STAT3-IN-17

Name: STAT3-IN-17
Brand: MedChemExpress
SKU: HY-148706
Rating: 4.5 (1 reviews)

Cat. No.: HY-148706 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

STAT3-IN-17 is a moderate STAT3 inhibitor (IC₅₀=0.7 μM; HEK-Blue IL-6), with antiproliferative activity in HeLa cells. STAT3-IN-17 has good pharmacokinetic characteristics. STAT3-IN-17 also inhibits pyruvate-ferredoxin oxidoreductase (PFOR), and inhibits Helicobacter pylori.

For research use only. We do not sell to patients.

STAT3-IN-17 Chemical Structure

CAS No. : 1245814-52-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 181	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 181	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 74	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 950	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1530	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 2450	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

STAT3

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3 μM Compound: 15	Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 34055214]
Caco-2	IC₅₀	1.8 μM Compound: 15	Antiproliferative activity against human Caco-2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human Caco-2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 34055214]
HeLa	IC₅₀	1.8 μM Compound: 15	Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 34055214]
HeLa	IC₅₀	2.7 μM Compound: 15	Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as inhibition of cell viability measured after 48 hrs by MTT assay	[PMID: 34055214]
HL-60	IC₅₀	1.2 μM Compound: 15	Antiproliferative activity against human HL60 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human HL60 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 34055214]
HT-29	IC₅₀	> 10 μM Compound: 15	Antiproliferative activity against human HT29 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human HT29 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 34055214]
PC-3	IC₅₀	> 10 μM Compound: 15	Antiproliferative activity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human PC3 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 34055214]

In Vitro

STAT3-IN-17 (compound 15) (10 μM; 20 h, 48 h) inhibits STAT3 pathway with inhibition rate of 76.5%, and also inhibits HEK-Blue IL-6 cells viability to 15%^[1].
STAT3-IN-17 (2.5-40 μM; 24 h) inhibits the phosphorylation of STAT3 (Y705)^[1].
STAT3-IN-17 (10 μM, 50 μM; 48 h) inhibits HEK 293T cell growth, as well as inhibiting HeLa cell growth with an IC₅₀ value of 2.7 μM^[1].
(D)-PPA 1 (compound 24) inhibits microorganisms Helicobacter pylori and Campylobacter jejuni with MIC values of 1.6 μM and 4.7 μM, respectively^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

STAT3-IN-17 (compound 15) (5 mg/kg for ig, or 25 mg/kg for iv; single dose) exhibits greater pharmacokinetic properties than Nitazoxanide (HY-B0217) in rat, with a significantly longer half-life for elimination (t1/2β) (11.1 vs 0.8 h), greater absolute bioavailability (F) (87.4% vs 5.7%), and higher maximum plasma concentration (Cmax) (20.7 vs 1.0 mg/L) maximum plasma concentration (Cmax) (20.7 vs 1.0 mg/L)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

317.24

Formula

C₁₁H₆F₃N₃O₃S

CAS No.

1245814-52-1

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=C(C(F)(F)F)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (78.80 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1522 mL	15.7609 mL	31.5219 mL
5 mM	0.6304 mL	3.1522 mL	6.3044 mL
10 mM	0.3152 mL	1.5761 mL	3.1522 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (247 KB) HNMR (213 KB) LCMS (107 KB)

Handling Instructions (2659 KB)

References

[1]. Lü Z, et al. Structure-Activity Study of Nitazoxanide Derivatives as Novel STAT3 Pathway Inhibitors. ACS Med Chem Lett. 2021 Apr 1;12(5):696-703. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1522 mL	15.7609 mL	31.5219 mL	78.8047 mL
	5 mM	0.6304 mL	3.1522 mL	6.3044 mL	15.7609 mL
	10 mM	0.3152 mL	1.5761 mL	3.1522 mL	7.8805 mL
	15 mM	0.2101 mL	1.0507 mL	2.1015 mL	5.2536 mL
	20 mM	0.1576 mL	0.7880 mL	1.5761 mL	3.9402 mL
	25 mM	0.1261 mL	0.6304 mL	1.2609 mL	3.1522 mL
	30 mM	0.1051 mL	0.5254 mL	1.0507 mL	2.6268 mL
	40 mM	0.0788 mL	0.3940 mL	0.7880 mL	1.9701 mL
	50 mM	0.0630 mL	0.3152 mL	0.6304 mL	1.5761 mL
	60 mM	0.0525 mL	0.2627 mL	0.5254 mL	1.3134 mL

STAT3-IN-17 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-171245814-52-1STATInhibitorinhibitorinhibit

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STAT3-IN-17

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STAT3-IN-17 Related Antibodies

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Complete Stock Solution Preparation Table

STAT3-IN-17 Related Classifications

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