terazosin-d₈ is deuterium labeled Terazosin. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment[1][2][3].

HY-15033

ATB-343	Others	Infection Inflammation/Immunology
ATB-343 is a derivative of Indomethacin that releases H2S. H2S has cytoprotective and anti-inflammatory effects, inhibiting leukocyte adhesion to vascular endothelium and leukocyte migration to inflammatory sites. ATB-343 can be used to suppress respiratory infections .

HY-103293

Lys-Bradykinin Kallidin (380-389) (human, porcine, bovine)	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin involves in vascular regulation, inflammation and pain sensation .

Cat. No.	Product Name

HY-L117

Calcium Channel Blocker Library

160 compounds

Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

MCE supplies a unique collection of 160 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.

HY-L136

Coagulation and Anti-coagulation Compound Library

1,034 compounds

Coagulation, also known as clotting, is the process in which blood changes from a liquid to a solid gel to form a blood clot. Thrombin, which is accurately and evenly generated in the injured part of blood vessels, is a key effector enzyme of the blood coagulation system and participates in many important biological processes, such as platelet activation, fibrinogen conversion to fibrin network, coagulation feedback amplification, etc. At the same time, to avoid the accidental formation of thrombus in the body, there is also an anticoagulant mechanism that inhibits blood coagulation.

Normal coagulation mechanism represents a balance between the pro-coagulant pathway in the injured site and anti-coagulant pathway beyond it. The blood coagulation system may be out of balance during the perioperative period or critical illness, which may lead to thrombosis or excessive bleeding. Therefore, the physiological study of coagulation balance is an important basis for clinical diagnosis and treatment of the abnormal coagulation process.

MCE supplies a unique collection of 1,034 compounds targeting key proteins in coagulation and anti-coagulation system. MCE Coagulation and Anti-coagulation Compound Library is a useful tool for study the mechanism of coagulation and anticoagulation.

HY-L088

Angiogenesis-Related Compound Library

2,189 compounds

Angiogenesis is the physiological process through which new blood vessels are formed from pre-existing vessels. It occurs in various physiological processes e.g. embryonic development, menstrual cycle, exercise and wound healing etc. Angiogenesis is regulated by both endogenous activators and inhibitors. Some key activators of angiogenesis include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin, TGF-β, etc. whereas angiogenesis inhibitors are angiostatin, endostatin, interferon, platelet factor 4, etc. The loss of balance between these opposing signals leads to life threatening diseases like cancer, cardiovascular and ischemic diseases etc. which are thus controlled by exogenous angiogenesis activators (for cardiovascular/ischemic disorders) and inhibitors (for cancer).

MCE offers a unique collection of 2,189 compounds with validated angiogenesis targets modulating properties. MCE angiogenesis-related compound library is an effective tool for angiogenesis research and discovery of angiogenesis-related drugs.

HY-L046

Anti-Cardiovascular Disease Compound Library

1,695 compounds

Cardiovascular diseases (CVDs) are a group of disorders of the heart and blood vessels which include coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, etc. CVDs are the number 1 cause of death globally. Smoking, unhealthy nutrition, aging population, lack of physical activity, arterial hypertension, or diabetes can promote cardiovascular disease like myocardial infarction or stroke. It is multifactorial and encompasses a multitude of mechanisms, such as eNOS uncoupling, reactive oxygen species formation, chronic inflammatory disorders and abnormal calcium homeostasis. Antioxidant, anti-inflammatory and anti-diabetes agents may reduce the cardiovascular disease risk.

MCE supplies a unique collection of 1,695 compounds with confirmed anti-cardiovascular activity. These compounds mainly target metabolic enzyme, membrane transporter, ion channel, inflammation related signaling pathways. MCE Anti-Cardiovascular Disease Compound Library can be used for cardiovascular diseases related research and high throughput and high content screening for new drugs.

Cat. No.	Product Name	Type

HY-158082

TRITC-dextran, MW 4000

Tetramethyl rhodamine isothiocyanate glucan, MW 4000

Cell Assay Reagents

TRITC-dextran MW 4000 (Tetramethyl rhodamine isothiocyanate glucan, MW 4000) is a fluorescent dye, with the molecular weight of 4 kD. TRITC-dextran MW 4000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 4000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 4000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082A

TRITC-dextran, MW 20000

Tetramethyl rhodamine isothiocyanate glucan, MW 20000

Cell Assay Reagents

TRITC-dextran, MW 20000 (Tetramethyl rhodamine isothiocyanate glucan, MW 20000) is a fluorescent dye, with the molecular weight of 20 kD. TRITC-dextran MW 20000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 20000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 20000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

HY-158082B

TRITC-dextran, MW 40000

Tetramethyl rhodamine isothiocyanate glucan, MW 40000

Cell Assay Reagents

TRITC-dextran, MW 40000 (Tetramethyl rhodamine isothiocyanate glucan, MW 40000) is a fluorescent dye, with the molecular weight of 40 kD. TRITC-dextran MW 40000 exhibits an excitation wavelength of 555 nm. TRITC-dextran MW 40000 is vessel penetrate, which could label blood plasma to visualize the vasculature. TRITC-dextran MW 40000 is utilized in drug delivery for the stability of TRITC over a wide pH range (i.e. pH 2–11) and resistance to photo-bleaching .

Cat. No.	Product Name	Target	Research Area

HY-P4896

FITC-Ahx-Gly-Arg-Gly-Asp-Ser-Pro	Integrin	Cancer
FITC-Ahx Gly Arg Gly Asp Ser Pro is a GRGDSP (HY-P0290) coupled to FITC. GRGDSP is an integrin inhibitor that can inhibit the adherence of tumor cells to endothelial cells of blood vessels and limit its metastasis .

HY-P0004

Lysipressin 2 Publications Verification Lysine vasopressin; [Lys8]-Vasopressin	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-P0004A

Lysipressin acetate 2 Publications Verification Lysine vasopressin acetate; [Lys8]-Vasopressin acetate	Adenylate Cyclase	Others
Lysipressin (Lysine vasopressin) acetate is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin acetate induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

HY-103293A

Lys-Bradykinin TFA Kallidin (380-389) (human, porcine, bovine) TFA	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin TFA is the TFA salt form of Lys-Bradykinin (HY-103293). Lys-Bradykinin TFA is a ligand for kallidin and bradykinin receptor, which can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin TFA serves as a vasodilator, which widens blood vessels and increases blood flow. Lys-Bradykinin TFA stimulates net Na+ influx, and contributes to DNA synthesis. Lys-Bradykinin TFA involves in vascular regulation, inflammation and pain sensation .

HY-103293

Lys-Bradykinin Kallidin (380-389) (human, porcine, bovine)	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin involves in vascular regulation, inflammation and pain sensation .

HY-103293B

Lys-Bradykinin tetraacetate Kallidin (380-389) (human, porcine, bovine) tetraacetate	Bradykinin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Lys-Bradykinin (Kallidin (380-389) (human, porcine, bovine)) tetraacetate, a kind of kallidin and bradykinin receptor ligand, can be generated by kininogen protein through enzymatic cleavage by the protease kallikrein. Lys-Bradykinin tetraacetate, also a vasodilator, can widen blood vessels and increase blood flow. ys-Bradykinin stimulates net Na+ influx, and also the DNA synthesis. Lys-Bradykinin tetraacetate involves in vascular regulation, inflammation and pain sensation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W005288

4-Vinylphenol	Monophenols Microorganisms Classification of Application Fields Source classification Rubiaceae Phenols Plants Endogenous metabolite Disease Research Fields Cancer Hedyotis diffusa Willd.	Apoptosis Endogenous Metabolite
4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo .

HY-B0642

Isosorbide mononitrate 4 Publications Verification Isosorbide-5-mononitrate	Cardiovascular Disease Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Autophagy Endogenous Metabolite Apoptosis
Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease .

HY-N0293

Paeoniflorin 15+ Cited Publications Peoniflorin	Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Source classification Plants Paeoniaceae	HSP
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .

HY-N0766

Isorhynchophylline	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Cardiovascular Disease Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Other Diseases Plants Disease Research Fields Indole Alkaloids	SOD
Isorhynchophylline is an alkaloid compound isolated from Uncaria. It can lower blood pressure, relax blood vessels, and protect nerves from damage caused by local ischemia.

HY-101952

Prostaglandin E2 Maximum Cited Publications 30 Publications Verification PGE2; Dinoprostone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Endocrinology	Organoid Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

HY-N0293R

Paeoniflorin (Standard)	Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Source classification Plants Paeoniaceae	HSP
Paeoniflorin (Standard) is the analytical standard of Paeoniflorin. This product is intended for research and analytical applications. Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .

HY-153528

DMAA	Structural Classification Natural Products Source classification Plants Geraniaceae	Biochemical Assay Reagents
DMAA is an indirect sympathomimetic amine. DMAA constricts blood vessels and raises blood pressure. DMAA can be used for neurological and cardiovascular disease research .

HY-130429

14,15-Leukotriene C4 Eoxin C4	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Endogenous Metabolite
14,15-Leukotriene C4 (Eoxin C4) is a Leukotriene compound produced by the enzymatic reaction of arachidonic acid. 14,15-Leukotriene C4 has the activity of promoting inflammatory response. 14,15-Leukotriene C4 can increase the permeability of blood vessels, causing fluid and white blood cells to leak out of the blood vessels, which increases the number of inflammatory cells in the tissue. 14,15-Leukotriene C4 can be used in studies of asthma and other inflammatory diseases .

HY-B0642R

Isosorbide mononitrate (Standard)	Structural Classification Natural Products Source classification Endogenous metabolite	Autophagy Endogenous Metabolite
Isosorbide mononitrate (Standard) is the analytical standard of Isosorbide mononitrate. This product is intended for research and analytical applications. Isosorbide mononitrate (Isosorbide-5-mononitrate) is a nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure.

HY-N0766R

Isorhynchophylline (Standard)	Uncaria rhynchophylla (Miq.) Miq. ex Havil. Alkaloids Structural Classification Source classification Rubiaceae Plants Indole Alkaloids	SOD
Isorhynchophylline (Standard) is the analytical standard of Isorhynchophylline. This product is intended for research and analytical applications. Isorhynchophylline is an alkaloid compound isolated from Uncaria. It can lower blood pressure, relax blood vessels, and protect nerves from damage caused by local ischemia.

HY-B0371

Terazosin	Classification of Application Fields Disease Research Fields Endocrinology	Adrenergic Receptor
Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment .

HY-101952R

Prostaglandin E2 (Standard) Maximum Cited Publications 30 Publications Verification PGE2(Standard); Dinoprostone (Standard)	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Endocrinology	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E2 (Standard) is the analytical standard of Prostaglandin E2. This product is intended for research and analytical applications. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation.

HY-107802

Breviscapine Breviscapinun	Structural Classification Natural Products Source classification Plants Compositae Erigeron breviscapus (Vant.) Hand.-Mazz.	Others
Breviscapine is a crude flavonoid extract of Breviscapine, which is more than 85% of the active ingredient, Breviscapine. Breviscapine has a wide range of cardiovascular pharmacological activities, such as increasing blood flow, improving microcirculation, dilating blood vessels, reducing blood viscosity, promoting fibrinolysis, inhibiting platelet aggregation and thrombosis. Breviscapine has been used in the study of cerebral infarction and its sequelae, cerebral thrombosis, coronary heart disease and angina pectoris .

HY-P0004

Lysipressin 2 Publications Verification Lysine vasopressin; [Lys8]-Vasopressin	Structural Classification Monophenols Classification of Application Fields Animals Source classification Other Diseases Phenols Disease Research Fields	Adenylate Cyclase
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs and some marsupial families. Lysipressin induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase .

Cat. No.	Product Name	Chemical Structure

HY-B0309S2

Felodipine-d3
Felodipine-d₃ is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

HY-101952S

Prostaglandin E2-d4
Prostaglandin E2-d₄ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-W127505S

trans-2-Undecenal-d5
trans-2-Undecenal-d₅ is deuterated labeled 4-Vinylphenol (HY-W005288). 4-Vinylphenol is found in the medicinal herb Hedyotis diffusa Willd, wild rice and is also the metabolite of p-coumaric and ferulic acid by lactic acid bacteria in wine. 4-Vinylphenol induces apoptosis and inhibits blood vessels formation and suppresses invasive breast tumor growth in vivo .

HY-B0202S3

Irbesartan-d7
Irbesartan-d₇ is deuterated labeled Irbesartan (HY-B0202). Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0202AS

Irbesartan-d7 hydrochloride

Irbesartan-d₇ hydrochloride is deuterated labeled Irbesartan hydrochloride (HY-B0202A). Irbesartan (SR-47436) hydrochloride is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan hydrochloride can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan hydrochloride can be used for the research of high blood pressure, heart failure, and diabetic kidney disease .

HY-B0475S

Xylometazoline-d4 hydrochloride
Xylometazoline-d₄ hydrochloride is deuterated labeled Xylometazoline hydrochloride (HY-B0475). Xylometazoline hydrochloride is an α-adrenergic receptor agonist (K_i=0.05-1.7 μM). Xylometazoline hydrochloride can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research .

HY-B0202S2

Irbesartan-d6-1
Irbesartan-d₆-1 is the deuterium labeled Irbesartan[1]. Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease[2].

HY-101952S1

Prostaglandin E2-d9
Prostaglandin E2-d₉ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation[1][2].

HY-B0309S1

Felodipine-d5
Felodipine-d₅ is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

HY-B0371S

Terazosin-d8
Terazosin-d₈ is deuterium labeled Terazosin. Terazosin is a quinazoline derivative and a competitive and orally active α1-adrenoceptor antagonist. Terazosin works by relaxing blood vessels and the opening of the bladder. Terazosin has the potential for benign prostatic hyperplasia (BPH) and high blood pressure treatment[1][2][3].

HY-132670S

(R)-(-)-Felodipine-d5

(R)-(-)-Felodipine-d₅ is the deuterium labeled (R)-(-)-Felodipine. (R)-(-)-Felodipine is the S enantiomer of Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3].

HY-12717AS

Phentolamine-d4 hydrochloride

Phentolamine-d₄ (hydrochloride) is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction[1][2][3].

HY-17034BS1

Medetomidine-13C,d3 hydrochloride
Medetomidine-13C,d3 (hydrochloride) is a deuterated labeled Medetomidine (hydrochloride) . Medetomidine hydrochloride is an orally active α2-adrenoceptor agonist (K_i: 1.08 nM). Medetomidine hydrochloride has sedative and analgesic effects. Medetomidine hydrochloride can cause peripheral vasoconstriction through the activation of α2 adrenoceptors on blood vessels .

HY-B0263S

Thiabendazole-d4
Thiabendazole-d₄ is a deuterated form of Thiabendazole, which is an antiseptic, antifungal and antiparasitic agent[1].

Cat. No.	Product Name		Classification

HY-160048

PEG40K unconjugated/naked AX102 sodium		Aptamers
PEG40K unconjugated/naked AX102 sodium is AX102 without PEG40K conjugation. AX102 is a DNA oligonucleotide aptamer for platelet-derived growth factor PDGF-B. AX102 is 34 bases in length, selectively binds platelet-derived growth factor B (PDGF-B), and causes tumor vessel regression .

HY-160047

AX102 sodium		Aptamers
AX102 sodium is a 34 bp length nucleotide aptamer modified at the 5' end with a 40 kDa polyethylene glycol moiety. AX102 selectively binds platelet-derived growth factor B (PDGF-B) and causes tumor vessel regression .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

blood vessels

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products