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Results for "

broad spectrum cytotoxic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Akt (1) Aldose Reductase (1) AMPK (1) Antibiotic (7) Apoptosis (10) Autophagy (1) Bacterial (11) Bcl-2 Family (2) Caspase (2) CDK (1) Cytochrome P450 (1) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (1) EGFR (3) Endogenous Metabolite (2) Enterovirus (2) Farnesyl Transferase (1) Ferroptosis (1) FGFR (1) Filovirus (1) Fluorescent Dye (2) Fungal (9) HBV (1) HIV (2) HSP (1) Influenza Virus (1) Integrin (2) MDM-2/p53 (2) Microtubule/Tubulin (3) Mitophagy (1) Necroptosis (2) NOD-like Receptor (NLR) (1) Parasite (3) PARP (2) Src (1) Syk (1) Topoisomerase (3)
By Research Areas:	Cancer (26) Cardiovascular Disease (1) Infection (19) Inflammation/Immunology (2)

By Targets:

ADC Cytotoxin (1)

Akt (1)

Aldose Reductase (1)

AMPK (1)

Antibiotic (7)

Apoptosis (10)

Autophagy (1)

Bacterial (11)

Bcl-2 Family (2)

Caspase (2)

CDK (1)

Cytochrome P450 (1)

Dihydrofolate reductase (DHFR) (1)

DNA/RNA Synthesis (1)

EGFR (3)

Endogenous Metabolite (2)

Enterovirus (2)

Farnesyl Transferase (1)

Ferroptosis (1)

FGFR (1)

Filovirus (1)

Fluorescent Dye (2)

Fungal (9)

HBV (1)

HIV (2)

HSP (1)

Influenza Virus (1)

Integrin (2)

MDM-2/p53 (2)

Microtubule/Tubulin (3)

Mitophagy (1)

Necroptosis (2)

NOD-like Receptor (NLR) (1)

Parasite (3)

PARP (2)

Src (1)

Syk (1)

Topoisomerase (3)

By Research Areas:

Cancer (26)

Cardiovascular Disease (1)

Infection (19)

Inflammation/Immunology (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Targets Recommended: CTLA-4

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14907

Verubulin MPC 6827	Microtubule/Tubulin Apoptosis	Cancer
Verubulin (MPC-6827) is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities, and acts as a promising candidate for the treatment of multiple cancer types .

HY-W018025

5,6-Dihydroxyindole	Bacterial Fungal Parasite Endogenous Metabolite	Infection Inflammation/Immunology
5,6-Dihydroxyindole, a melanin precursor, has a broad-spectrum antibacterial, antifungal, antiviral, antiparasitic activity. 5,6-Dihydroxyindole has cytotoxic effects and is strongly toxic against various pathogens .

HY-B0608

Chlorhexidine digluconate (20% in water) 10+ Cited Publications	Bacterial Antibiotic Apoptosis Necroptosis	Infection Cancer
Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis .

HY-100506

GLPG0187 10+ Cited Publications	Integrin	Cancer
GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits α_vβ₁-integrin with an IC₅₀ of 1.3 nM . GLPG0187 inhibits migrasome biogenesis without cytotoxicity .

HY-W042191

Oxychlororaphine	Fungal Apoptosis Caspase Bcl-2 Family MDM-2/p53 PARP	Infection Cancer
Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer .

HY-137498

EBOV/MARV-IN-1	Filovirus	Infection
EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC₅₀=0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells .

HY-141426

MDL-860	Enterovirus	Infection
MDL-860 is a broad-spectrum antipicornavirus compound that has low cytotoxicity toward human cells. MDL-860 can be used for the research of virus infection .

HY-161763

Tubulin polymerization-IN-65	Microtubule/Tubulin	Cancer
Tubulin polymerization-IN-65 is a tubulin polymerisation inhibitor with a broad spectrum cytotoxic. Tubulin polymerization-IN-65 induces G2 + M cell cycle arrest .

HY-155546

Antimicrobial agent-22	Bacterial	Infection
Antimicrobial agent-22 (THI 6c) is a multi-target broad-spectrum antibacterial agent. Antimicrobial agent-22 has low cytotoxicity, hemolytic property, rapid bactericidal ability and good anti-biofilm activity .

HY-170433

DefNEtTrp	Apoptosis Ferroptosis	Cancer
DefNEtTrp is a Fe dual chelator ligand, consisting of the Def and Trp moieties. DefNEtTrp exhibits potent and broad-spectrum antiproliferative and cell death behavior in cancer cell lines. DefNEtTrp induces both apoptosis and ferroptosis and has cytotoxicity with an IC₅₀ value of 0.77 μM .

HY-151156

EGFR/HER2-IN-6	EGFR Apoptosis	Cancer
EGFR/HER2-IN-6 (compound 43) is an EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-6 inhibits EGFR kinase, HER2 kinase and DHFR with IC₅₀s of 0.122, 0.078 and 0.585 μM, respectively. EGFR/HER2-IN-6 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 can be used for the research of cancer .

HY-151161

EGFR/HER2-IN-8	EGFR	Cancer
EGFR/HER2-IN-8 (compound 34) is a EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-8 inhibits EGFR kinase, HER2 kinase and DHFR with IC₅₀s of 0.45, 0.244 and 5.669 μM, respectively. EGFR/HER2-IN-8 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 can be used for the research of cancer .

HY-137139

10'-Desmethoxystreptonigrin	Antibiotic Bacterial Farnesyl Transferase	Infection Cancer
10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC₅₀ of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD₅₀ is 8.8 mg/kg) .

HY-149486

FGFR1 inhibitor 7	FGFR	Cancer
FGFR1 inhibitor 7 (compound 5) is an inhibitor of FGFR1 Tyrosine Kinase with IC₅₀ value of 0.33 nM. FGFR1 inhibitor 7 shows broad-spectrum cytotoxicity agasinst human cancer cell lines, and inhibits MOLT3 cells with IC₅₀ of 2.1 μM .

HY-161144

AKT-IN-21	Akt Apoptosis	Cancer
AKT-IN-21 (compound C36) is a potent AKT inhibitor with broad-spectrum cytotoxicity and anticancer activity. AKT-IN-21 also blocks the cell cycle and induces apoptosis of cancer cells by down-regulating the PI3K/AKT pathway .

HY-B0608R

Chlorhexidine (digluconate) (Standard)	Bacterial Antibiotic Apoptosis Necroptosis	Infection Cancer
Chlorhexidine (digluconate) (Standard) is the analytical standard of Chlorhexidine (digluconate). This product is intended for research and analytical applications. Chlorhexidine digluconate is a chlorophenyl biguanide with broad antibacterial action against both Gram (+) and (-) bacteria and fungi. Chlorhexidine digluconate is a broad-spectrum antiseptic and disinfectant. Chlorhexidine digluconate is effective to prevent and control infectious diseases of the mouth by killing bacteria in saliva and tongue. Chlorhexidine digluconate is a cytotoxic agent and induces cell necrosis and apoptosis .

HY-138540

1-Dodecylimidazole 1 Publications Verification N-Dodecylimidazole	Fungal	Cancer
1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity .

HY-151159

DHFR-IN-4	Dihydrofolate reductase (DHFR) EGFR	Cancer
DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with an IC₅₀ value of 123 nM. DHFR-IN-4 also has inhibitory activity against EGFR and HER2 with IC₅₀s of 246 nM and 357 nM, respectively. DHFR-IN-4 has remarkable broad spectrum cytotoxic potency against cancer cells .

HY-W042191R

Oxychlororaphine (Standard)	Fungal Apoptosis Caspase Bcl-2 Family MDM-2/p53 PARP	Infection Cancer
Oxychlororaphine (Standard) is the analytical standard of Oxychlororaphine. This product is intended for research and analytical applications. Oxychloroaphine could be isolated from the bacterium Pantoea agglomerans naturally present in soil. Oxychloroaphine has broad-spectrum antifungal activity. Oxychloroaphine has cytotoxicity in a dose-dependent manner and induces apoptosis. Oxychloroaphine can be used in research of cancer[1][2].

HY-W018025R

5,6-Dihydroxyindole (Standard)	Bacterial Fungal Parasite Endogenous Metabolite	Infection Inflammation/Immunology
5,6-Dihydroxyindole (Standard) is the analytical standard of 5,6-Dihydroxyindole. This product is intended for research and analytical applications. 5,6-Dihydroxyindole, a melanin precursor, has a broad-spectrum antibacterial, antifungal, antiviral, antiparasitic activity. 5,6-Dihydroxyindole has cytotoxic effects and is strongly toxic against various pathogens .

HY-170646

Influenza A virus-IN-15	Influenza Virus	Infection
Influenza A virus-IN-15 (Compound 9b), a quinoline derivative, is a broad-spectrum inhibitor of influenza A viruses with acceptable cytotoxicity (IC₅₀: 0.88-6.33 μM). Influenza A virus-IN-15 can inhibit the transcription and replication of viral RNA and is used in research for its antiviral effects against influenza A viruses (IAV) .

HY-120638

BMS-250749	Topoisomerase	Cancer
BMS-250749 is a topoisomerase I (Top I) inhibitor of the fluoroglycosyl-3,9-difluoroindolecarbazole class. BMS-250749 exhibits potent cytotoxicity and selectivity, and shows curative antitumor activity against Lewis lung cancer. BMS-250749 exhibits broad-spectrum antitumor activity superior to CPT-11 in certain preclinical xenograft models. .

HY-12098

Verubulin hydrochloride MPC-6827 hydrochloride	Microtubule/Tubulin	Cancer
Verubulin hydrochloride (MPC-6827 hydrochloride) is a blood brain barrier permeable microtubule-disrupting agent, with potent and broad-spectrum in vitro and in vivo cytotoxic activities. Verubulin hydrochloride (MPC-6827 hydrochloride) exhibits potent anticancer activity in human MX-1 breast and other mouse xenograft cancer models. Verubulin hydrochloride (MPC 6827 hydrochloride) is a promising candidate for the treatment of multiple cancer types .

HY-152479

Topoisomerase IIα-IN-7	Topoisomerase	Cancer
Topoisomerase IIα-IN-7 is an DNA topoisomerase IIα inhibitor with an IC₅₀ value of 7.7 µM. Topoisomerase IIα-IN-7 has broad-spectrum cytotoxicity to leukemia, lung, colon, melanoma, ovarian, kidney, prostate and breast cancer cells. Topoisomerase IIα-IN-7 has metabolic stability .

HY-D2437

DOX-PEG-Cy3	Fluorescent Dye Antibiotic	Cardiovascular Disease Cancer
DOX-PEG-Cy3 (Doxorubicin-PEG-Cy3) is a Cy3 (HY-D0822) labeled DOX-PEG conjugate. The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. Cy3 has an emission maximum around 562-570 nm. DOX is a broad-spectrum anthracycline antibiotic with cytotoxic properties .

HY-P10228

S-Thanatin	Fungal Bacterial	Infection
S-Thanatin is an insect antimicrobial peptide with potent broad-spectrum antibacterial activity. S-Thanatin can inhibit the activity of Gram-negative bacteria, Gram-positive bacteria, and fungi, without cytotoxicity. The antibacterial activity of S-Thanatin is not affected by PH value, but monovalent cations (Na ⁺/K ⁺) can reduce its antibacterial activity against Gram-negative bacteria in a dose-dependent manner .

HY-168210

Antifungal agent 122	Fungal Cytochrome P450	Infection
Antifungal agent 122 (compound 201) is a potent and broad-spectrum antifungal agent. Antifungal agent 122 prevents fungal phase transition and the formation of fungal biofilm. Antifungal agent 122 inhibits CYP3A4-M and CYP3A4-T enzyme activity with IC₅₀ values of 2.11, 4.53 µM. Antifungal agent 122 shows no cytotoxicity .

HY-15096

MKT-077 5+ Cited Publications FJ-776	Fluorescent Dye HSP	Cancer
MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity . MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm .

HY-146226

Viral 2C protein inhibitor 1	Enterovirus	Infection
Viral 2C protein inhibitor 1 (compound 6aw) is a potent and broad-spectrum enterovirus antiviral agent, inhibiting viral 2C protein. Viral 2C protein inhibitor 1 inhibits multiple strains of EV-D68, EV-A71 and CVB3 with EC₅₀s of 0.1~3.6 µM, and exhibits high selectivity index and relatively low cytotoxicity .

HY-B1064

Clindamycin phosphate 5+ Cited Publications Clindamycin 2-phosphate; U-28508	Bacterial Antibiotic Parasite	Infection Cancer
Clindamycin phosphate (Clindamycin 2-phosphate) is a broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin phosphate is the proagent of Clindamycin (HY-B1455) with no antimicrobial activity in vitro but can be rapidly converted in vivo to the active parent agent, Clindamycin, by phosphatase ester hydrolysis. Clindamycin phosphate can be used for researching acne and bacterial vaginosis .Clindamycin phosphate has no cytotoxicity. Combined with platelet rich fibrin (PRF), PRF-Clindamycin phosphate enhances antimicrobial properties .

HY-147646

CDK1/Cyc B-IN-1	CDK Apoptosis	Cancer
CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC₅₀ of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines .

HY-15142A

Doxorubicin Hydroxydaunorubicin	ADC Cytotoxin Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV	Infection Cancer
Doxorubicin (Hydroxydaunorubicin), a broad-spectrum anthracycline antibiotic with cytotoxic properties, is an anti-cancer chemotherapy agent. Doxorubicin has fluorescence properties. Doxorubicin inhibits topoisomerase II with an IC₅₀ of 2.67 μM, thus stopping DNA replication. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy . Doxorubicin inhibits human DNA topoisomerase I with an IC₅₀ of 0.8 μM .

HY-W391625

(Rac)-Dehydrocostus Lactone (Rac)-Epiligulyl oxide	Fungal	Cancer
(Rac)-Dehydrocostus Lactone ((Rac)-Epiligulyl oxide) is a natural product with antiparasitic activity. (Rac)-Dehydrocostus Lactone can significantly inhibit the growth of Trypanosoma brucei rhodesiense. (Rac)-Dehydrocostus Lactone exhibits a broad spectrum of biological effects, including anti-inflammatory, anticancer, antiviral and antimicrobial activities. (Rac)-Dehydrocostus Lactone also has antifungal, antioxidant, antidiabetic, antiulcer and antihelminthic effects. (Rac)-Dehydrocostus Lactone exhibits different IC(50) values in cytotoxicity tests and has a high selectivity index .

HY-161986

HIV-1 inhibitor-74	HIV	Infection
HIV-1 inhibitor-74 (compound 10c) is a potent HIV-1 inhibitor with an EC₅₀ value of 0.0047 µM for HIV-1 IIIB. HIV-1 inhibitor-74 shows cytotoxicity. HIV-1 inhibitor-74 inhibits WT HIV-1 RT activity with an IC₅₀ value of 0.134 µM. HIV-1 inhibitor-74 shows broad-spectrum anti HIV-1 activity .

HY-172264

XT17	Antibiotic Bacterial DNA/RNA Synthesis	Infection
XT17 is an anthrone compound with broad-spectrum antibacterial activity. It exerts its antibacterial effect by disrupting the cell wall and inhibiting DNA synthesis. XT17 exhibits weak hemolytic activity, low cytotoxicity against mammalian cell lines, and a low frequency of drug resistance. Meanwhile, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies have confirmed that XT17 can form a stable complex with bacterial gyrase. XT17 can be used in the research of the anti - infection field .

HY-78263

MNS NSC 170724; 5-(2-Nitrovinyl)benzodioxole	Src Syk NOD-like Receptor (NLR) Integrin	Cancer
MNS (NSC 170724), the beta-nitrostyrene derivative, is an orally active tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. MNS inhibits Src, Syk, and FAK with IC₅₀ of 27.3, 2.8, and 97.6 μM, respectively. MNS inhibits NLRP3 inflammasome and β1 integrin. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC₅₀ values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM, respectively. MNS is cytotoxic to a variety of cells .

HY-126637

Marasmic acid	Bacterial Fungal	Infection
Marasmic acid is a sesquiterpenoid with unsaturated dialdehyde functionality, first isolated from the Basidiomycete Marasmus conigenus. Marasmic acid has antibacterial, antifungal, cytotoxic and mutagenic activities, and its broad-spectrum activity is related to the α,β-unsaturated aldehyde group. However, its detailed biological mechanism of action has not been clarified. Previous studies have suggested that marasmic acid may exert its effects by reacting with endogenous nucleophiles or forming pyrrole derivatives. This study found that marasmic acid interferes with the membrane sensor histidine kinase MoSln1p of M. oryzae, superactivates the HOG pathway and causes cell death, indicating that its mechanism of action is different from other unsaturated dialdehyde sesquiterpenoids.

HY-173132

AKR1Cs-IN-1	Aldose Reductase	Cancer
AKR1Cs-IN-1 (Compound 29) is a potent and broad-spectrum inhibitor targeting members of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). By simultaneously occupying the SP2 and SP3 pockets, it effectively inhibits multiple isoforms and disrupts metabolic pathways associated with drug resistance. In enzymatic activity assays, AKR1Cs-IN-1 exhibited significant inhibitory potency, with IC₅₀ values of 0.09, 0.28, 0.05, and 0.51 µM against AKR1C1, AKR1C2, AKR1C3, and AKR1C4, respectively. In the doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, AKR1Cs-IN-1 showed remarkable resensitization effects and significantly enhanced the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on overcoming drug resistance in breast cancer .

Cat. No.	Product Name	Type