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Results for "

kinase assay

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) AAK1 (2) Anaplastic lymphoma kinase (ALK) (2) Apoptosis (4) ATM/ATR (1) Aurora Kinase (1) Autophagy (2) Bcr-Abl (1) Btk (2) c-Kit (2) c-Met/HGFR (1) CaMK (1) Casein Kinase (1) Checkpoint Kinase (Chk) (2) Cholinesterase (ChE) (1) Complement System (1) DAPK (1) Endogenous Metabolite (1) Eukaryotic Initiation Factor (eIF) (2) FGFR (1) FLT3 (3) Fluorescent Dye (3) Insulin Receptor (1) IRAK (3) Isotope-Labeled Compounds (1) Itk (1) JAK (3) JNK (1) Kinesin (1) MAP4K (1) MAPKAPK2 (MK2) (1) mTOR (3) p38 MAPK (1) Parasite (1) PDGFR (2) PDK-1 (1) PI3K (2) PKC (3) Raf (2) RIP kinase (5) ROCK (1) Src (2) TAM Receptor (2) Tie (1) Trk Receptor (2) TRP Channel (1) ULK (1) VEGFR (8) Wee1 (1)
By Research Areas:	Cancer (31) Cardiovascular Disease (1) Inflammation/Immunology (18) Metabolic Disease (2) Neurological Disease (9)

By Targets:

Biochemical Assay Reagents (1)

AAK1 (2)

Anaplastic lymphoma kinase (ALK) (2)

Apoptosis (4)

ATM/ATR (1)

Aurora Kinase (1)

Autophagy (2)

Bcr-Abl (1)

Btk (2)

c-Kit (2)

c-Met/HGFR (1)

CaMK (1)

Casein Kinase (1)

Checkpoint Kinase (Chk) (2)

Cholinesterase (ChE) (1)

Complement System (1)

DAPK (1)

Endogenous Metabolite (1)

Eukaryotic Initiation Factor (eIF) (2)

FGFR (1)

FLT3 (3)

Fluorescent Dye (3)

Insulin Receptor (1)

IRAK (3)

Isotope-Labeled Compounds (1)

Itk (1)

JAK (3)

JNK (1)

Kinesin (1)

MAP4K (1)

MAPKAPK2 (MK2) (1)

mTOR (3)

p38 MAPK (1)

Parasite (1)

PDGFR (2)

PDK-1 (1)

PI3K (2)

PKC (3)

Raf (2)

RIP kinase (5)

ROCK (1)

Src (2)

TAM Receptor (2)

Tie (1)

Trk Receptor (2)

TRP Channel (1)

ULK (1)

VEGFR (8)

Wee1 (1)

By Research Areas:

Cancer (31)

Cardiovascular Disease (1)

Inflammation/Immunology (18)

Metabolic Disease (2)

Neurological Disease (9)

Inhibitors & Agonists

Fluorescent Dye

Peptides

MCE Kits

Isotope-Labeled Compounds

Targets Recommended: Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-130433

NBD Sphingosine	Fluorescent Dye	Others
NBD Sphingosine (NBD-Sph), a fluorochrome, is a fluorescence-labeled sphingosine. NBD Sphingosine can be uesd for fluorescence assay for sphingosine kinases .

HY-P5426

Abl protein tyrosine kinase substrate	Bcr-Abl	Others
Abl protein tyrosine kinase substrate is a biological active peptide. (Abltide is a peptide substrate for Abl Kinase (Abl protein tyrosine kinase), a partner in the gag-Abl fusion protein of the Abelson murine leukemia virus. Used in Western blot and kinase assay.)

HY-136567

TBAP-001	Raf	Cancer
TBAP-001 (Synthesis 13), extracted from patent WO2015075483A1, is a pan-RAF kinase inhibitor, with an IC₅₀ of 62 nM in BRAF V600E kinase assay .

HY-125012

MAP4K4-IN-3 1 Publications Verification	MAP4K	Metabolic Disease
MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC₅₀ of 14.9 nM in kinase assay, an IC₅₀ of 470 nM in cell assay. Antidiabetic agent .

HY-100877

GCN2-IN-1 Maximum Cited Publications 19 Publications Verification A-92	Eukaryotic Initiation Factor (eIF)	Cancer
GCN2-IN-1 (A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with an IC₅₀ of <0.3 μM in the enzyme assay and an IC₅₀ of 0.3-3 μM in the cell assay .

HY-P5961

Chktide	Checkpoint Kinase (Chk)	Cancer
Chktide is a substrate for CHK1 and CHK2. Chktide can be used in kinase assays .

HY-P10609

Btk substrate peptide	Btk	Others
Btk substrate peptide is a peptide substrate corresponding to residues 217-229 of human Bruton’s tyrosine kinase (Btk), of which the tyrosine at residue 223 is the major autophosphorylation site of Btk. Btk substrate peptide is used as a substrate in in vitro kinase assays to evaluate the activity of Btk or other tyrosine kinases .

HY-P2547

Tyrosine Kinase Peptide 1	Src	Others
Tyrosine Kinase Peptide 1 is a control substrate peptide for c-Src assay .

HY-153436

RIP1 kinase inhibitor 6	RIP kinase	Cancer
RIP1 kinase inhibitor 6 is a potent and selective RIP1 kinase inhibitor with an IC₅₀ of < 100 nM in human R1P1 kinase assay. RIP1 kinase inhibitor 6 is extracted from patent WO2020103884, example 80 .

HY-153437

RIP1 kinase inhibitor 7	RIP kinase	Cancer
RIP1 kinase inhibitor 7 (compound 41) is a potent *receptor interacting protein 1 kinase* (RIP1) Inhibitor with an IC₅₀** of <100 nM for human RIP1. RIP1 kinase inhibitor 7 has an EC₅₀ of 1-100 nM in the cell necrosis assay .

HY-P0225

Autocamtide 2 Autocamtide II	CaMK Autophagy	Neurological Disease
Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay.

HY-13343

ZM 336372 2 Publications Verification	Raf Apoptosis	Cancer
ZM 336372 is a potent inhibitor of the protein kinase c-Raf. The IC₅₀ value is 0.07 μM in the standard assay, which contains 0.1 mM ATP.

HY-D2415

BODIPY-FL staurosporine	Fluorescent Dye	Others
BODIPY-FL staurosporine (Compound 8a) is a fluorescence probe based on staurosporine, exhibiting high specificity towards tyrosine kinases (TK) and tyrosine kinase-like (TKL) family kinases. BODIPY-FL staurosporine has the potential to develop binding assays for kinases that are not recommended for use with Kinase Tracer 236, such as PIM3, CDC42BPG, MAP2K7, TXK, and SIK3. BODIPY-FL staurosporine can be a powerful tool for analyzing kinase selectivity in kinase drug discovery .

HY-P3904

P34cdc2 Kinase Substrate Peptide	Biochemical Assay Reagents	Others
P34cdc2 Kinase Substrate Peptide is a synthetic peptide substrates for P34 ^cdc2 kinase, with a K_m of 74 μM for the purified human enzyme. P34cdc2 Kinase Substrate Peptide can be used in a rapid assay of P34 ^cdc2 phosphorylation in vitro. P34 ^cdc2, a protein serinehhreonine kinase, is a cell division cycle-regulated protein kinase .

HY-129634

TrkA-IN-1	Trk Receptor	Neurological Disease
TrkA-IN-1 is a potent and selective *Tropomyosin-related kinase* A (TrkA) inhibitor with an IC₅₀** of 99 nM in a cell-based assay. TrkA-IN-1 has analgesic activity .

HY-13232

ITK antagonist	Itk	Inflammation/Immunology
ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC₅₀=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC₅₀ of 160 nM .

HY-139504

Gamcemetinib CC-99677	MAPKAPK2 (MK2)	Inflammation/Immunology
Gamcemetinib (CC-99677) is a potent, covalent, and irreversible inhibitor of the mitogen-activated protein (MAP) kinase-activated protein kinase-2 (MK2) pathway in both biochemical (IC₅₀=156.3 nM) and cell based assays (EC₅₀=89 nM). Gamcemetinib is extracted from patent WO2020236636, compound 1 .

HY-112622

GSK3186899 DDD-853651	Parasite	Cancer
GSK3186899 (DDD-853651) is an inhibitor of cdc-2-related kinase 12 (CRK12), with an EC₅₀ of 1.4 μM for L. donovani in an intra-macrophage assay.

HY-108606

PI-828 1 Publications Verification	PI3K Casein Kinase	Cancer
PI-828 is a dual PI3K and *casein kinase* 2 (CK2) inhibitor with IC₅₀s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2** in lipid kinase assay, respectively .

HY-P1821

Myelin Basic Protein MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-P1821A

Myelin Basic Protein TFA 2 Publications Verification MHP4-14 TFA	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-100315

XL 999 Tyrosine kinase-IN-1	VEGFR PDGFR FGFR	Cardiovascular Disease
**Kinase Assay:** ^[1]Kinase Inhibition Assays Kinase activities of KDR and PDGFRα are measured as the percent of ATP consumed following the kinase reaction using luciferaseluciferin-coupled chemiluminescence. Kinase reactions are initiated by combining test compound (XL 999), ATP, kinases and substrates in a 20 mL volume using 384-well microtiter plates. For KDR, the final reaction mixture contained 3 mM ATP, 1.6 mM poly(Glu, Tyr) 4:1 and 1.5 nM KDR of residues D807-V1356 with an N-terminal GST tag. For PDGFRα, the final reaction mixture contained 2 mM ATP, 10 mM MBP and 14 nM PDGFRα of residues Q551-L1089 with an N-terminal GST tag. The reaction mixture is incubated at room temperature for 4 h (KDR) or 2 h PDGFRα before a 20 mL aliquot of Kinase Glo is added and luminescence signal is measured using a Victor2 plate reader. Total ATP consumption is limited below 50% .

HY-18179

AZD2932	PDGFR VEGFR FLT3 c-Kit	Cancer
AZD2932 is a potent and multi-targeted kinase inhibitor VEGFR2, PDGFβ, Flt-3 and c-Kit with IC₅₀s of 8, 4, 7 and 9 nM in cell assay, respectively.

HY-115869

RMC-4529	mTOR	Cancer
RMC-4529 has an IC₅₀ value of 1.0 nM against p-4E-BP1-(T37/46) in mTOR kinase cellular assay.

HY-167877

PS-166276	p38 MAPK	Inflammation/Immunology
PS-166276 is a highly potent and less cytotoxic inhibitor of p38. PS166276 has an IC₅₀ of 28 nM at p38 kinase and 170 nM in the THP-1 TNFα assay .

HY-P3940

Ac-MBP (4-14) Peptide	PKC	Others
Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .

HY-10515

BX-320	PDK-1	Cancer
BX-320 is a selective, ATP-competitive, orally acitive, and direct PDK1 inhibitor with an IC₅₀ of 30 nM in a direct kinase assay format. BX-320 also induces apoptosis. Anticancer effect .

HY-18302

c-Kit-IN-5-1	c-Kit	Inflammation/Immunology
c-Kit-IN-5 is potent inhibitor of c-Kit, with IC₅₀s of 22 nM and 16 nM in kinase assay and cell assay, respectively. c-Kit-IN-5 shows more than 200-fold selectivity for c-Kit over KDR, p38, Lck, and Src. c-Kit-IN-5 also exhibits desirable pharmacokinetic properties .

HY-160691

GW814408X	Aurora Kinase	Others
GW814408X is a kinase chemical genome group (KCGS) compound that inhibits the AURKC kinase involved in cell cycle progression, checkpoint regulation, and cell division. GW814408X exhibits cell line-dependent toxicity, e.g., cytotoxic effects on HeLa cells. GW814408X acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential implications for Fluc reporter assays .

HY-162237

RIPK1-IN-22	RIP kinase	Inflammation/Immunology
RIPK1-IN-13 (compound 28) is a selective inhibitor for receptor-interacting serine/threonine-protein kinase 1 (RIPK1), the inhibitory activity is measured by ADP-Glo Kinase Assay with a pK_i of 7.66. RIPK1-IN-13 inhibits human leukaemia cells U937 with a pIC₅₀ of 7.2 .

HY-P10574

Phosphorylated CHKtide	Checkpoint Kinase (Chk)	Cancer
Phosphorylated CHKtide is a synthetic peptide substrate derived from CDC25C, which is phosphorylated by CHK1/CHK2 in one of the DNA repair pathways. Phosphorylated CHKtide is used in the assays of cell cycle checkpoint kinases 1 and 2 (CHK1/CHK2) and salt-inducible kinases (SIKs) .

HY-145817A

lunresertib 1 Publications Verification RP-6306	Wee1	Cancer
lunresertib (RP-6306) is a potent, selective and orally active PKMYT1 inhibitor with an IC₅₀ of 14 nM. lunresertib shows a high degree of selectivity over other kinases in cellular binding assays. lunresertib shows anticancer effects .

HY-160685

GW809897X	VEGFR	Others
GW809897X is a dual inhibitor of Fluc and VEGFR with IC₅₀ of 0.58 μM and 65 nM, respectively. GW809897X is a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential impact on Fluc reporter assays .

HY-160684

GW701427A	VEGFR	Others
GW701427A is a dual inhibitor of Fluc and VEGFR2 with IC₅₀ of 0.12 μM and 603 nM, respectively. GW701427A acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential implications for Fluc reporter assays .

HY-112362

3-(4-Pyridyl)indole Rockout; 3-(4-Pyridinyl)-1H-indole; Rho kinase Inhibitor III, Rockout	ROCK	Inflammation/Immunology
3-(4-Pyridyl)indole (Rockout) is a *Rho-kinase* (ROCK) inhibitor, with an IC₅₀** of 25 μM. 3-(4-Pyridyl)indole can inhibit blebbing and cause dissolution of actin stress fibers in a wound healing assay .

HY-138696

Zanzalintinib 1 Publications Verification XL092	TAM Receptor c-Met/HGFR VEGFR	Cancer
Zanzalintinib (XL092) is an orally active, ATP-competitive inhibitor of multiple receptor tyrosine kinases (RTKs) including MET, VEGFR2, AXL and MER, with IC₅₀s in cell-based assays of 15 nM, 1.6 nM, 3.4 nM, 7.2 nM respectively. Zanzalintinib exhibits anti-tumor activity. Zanzalintinib has the potential for kinase-dependent diseases and conditions research .

HY-120179

LP-922761 1 Publications Verification	AAK1	Neurological Disease
LP-922761 is a potent, selective and orally active *adapter protein-2 associated kinase* 1 (AAK1) inhibitor with IC₅₀*s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 also inhibits BMP-2-inducible protein kinase* (BIKE) with an IC₅₀** of 24 nM. LP-922761 exhibits no significant activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors .

HY-120179A

LP-922761 hydrate	AAK1	Neurological Disease
LP-922761 hydrate is a potent, selective and orally active *adapter protein-2 associated kinase* 1 (AAK1) inhibitor with IC₅₀*s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibits BMP-2-inducible protein kinase* (BIKE) with an IC₅₀** of 24 nM. LP-922761 hydrate shows less activity at cyclin G-associated kinase (GAK), opioid, adrenergic α2 or GABAa receptors .

HY-135317

Emavusertib 3 Publications Verification CA-4948	IRAK Apoptosis FLT3	Inflammation/Immunology Cancer
Emavusertib (CA-4948) is a potent and orally active IRAK4/FLT3 inhibitor. Emavusertib has an IC₅₀ of 57 nM for IRAK4 in a FRET kinase assay. Emavusertib shows anti-tumor activity .

HY-18012A

Spebrutinib besylate AVL-292 benzenesulfonate; CC-292 besylate	Btk	Cancer
Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a potent inhibitor of Btk kinase activity (IC₅₀<0.5 nM, K_inact/K_i=7.69×10 ⁴ M ^-1s ^-1s) in biochemical assays.

HY-135317B

Emavusertib hydrochloride CA-4948 hydrochloride	IRAK FLT3 Apoptosis	Inflammation/Immunology Cancer
Emavusertib (CA-4948) hydrochloride is a potent and orally active IRAK4/FLT3 inhibitor. Emavusertib hydrochloride has an IC₅₀ of 57 nM for IRAK4 in a FRET kinase assay. Emavusertib hydrochloride shows anti-tumor activity .

HY-135985

DCLK1-IN-1 1 Publications Verification	Fluorescent Dye	Cancer
DCLK1-IN-1 is a selective, oral bioavailability in vivo-compatible chemical probe of the doublecortin like kinase 1 (DCLK1 kinase) domain. DCLK1-IN-1 inhibits DCLK1 and DCLK2 kinases (IC₅₀: DCLK1=9.5/57.2 nM and DCLK2=31/103 nM in binding and kinase assay, respectively). DCLK1-IN-1 shows low toxicity, and can investigate DCLK1 biology and establish its role in cancer, like DCLK1 ⁺ pancreatic ductal adenocarcinoma (PDAC) .

HY-139609

Camonsertib RP-3500; ATR inhibitor 4	ATM/ATR mTOR	Cancer
Camonsertib (RP-3500) is an orally active, selective ATR kinase inhibitor (ATRi) with an IC₅₀ of 1.00 nM in biochemical assays. Camonsertib shows 30-fold selectivity for ATR over mTOR (IC₅₀=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. Camonsertib has potent antitumor activity .

HY-115570

GW406108X 1 Publications Verification GW108X	Kinesin ULK Autophagy	Cancer
GW406108X is a specific Kif15 (Kinesin-12) inhibitor with an IC₅₀ of 0.82 uM in ATPase assays. GW406108X, a potent autophagy inhibitor, shows ATP competitive inhibition against ULK1 with a pIC₅₀ of 6.37 (427 nM). GW406108X inhibits ULK1 kinase activity and blocks autophagic flux, without affecting the upstream signaling kinases mTORC1 and AMPK .

HY-14243

CEP-14083	Anaplastic lymphoma kinase (ALK) Insulin Receptor VEGFR Tie	Cancer
CEP-14083 is a ATP-competitive ALK kinase inhibitor with an IC₅₀ value in enzymatic assays of 2 nM. CEP-14083 also inhibits other kinases, such as insulin receptor (IR), vascular endothelial growth factor receptor 2 (VEGFR2), angiopoietin-1 receptor (TIE2) and dual leucine zipper kinase (DLK). CEP-14083 suppresses CD274 mRNA expression and the NPM/ALK function in the NPM/ALK-carrying T cell lymphoma (ALK+TCL) cells. CEP-14083 is promising for research of lymphoma .

HY-122700

Factor D inhibitor 6	Complement System	Inflammation/Immunology
Factor D inhibitor 6 is a potent, highly selective and orally active factor D (FD) inhibitor with an IC₅₀ of 30 nM and a K_d of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases .

HY-130254

CSK-IN-1 1 Publications Verification	Src	Inflammation/Immunology Cancer
CSK-IN-1 (compound 13) is a potent, orally active *c-terminal Src kinase* (CSK) with IC₅₀** values below 3 nM and 4 nM in CSK HTRF and Caliper assay, respectively. CSK-IN-1 shows the ability to increase T cell proliferation induced by T cell receptor signaling .

HY-160686

GSK248233A	VEGFR	Others
GSK248233A is a dual inhibitor of Fluc and VEGFR2 with IC₅₀ of 1.03 μM and 2 nM, respectively. GSK248233A also shows activity against the AGC family. GSK248233A acts as a protein kinase inhibitor across ATP-dependent and -independent luciferases with potential implications for Fluc reporter assays .

HY-148629

GDC-0134	JNK	Neurological Disease
GDC-0134 is a potent, selective, orally active, brain-penetrant *dual leucine zipper kinase* (DLK)** inhibitor. GDC-0134 blocks DLK activity in cellular assays and in animal models of neuronal injury. GDC-0134 can be used for the study of amyotrophic lateral sclerosis (ALS) .

HY-19836

Zimlovisertib 5+ Cited Publications PF-06650833	IRAK	Inflammation/Immunology
Zimlovisertib (PF-06650833) is a potent, selective and orally active inhibitor of *interleukin-1 receptor associated kinase* 4 (IRAK4) with IC₅₀*s of 0.2 and 2.4 nM in the cell and PBMC assay*, respectively. Zimlovisertib is used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas .

Cat. No.	Product Name	Type

HY-130433

NBD Sphingosine	Dyes
NBD Sphingosine (NBD-Sph), a fluorochrome, is a fluorescence-labeled sphingosine. NBD Sphingosine can be uesd for fluorescence assay for sphingosine kinases .

HY-D2415

BODIPY-FL staurosporine

Fluorescent Dyes/Probes

BODIPY-FL staurosporine (Compound 8a) is a fluorescence probe based on staurosporine, exhibiting high specificity towards tyrosine kinases (TK) and tyrosine kinase-like (TKL) family kinases. BODIPY-FL staurosporine has the potential to develop binding assays for kinases that are not recommended for use with Kinase Tracer 236, such as PIM3, CDC42BPG, MAP2K7, TXK, and SIK3. BODIPY-FL staurosporine can be a powerful tool for analyzing kinase selectivity in kinase drug discovery .

Cat. No.	Product Name	Target	Research Area

HY-P1797A

Sakamototide substrate peptide TFA	Peptides	Others
Sakamototide substrate peptide TFA is a peptide substrate for members of the AMPK family of kinases, used in kinase activity assays .

HY-P5426

Abl protein tyrosine kinase substrate	Bcr-Abl	Others
Abl protein tyrosine kinase substrate is a biological active peptide. (Abltide is a peptide substrate for Abl Kinase (Abl protein tyrosine kinase), a partner in the gag-Abl fusion protein of the Abelson murine leukemia virus. Used in Western blot and kinase assay.)

HY-P0225

Autocamtide 2 Autocamtide II	CaMK Autophagy	Neurological Disease
Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII activity assay.

HY-P1821A

Myelin Basic Protein TFA 2 Publications Verification MHP4-14 TFA	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-P5961

Chktide	Checkpoint Kinase (Chk)	Cancer
Chktide is a substrate for CHK1 and CHK2. Chktide can be used in kinase assays .

HY-P10609

Btk substrate peptide	Btk	Others
Btk substrate peptide is a peptide substrate corresponding to residues 217-229 of human Bruton’s tyrosine kinase (Btk), of which the tyrosine at residue 223 is the major autophosphorylation site of Btk. Btk substrate peptide is used as a substrate in in vitro kinase assays to evaluate the activity of Btk or other tyrosine kinases .

HY-P10044

IGF1Rtide	Peptides	Others
IGF1Rtide can be used as a RET kinase substrate for RET kinase assays .

HY-P2547

Tyrosine Kinase Peptide 1	Src	Others
Tyrosine Kinase Peptide 1 is a control substrate peptide for c-Src assay .

HY-P3904

P34cdc2 Kinase Substrate Peptide	Biochemical Assay Reagents	Others
P34cdc2 Kinase Substrate Peptide is a synthetic peptide substrates for P34 ^cdc2 kinase, with a K_m of 74 μM for the purified human enzyme. P34cdc2 Kinase Substrate Peptide can be used in a rapid assay of P34 ^cdc2 phosphorylation in vitro. P34 ^cdc2, a protein serinehhreonine kinase, is a cell division cycle-regulated protein kinase .

HY-P1821

Myelin Basic Protein MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-P3940

Ac-MBP (4-14) Peptide	PKC	Others
Ac-MBP (4-14) Peptide is an acetylated MBP (4-14) peptide. MBP (4-14) Peptide is a very selective (protein kinase C) PKC substrate. Ac-MBP (4-14) Peptide can be used for PKC assay in extracts without prior purification to eliminate interfering protein kinases or phosphatases .

HY-P5434

Jak3tide JAK3 Peptide substrate	Peptides	Others
Jak3tide (JAK3 Peptide substrate) is a biological active peptide. (This peptide is a substrate for Jak3. It may be used used in kinase assays. Jak3tide contains the phosphorylation site at Tyr7.)

HY-P10574

Phosphorylated CHKtide	Checkpoint Kinase (Chk)	Cancer
Phosphorylated CHKtide is a synthetic peptide substrate derived from CDC25C, which is phosphorylated by CHK1/CHK2 in one of the DNA repair pathways. Phosphorylated CHKtide is used in the assays of cell cycle checkpoint kinases 1 and 2 (CHK1/CHK2) and salt-inducible kinases (SIKs) .

HY-P5429

DNA-PK Substrate	Peptides	Others
DNA-PK Substrate is a biological active peptide. (A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11–24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activityPyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

Cat. No.	Product Name

HY-K0016

Kinase Assay Buffer
MCE Kinase Assay Buffer can be used for assaying kinase protein.

Cat. No.	Product Name	Chemical Structure

HY-W727879

Upadacitinib-15N,d2

Upadacitinib- ¹⁵N,d₂ (ABT-494- ¹⁵N,d₂) is the deuterium-labeled Upadacitinib (HY-19569). Upadacitinib- ¹⁵N,d₂ (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC₅₀=43 nM). Upadacitinib- ¹⁵N,d₂ (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib- ¹⁵N,d₂ (ABT-494) can be used for several autoimmune disorders research .

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