Taurodeoxycholic acid sodium hydrate (Synonyms: Sodium taurodeoxycholate monohydrate)

Name: Taurodeoxycholic acid sodium hydrate
Brand: MedChemExpress
SKU: HY-B1899A
Rating: 5.0 (2 reviews)

Cat. No.: HY-B1899A Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a bile acid, is an amphiphilic surfactant molecule synthesized from cholesterol in the liver. Taurodeoxycholic acid sodium hydrate activates the S1PR2 pathway in addition to the TGR5 pathway.

For research use only. We do not sell to patients.

Taurodeoxycholic acid sodium hydrate Chemical Structure

CAS No. : 110026-03-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 30	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 30	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 38	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 75	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 2 publication(s) in Google Scholar

Other Forms of Taurodeoxycholic acid sodium hydrate:

Taurodeoxycholic acid-d₄ sodium Get quote
Taurodeoxycholate sodium salt Get quote
Taurodeoxycholic acid Get quote
Sodium taurodeoxycholate hydrate Get quote

2 Publications Citing Use of MCE Taurodeoxycholic acid sodium hydrate

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Microbial Metabolite

In Vitro

The median plasma concentration of Taurodeoxycholate is 33.9 nM in healthy individuals^[1].
Taurodeoxycholate inhibits the binding of N-³H-methylscopolamine to the M3 muscarinic receptor of acetylcholine with an IC₅₀ of 170 μM^[1].
Taurodeoxycholate (0.05-1.00 mM; 1-6 days) stimulates intestinal epithelial cell proliferation^[2].
Taurodeoxycholate (0.05-1.00 mM; 24 h) induces a significant increase in S-phase concentration and a significant decrease in G1-phase concentration of the cell cycle, increases c-myc protein and mRNA expression in IEC-6 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[2]

Cell Line:	IEC-6 and caco-2 cells
Concentration:	0, 0.05, 0.50, and 1.00 mM
Incubation Time:	1, 2, 4 and 6 days
Result:	Significantly stimulated intestinal epithelial cell proliferation in a dose-dependent manner.

Cell Cycle Analysis^[2]

Cell Line:	IEC-6 cells
Concentration:	0, 0.05, 0.50, and 1.00 mM
Incubation Time:	24 h
Result:	Significantly increased cells in S phase and decreased cells in G1-phase.

Western Blot Analysis^[2]

Cell Line:	IEC-6 cells
Concentration:	0.5 mM
Incubation Time:	1 and 6 days
Result:	Significantly increased c-myc protein expression.

In Vivo

Taurodeoxycholate (0.5 mg/kg; i.v.; once) confers protection to C57BL/6N mice with sepsis, but does not protect TGR5 KO mice under sepsis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6N mice, Lipopolysaccharides (HY-D1056) injection model of sepsis^[1]
Dosage:	0.5 mg/kg
Administration:	Intravenous injection, 30 min or 24 h after LPS injection
Result:	Improved the survival rate of mice with sepsis. Decreased liver and kidney damage in septic mice. Ameliorated systemic inflammation and normalized blood pressure in septic mice.

Molecular Weight

539.70

Formula

C₂₆H₄₆NNaO₇S

CAS No.

110026-03-4

Appearance

Solid

Color

White to off-white

SMILES

C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C.O

Structure Classification

Steroids

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (231.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8529 mL	9.2644 mL	18.5288 mL
5 mM	0.3706 mL	1.8529 mL	3.7058 mL
10 mM	0.1853 mL	0.9264 mL	1.8529 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 0.5% CMC-Na/saline water
Solubility: 20 mg/mL (37.06 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (251 KB) HNMR (295 KB) MS (80 KB)

Handling Instructions (2659 KB)

References

[1]. Chang S, et al. Taurodeoxycholate Increases the Number of Myeloid-Derived Suppressor Cells That Ameliorate Sepsis in Mice. Front Immunol. 2018 Sep 18;9:1984. [Content Brief]

[2]. Yamaguchi J, et al. Taurodeoxycholate increases intestinal epithelial cell proliferation through c-myc expression. Surgery. 2004 Feb;135(2):215-21. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8529 mL	9.2644 mL	18.5288 mL	46.3220 mL
	5 mM	0.3706 mL	1.8529 mL	3.7058 mL	9.2644 mL
	10 mM	0.1853 mL	0.9264 mL	1.8529 mL	4.6322 mL
	15 mM	0.1235 mL	0.6176 mL	1.2353 mL	3.0881 mL
	20 mM	0.0926 mL	0.4632 mL	0.9264 mL	2.3161 mL
	25 mM	0.0741 mL	0.3706 mL	0.7412 mL	1.8529 mL
	30 mM	0.0618 mL	0.3088 mL	0.6176 mL	1.5441 mL
	40 mM	0.0463 mL	0.2316 mL	0.4632 mL	1.1581 mL
	50 mM	0.0371 mL	0.1853 mL	0.3706 mL	0.9264 mL
	60 mM	0.0309 mL	0.1544 mL	0.3088 mL	0.7720 mL
	80 mM	0.0232 mL	0.1158 mL	0.2316 mL	0.5790 mL
	100 mM	0.0185 mL	0.0926 mL	0.1853 mL	0.4632 mL

Taurodeoxycholic acid sodium hydrate Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taurodeoxycholic acid sodium110026-03-4Sodium taurodeoxycholateG protein-coupled Bile Acid Receptor 1Endogenous MetaboliteG-protein coupled receptor 19GPCR19TGR5GPBAR1amphiphilic surfactantbile acidS1PR2 pathwayTGR5 pathwayInhibitorinhibitorinhibit

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Taurodeoxycholic acid sodium hydrate (Synonyms: Sodium taurodeoxycholate monohydrate)

Customer Review

Other Forms of Taurodeoxycholic acid sodium hydrate:

Taurodeoxycholic acid sodium hydrate Related Antibodies

2 Publications Citing Use of MCE Taurodeoxycholic acid sodium hydrate

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Taurodeoxycholic acid sodium hydrate Related Antibodies

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Dilution Calculator

Complete Stock Solution Preparation Table

Taurodeoxycholic acid sodium hydrate Related Classifications

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