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Results for "

mAChR antagonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	mAChR (86) Adrenergic Receptor (5) Autophagy (1) Calcium Channel (4) Endogenous Metabolite (2) Histamine Receptor (3) Isotope-Labeled Compounds (7) nAChR (1) Neurokinin Receptor (1) Phosphodiesterase (PDE) (4) Potassium Channel (2)
By Research Areas:	Cancer (15) Cardiovascular Disease (11) Endocrinology (5) Inflammation/Immunology (13) Metabolic Disease (7) Neurological Disease (66)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Fluorescent Dye

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Natural
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Isotope-Labeled Compounds

Click Chemistry

Targets Recommended: mAChR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155367

mAChR antagonist 1	mAChR	Neurological Disease
mAChR antagonist 1 (compound 4a) is a *mAChR* antagonist with K_i values of 255 nM, 121 nM, 158 nM, and 255 nM for M1, M3, M4, and M5 subtype, respectively .

HY-12426A

mAChR-IN-1 hydrochloride	mAChR	Neurological Disease
mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC₅₀ of 17 nM .

HY-U00119

Nuvenzepine	mAChR	Cardiovascular Disease
Nuvenzepine is an *mAChR* antagonist, has the potential for gastrospasm treatment.

HY-12100

Umeclidinium bromide 1 Publications Verification GSK573719A	mAChR	Inflammation/Immunology Cancer
Umeclidinium bromide is a novel *mAChR* antagonist. The affinity (K_i) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-U00106

Cimetropium Bromide DA-3177	mAChR	Neurological Disease Inflammation/Immunology
Cimetropium Bromide (DA-3177) is a *mAChR* antagonist for long-term treatment of irritable bowel syndrome.

HY-120682

UH-AH 37	mAChR	Neurological Disease
UH-AH 37 is a muscarinic (mAChR) antagonist. UH-AH 37 exhibits a higher potency in inhibiting muscarinic responses in intestinal tissue than cardiac tissue .

HY-124223

AF-DX 384 methanesulfonate	mAChR	Neurological Disease
AF-DX 384 (methanesulfonate) is a selective antagonist of M2 and M4 muscarinic acetylcholine receptors (K_is=6.03 and 10 nM, respectively) . AF-DX 384 (methanesulfonate) reverses deficits in novel object recognition and passive avoidance in aged rats, as well as in young rats with impairments induced by scopolamine .

HY-12426

mAChR-IN-1	mAChR	Neurological Disease
mAChR-IN-1 is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC₅₀ of 17 nM .

HY-U00139

Cyclodrine hydrochloride	mAChR nAChR	Neurological Disease
Cyclodrine hydrochloride is a cholinergic (muscarinic, nicotinic) (mAChR and nAChR) receptor antagonist.

HY-43711

Nor-benzetimide	mAChR	Neurological Disease
Nor-benzetimide is a major metabolite of Benzetimide. Benzetimide is a *mAChR* antagonist with anticholinergic activity .

HY-105771

Parapenzolate bromide	mAChR	Neurological Disease
Parapenzolate bromide, an antispasmodic, is an orally active *mAChR* antagonist. Parapenzolate bromide is an anticholinergic agent .

HY-N0340

Scopolamine butylbromide 1 Publications Verification Hyoscine butylbromide; (-)-Scopolamine butylbromide; Butylscopolamine bromide	mAChR	Neurological Disease
Scopolamine butylbromide is a competitive antagonist of muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 ± 4.3 nM.

HY-B1205

Atropine Maximum Cited Publications 16 Publications Verification Tropine tropate; DL-Hyoscyamine	mAChR Endogenous Metabolite	Cardiovascular Disease Neurological Disease Cancer
Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .

HY-U00105

Oxitropium Bromide	mAChR	Inflammation/Immunology
Oxitropium bromide is an *mAChR* antagonist used as an anticholinergic bronchodilator agent for the treatment of asthma and chronic obstructive pulmonary disease.

HY-137040A

Tiemonium iodide	mAChR	Neurological Disease
Tiemonium iodide is a *mAChR* antagonist with antispasmodic properties. Tiemonium iodide can be used in nervous system research .

HY-U00079A

Vamicamide FK-176	mAChR	Neurological Disease
Vamicamide (FK-176) is an orally active competitive *mAChR* antagonist that inhibits contractions induced by cholinergic nerve stimulation by preventing *mAChR* agonists from binding to *mAChR. Vamicamide exhibits a good anti-bladder spasm effect, with a pA2* value of 6.82 in bladder tissue. Vamicamide can be used in research within the field of neurological diseases .

HY-B0394

Atropine sulfate monohydrate Maximum Cited Publications 16 Publications Verification Tropine tropate sulfate monohydrate; DL-Hyoscyamine sulfate monohydrate	mAChR	Cardiovascular Disease Neurological Disease Cancer
Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

HY-B1205A

Atropine sulfate Maximum Cited Publications 16 Publications Verification Tropine tropate sulfate; DL-Hyoscyamine sulfate; Sulfatropinol	mAChR	Cardiovascular Disease Neurological Disease Cancer
Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .

HY-B1205B

Atropine hydrobromide Tropine tropate hydrobromide; DL-Hyoscyamine hydrobromide	mAChR	Cardiovascular Disease Neurological Disease Cancer
Atropine (Tropine tropate) hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia .

HY-12100S

Umeclidinium-d5 bromide GSK573719A-d₅	Isotope-Labeled Compounds mAChR	Inflammation/Immunology
Umeclidinium-d₅ (bromide) is the deuterium labeled Umeclidinium bromide. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-12100S1

Umeclidinium-d10 bromide GSK573719A-d₁₀	mAChR	Inflammation/Immunology
Umeclidinium-d₁₀ (bromide) is the deuterium labeled Umeclidinium bromide. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-15851

Revefenacin TD-4208; GSK1160724	mAChR	Cardiovascular Disease Inflammation/Immunology
Revefenacin (TD-4208; GSK1160724) is a potent *mAChR* antagonist; has a high affinity on M3 receptor with a K_i of 0.18 nM.

HY-12100R

Umeclidinium bromide (Standard)	mAChR	Inflammation/Immunology Cancer
Umeclidinium (bromide) (Standard) is the analytical standard of Umeclidinium (bromide). This product is intended for research and analytical applications. Umeclidinium bromide is a novel *mAChR* antagonist. The affinity (K_i) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-B1205R

Atropine (Standard) Tropine tropate (Standard); DL-Hyoscyamine (Standard)	mAChR Endogenous Metabolite	Cardiovascular Disease Neurological Disease
Atropine (Standard) is the analytical standard of Atropine. This product is intended for research and analytical applications. Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .

HY-B1719A

Oxyphenonium bromide	mAChR	Inflammation/Immunology
Oxyphenonium bromide is an antiacetylcholine compound. Oxyphenonium bromide is an antagonist of *mAChR*. Oxyphenonium bromide protects against the bronchial obstructive effects .

HY-141711

VU6028418	mAChR	Neurological Disease
VU6028418 is a potent, highly selective and orally bioavailable M₄ mAChR antagonist with an IC₅₀ of 4.1 nM against hM₄ .

HY-P0102

Dipeptide diaminobutyroyl benzylamide diacetate	mAChR	Neurological Disease
Dipeptide diaminobutyroyl benzylamide diacetate, a Wagerlin-1-mimicking peptide, is a *mAChR* antagonist. Dipeptide diaminobutyroyl benzylamide diacetate can induce muscle relaxation .

HY-B1205AR

Atropine sulfate (Standard)	mAChR	Cardiovascular Disease Neurological Disease
Atropine (sulfate) (Standard) is the analytical standard of Atropine (sulfate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .

HY-B0394R

Atropine sulfate monohydrate (Standard)	mAChR	Cardiovascular Disease Neurological Disease
Atropine (sulfate monohydrate) (Standard) is the analytical standard of Atropine (sulfate monohydrate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

HY-17360

Tiotropium Bromide 1 Publications Verification BA679 BR	mAChR	Neurological Disease
Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-U00104

YM-46303	mAChR	Endocrinology
YM-46303 is an *mAChR* antagonist which exhibits the highest affinities for M1 and M3 receptors, and selectivity for M3 over M2 receptor.

HY-160440A

VU6021625	mAChR	Neurological Disease
VU6021625 is a selective antagonist muscarinic acetylcholine receptors (mAChRs), with the IC₅₀ value of 0.44 nM, 57 nM for human M4 and rat M4, respectively .

HY-116569

VU0455691	mAChR	Cardiovascular Disease
VU0455691 is a potent, selective orthosteric M₁ mAChR antagonist (pIC₅₀=6.64; IC₅₀=0.23 µM for hM1) .

HY-15502

PF-3635659	mAChR	Neurological Disease Inflammation/Immunology
PF-3635659 is a potent antagonist of the muscarinic M3 receptor (mAChR3). PF-3635659 can be used for chronic obstructive pulmonary disease (COPD) research .

HY-B1188A

Propantheline	mAChR	Neurological Disease
Propantheline is an orally active *mAChR* antagonist. Propantheline can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination .

HY-B0549A

Flavoxate hydrochloride Rec-7-0040; DW61	Phosphodiesterase (PDE) Calcium Channel mAChR	Neurological Disease
Flavoxate hydrochloride is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate hydrochloride is an antispasmodic agent and muscarinic *mAChR* antagonist. Flavoxate hydrochloride shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate hydrochloride can be used for the research of overactive bladder (OAB) and lower urinary tract infections .

HY-B0549

Flavoxate Rec-7-0040 free base; DW61 free base	Phosphodiesterase (PDE) Calcium Channel mAChR	Neurological Disease
Flavoxate is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate is an antispasmodic agent and muscarinic *mAChR* antagonist. Flavoxate shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate can be used for the research of overactive bladder (OAB) and lower urinary tract infections .

HY-B0394S

Atropine-d5 Tropine tropate-d₅; DL-Hyoscyamine-d₅	mAChR Autophagy	Neurological Disease
Atropine-d₅ is the deuterium labeled Atropine (sulfate monohydrate). Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect[1].

HY-B1188

Propantheline bromide	mAChR	Neurological Disease
Propantheline bromide is an orally active *mAChR* antagonist. Propantheline bromide can be used in the research of smooth muscle dysfunction, excessive sweating, cramps or spasms of the stomach, intestines or bladder, and involuntary urination .

HY-15851R

Revefenacin (Standard)	mAChR	Cardiovascular Disease Inflammation/Immunology
Revefenacin (Standard) is the analytical standard of Revefenacin. This product is intended for research and analytical applications. Revefenacin (TD-4208; GSK1160724) is a potent *mAChR* antagonist; has a high affinity on M3 receptor with a K_i of 0.18 nM.

HY-B0461

Trospium chloride	mAChR	Neurological Disease Cancer
Trospium chloride is an orally active, specific and competitive antagonist of muscarinic cholinergic receptors (mAChRs), with antimuscarinic activity. Trospium chloride binds to muscarinic receptors M1, M2 and M3 with high affinity, but not nicotinic, cholinergic receptors .

HY-17360S

Tiotropium-d3 bromide BA679 BR-d₃	Isotope-Labeled Compounds mAChR	Neurological Disease
Tiotropium-d₃ (bromide) is the deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-17360S1

Tiotropium-d6 bromide BA679 BR-d₆	Isotope-Labeled Compounds mAChR	Neurological Disease
Tiotropium-d₆ (bromide) is deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-119918

Cycrimine	mAChR	Neurological Disease
Cycrimine is an orally active *muscarinic cholinergic receptor (mAChR) M1* antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder .

HY-B0954A

Oxyphencyclimine	mAChR	Endocrinology
Oxyphencyclimine is an orally active muscarinic receptor (mAChR) antagonist. Oxyphencyclimine is effective in reducing ulceration index and increasing pepsin activity in rat gastric ulcer model. Oxyphencyclimine can be used in studies of peptic ulcer disease and gastrointestinal spasm .

HY-B1806A

Tridihexethyl chloride Pathilon chloride	mAChR	Neurological Disease Inflammation/Immunology
Tridihexethyl (Pathilon) chloride is an orally active anticholinergic agent and *mAChR* antagonist, shows activities of antimuscarinic and anticholinergic. Tridihexethyl chloride shows pronounced antispasmodic and antisecretory effects on the gastrointestinal tract. Tridihexethyl chloride can be used in studies of peptic ulcer disease and acquired nystagmus .

HY-118356

WIN 62,577	Neurokinin Receptor mAChR	Neurological Disease
WIN 62,577 is a rat-specific, but non-human, NK1 receptor antagonist. WIN 62,577 interacts with M1-M4 mAChRs and is an allosteric enhancer of acetylcholine affinity targeting the M3 receptor.

HY-B0781

Promethazine hydrochloride 1 Publications Verification	Histamine Receptor mAChR Adrenergic Receptor	Neurological Disease Endocrinology
Promethazine hydrochloride is an orally active phenothiazine derivative with antihistaminic (H1), sedative, antiemetic, anticholinergic, and antimotion sickness properties. Promethazine hydrochloride is a potent H1 receptor antagonist and a mAChR antagonist. It also has a certain affinity for 5-HT2A and 5-HT2C receptors .

HY-B0549AR

Flavoxate hydrochloride (Standard)	Phosphodiesterase (PDE) Calcium Channel mAChR	Neurological Disease
Flavoxate (hydrochloride) (Standard) is the analytical standard of Flavoxate (hydrochloride). This product is intended for research and analytical applications. Flavoxate hydrochloride is a potent and competitive phosphodiesterase (PDE) inhibitor. Flavoxate hydrochloride is an antispasmodic agent and muscarinic mAChR antagonist. Flavoxate hydrochloride shows moderate calcium antagonistic activity and local anesthetic effect. Flavoxate hydrochloride can be used for the research of overactive bladder (OAB) and lower urinary tract infections .

HY-17037

Pirenzepine dihydrochloride 1 Publications Verification LS 519; Pirenzepin dihydrochloride; Gastrozepin dihydrochloride	mAChR	Metabolic Disease Cancer
Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

Cat. No.	Product Name	Type

HY-151801

DIBA-Cy5

Fluorescent Dyes/Probes

DIBA-Cy5 is a fluorescent DIBA antagonist made up be DIBA-alkyne binding Cyanine5 fluorophores (Cy5) and polyethylene glycol (PEG) biomolecules. DIBA-Cy5 can serve as a fluorescent ligand, suitable for probe attachment through click chemistry. DIBA-Cy5 exerts a high binding affinity to type-2 mAChR (M2R) with the K_d value of 1.80 nM, can directly stain M2R receptors in the sinoatrial node of a mouse heart .

Cat. No.	Product Name	Target	Research Area

HY-P0102

Dipeptide diaminobutyroyl benzylamide diacetate	mAChR	Neurological Disease
Dipeptide diaminobutyroyl benzylamide diacetate, a Wagerlin-1-mimicking peptide, is a *mAChR* antagonist. Dipeptide diaminobutyroyl benzylamide diacetate can induce muscle relaxation .

HY-P1376A

G-Protein antagonist peptide TFA	mAChR Adrenergic Receptor	Endocrinology
G-Protein antagonist peptide TFA is a truncated substance P-related peptide, competes with receptor for G protein binding. G-Protein antagonist peptide TFA inhibits the activation of G_i or G_o by M2 muscarinic cholinergic receptor (M2 mAChR) or of G_s by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis .

HY-P5846

Muscarinic toxin 3 MT3	mAChR Adrenergic Receptor	Neurological Disease
Muscarinic toxin 3 (MT3) is a potent and non-competitive *mAChR* and adrenoceptors antagonist with pIC₅₀s of 6.71, 8.79, 8.86, 7.57, 8.13, 8.49, <6.5, 7.29 against M₁, M₄, α_1A, α_1B, α_1D,α_2A,α_2B and α_2C receptors, respectively. Muscarinic toxin 3 displays prominent adrenoceptor activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0340

Scopolamine butylbromide 1 Publications Verification Hyoscine butylbromide; (-)-Scopolamine butylbromide; Butylscopolamine bromide	Alkaloids Structural Classification Other Alkaloids Source classification Datura metel L. Solanaceae Plants	mAChR
Scopolamine butylbromide is a competitive antagonist of muscarinic acetylcholine receptor (mAChR) with an IC50 of 55.3 ± 4.3 nM.

HY-B1205

Atropine 15+ Cited Publications Tropine tropate; DL-Hyoscyamine	Alkaloids Structural Classification Microorganisms Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants Endogenous metabolite	mAChR Endogenous Metabolite
Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .

HY-B1205R

Atropine (Standard) Tropine tropate (Standard); DL-Hyoscyamine (Standard)	Source classification Atropa belladonna Linn. Solanaceae Plants Endogenous metabolite	mAChR Endogenous Metabolite
Atropine (Standard) is the analytical standard of Atropine. This product is intended for research and analytical applications. Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M₄ and Chicken mAChR M₄, respectively. Atropine inhibits ACh-induced relaxations in human pulmonary veins. Atropine can be used for research of anti-myopia and bradycardia .

HY-B1205AR

Atropine sulfate (Standard)	Alkaloids Structural Classification Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants	mAChR
Atropine (sulfate) (Standard) is the analytical standard of Atropine (sulfate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate can be used for research of anti-myopia and bradycardia .

HY-B0394R

Atropine sulfate monohydrate (Standard)	Alkaloids Structural Classification Other Alkaloids Source classification Atropa belladonna Linn. Solanaceae Plants	mAChR
Atropine (sulfate monohydrate) (Standard) is the analytical standard of Atropine (sulfate monohydrate). This product is intended for research and analytical applications. Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC₅₀ values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia .

Cat. No.	Product Name	Chemical Structure

HY-B0394S

Atropine-d5
Atropine-d₅ is the deuterium labeled Atropine (sulfate monohydrate). Atropine (Tropine tropate) sulfate monohydrate is a broad-spectrum and competitive muscarinic acetylcholine receptor (mAChR) antagonist with anti-myopia effect[1].

HY-12100S

Umeclidinium-d5 bromide
Umeclidinium-d₅ (bromide) is the deuterium labeled Umeclidinium bromide. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-12100S1

Umeclidinium-d10 bromide
Umeclidinium-d₁₀ (bromide) is the deuterium labeled Umeclidinium bromide. Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM.

HY-17360S

Tiotropium-d3 bromide
Tiotropium-d₃ (bromide) is the deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-17360S1

Tiotropium-d6 bromide
Tiotropium-d₆ (bromide) is deuterium labeled Tiotropium (Bromide). Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.

HY-B1296S1

Promethazine-d4
Promethazine-d4 is a deuterated-labeled promethazine (HY-B0781). Promethazine is an orally active H1 receptor and mAChR antagonist with antihistamine (H1), sedative, antiemetic, anticholinergic, and anti-motion sickness properties .

HY-B0461S

Trospium-d8 chloride
Trospium-d₈ (chloride) is the deuterium labeled Trospium chloride. Trospium chloride is an orally active, specific and competitive antagonist of muscarinic cholinergic receptors (mAChRs), with antimuscarinic activity. Trospium chloride binds to muscarinic receptors M1, M2 and M3 with high affinity, but not nicotinic, cholinergic receptors[1][2].

HY-159578S

VU6036864
VU6036864 (compound 45) is an orally active, selective mAChR M5 antagonist with IC₅₀=20 nM for human M5. VU6036864 is >500-fold selective for human M1-4, with BBB characteristic and high oral bioavailability (%F>100%) .

HY-A0030S

Fesoterodine-d7 fumarate
Fesoterodine-d₇ (fumarate) is the deuterium labeled Fesoterodine fumarate[1]. Fesoterodine Fumarate is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine Fumarate is used for the overactive bladder (OAB)[2][3].

HY-17037S1

Pirenzepine-d8 dihydrochloride

Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-76569S1

(R)-Hydroxytolterodine-d14

(R)-Hydroxytolterodine-d₁₄ is deuterated labeled Desfesoterodine (HY-76569). Desfesoterodine (PNU-200577) is a potent and selective muscarinic receptor (mAChR) antagonist with a K_B and a pA₂ of 0.84 nM and 9.14, respectively . Desfesoterodine is a major pharmacologically active metabolite of Tolterodine (PNU-200583; HY-A0024) and Fesoterodine (HY-70053) . Desfesoterodine improves cerebral infarction induced detrusor overactivity in rats .

HY-76570S

(Rac)-5-Hydroxymethyl Tolterodine-d14

(Rac)-5-Hydroxymethyl Tolterodine-d₁₄ is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].

HY-76570S1

5-Hydroxymethyl Tolterodine-d14 formate

5-Hydroxymethyl Tolterodine-d₁₄ (formate) is deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].

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