2-Hydrazinobenzothiazole

Cat. No.: HY-78699 Purity: 99.95%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

2-Hydrazinobenzothiazole is a potent IDO1 inhibitor with an IC₅₀ of 8 μM. 2-hydrazinobenzothiazole interacts with the IDO1 haem through hydrazine. 2-hydrazinobenzothiazole has the potential for immune system related diseases research.

For research use only. We do not sell to patients.

2-Hydrazinobenzothiazole Chemical Structure

CAS No. : 615-21-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 g	Get quote	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

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View All Isoforms

IDO1 IDO2 IDO

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

IDO1

8 μM (IC₅₀)

Molecular Weight

165.22

Formula

C₇H₇N₃S

CAS No.

615-21-4

Appearance

Solid

Color

White to off-white

SMILES

NNC1=NC2=CC=CC=C2S1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (605.25 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.0525 mL	30.2627 mL	60.5254 mL
5 mM	1.2105 mL	6.0525 mL	12.1051 mL
10 mM	0.6053 mL	3.0263 mL	6.0525 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.95%

Select Batch:

Data Sheet (271 KB) SDS (420 KB)

COA (247 KB) HNMR (111 KB) RP-HPLC (230 KB)

Handling Instructions (2659 KB)

References

[1]. Sai-Parng S Fung, et al. Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1). Bioorg Med Chem. 2013 Dec 15;21(24):7595-603. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.0525 mL	30.2627 mL	60.5254 mL	151.3134 mL
	5 mM	1.2105 mL	6.0525 mL	12.1051 mL	30.2627 mL
	10 mM	0.6053 mL	3.0263 mL	6.0525 mL	15.1313 mL
	15 mM	0.4035 mL	2.0175 mL	4.0350 mL	10.0876 mL
	20 mM	0.3026 mL	1.5131 mL	3.0263 mL	7.5657 mL
	25 mM	0.2421 mL	1.2105 mL	2.4210 mL	6.0525 mL
	30 mM	0.2018 mL	1.0088 mL	2.0175 mL	5.0438 mL
	40 mM	0.1513 mL	0.7566 mL	1.5131 mL	3.7828 mL
	50 mM	0.1211 mL	0.6053 mL	1.2105 mL	3.0263 mL
	60 mM	0.1009 mL	0.5044 mL	1.0088 mL	2.5219 mL
	80 mM	0.0757 mL	0.3783 mL	0.7566 mL	1.8914 mL
	100 mM	0.0605 mL	0.3026 mL	0.6053 mL	1.5131 mL