Sodium taurodeoxycholate hydrate

Name: Sodium taurodeoxycholate hydrate
Brand: MedChemExpress
SKU: HY-W089835
Rating: 5.0 (2 reviews)

Cat. No.: HY-W089835 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Sodium taurodeoxycholate hydrate, a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Sodium taurodeoxycholate hydrate activates the S1PR2 pathway in addition to the TGR5 pathway.

For research use only. We do not sell to patients.

Sodium taurodeoxycholate hydrate Chemical Structure

CAS No. : 207737-97-1

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Based on 2 publication(s) in Google Scholar

Other Forms of Sodium taurodeoxycholate hydrate:

Taurodeoxycholate-d₆ sodium salt Get quote
Taurodeoxycholate sodium salt Get quote
Taurodeoxycholic acid Get quote
Taurodeoxycholic acid sodium hydrate Get quote

2 Publications Citing Use of MCE Sodium taurodeoxycholate hydrate

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Microbial Metabolite

In Vitro

The median plasma concentration of Taurodeoxycholate is 33.9 nM in healthy individuals^[1].
Taurodeoxycholate inhibits the binding of N-³H-methylscopolamine to the M3 muscarinic receptor of acetylcholine with an IC₅₀ of 170 µM^[1].
Taurodeoxycholate (0.05-1.00 mM; 1-6 days) stimulates intestinal epithelial cell proliferation^[2].
Taurodeoxycholate (0.05-1.00 mM; 24 h) induces a significant increase in S-phase concentration and a significant decrease in G1-phase concentration of the cell cycle, increases c-myc protein and mRNA expression in IEC-6 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:	IEC-6 and caco-2 cells
Concentration:	0, 0.05, 0.50, and 1.00 mM
Incubation Time:	1, 2, 4 and 6 days
Result:	Significantly stimulated intestinal epithelial cell proliferation in a dose-dependent manner.

Cell Cycle Analysis^[2]

Cell Line:	IEC-6 cells
Concentration:	0, 0.05, 0.50, and 1.00 mM
Incubation Time:	24 h
Result:	Significantly increased cells in S phase and decreased cells in G1-phase.

Western Blot Analysis^[2]

Cell Line:	IEC-6 cells
Concentration:	0.5 mM
Incubation Time:	1 and 6 days
Result:	Significantly increased c-myc protein expression.

In Vivo

Taurodeoxycholate (0.5 mg/kg; i.v.; once) confers protection to C57BL/6N mice with sepsis, but does not protect TGR5 KO mice under sepsis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6N mice, Lipopolysaccharides (HY-D1056) injection model of sepsis^[1]
Dosage:	0.5 mg/kg
Administration:	Intravenous injection, 30 min or 24 h after LPS injection
Result:	Improved the survival rate of mice with sepsis. Decreased liver and kidney damage in septic mice. Ameliorated systemic inflammation and normalized blood pressure in septic mice.

Molecular Weight

521.69

Formula

C₂₆H₄₄NNaO₆S

CAS No.

207737-97-1

Appearance

Solid

Color

White to off-white

SMILES

O=S([O-])(CCNC(CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C)=O)=O.[Na+].[x H2O]

Structure Classification

Steroids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (191.68 mM; Need ultrasonic)

DMSO : 100 mg/mL (191.68 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9168 mL	9.5842 mL	19.1685 mL
5 mM	0.3834 mL	1.9168 mL	3.8337 mL
10 mM	0.1917 mL	0.9584 mL	1.9168 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (279 KB) SDS (393 KB)

COA (252 KB)

Handling Instructions (2659 KB)

References

[1]. Chang S, et al. Taurodeoxycholate Increases the Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice. Front Immunol. 2018 Sep 18;9:1984. [Content Brief]

[2]. Yamaguchi J, et al. Taurodeoxycholate increases intestinal epithelial cell proliferation through c-myc expression. Surgery. 2004 Feb;135(2):215-21. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.9168 mL	9.5842 mL	19.1685 mL	47.9212 mL
	5 mM	0.3834 mL	1.9168 mL	3.8337 mL	9.5842 mL
	10 mM	0.1917 mL	0.9584 mL	1.9168 mL	4.7921 mL
	15 mM	0.1278 mL	0.6389 mL	1.2779 mL	3.1947 mL
	20 mM	0.0958 mL	0.4792 mL	0.9584 mL	2.3961 mL
	25 mM	0.0767 mL	0.3834 mL	0.7667 mL	1.9168 mL
	30 mM	0.0639 mL	0.3195 mL	0.6389 mL	1.5974 mL
	40 mM	0.0479 mL	0.2396 mL	0.4792 mL	1.1980 mL
	50 mM	0.0383 mL	0.1917 mL	0.3834 mL	0.9584 mL
	60 mM	0.0319 mL	0.1597 mL	0.3195 mL	0.7987 mL
	80 mM	0.0240 mL	0.1198 mL	0.2396 mL	0.5990 mL
	100 mM	0.0192 mL	0.0958 mL	0.1917 mL	0.4792 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.