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xanthine oxidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Monoamine Oxidase (1) NADPH Oxidase (1) Xanthine Oxidase (62) Adenosine Receptor (1) Angiotensin-converting Enzyme (ACE) (1) Apoptosis (3) Bacterial (3) COX (1) DNA/RNA Synthesis (1) Drug Metabolite (12) Endogenous Metabolite (8) Ferroptosis (3) HBV (1) HIV (1) Influenza Virus (3) Isotope-Labeled Compounds (4) Lipoxygenase (1) NF-κB (1) NO Synthase (1) Nucleoside Antimetabolite/Analog (7) Reactive Oxygen Species (5) Reverse Transcriptase (1) Ser/Thr Protease (1) Thrombopoietin Receptor (1) TNF Receptor (1) Toll-like Receptor (TLR) (1) URAT1 (2)
By Research Areas:	Cancer (21) Cardiovascular Disease (5) Endocrinology (2) Infection (12) Inflammation/Immunology (30) Metabolic Disease (32) Neurological Disease (10)
Oligonucleotides:	Nucleosides and their Analogs (4) Nucleoside Phosphoramidites (2)

Inhibitors & Agonists

Biochemical Assay Reagents

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Isotope-Labeled Compounds

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Oligonucleotides

Xanthine oxidase-IN-10	Xanthine Oxidase	Others
Xanthine oxidase-IN-10 (XO8 analog) is an **xanthine oxidase** (XO) inhibitor .

Xanthine oxidase-IN-11	Xanthine Oxidase	Others
Xanthine oxidase-IN-11 (XO8 analog) is an **xanthine oxidase** (XO) inhibitor .

Xanthine oxidase-IN-8 Icarisids J	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-8 (Icarisids J) (Compound 7) is a XOD inhibitor with an IC₅₀ of 29.71 μM .

Xanthine oxidase-IN-13	Xanthine Oxidase	Inflammation/Immunology
Xanthine oxidase-IN-13 (Compound 10) is a selective **xanthine oxidase** inhibitor (IC₅₀: 149.56 μM for bovine xanthine oxidase). Xanthine oxidase-IN-13 can be used for research of inflammatory arthritis .

Xanthine oxidase-IN-12	Xanthine Oxidase Reactive Oxygen Species	Inflammation/Immunology
Xanthine oxidase-IN-12 (Compound 11) is a xanthine oxidase (XO) inhibitor with an IC₅₀ of 91 nM. Xanthine oxidase-IN-12 also has antioxidant activity and reduces intracellular ROS .

Xanthine oxidase-IN-7	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-7 (compound1h) is a potent andorally active XO (xanthine oxidase) inhibitor with an IC₅₀ of 0.36 µM. Xanthine oxidase-IN-7 effectively reduces serum uric acid levels. Xanthine oxidase-IN-7 has the potential for the research of hyperuricemia and gout .

Xanthine oxidase-IN-4	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-4 (compound 19a) is an orally active and potent xanthine oxidase (XO) inhibitor, with an IC₅₀ of 0.039 μM. Xanthine oxidase-IN-4 exhibits hypouricemic potency in potassium oxonate induced hyperuricemia rats. Xanthine oxidase-IN-4 can be used for hyperuricemia and gout research .

Xanthine oxidase-IN-15	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-15 (Compound 6c) is a selective inhibitor of Xanthine oxidase (XO) (IC₅₀=0.13 μM). Xanthine oxidase-IN-15 inhibits XO catalysis by forming a stable interaction with the active site of XO. Xanthine oxidase-IN-15 is mainly used in the study of hyperuricemia and gout .

Xanthine oxidase-IN-6	Xanthine Oxidase NF-κB Toll-like Receptor (TLR) TNF Receptor	Metabolic Disease Inflammation/Immunology
Xanthine oxidase-IN-6 (Compound 6c) is a potent, orally active, mixed-type xanthine oxidase (XOD) inhibitor with an IC₅₀ value of 1.37 µM. Xanthine oxidase-IN-6 shows strong anti-hyperuricemia and renal protective activity .

Xanthine oxidase-IN-5	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-5 is an effective and orally active **xanthine oxidase (XO) inhibitor with IC₅₀** value of 0.70 μM. Xanthine oxidase-IN-5 displays favorable agent-like properties with ligand efficiency (LE) and lipophilic ligand efficiency (LLE) values of 0.33 and 3.41, respectively. Xanthine oxidase-IN-5 shows potent hypouricemic effects in hyperuricemic rat model .

Xanthine oxidase-IN-14	Xanthine Oxidase	Cancer
Xanthine oxidase-IN-14 (Compound 3f) is an inhibitor for xanthine oxidase, with IC₅₀ >100 μM. Xanthine oxidase-IN-14 inhibits proliferations of cancer cells MCF-7, NCI-H460 and SF-268, with IC₅₀ greater than 150 μM .

Xanthine oxidase, bovine milk	Reactive Oxygen Species	Inflammation/Immunology Endocrinology
Xanthine oxidase, bovine milk is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid .

Xanthine oxidase, Microorganism 1 Publications Verification XO; XOD	Reactive Oxygen Species	Inflammation/Immunology Endocrinology
Xanthine oxidase, Microorganism (XO) is a xanthine oxidoreductase enzyme that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid .

Xanthine oxidase-IN-9 Icarisids E	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-9 (Icarisids E) (Compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC₅₀ of 31.81 μM .

Xanthine oxidase-IN-1 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid	Xanthine Oxidase	Metabolic Disease
Xanthine oxidase-IN-1 is a **xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC₅₀** of 6.5 nM.

Forsythoside F Arenarioside	Xanthine Oxidase	Metabolic Disease
Forsythoside F (Arenarioside) is a **xanthine oxidase** inhibitor and possesses antihyperuricemic effects in vivo .

Febuxostat isopropyl isomer	Drug Metabolite	Others
Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

Febuxostat sec-butoxy acid	Drug Metabolite	Others
Febuxostat sec-butoxy acid is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

Febuxostat impurity 7	Drug Metabolite	Others
Febuxostat impurity 7 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

Febuxostat impurity 8	Drug Metabolite	Others
Febuxostat impurity 8 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

Febuxostat impurity 6	Drug Metabolite	Others
Febuxostat impurity 6 is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

Febuxostat dicarboxylic acid impurity	Drug Metabolite	Others
Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

Febuxostat amide impurity	Drug Metabolite	Others
Febuxostat amide impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM

Febuxostat n-butyl isomer	Drug Metabolite	Others
Febuxostat n-butyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a K_i of 0.6 nM .

Renierol	Xanthine Oxidase	Metabolic Disease
Renierol is an orally active xanthine oxidase (XO) inhibitor. Renierol has urate-lowering activity .

Eupatoriochromene	Xanthine Oxidase	Others
Eupatoriochromene is a chromene and has inhibitory activity against xanthine oxidase (XO) .

Desciclovir BW A515U	Others	Infection
Desciclovir is a potent and orally active proagent of the antiherpetic agent Acyclovir (ACV). Desciclovir is converted to acyclovir in vivo by xanthine oxidase .

Ellagic acid 4-O-β-D-xylopyranoside	Xanthine Oxidase Bacterial	Infection
Ellagic acid 4-O-β-D-xylopyranoside is a natural ellagitannin with antimicrobial activity. Ellagic acid 4-O-β-D-xylopyranoside is an **xanthine oxidase** inhibitor with an ₅₀ of 2.1 μg/mL .

6-Formylpterin	Xanthine Oxidase Apoptosis Reactive Oxygen Species	Metabolic Disease
6-Formylpterin is an inhibitor of **Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis** in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells .

(±)-Dihydroactinidiolide	Others	Others
(±)-Dihydroactinidiolide, an important aroma compound of black tea and tobacco, has been isolated from several plants. (±)-Dihydroactinidiolide can be formation from β-Carotene by the treatment of polyphenoloxidase, the lipoxygenase, and the xanthine oxidase .

Tetrahydroamentoflavone Amentoflavanone	Xanthine Oxidase	Infection Inflammation/Immunology
Tetrahydroamentoflavone (Amentoflavanone) is a potent xanthine oxidase (XO) inhibitor. Tetrahydroamentoflavone has inhibitory activity for XO with IC₅₀ and K_i values of 92 nM and 0.982 μM, respectively. Tetrahydroamentoflavone can be used for the research of inflammatory disorders and gout .

Lobetyolin 2 Publications Verification	Apoptosis Xanthine Oxidase	Metabolic Disease
Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and **xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2**-mediated glutamine metabolism . Lobetyolin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

BOF-4272	Xanthine Oxidase	Metabolic Disease
BOF-4272 is a xanthine oxidase/xanthine dehydrogenase inhibitor. BOF-4272 can be used for hyperuricemia research .

Broussoflavonol F	Xanthine Oxidase	Others
Broussoflavonol F possess **xanthine oxidase** inhibitory activity .

8-Azaadenine	Xanthine Oxidase	Metabolic Disease
8-Azaadenine is a **Xanthine Oxidase inhibitor (IC₅₀** = 0.54 μM) .

Xanthine (Standard)	Endogenous Metabolite	Inflammation/Immunology
Xanthine (Standard) is the analytical standard of Xanthine. This product is intended for research and analytical applications. Xanthine, a plant alkaloid found in tea, coffee, and cocoa, is a mild stimulant of the central nervous system. Xanthine also acts as an intermediate product on the pathway of purine degradation . In Vitro: A number of stimulants are derived from Xanthine including caffeine and theobromine. Xanthine is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme.

Fraxamoside	Xanthine Oxidase	Metabolic Disease
Fraxamoside is a competitive **xanthine oxidase inhibitor with an IC₅₀ of 16.1 μM and a K_i** of 0.9 μM .

Baicalein Maximum Cited Publications 20 Publications Verification 5,6,7-Trihydroxyflavone	Xanthine Oxidase Influenza Virus Ferroptosis	Cancer
Baicalein (5,6,7-Trihydroxyflavone) is a **xanthine oxidase inhibitor with an IC₅₀** value of 3.12 μM.

O-Desisobutyl-O-n-propyl Febuxostat	Xanthine Oxidase	Metabolic Disease
O-Desisobutyl-O-n-propyl Febuxostat, extracted from the patent CN 103467412, is an **xanthine oxidase** inhibitor .

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology Cancer
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells .

Amflutizole LY-141894	Xanthine Oxidase	Others
Amflutizole (LY-141894) is an inhibitor of **xanthine oxidase**. Amflutizole abolishes free radical formation and release in cerebral ischemia/reperfusion mice .

7,8,3′,4′-Tetrahydroxyflavone	Xanthine Oxidase	Metabolic Disease
7,8,3′,4′-Tetrahydroxyflavone (compound 2) is a potent xanthine oxidase (XOD) inhibitor with an IC₅₀ value of 10.488 µM .

Oxypurinol Oxipurinol	Drug Metabolite Endogenous Metabolite Xanthine Oxidase	Metabolic Disease Inflammation/Immunology
Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of **xanthine oxidase**. Oxipurinol can be used to regulate blood urate levels and treat gout .

DEANO sodium Diethylamine NONOate sodium; Diethylamine nitric oxide sodium	Others	Others
DEANO sodium is notric oxide donor. DEANO sodium potentiates the abilitv of hypoxanthine/xanthine oxidase to induce lipid peroxidation as well as DNA single- and double-strand breaks .

Cat. No.	Product Name	Type

HY-D0837

Imidazole

2 Publications Verification

Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene

Cell Assay Reagents

Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG₂ and PGH₂) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL ^Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .

Cat. No.	Product Name	Target	Research Area

HY-W011258

H-Tyr-Phe-OH L-Tyrosyl-L-phenylalanine	Xanthine Oxidase Angiotensin-converting Enzyme (ACE)	Inflammation/Immunology Cancer
H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC). H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells .

HY-P1435A

NoxA1ds TFA	NADPH Oxidase	Cancer
NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

Cat. No.	Product Name	Chemical Structure

HY-14268S

Febuxostat-d9
Febuxostat-d₉ is deuterium labeled Febuxostat, which is a selective xanthine oxidase inhibitor with a Ki of 0.6 nM.

HY-B0219S

Allopurinol-d2
Allopurinol-d₂ is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].

HY-14268S1

Febuxostat-d7
Febuxostat-d₇ is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is selective xanthine oxidase inhibitor with a Ki of 0.6 nM[1].

HY-19657S

Oxypurinol-13C,15N2
Oxypurinol- ¹³C, ¹⁵N₂ is ¹⁵N and ¹³C labeled Oxypurinol (HY-19657). Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of **xanthine oxidase**. Oxipurinol can be used to regulate blood urate levels and treat gout .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82212

	Xanthine Oxidase Antibody (YA1957) xanthine dehydrogenase; xanthine oxidase; xanthine oxidoreductase; XD; XDH; xdha; XO; xor	WB, IHC-P	Human, Mouse, Rat
	Xanthine Oxidase Antibody (YA1957) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1957), targeting Xanthine Oxidase, with a predicted molecular weight of 146 kDa (observed band size: 146 kDa). Xanthine Oxidase Antibody (YA1957) can be used for WB, IHC-P experiment in human, mouse, rat background.

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Cat. No.	Product Name		Classification

HY-152696

6-O-Methylinosine		Nucleosides and their Analogs
6-O-Methylinosine is a hypoxanthine analogue. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-154017

2′-C-Methyl-6-O-methylinosine		Nucleosides and their Analogs
2′-C-Methyl-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-154393

2-Chloro-2'-deoxy-6-O-methylinosine		Nucleosides and their Analogs
2-Chloro-2'-deoxy-6-O-methylinosine is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-152678

6-Methoxypurine-9-β-D-5’(R)-C-methylriboside		Nucleosides and their Analogs
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-W141392

2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite		Nucleoside Phosphoramidites
2'-Fluoro-5'-O-DMT-2'-deoxyinosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

HY-W392836

2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite		Nucleoside Phosphoramidites
2'-O-Methyl-5'-O-dmt-inosine-3'-CE-phosphoramidite is a hypoxanthine analog. Hypoxanthine is a kind of purine base mainly present in muscle tissue. And it is a metabolite produced by purine oxidase acting on xanthine. Hypoxanthine has typical anti-inflammatory effects and is a potential endogenous poly(ADP-ribose) polymerase (PARP) inhibitor. It is cytoprotective by inhibiting PAPR activity, inhibiting peroxynitrite-induced mitochondrial depolarization and secondary superoxide production. Hypoxanthine can also be used as an indicator of hypoxia .

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