2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis
  4. Topoisomerase IIα-IN-3

Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis.

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Topoisomerase IIα-IN-3 Chemical Structure

Topoisomerase IIα-IN-3 Chemical Structure

CAS No. : 2538528-11-7

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Topoisomerase IIα-IN-3 Related Antibodies

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Description

Topoisomerase IIα-IN-3 (Compound 12c) is a DNA intercalative topoisomerase-IIα inhibitor. Topoisomerase IIα-IN-3 arrests cell cycle at the G0/G1 phase and induces apoptosis[1].

IC50 & Target

topoisomerase II alpha

 

In Vitro

Topoisomerase IIα-IN-3 (Compound 12c) shows cytotoxic potential with IC50 values of 2.82 ± 0.10, 3.28 ± 0.43, 4.09 ± 0.59, 4.78 ± 1.29, 3.83 ± 0.9,4 3.18 ± 0.49 and 71.25 ± 7.95 μM against A549, MDA-MB-231, BT-474, HCT-116, HL-60, THP-1 and BEAS-2B cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase IIα-IN-3 Related Antibodies
Molecular Weight

516.57

Formula

C29H20N6O2S
CAS No.
SMILES

O=C(C1=CC2=C(C(C3=CC=C(OC)C=C3)=N1)NC4=C2C=CC=C4)NC5=NN=C(C(N6)=CC7=C6C=CC=C7)S5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topoisomerase IIα-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase IIα-IN-32538528-11-7TopoisomeraseApoptosisA549MDA-MB-231BT-474HCT-116THP-1Inhibitorinhibitorinhibit

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