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Results for "

oral administration

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) Adrenergic Receptor (1) Amino Acid Derivatives (1) Aminopeptidase (1) Amyloid-β (3) Androgen Receptor (2) Antibiotic (4) Apoptosis (4) Bacterial (5) Bcl-2 Family (2) Beta-lactamase (2) Biochemical Assay Reagents (4) Bradykinin Receptor (1) c-Myc (1) Caspase (1) Checkpoint Kinase (Chk) (1) Chloride Channel (2) Cholinesterase (ChE) (1) Cytochrome P450 (1) DNA-PK (1) Drug Derivative (1) Drug Metabolite (7) EGFR (1) Endogenous Metabolite (9) Endothelin Receptor (1) Factor Xa (1) Farnesyl Transferase (1) Fatty Acid Synthase (FASN) (1) GABA Receptor (1) GCGR (1) Glycosidase (1) HBV (1) HCV (1) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (2) HIV (2) HSV (1) Insulin Receptor (1) Interleukin Related (1) Isotope-Labeled Compounds (1) JAK (1) Keap1-Nrf2 (2) LPL Receptor (2) MAP4K (1) mGluR (2) Microtubule/Tubulin (1) Mucin (1) nAChR (1) Neprilysin (1) Neurokinin Receptor (1) Opioid Receptor (2) Parasite (2) PARP (1) PD-1/PD-L1 (1) PGE synthase (1) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (1) PPAR (3) Prostaglandin Receptor (4) Ras (1) Renin (2) Reverse Transcriptase (1) Ser/Thr Protease (1) SHP2 (1) TGF-beta/Smad (1) VEGFR (2) Virus Protease (1)
By Research Areas:	Cancer (20) Cardiovascular Disease (10) Endocrinology (4) Infection (11) Inflammation/Immunology (17) Metabolic Disease (13) Neurological Disease (18)

By Targets:

5-HT Receptor (2)

Adrenergic Receptor (1)

Amino Acid Derivatives (1)

Aminopeptidase (1)

Amyloid-β (3)

Androgen Receptor (2)

Antibiotic (4)

Apoptosis (4)

Bacterial (5)

Bcl-2 Family (2)

Beta-lactamase (2)

Biochemical Assay Reagents (4)

Bradykinin Receptor (1)

c-Myc (1)

Caspase (1)

Checkpoint Kinase (Chk) (1)

Chloride Channel (2)

Cholinesterase (ChE) (1)

Cytochrome P450 (1)

DNA-PK (1)

Drug Derivative (1)

Drug Metabolite (7)

EGFR (1)

Endogenous Metabolite (9)

Endothelin Receptor (1)

Factor Xa (1)

Farnesyl Transferase (1)

Fatty Acid Synthase (FASN) (1)

GABA Receptor (1)

GCGR (1)

Glycosidase (1)

HBV (1)

HCV (1)

HIF/HIF Prolyl-Hydroxylase (1)

Histamine Receptor (2)

HIV (2)

HSV (1)

Insulin Receptor (1)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

JAK (1)

Keap1-Nrf2 (2)

LPL Receptor (2)

MAP4K (1)

mGluR (2)

Microtubule/Tubulin (1)

Mucin (1)

nAChR (1)

Neprilysin (1)

Neurokinin Receptor (1)

Opioid Receptor (2)

Parasite (2)

PARP (1)

PD-1/PD-L1 (1)

PGE synthase (1)

Platelet-activating Factor Receptor (PAFR) (1)

Potassium Channel (1)

PPAR (3)

Prostaglandin Receptor (4)

Ras (1)

Renin (2)

Reverse Transcriptase (1)

Ser/Thr Protease (1)

SHP2 (1)

TGF-beta/Smad (1)

VEGFR (2)

Virus Protease (1)

By Research Areas:

Cancer (20)

Cardiovascular Disease (10)

Endocrinology (4)

Infection (11)

Inflammation/Immunology (17)

Metabolic Disease (13)

Neurological Disease (18)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108288

Sulbactam pivoxil CP 47904	Beta-lactamase Antibiotic Bacterial	Infection
Sulbactam pivoxil is a proagent of sulbactam. Sulbactam is a β-lactamase inhibitor which poorly adsorbed from gastrointestinal tract. Sulbactam pivoxil has a better absorption than the parent agent and provides high serum levels after oral administration .

HY-A0234

Stepronin Prostenoglycine; TTPG; Tiase	Chloride Channel	Endocrinology
Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl ^- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands .

HY-B0967

Phthalylsulfacetamide	Bacterial	Infection
Phthalylsulfacetamide is a sulfa drug, after oral administration, slowly decompose in the intestine,and release sulfacetamide ,generating antibacterial effect.

HY-N0864

Macranthoidin B Macranthoiside I	Others	Cancer
Macranthoidin B is a major bioactive saponin in rat plasma after oral administration of extraction of saponins from Flos Lonicerae.

HY-N10225

Thielavin A	Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Thielavin A is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin A specifically inhibits the conversion of arachidonic acid into prostaglandin H2. Thielavin A has no anti-inflammatory activity on intravenous injection or on oral administration .

HY-146012

HIV-1 protease-IN-4	HIV	Infection
HIV-1 protease-IN-4 (Compound II-22) is a potent HIV-1 protease inhibitor. HIV-1 protease-IN-4 is a proagent of atazanavir. HIV-1 protease-IN-4 as a proagent that delivers the parent 1 to rat plasma with a 5-fold higher AUC and 67-fold higher C24 when compared to oral administration of the parent agent .

HY-118683

KR-31378	Potassium Channel	Others
KR-31378 is a neuroprotectant with dose-dependent pharmacokinetic properties and relevant activity in rats. After intravenous and oral administration of KR-31378 in rats, its pharmacokinetic parameters showed dose-dependent changes, such as decreased clearance with increasing doses, good oral absorption, and comparable AUCs for intravenous and oral administration at different doses.

HY-126835

A924	Amino Acid Derivatives	Cancer
A 924 is an amino acid derivative-based, orally active antitumor agent. A 924 is effective in inhibiting ascites tumors in rat models by intraperitoneal injection or oral administration. The LD₅₀ of A 924 in mice is >1.5 g/kg and >4.5 g/kg by intraperitoneal injection or oral administration, respectively. A 924 does not cause teratogenicity or adverse reactions in normal or pregnant mice .

HY-A0234R

Stepronin (Standard)	Chloride Channel	Endocrinology
Stepronin (Standard) is the analytical standard of Stepronin. This product is intended for research and analytical applications. Stepronin (Prostenoglycine) is an orally active expectorant (inhalation administration is preferable to oral administration). Stepronin inhibits airway secretion in vitro by reducing Cl ^- secretion from epithelial cells and mucus glycoprotein secretion from submucosal glands .

HY-W031110

2-Methyl-tetrahydro-β-carboline 2-MTHBC	Drug Metabolite	Neurological Disease
2-Methyl-tetrahydro-β-carboline is a cyclization product of N,N-dimethyltryptamine after oral administration of ayahuasca .

HY-W740380

21-Carboxylic acid triamcinolone acetonide	Drug Metabolite	Others
21-Carboxylic acid triamcinolone acetonide is a metabolite produced in the body after oral administration of [14C]-triamcinolone acetonide .

HY-U00122

Antiulcer Agent 1	Drug Derivative	Inflammation/Immunology
Antiulcer Agent 1 is a 2-(3,4-dimethoxyphenyl)ethylamine derivative for oral administration at an exploratory stage of new agent development.

HY-20559

4-Chloro-3-nitrobenzoic acid	Biochemical Assay Reagents	Others
4-Chloro-3-nitrobenzoic acid has oral activity，and oral administration can affect the synthesis activity of liver proteins and the activities of urokinase and histidine kinase .

HY-122307

Sulisatin DAN-603	Bacterial	Metabolic Disease
Sulisatin (DAN-603) is an anionic laxative that is hydrolyzed to diphenolic derivatives by bacterial aryl sulfate sulfohydrolases in the colon during oral administration .

HY-120639

BMS-663749 lysine	HIV	Others
BMS-663749 lysine is a prodrug of an HIV-1 attachment inhibitor with the potential to enhance the delivery of the parent compound following oral administration.

HY-N4173

8-Oxoepiberberine	Drug Metabolite	Metabolic Disease
8-Oxoepiberberine is an alkaloid metabolite in the plasma after oral administration of Zuojin formula, a traditional chinese medicine used to treat gastrointestinal disease .

HY-N0856

Alisol C 23-acetate 23-O-Acetylalisol C; Alisol C monoacetate	Others	Cardiovascular Disease
Alisol C 23-acetate, a natural product extracted from Alisma orinentale, can significantly and strongly inhibit DTH response after oral administration.

HY-118543

TM6089	HIF/HIF Prolyl-Hydroxylase	Cardiovascular Disease
TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia. Local administration of TM6089 enhances angiogenesis, and oral administration stimulates HIF activity in transgenic rats expressing a hypoxia-responsive reporter vector .

HY-135245

Ezetimibe hydroxy glucuronide SCH 488128; Ezetimibe hydroxy β-D-Glucuronide	Drug Metabolite	Cardiovascular Disease
Ezetimibe hydroxy glucuronide (SCH 488128) is a trace metabolite detected in dog and human plasma samples after oral administration of Ezetimibe (HY-17376) .

HY-123367

Rubraxanthone	Platelet-activating Factor Receptor (PAFR)	Others
Rubraxanthone is a compound with multiple biological activities. Its pharmacokinetic parameters were determined in mice and it showed a certain concentration variation pattern in plasma after oral administration.

HY-105919

Naroparcil	Factor Xa	Cardiovascular Disease
Naroparcil is an orally active antithrombotic agent. Naroparcil exhibits antithrombotic effects in rabbit Wessler stasis model with EC₅₀s of 21.9 mg/kg and 36.0 mg/kg after respectively intravenous injection and oral administration .

HY-129579

Linadryl	Histamine Receptor	Others
Linadryl is a compound with antihistamine and other effects. It has a variable effect on gastric acid secretion after oral administration, and its effect is about half that of Diphenhydramine (HY-B0303).

HY-122307A

Sulisatin disodium DAN-603 disodium	Bacterial	Metabolic Disease
Sulisatin (DAN-603) disodium is an anionic diarrhea-promoting compound. During oral administration, Sulisatin disodium is hydrolyzed to diphenolic derivatives by bacterial aryl sulfate sulfohydrolases in the colon .

HY-169199

BAY-405	MAP4K	Cancer
BAY-405 (compund 38) is a MAP4K1 inhibitor that exhibits nanomolar potency in biochemical and cellular assays and achieves in vivo exposure after oral administration .

HY-135578

Artelinic acid	Parasite	Infection
Artelinic acid, a derivative of Artemisinin, is an antimalarial agent for the treatment of multidrug resistant strains of Plasmodium falciparum. Artelinic acid can be administered by various routes of administration, including intravenous, intramuscular and oral routes .

HY-24238

DLCI-1	Cytochrome P450	Others
DLCI-1 is a potent and selective oral inhibitor of cytochrome P450 2A6 (CYP2A6) that markedly reduces nicotine self-administration in both male and female mice.

HY-165529

Camostat	Ser/Thr Protease	Inflammation/Immunology
Camostat is an orally active trypsin inhibitor. Camostat can reduce pancreatic fibrosis induced by repeated administration of superoxide dismutase inhibitors in rats, and decrease the proliferation and activation of pancreatic stellate cells (PSCs) .

HY-102061

Naronapride dihydrochloride ATI 7505 dihydrochloride	5-HT Receptor	Others
Naronapride (dihydrochloride) (ATI 7505 (dihydrochloride)) is a compound that regulates gastrointestinal motility. It is a 5-HT? receptor agonist. It is extensively metabolized after oral administration and is mainly excreted through feces. It has certain pharmacokinetic properties.

HY-N6910

Pseudolaric Acid C2	Others	Metabolic Disease
Pseudolaric Acid C2, a diterpenoid isolated from Pseudolarix kaempferi, is identified as the specific metabolite of Pseudolaric acid B in plasma, urine, bile and feces after both oral and intravenous administration to rats .

HY-118301

ADX71441	GABA Receptor	Neurological Disease
ADX71441 is a potent and selective positive allosteric modulator of the GABA_B receptor. ADX71441 is bioavailable after oral administration and is brain penetrant. ADX71441 has the potential for research of anxiety, pain and spasticity .

HY-145461

Hydroxy lenalidomide 5-Hydroxy lenalidomide	Drug Metabolite	Others
Hydroxy lenalidomide (5-Hydroxy lenalidomide) is a metabolite of lenalidomide that is present as a minor component in plasma and excreta, accounting for less than 5% of the total radioactivity, following oral administration of lenalidomide in healthy male subjects.

HY-W011309

1-O-Hexadecylglycerol 1-O-HDG; HXDG	PPAR PGE synthase	Inflammation/Immunology
1-O-Hexadecylglycerol can up-regulate PPAR-γ expression, inhibit pGE2, and exhibit anti-inflammatory properties . 1-O-Hexadecylglycerol is effective in oral administration .

HY-162893

SX29	Glycosidase	Metabolic Disease
SX29 is an orally active non-competitive α-glucosidase inhibitor with an IC₅₀ value of 2.12 μM. SX29 exhibits hypoglycemic activity, and oral administration of SX29 can reduce blood glucose levels and improve glucose tolerance in diabetic mice .

HY-14795

Mimopezil ZT-1	Cholinesterase (ChE)	Neurological Disease
Mimopezil (ZT-1) is an cholinesterase (ChE) inhibitor that rapidly degrades into the active metabolite Huperzine A (HY-17388) in water or aqueous organic solvents. After oral administration, Mimopezil is rapidly absorbed but has low bioavailability (0.37%) in rats. However, after metabolism, it is converted into Huperzine A, which accumulates in the blood and exhibits strong activity. Following intravenous administration, Mimopezil reaches higher blood concentrations and is also rapidly metabolized into Huperzine A .

HY-19899

APD-916	Histamine Receptor	Neurological Disease
APD-916 is an H3 receptor antagonist. APD-916 shows good pharmacokinetic properties, and oral administration of APD-916 has been shown to enhance wakefulness in various animal models .

HY-122309

A-71497	Antibiotic	Infection
A-71497 is the 3-formyl derivative of the antibiotic Tosufloxacin (HY-B1802). A-71497 can produce high plasma levels of tosufloxacin upon both oral and subcutaneous administration to mice .

HY-144110

HCV-IN-37	HCV	Infection
HCV-IN-37 (Compound 3d) is a potent inhibitor of HCV. HCV-IN-37 is orally available and long-lasting in rat plasma after oral administration to rats by a single dose of 15 mg/kg. The high potency of active derivative HCV-IN-37 is primarily driven by the inhibitory effect on the virus entry stage .

HY-144878

VPC-70619 2 Publications Verification	c-Myc	Cancer
VPC-70619 is a potent, orally active N-Myc inhibitor. VPC-70619 blocks the N-Myc-Max heterocomplex from binding to DNA E-boxes and demonstrated strong inhibition activity against N-Myc-dependent cell lines as well as high bioavailability in both oral and intraperitoneal administration .

HY-149900

Antiviral agent 33	Biochemical Assay Reagents	Infection
Antiviral agent 33 (compound 1c) is a double-stranded DNA (dsDNA) virus inhibitor with IC₅₀ values of 0.0790 and 0.1572 µM for VACV and AdV5, respectively. Antiviral agent 33 also has potential for oral administration .

HY-108288R

Sulbactam pivoxil (Standard)	Beta-lactamase Antibiotic Bacterial	Infection

HY-170961

SDUY816	Aminopeptidase Neprilysin	Neurological Disease
SDUY816 is an oral active dual APN/NEP inhibitor, with IC₅₀ values of 0.68 μM for APN and 6.9 μM for NEP. SDUY816 exhibits analgesic effects and demonstrates good safety and pharmacokinetic profiles, with an oral bioavailability of 27% and a half-life of 4.02 hours in rats (oral administration, 10 mg/kg). SDUY816 has potential applications in the research of neuropathic pain disorders .

HY-118426

(Rac)-Tipifarnib (Rac)-IND 58359; (Rac)-R115777	Farnesyl Transferase Ras	Cancer
(Rac)-Tipifarnib ((Rac)-IND 58359; (Rac)-R115777) is a potent farnesyl protein transferase inhibitor that specifically targets the pro-tailation process of Ras proteins. (Rac)-Tipifarnib showed significant in vivo antitumor effects after oral administration to mice .

HY-118189

Misoprostol acid	Prostaglandin Receptor	Inflammation/Immunology
Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers . Misoprostol is an oral agent used to induce labor .

HY-122968

Brocresine NSD-1065	Endogenous Metabolite	Neurological Disease
Brocresine (NSD-1065) is an orally active histidine decarboxylase inhibitor and inhibits the formation of histamine from histidine. Brocresine is also a L-amino acid decarboxylase inhibitor with both a peripheral and central action. Brocresine inhibits gastric secretory response to administration of exogenous gastrin .

HY-100085

21-Desacetyldeflazacort 21-desDFZ	Drug Metabolite	Inflammation/Immunology
21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration .

HY-147152

1-Myristoyl-3-chloropropanediol	Biochemical Assay Reagents	Others
1-Myristoyl-3-chloropropanediol is a 3-monochloropropanediol (3-MCPD) fatty acid ester. 3-MPCD causes nephropathy and tubular hyperplasia and adenomas by chronic oral administration; also reduces fertility, or provokes infertility in rats and suppresses the immune function .

HY-111073

Bentysrepinine Y101	HBV	Infection Inflammation/Immunology
Bentysrepinine (Y101) is an orally active HBV inhibitor with anti-hepatitis B virus infection activity. Bentysrepinine exhibits favorable pharmacokinetic characteristics, with absolute bioavailability of 44.9%, 43.1%, and 19.2% in rats, dogs, and monkeys, respectively, and it does not accumulate in monkeys after 90 days of oral administration. Bentysrepinine is under research in the antiviral and hepatitis fields .

HY-156466

QL-1200186	JAK	Inflammation/Immunology
QL-1200186 is anorally activeand selective inhibitor ofTYK2. Oral administration of QL-1200186, dose-dependently inhibitsinterferon-γ(IFNγ) production afterinterleukin-12(IL-12) challenge and significantly ameliorates skin lesions in psoriatic mice .

HY-103459

CI-1020 PD156707	Endothelin Receptor	Cardiovascular Disease
CI-1020 (PD156707) is an orally active and selective antagonist targeting endothelin (ET_A) with an IC₅₀ value of 0.3 nM. CI-1020 blocks intimal hyperplasia in human saphenous veins completely in organ culture. CI 1020 inhibits hypoxic pulmonary hypertension and blocks ET-1-induced pressor responses following oral administration .

HY-114452

LY2940094 1 Publications Verification BTRX-246040	Opioid Receptor	Neurological Disease
LY2940094 (BTRX-246040) is a potent, selective and orally available nociceptin receptor (NOP receptor) antagonist with high affinity (K_i=0.105 nM) and antagonist potency (K_b=0.166 nM). LY2940094 reduces ethanol self-administration in animal models .

Cat. No.	Product Name

HY-L061

Orally Active Compound Library

4,058 compounds

Most of the drugs that are available in the marketplace are administered via the oral route, which is a convenient and cost effective route of administration. Thus, oral bioavailability is one of the key considerations in drug design and development. A high oral bioavailability reduces the amount of an administered drug necessary to achieve a desired pharmacological effect and therefore could reduce the risk of side-effects and toxicity. A poor oral bioavailability can result in low efficacy and higher inter-individual variability and therefore can lead to unpredictable response to a drug. Low oral bioavailability in clinical trials is a major reason for drug candidates failing to reach the market.

MCE offers a unique collection of 4,058 compounds with confirmed high oral bioavailability. MCE Orally Active Compound Library is a useful tool for discovering new drugs with oral bioavailability.

Cat. No.	Product Name	Type

HY-20559

4-Chloro-3-nitrobenzoic acid	Cell Assay Reagents
4-Chloro-3-nitrobenzoic acid has oral activity，and oral administration can affect the synthesis activity of liver proteins and the activities of urokinase and histidine kinase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0864

Macranthoidin B Macranthoiside I	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Cancer	Others
Macranthoidin B is a major bioactive saponin in rat plasma after oral administration of extraction of saponins from Flos Lonicerae.

HY-N4173

8-Oxoepiberberine	Structural Classification other families Stilbenes Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Drug Metabolite
8-Oxoepiberberine is an alkaloid metabolite in the plasma after oral administration of Zuojin formula, a traditional chinese medicine used to treat gastrointestinal disease .

HY-N0856

Alisol C 23-acetate 23-O-Acetylalisol C; Alisol C monoacetate	Cardiovascular Disease Triterpenes Alisma plantago-aquatica Linn. Classification of Application Fields Terpenoids Source classification Alisma orinentale (Samuel.) Juz. Plants Alismataceae Disease Research Fields	Others
Alisol C 23-acetate, a natural product extracted from Alisma orinentale, can significantly and strongly inhibit DTH response after oral administration.

HY-N6910

Pseudolaric Acid C2	other families Classification of Application Fields Terpenoids Source classification Metabolic Disease Diterpenoids Plants Disease Research Fields	Others
Pseudolaric Acid C2, a diterpenoid isolated from Pseudolarix kaempferi, is identified as the specific metabolite of Pseudolaric acid B in plasma, urine, bile and feces after both oral and intravenous administration to rats .

HY-N6641

Monascin	Structural Classification Natural Products Microorganisms other families Classification of Application Fields Source classification Pigments Plants Inflammation/Immunology Disease Research Fields Food Research	Keap1-Nrf2 PPAR
Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor). Monascin is a Nrf2 activator and PPARγ agonist .

HY-N0307

Ciwujianoside B	Triterpenes Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	Bcl-2 Family
Ciwujianoside B is isolated from Eleutherococcus senticosus leaf, is able to penetrate and work in the brain after the oral administration. Ciwujianoside B significantly enhances object recognition memory . Ciwujianoside B shows radioprotective effects on the hematopoietic system in mice, which is associated with changes in the cell cycle, reduces DNA damage and down-regulates the ratio of Bax/Bcl-2 in bone marrow cells exposed to radiation .

HY-N10225

Thielavin A	Cardiovascular Disease Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields	Prostaglandin Receptor
Thielavin A is an inhibitor of prostaglandin biosynthesis produced by Thielavia terricola. Thielavin A specifically inhibits the conversion of arachidonic acid into prostaglandin H2. Thielavin A has no anti-inflammatory activity on intravenous injection or on oral administration .

HY-N6641R

Monascin (Standard)	Structural Classification Natural Products Microorganisms other families Source classification Plants	Keap1-Nrf2 PPAR
Monascin (Standard) is the analytical standard of Monascin. This product is intended for research and analytical applications. Monascin is a kind of azaphilonoid pigments extracted from Monascus pilosus-fermented rice (red-mold rice). Monascin also exhibits anti-tumor-initiating activity and anti-inflammatory activity with oral administration. Monascin inhibits the activation of NOR 1 (an NO donor). Monascin is a Nrf2 activator and PPARγ agonist .

HY-N0307R

Ciwujianoside B (Standard)	Triterpenes Structural Classification Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Araliaceae	Bcl-2 Family
Ciwujianoside B (Standard) is the analytical standard of Ciwujianoside B. This product is intended for research and analytical applications. Ciwujianoside B is isolated from Eleutherococcus senticosus leaf, is able to penetrate and work in the brain after the oral administration. Ciwujianoside B significantly enhances object recognition memory . Ciwujianoside B shows radioprotective effects on the hematopoietic system in mice, which is associated with changes in the cell cycle, reduces DNA damage and down-regulates the ratio of Bax/Bcl-2 in bone marrow cells exposed to radiation .

HY-W001083R

3-Hydroxyphenylacetic acid (Standard)	Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Endogenous Metabolite
Ciwujianoside B (Standard) is the analytical standard of Ciwujianoside B. This product is intended for research and analytical applications. Ciwujianoside B is isolated from Eleutherococcus senticosus leaf, is able to penetrate and work in the brain after the oral administration. Ciwujianoside B significantly enhances object recognition memory . Ciwujianoside B shows radioprotective effects on the hematopoietic system in mice, which is associated with changes in the cell cycle, reduces DNA damage and down-regulates the ratio of Bax/Bcl-2 in bone marrow cells exposed to radiation .

HY-N7545

Protorubradirin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Reverse Transcriptase
Protorubradirin is an antibiotic that can be isolated from Streptomyces achromogenes var. rubradirin together with Rubradirin. Protorubradirin has inhibitory activity against HIV reverse transcriptase. In vitro studies have shown that Protorubradirin also inhibits Staphylococcus aureus strains and Streptococci. In infected mice, subcutaneous injection of Protorubradirin showed in vivo inhibitory efficacy against antibiotic-resistant Staphylococcus aureus strains. However, oral administration may result in a significant reduction in the activity of Protorubradirin, possibly due to faster cleavage of its C-nitroso sugar in the acidic gastric environment compared to Rubradirin .

HY-N0469R

L-Lysine (Standard)	Structural Classification Microorganisms Source classification Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite	Endogenous Metabolite Virus Protease HSV
L-Lysine (Standard) is the analytical standard of L-Lysine. This product is intended for research and analytical applications. L-lysine is an essential amino acid for humans with orally activity. L-lysine can inhibit the occurrence of HSV infections and is used in herpes research. L-lysine increases calcium absorption, reduces diabetes-related diseases, improves gut health, and alleviates pancreatic inflammation. L-lysine can be used in research on metabolism, infection, and inflammation . IC₅₀ & Target:L-lysine (150 mg/kg) promotes, but not initiates, bladder cancer. The administration of L-lysine to rats submitted to colovesical cystoplasty accelerates the development of transitional metaplasia of the intestinal epithelium . L-lysine (10 mg/kg) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity . In Vivo:L-lysine (10?mg/kg, p.o., pre-treated or post-treated, administration duration 15 days) treatment attenuates pancreatic tissue injury induced by L-arginine by inhibiting the release of the inflammatory cytokine IL-6 and enhance antioxidant activity in acute pancreatitis mice model . L-lysine (5 or 10?mg/kg, p.o., 45 days) ameliorates sepsis-induced acute lung injury in a lipopolysaccharide (HY-D1056)-induced mouse model .

Cat. No.	Product Name	Chemical Structure

HY-118189S

Misoprostol acid-d5

Misoprostol acid-d₅ is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers[1]. Misoprostol is an oral agent used to induce labor[2].

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