Search Result

Results for "

mouse macrophage

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) ADC Cytotoxin (1) Adrenergic Receptor (1) Akt (1) Apoptosis (3) Atg8/LC3 (2) Autophagy (3) Bacterial (3) Calmodulin (1) COX (1) Cyclic GMP-AMP Synthase (1) DAGL (1) Dengue virus (1) Endogenous Metabolite (1) ERK (1) FABP (1) Farnesyl Transferase (1) Ferroptosis (1) Flavivirus (1) HDAC (2) HIV Protease (1) IKK (3) Interleukin Related (4) IRAK (1) JNK (2) Leukotriene Receptor (1) MAGL (1) MMP (1) NF-κB (9) NO Synthase (5) NOD-like Receptor (NLR) (5) p38 MAPK (4) p62 (2) Parasite (1) PGE synthase (1) Phosphatase (1) Phospholipase (1) Prostaglandin Receptor (1) PROTAC Linkers (4) Pyroptosis (1) Ser/Thr Protease (1) TNF Receptor (7) Toll-like Receptor (TLR) (14) TRP Channel (1) VD/VDR (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (4) Endocrinology (2) Infection (9) Inflammation/Immunology (44) Metabolic Disease (6) Neurological Disease (2)

By Targets:

5-HT Receptor (1)

ADC Cytotoxin (1)

Adrenergic Receptor (1)

Akt (1)

Apoptosis (3)

Atg8/LC3 (2)

Autophagy (3)

Bacterial (3)

Calmodulin (1)

COX (1)

Cyclic GMP-AMP Synthase (1)

DAGL (1)

Dengue virus (1)

Endogenous Metabolite (1)

ERK (1)

FABP (1)

Farnesyl Transferase (1)

Ferroptosis (1)

Flavivirus (1)

HDAC (2)

HIV Protease (1)

IKK (3)

Interleukin Related (4)

IRAK (1)

JNK (2)

Leukotriene Receptor (1)

MAGL (1)

MMP (1)

NF-κB (9)

NO Synthase (5)

NOD-like Receptor (NLR) (5)

p38 MAPK (4)

p62 (2)

Parasite (1)

PGE synthase (1)

Phosphatase (1)

Phospholipase (1)

Prostaglandin Receptor (1)

PROTAC Linkers (4)

Pyroptosis (1)

Ser/Thr Protease (1)

TNF Receptor (7)

Toll-like Receptor (TLR) (14)

TRP Channel (1)

VD/VDR (1)

By Research Areas:

Cancer (7)

Cardiovascular Disease (4)

Endocrinology (2)

Infection (9)

Inflammation/Immunology (44)

Metabolic Disease (6)

Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: Macrophage migration inhibitory factor (MIF)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3595

Cleomiscosin A	TNF Receptor	Inflammation/Immunology
Cleomiscosin A is a coumarino-lignoid from branch of Macaranga adenantha. Cleomiscosin A is active against TNF-alpha secretion of the mouse peritoneal macrophages .

HY-156175

TLR7 agonist 14	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 14 (compound 17b) is a highly potent TLR7 agonist with an EC₅₀ of 18 nM. TLR7 agonist 14 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations .

HY-156176

TLR7 agonist 15	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 15 (compound 16b) is a highly potent TLR7 agonist with an EC₅₀ of 18 nM. TLR7 agonist 15 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations .

HY-156177

TLR7 agonist 16	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR7 agonist 16 (compound 16d) is a highly potent TLR7 agonist with an EC₅₀ of 18 nM. TLR7 agonist 16 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations .

HY-159669

Stercobilin hydrochloride (mixture of isomers)	HIV Protease	Infection Inflammation/Immunology
Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a K_i of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections .

HY-155820

Anti-inflammatory agent 54	NF-κB NO Synthase TNF Receptor Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 54 (compound 9c) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC₅₀: 2.4 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .

HY-155821

Anti-inflammatory agent 55	NF-κB NO Synthase TNF Receptor Interleukin Related	Inflammation/Immunology
Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC₅₀: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model .

HY-N11494

Dauricumine	NF-κB	Others
Dauricumine is a chlorinated alkaloid that inhibits NF-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts .

HY-N4022

Hyuganin D Isobocconin; Seravschanin	Others	Inflammation/Immunology
Hyuganin D (Isobocconin) is a Coumarin (HY-N0709) constituent that substantially inhibits LPS (HY-D1056)-induced NO production in mouse peritoneal macrophages .

HY-P3600

FIZZ-1 (32-51) (mouse)	Apoptosis	Inflammation/Immunology
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .

HY-N2556

Tirucallol	Others	Inflammation/Immunology
Tirucallol, a tetracyclic triterpene, is isolated from Euphorbia lacteal latex. Tirucallol has topical anti-inflammatory effect. Tirucallol can suppress ear edema in the mouse model and inhibit nitrite production in lipopolysaccharide-stimulated macrophages .

HY-N7699A

D-Trimannuronic acid	TNF Receptor	Neurological Disease Inflammation/Immunology
D-Trimannuronic acid, an alginate oligomer is extracted from seaweed. D-Trimannuronic acid can induce TNF‐α secretion by mouse macrophage cell lines. D-Trimannuronic acid can be used for the research of pain and vascular dementia .

HY-156174

E104	Toll-like Receptor (TLR) ADC Cytotoxin	Cancer
E104 (compound 1) is a potent and selective TLR7 agonist. E104 can be delivered by antibody-drug conjugate (ADC) technology to elicit potent anticancer activity. E104 induces the activation of mouse macrophages and hPBMCs .

HY-120299

KC01	Others	Inflammation/Immunology
KC01 is an effective inhibitor of ABHD16A, with IC₅₀s of 90 nM for hABHD16A and 520 nM for mABHD16A. KC01 significantly reduces lyso-PSs, and decreases lyso-PS and LPS-induced cytokine production in mouse macrophages .

HY-N0223

Epibetulinic acid	NO Synthase Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC₅₀s of 0.7 and 0.6 μM, respectively. Anti-inflammatory activity .

HY-124911

LY53857 free base	5-HT Receptor	Infection
LY53857 free base is a selective 5-HT2 receptor antagonist with the ED₅₀ of 17.5 nM. LY53857 free base shows antiviral activity against influenza A virus .

HY-N2149A

Tomatidine hydrochloride 5 Publications Verification	NF-κB JNK Autophagy Endogenous Metabolite	Cardiovascular Disease Inflammation/Immunology
Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling . Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans .

HY-158093

NIC-12	NOD-like Receptor (NLR)	Inflammation/Immunology
NIC-12 is a potent NLRP3 inhibitor. NIC-12 selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice model. NIC-12 inhibits NLRP3 inflammasome activation in mouse macrophages .

HY-118131

PKR-IN-C51	Ser/Thr Protease	Infection
PKR-IN-C51(compound 51) is an ATP-competitive double-stranded RNA-activated protein kinase (PKR) inhibitor with an IC₅₀ of 9 μM. PKR-IN-C51 inhibits intracellular PKR activation in a dose-dependent manner in primary mouse macrophages .

HY-161954

HDAC8-IN-12	HDAC	Cancer
HDAC8-IN-12 (compound 5k) is a non-hydroxamic acid, selective inhibitor of HDAC8 (IC₅₀: 0.12 nM) and a potent inhibitor of breast cancer. HDAC8-IN-12 triggers anti-tumor immunity by activating T cells, increasing the proportion of M1 macrophages and decreasing the proportion of M2 macrophages. HDAC8-IN-12 (50 mg/kg) exerts tumor suppressive effects in an orthotopic mouse model of breast cancer .

HY-145846

iNOs-IN-1 1 Publications Verification	NO Synthase Interleukin Related	Inflammation/Immunology
iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects .

HY-121365

Forphenicinol	Others	Infection
Forphenicinol is an immunomodulator and a derivative of the bacterial metabolite forphenicine. It increases the phagocytosis of yeast by peritoneal macrophages isolated from thioglycolate-stimulated mice. Forphenicinol (100 μg/animal) prevents cyclophosphamide-induced suppression of delayed-type hypersensitivity (DTH), as well as enhances DTH in response to the hapten oxazolone or sheep red blood cells in mice. It enhances the bactericidal activity of macrophages against P. aeruginosa in mice when administered at a dose of 0.5 mg/kg.2 Forphenicinol (15.6-1,000 μg/animal) increases survival in a mouse model of P. aeruginosa infection. It also inhibits tumor growth in S180 sarcoma and IMC carcinoma mouse xenograft models when administered at doses ranging from 0.05 to 5 mg/kg per day.

HY-113628

ABT-080 VML-530	Leukotriene Receptor	Inflammation/Immunology
ABT-080 is an orally active inhibitor of leukotriene biosynthesis. ABT-080 simultaneously blocks the leukotriene pathways leading to the synthesis of LTB₄ and LTC₄, but does not inhibit PGH2 biosynthesis. ABT-080 can block bronchoconstriction and be used in the research of asthma and related inflammations

HY-155864

AJ2-30	Others	Inflammation/Immunology
AJ2-30 is a SLCl5A4 inhibitor. AJ2-30 inhibits TLR9-mediated B cell activation. AJ2-30 block endogenous NOD signaling in human and mouse macrophages. AJ2-30 can be used for research of inflammation .

HY-164304

INF 195	Pyroptosis Interleukin Related NOD-like Receptor (NLR)	Cardiovascular Disease Inflammation/Immunology
INF 195 is an NLRP3 inhibitor. INF 195 can inhibit NLRP3 driven macrophage pyroptosis and IL-1β release, with an EC₅₀ value of 0.15 μM. INF 195 can reduce the infarct size of isolated mouse hearts at low doses, effectively preventing myocardial ischemia/reperfusion injury .

HY-135517

RXP470.1 RXP-470	MMP	Cardiovascular Disease
RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a K_i of 0.2 nM against human MMP-12. RXP470.1 is 2 to 4 orders of magnitude less potent against other MMPs. RXP470.1 significantly reduces atherosclerotic plaque cross-sectional area in mouse. RXP470.1 results in less complex plaques with increased smooth muscle cell:macrophage ratio, less macrophage apoptosis, increased cap thickness, smaller necrotic cores, and decreased incidence of calcification .

HY-N2939

Bis-5,5-Nortrachelogenin	Others	Others
Bis-5,5-Nortrachelogenin is isolated from active extract of root of Wikstroemia indica. Bis-5,5-Nortrachelogenin inhibits nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-γ(IFN-γ) activated murine macrophage-like cell line, RAW 264.7 with an IC₅₀ value of 48.6 mM .

HY-149121

NLRP3-IN-14	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-14 is a potent and selective NLRP3 inflammasome inhibitor (K_D: 5.87 μM). NLRP3-IN-14 inhibits IL-1β release with an IC₅₀ of 0.131 μM. NLRP3-IN-14 can be used for the research of inflammation .

HY-149122

NLRP3-IN-15	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-15 is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-15 inhibits IL-1β release with an IC₅₀ of 0.114 μM. NLRP3-IN-15 can be used for the research of inflammation .

HY-149123

NLRP3-IN-16	NOD-like Receptor (NLR)	Inflammation/Immunology
NLRP3-IN-16 is a potent and selective NLRP3 inflammasome inhibitor. NLRP3-IN-16 inhibits IL-1β release with an IC₅₀ of 0.065 μM. NLRP3-IN-16 can be used for the research of inflammation .

HY-118282

mPGES1-IN-7	PGE synthase	Endocrinology
mPGES-1-IN-2 (compound III) is a benzimidazole-based mPGES-1 inhibitor that also inhibits adipophysin PGD synthase (I-PGDS) (5 μM, IR=60 %). mPGES-1-IN-2 reduces PGE2 production and tends to reduce levels of other prostaglandins. mPGES-1-IN-2 effectively inhibits acute inflammation in an air sac model stimulated by Carrageenan (HY-125474) in mice .

HY-114180

RU.521 Maximum Cited Publications 32 Publications Verification RU320521	Cyclic GMP-AMP Synthase	Metabolic Disease
RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC₅₀ of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS) .

HY-W092043

TLR4-IN-C34-C2-COOH 1 Publications Verification	PROTAC Linkers Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4-IN-C34-C2-COO is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis .

HY-146723

IKKβ-IN-1	IKK	Inflammation/Immunology
IKKβ-IN-1 is a potent and orally active IkappaB (IKK-β) inhibitor with IC₅₀ of 0.20 μM. IKKβ-IN-1 can reduce PGE₂ and TNF-α production in mouse macrophage cells. IKKβ-IN-1 has the ability to protect mice against septic shock induced mortality .

HY-18540

KT109	DAGL MAGL	Metabolic Disease Inflammation/Immunology
KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC₅₀ of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC₅₀=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages .

HY-145245

TLR4-IN-C34-C2-amide-C6-OH	PROTAC Linkers Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4-IN-C34-C2-amide-C6-OH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis .

HY-P1181

Pam2CSK4	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 also activates iNOS expression and NO production in mouse macrophages .

HY-123245

Scalaradial	TRP Channel Phospholipase ERK Akt	Inflammation/Immunology Cancer
Scalaradial is an inhibitor for bee venom phospholipase A2 (PLA2) and transient receptor potential melastatin 2 (TRPM2) ion channels, with IC₅₀ of 0.07 and 0.21 μM. Scalaradial regulates the phosphorylation of ERK, by inhibiting secretory PLA2 and Akt. Scalaradial inhibits the PMA (HY-18739)-induced release of Arachidonic acid (HY-109590) in the mouse peritoneal macrophage .

HY-162004

NF-κB-IN-14	NF-κB Toll-like Receptor (TLR)	Inflammation/Immunology
NF-κB-IN-14 (compound 5e) significantly inhibits nitric oxide production in LPS-induced macrophages (IC₅₀: 6.4 μM). NF-κB-IN-14 disrupts the TLR4-MyD88 protein interaction, leading to the suppression of the NF-κB signaling pathway suppression. NF-κB-IN-14 reduces ear edema and inflammation in an atopic dermatitis mouse model .

HY-P1181A

Pam2CSK4 TFA	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4 (TFA), a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 (TFA) promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages .

HY-145253

Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH	PROTAC Linkers Toll-like Receptor (TLR)	Inflammation/Immunology
Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis .

HY-145254

Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH	Toll-like Receptor (TLR)	Inflammation/Immunology
Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis .

HY-123942

Diprovocim 3 Publications Verification	Toll-like Receptor (TLR) TNF Receptor p38 MAPK NF-κB	Inflammation/Immunology Cancer
Diprovocim is a potent TLR1/TLR2 agonist. Diprovocim elicits full agonist activity in human THP-1 cells (EC₅₀=110 pM). Diprovocim stimulates the release of TNF-α from mouse macrophages (EC₅₀=1.3 nM). Diprovocim activates downstream MAPK and NF-κB signaling pathway. Diprovocim displays strong adjuvant activity in mice, particularly abetting cellular immune responses .

HY-W341547

3,4-Dihydro-6,7-isoquinolinediol	Adrenergic Receptor	Inflammation/Immunology
3,4-Dihydro-6,7-isoquinolinediol (compound 7) is a β2-AR agonist with an EC50 of 106.9 μM in CH-K1/GA1S cells. 3,4-Dihydro-6,7-isoquinolinediol can also inhibit the production of NO in mouse macrophage RAW 264.7 cells induced by lipopolysaccharide, showing anti-inflammatory activity .

HY-162649

TIC10g	Toll-like Receptor (TLR) NF-κB p38 MAPK	Inflammation/Immunology
TIC10g is a dual inhibitor for toll-like receptor 7 and 9 (TLR7 and TLR9), which inhibits TLR7 and TLR9 mediated TNF-α release in mouse macrophages (IC₅₀ is 14.5 μM and 6.5 μM) and human B lymphocytes (IC₅₀ is 7.69 μM and 11.5 μM). TIC10g inhibits the activation of NF-κB and MAPK, and exhibits anti-inflammatory activity against systemic lupus erythematosus and rheumatoid arthritis .

HY-I0501

2'-Aminoacetophenone o-aminoacetophenone	Bacterial Apoptosis Atg8/LC3 p62 Autophagy	Infection Inflammation/Immunology
2'-Aminoacetophenone is an orally active inducer of apoptosis and respiratory biomarker. 2'-Aminoacetophenone can be used to detect Pseudomonas aeruginosa infections in the lungs of cystic fibrosis patients. 2'-Aminoacetophenone can inhibit the protein levels of LC3BII and p62 in macrophages infected with pqsA or mvfR and regulate autophagy. 2'-Aminoacetophenone can disrupt mitochondrial function by inducing oxidative stress and apoptosis signaling, leading to dysfunction in mouse skeletal muscle .

HY-145255

Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH	PROTAC Linkers Toll-like Receptor (TLR)	Inflammation/Immunology
Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH is a linker that incorporates TLR4 inhibitor TLR4-IN-C34. TLR4-IN-C34 inhibits TLR4 in enterocytes and macrophages, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis .

HY-N3364

Lucidone	Flavivirus Dengue virus TNF Receptor NF-κB NO Synthase COX JNK p38 MAPK IKK	Infection Inflammation/Immunology
Lucidone, an anti-inflammatory agent that can be isolated from the fruit of Lindera erythrocarpa Makino. Lucidone inhibits LPS-induced NO and PGE₂ production in RAW 264.7 mouse macrophages. Lucidone also decreases TNF-α secretion, iNOS and COX-2 expression. Lucidone prevents NF-κB translocation and inhibits JNK and p38MAPK signals. Lucidone also has inhibitory activity against Dengue virus (DENV) (EC₅₀=25 μM) .

HY-100911

W-5 hydrochloride	Calmodulin	Neurological Disease
W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC₅₀ value of 240 µM. W-5 hydrochloride can be used as a negative control for W-7 (HY-100912) .

HY-B2097

Incadronate disodium YM 175; Bisphonal	Farnesyl Transferase	Metabolic Disease
Incadronate disodium (YM 175) is a bisphosphonate with strong inhibitory activity on bone resorption. Incadronate disodium indirectly stimulates renal 25-hydroxyvitamin D-1-hydroxylase by increasing circulating parathyroid hormone. Incadronate disodium, a cholesterol-lowering agent, is a potent inhibitor of rat liver microsomal squalene synthase (K_i=57 nM). Incadronate disodium inhibits sterol biosynthesis in mouse macrophage J774 cells (IC₅₀=64 μM). Incadronate disodium has the potential for malignant tumors research .

Cat. No.	Product Name	Type

HY-159669

Stercobilin hydrochloride (mixture of isomers)

Cell Assay Reagents

Stercobilin hydrochloride (amixture of isomers) is a bile pigment metabolized by gut bacteria, and it's also an HIV protease inhibitor, with a K_i of 4 μM. Stercobilin hydrochloride (a mixture of isomers) can induce pro-inflammatory activity in mouse macrophage RAW264 cells, including the production of TNF-α and IL-1β. Stercobilin hydrochloride (a mixture of isomers) can be used in studies of inflammation and viral infections .

Cat. No.	Product Name	Target	Research Area

HY-P1181A

Pam2CSK4 TFA	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4 (TFA), a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 (TFA) promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages .

HY-P2792

Beauveriolide III	Peptides	Metabolic Disease
Beauveriolide III is an inhibitor of lipid droplet formation in mouse macrophages .

HY-P3600

FIZZ-1 (32-51) (mouse)	Apoptosis	Inflammation/Immunology
FIZZ-1 (32-51) (mouse) is a cysteine-rich secretory protein that is highly expressed by macrophages, bronchial epithelial and type II alveolar epithelial cells (AEC) in allergic airway inflammation. FIZZ1 (32-51) (mouse) also shows an antiapoptotic effect on lung fibroblasts. FIZZ-1 (32-51) (mouse) can be used in the study of allergic pneumonia .

HY-P1181

Pam2CSK4	Toll-like Receptor (TLR)	Inflammation/Immunology
Pam2CSK4, a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 also activates iNOS expression and NO production in mouse macrophages .

Species:	Mouse (22)
Tag:	His (16) Tag Free (4) Fc (2) Flag (1)
Source:	HEK293 (14) P. pastoris (1) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P70855

	MARCO Protein, Mouse (HEK293, His) macrophage receptor MARCO; Marco; macrophage receptor with collage	Mouse	HEK293
	MARCO Protein, a pattern recognition receptor (PRR), binds Gram-positive and Gram-negative bacteria, exhibiting a crucial role in unopsonized particle binding by alveolar macrophages.Furthermore, it interacts with the secretoglobin SCGB3A2.MARCO Protein forms disulfide-linked homotrimer structures that assemble into larger oligomers, providing an extensive surface area for interactions with substantial ligands.MARCO Protein, Mouse (HEK293, His) is the recombinant mouse-derived MARCO protein, expressed by HEK293 , with N-8*His labeled tag.

HY-P701103

	MSP/MST1 Protein, Mouse (C677A, HEK293) Hepatocyte growth factor-like protein; MST1; macrophage stimulatory protein; macrophage-stimulating protein; MSP; D3F15S2; DNF15S2; HGFL; macrophage Stimulating Protein/macrophage Stimulating 1 [Hepatocyte Growth Factor-like] ; macrophage Stimulating Prot	Mouse	HEK293
	The MSP/MST1 protein, encoded by this gene, is predicted to have receptor tyrosine kinase binding activity. It is involved in various processes, including embryo implantation, mammary duct growth, and regulation of mammary gland cell proliferation. The protein is mainly found in the vacuole and expressed in tissues like the esophagus, liver, pharynx, and stomach. Notably, the gene shows liver-biased expression in both adult and embryonic stages. MSP/MST1 Protein, Mouse (C677A, HEK293) is the recombinant mouse-derived MSP/MST1 protein, expressed by HEK293 , with tag free. and C677A, , , , mutation.

HY-P73082

	GM-CSF Protein, Mouse (HEK293, Fc) Granulocyte-macrophage colony-stimulating factor; GM-CSF; CSF; CSF-2	Mouse	HEK293
	The GM-CSF protein acts as a potent cytokine that coordinates the growth and differentiation of hematopoietic precursor cells of different lineages, including granulocytes, macrophages, eosinophils, and erythrocytes. Structurally, GM-CSF exists as a monomer and its signaling is mediated through a dodecamer complex. GM-CSF Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived GM-CSF protein, expressed by HEK293 , with N-hFc labeled tag. The total length of GM-CSF Protein, Mouse (HEK293, Fc) is 124 a.a., with molecular weight of 45-60 kDa.

HY-P76782

	CD204/MSR1 Protein, Mouse (HEK293, His) macrophage scavenger receptor types I and II; SCARA1	Mouse	HEK293
	CD204/MSR1 Protein, a membrane glycoprotein, crucially contributes to cholesterol accumulation in arterial walls during atherogenesis. With two receptor subunits, it facilitates endocytosis of various macromolecules, including modified low-density lipoproteins (LDL). As a homotrimer, CD204/MSR1 engages in key interactions, including its association with MYO18A, highlighting its functional role in cellular processes. CD204/MSR1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD204/MSR1 protein, expressed by HEK293 , with N-His labeled tag.

HY-P70553

	M-CSF Protein, Mouse (HEK293) 1 Publications Verification macrophage colony-stimulating factor 1; CSF-1; MCSF; Csf1; Csfm	Mouse	HEK293
	M-CSF Protein, Mouse (HEK293) is a pro-inflammatory cytokine which binds to its receptor CSF1R, and is involved in the development and proliferation of cells of the monocyte/macrophage lineage and participates in the induction of osteoclasts.

HY-P70874

	MGL2/CD301b Protein, Mouse (HEK293, His) Mgl2; CD301b; macrophage galactose N-acetyl-galactosamine-specific lectin 2; macrophage Galactose-type C-lectin 2	Mouse	HEK293
	MGL2/CD301b is a type II lectin commonly used as a marker for alternatively activated macrophages. MGL2 can bind to terminal GalNAc residues, including the Tn antigen (GalNAc-αThr/Ser). MGL2 is mainly expressed on immature, tolerogenic or type-2 DCs and alternatively-activated macrophages. MGL2/CD301b Protein, Mouse (HEK293, His) is the recombinant mouse-derived MGL2/CD301b protein, expressed by HEK293, with N-6*His labeled tag. The total length of MGL2/CD301b Protein, Mouse (HEK293, His) is 261 a.a., with molecular weight of 30-40 kDa.

HY-P7768AF

	Animal-Free MIP-1 alpha/CCL3 Protein, Mouse (His) MIP-1a: macrophage Inflammatory Protein-1α; LD78α	Mouse	E. coli
	MIP-1 alpha/CCL3 protein, a monokine, displays inflammatory, pyrogenic, and chemokinetic properties.It induces potent chemotaxis in eosinophils and activates calcium release in neutrophils via high-affinity receptor binding.Animal-Free MIP-1 alpha/CCL3 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMIP-1 alpha/CCL3 protein, expressed by E.coli , with N-His, N-His labeled tag.

HY-P70623

	GM-CSF Protein, Mouse (HEK293, His) Granulocyte-macrophage Colony-Stimulating Factor; GM-CSF; Colony-Stimulating Factor; CSF; Molgramostin; Sargramostim; CSF2; GMCSF	Mouse	HEK293
	The GM-CSF protein acts as a potent cytokine that coordinates the growth and differentiation of hematopoietic precursor cells of different lineages, including granulocytes, macrophages, eosinophils, and erythrocytes. Structurally, GM-CSF exists as a monomer and its signaling is mediated through a dodecamer complex. GM-CSF Protein, Mouse (HEK293, His) is the recombinant mouse-derived GM-CSF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GM-CSF Protein, Mouse (HEK293, His) is 124 a.a., with molecular weight of 18-30 kDa.

HY-P700180AF

	Animal-Free GM-CSF Protein, Mouse (His) Granulocyte-macrophage Colony-Stimulating Factor; GM-CSF; Colony-Stimulating Factor; CSF; Molgramostin; Sargramostim; CSF2; GMCSF	Mouse	E. coli
	GM-CSF Protein, a renowned cytokine, promotes the growth and differentiation of hematopoietic precursor cells, including granulocytes, macrophages, eosinophils, and erythrocytes. Operating as a monomer, it interacts with the GM-CSF receptor complex. This complex, comprising two head-to-head hexamers with two alpha, two beta, and two ligand subunits, forms a dodecamer structure. Animal-Free GM-CSF Protein, Mouse (His) is the recombinant mouse-derived animal-FreeGM-CSF protein, expressed by E. coli , with N-His labeled tag. The total length of Animal-Free GM-CSF Protein, Mouse (His) is 124 a.a., with molecular weight of ~15.1 kDa.

HY-P71319

	SLAMF8 Protein, Mouse (HEK293, His) SLAM family member 8; B-lymphocyte activator macrophage expressed; CD353; Slamf8; Blame	Mouse	HEK293
	SLAMF8 protein may contribute to B-lineage commitment and modulation of B-cell receptor signaling, playing a crucial role in B-cell development and immune responses. Exploring its molecular mechanisms and downstream effects could provide insights into its significance in B-cell biology. SLAMF8 Protein, Mouse (HEK293, His) is the recombinant mouse-derived SLAMF8 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SLAMF8 Protein, Mouse (HEK293, His) is 211 a.a., with molecular weight of 32-38 kDa.

HY-P70342

	MMP-12 Protein, Mouse (HEK293, His) rMumacrophage metalloelastase/MMP12, His; macrophage metalloelastase; MME; Matrix metalloproteinase-12; MMP-12; Mmp12; Mme; Mmel	Mouse	HEK293
	MMP-12 protein has significant elastolytic activity and may contribute to tissue damage and remodeling.Its substrate preferences include preference for leucine at the P1' site and aromatic/hydrophobic residues at the P1 site, and preference for small hydrophobic residues such as alanine at the P3 site.MMP-12 Protein, Mouse (HEK293, His) is the recombinant mouse-derived MMP-12 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72951

	CSF1R Protein, Mouse (HEK293, Fc) macrophage colony-stimulating factor 1 receptor; CSF-1R; M-CSF-R; CD115; CSF1R; FMS	Mouse	HEK293
	The CSF1R protein is a tyrosine protein kinase receptor for CSF1 and IL34 and plays a critical regulatory role in hematopoietic cells, especially mononuclear phagocytes. Its effects span innate immunity, inflammation, osteoclast function, skeletal development, and fertility. CSF1R Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CSF1R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CSF1R Protein, Mouse (HEK293, Fc) is 492 a.a., with molecular weight of ~81.9 kDa.

HY-P72952

	CSF1R Protein, Mouse (HEK293, His) macrophage colony-stimulating factor 1 receptor; CSF-1R; M-CSF-R; CD115; CSF1R; FMS	Mouse	HEK293
	The CSF1R protein is a tyrosine protein kinase receptor for CSF1 and IL34 and plays a critical regulatory role in hematopoietic cells, especially mononuclear phagocytes. Its effects span innate immunity, inflammation, osteoclast function, skeletal development, and fertility. CSF1R Protein, Mouse (HEK293, His) is the recombinant mouse-derived CSF1R protein, expressed by HEK293 , with C-His labeled tag.

HY-P72953

	CSF1R Protein, Mouse (Biotinylated, HEK293, His) macrophage colony-stimulating factor 1 receptor; CSF-1R; M-CSF-R; CD115; CSF1R; FMS	Mouse	HEK293
	The CSF1R protein is a tyrosine protein kinase receptor for CSF1 and IL34 and plays a critical regulatory role in hematopoietic cells, especially mononuclear phagocytes. Its effects span innate immunity, inflammation, osteoclast function, skeletal development, and fertility. CSF1R Protein, Mouse (Biotinylated, HEK293, His) is the recombinant mouse-derived CSF1R protein, expressed by HEK293 , with C-His labeled tag. The total length of CSF1R Protein, Mouse (Biotinylated, HEK293, His) is 492 a.a., with molecular weight of ~56.8 kDa.

HY-P70263A

	M-CSF Protein, Mouse (HEK293, C-His) rMumacrophage colony-stimulating factor 1/M-CSF, His; macrophage colony-stimulating factor 1; CSF-1; MCSF; Csf1; Csfm	Mouse	HEK293
	The M-CSF protein is a key orchestrator in regulating the survival, proliferation, and differentiation of hematopoietic precursor cells, particularly mononuclear phagocytes, including macrophages and monocytes. It actively promotes the release of pro-inflammatory chemokines, thereby playing a key role in innate immunity and inflammatory processes. M-CSF Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived M-CSF protein, expressed by HEK293 , with C-His labeled tag. The total length of M-CSF Protein, Mouse (HEK293, C-His) is 230 a.a., with molecular weight (glycosylation form) of ~38-55 kDa.

HY-P700517

	MIF Protein, Mouse (P. pastoris, His) MIF; macrophage migration inhibitory factor; GIF; GLIF; MMIF; phenylpyruvate tautomerase; glycosylation-inhibiting factor; EC 5.3.2.1; Glycosylation-inhibiting factor; Phenylpyruvate tautomerase	Mouse	P. pastoris
	The MIF protein is a pro-inflammatory cytokine that plays a crucial role in the innate immune response against bacterial pathogens.Its presence at sites of inflammation suggests its role as a mediator in the regulation of macrophage function during host defense.MIF Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived MIF protein, expressed by P.pastoris , with N-6*His labeled tag.

HY-P7772

	CCL9/10/MIP-1 gamma Protein, Mouse rMuCCL9; C-C motif chemokine 9; macrophage inflammatory protein 1-gamma; Small-inducible cytokine A9; Scya9; CCL9.	Mouse	E. coli
	CCL9 Protein, Mouse, is often produced in macrophages, osteoclasts, and functions as a cell survival factor.

HY-P700293

	GDF-15 Protein, Mouse (HEK293, His-Flag) Growth Differentiation Factor 15; macrophage inhibitory cytokine 1; GDF-15; MIC-1; NAG-1; PLAB; PTGFB; Gdf15; Sbf	Mouse	HEK293
	The GDF-15 protein regulates food intake, energy balance, and body weight by binding to its receptor GFRAL.This activates GFRAL-expressing neurons in the brainstem, triggering "emergency circuits" in the central parabrachial nucleus and amygdala during stress.GDF-15 Protein, Mouse (HEK293, His-Flag) is the recombinant mouse-derived GDF-15 protein, expressed by HEK293 , with N-8*His, N-Flag labeled tag.

HY-P70341

	MIF Protein, Mouse (His) rMumacrophage migration inhibitory factor/MIF, His; macrophage migration inhibitory factor; Delayed early response protein 6; DER6; Glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase; Phenylpyruvate tautomerase;	Mouse	E. coli
	The MIF protein is a pro-inflammatory cytokine that plays a crucial role in the innate immune response against bacterial pathogens.Its presence at sites of inflammation suggests its role as a mediator in the regulation of macrophage function during host defense.MIF Protein, Mouse (His) is the recombinant mouse-derived MIF protein, expressed by E.coli , with C-6*His labeled tag.

HY-P70341AF

	Animal-Free MIF Protein, Mouse (His) rMumacrophage migration inhibitory factor/MIF, His; macrophage migration inhibitory factor; Delayed early response protein 6; DER6; Glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase; Phenylpyruvate tautomerase;	Mouse	E. coli
	The MIF protein is a pro-inflammatory cytokine that plays a crucial role in the innate immune response against bacterial pathogens.Its presence at sites of inflammation suggests its role as a mediator in the regulation of macrophage function during host defense.Animal-Free MIF Protein, Mouse (His) is the recombinant mouse-derived animal-FreeMIF protein, expressed by E.coli , with C-His labeled tag.

HY-P71889

	CCL4 Protein, Mouse Ccl4; Mip1b; Scya4; C-C motif chemokine 4; Immune activation protein 2; ACT-2; ACT2; macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4	Mouse	E. coli
	CCL4 protein, with inflammatory and chemokinetic properties, acts as a monokine and self-associates to form homodimers.CCL4 Protein, Mouse is the recombinant mouse-derived CCL4 protein, expressed by E.coli , with tag free.

HY-P700165AF

	Animal-Free CCL4 Protein, Mouse (His) Ccl4; Mip1b; Scya4; C-C motif chemokine 4; Immune activation protein 2; ACT-2; ACT2; macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4	Mouse	E. coli
	CCL4 protein, with inflammatory and chemokinetic properties, acts as a monokine and self-associates to form homodimers.Animal-Free CCL4 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeCCL4 protein, expressed by E.coli , with N-His labeled tag.

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HY-P81235

	IL-4 Antibody Interleukin-4; IL4; IL 4; B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory Factor 1; BCGF 1; BCGF1; Binetrakin; BSF 1; BSF1; HCGF; Hodgkin’s Cell Growth Factor; IA Inducing Factor; IGG1 induction factor; Il4e12; Interleukin 4; Interleukin 4, isoform 1; Interleukin4; Lymphocyte stimulatory factor 1; macrophage fusion factor; Mast cell growth factor 2; MCGF2; MFF; MGC79402; Pitrakinra; T cell growth factor 2; TCGF2; IL4_mouse; B-cell stimulatory factor 1; BSF-1.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	IL-4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 14 kDa, targeting to IL-4. It can be used for WB、ELISA、IHC-P、IHC-F、IF assays with tag free, in the background of Transfected.