PKC

Protein kinase C

PKC

PKC Isoform Specific Products:

PKC Isoform Comparison

PKC Related Products (384)
Antibodies (21)
PKC Isoform Comparison

By Effects:	Controls (4) Ligand (1) Inhibitors (267) Substrates (2) Agonist (1) Antagonists (2) Activators (60) Modulators (5)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-18981R

Decursin (Standard)	Activator
Decursin (Standard) is the analytical standard of Decursin. This product is intended for research and analytical applications. Decursin ((+)-Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities[4].

HY-P5456

KRPpSQRHGSKY-NH2
KRPpSQRHGSKY-NH2 is a biological active peptide. (This is a phosphorylated PKC substrate peptide)

HY-135254

CP-46665 dihydrochloride	Inhibitor
CP-46665 dihydrochloride is an anticancer agent that inhibits the incorporation of tritiated thymidine into leukemia cells and human solid tumor cells in vitro. It can lead to the loss of surface characteristics in tumor cells and disrupt cell membranes, inhibiting cell proliferation.

HY-RS11120

Prkcb Mouse Pre-designed siRNA Set A	Inhibitor
Prkcb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkcb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prkcb Mouse Pre-designed siRNA Set A Prkcb Mouse Pre-designed siRNA Set A

HY-10539

Enzastaurin di(hydrochloride)	Inhibitor
Enzastaurin (LY317615) dihydrochloride is a potent and selective PKCβ inhibitor with an IC₅₀ of 6 nM, showing 6- to 20-fold selectivity over PKCα, PKCγ and PKCε.

HY-D1751

RIM-1
RIM-1 is a fluorescent probe for protein kinase C (PKC) that can be used to visualize the distribution of PKC in cells.

HY-124308

PS315	Inhibitor
PS315, a derivative of PS48 (HY-15967), is an allosteric PKC inhibitor by binding to the PIF-pocket of aPKC and inducing a displacement of the active site residue Lys111. PS315 inhibits the full-length and catalytic domain constructs of PKC_ζ (IC₅₀=10 μM) and PKC_η (IC₅₀=30 μM). PS315 has anti-cancer activity.

HY-108599R

DCP-LA (Standard)	Activator
DCP-LA (Standard) is the analytical standard of DCP-LA. This product is intended for research and analytical applications. DCP-LA (FR236924), a linoleic acid derivative, selectively and directly activates PKCε. DCP-LA activates Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and inhibits protein phosphatase-1 (PP-1) to stimulate AMPA receptor exocytosis. DCP-LA inhibits activation of caspase-3/-9 and protects neurons at least in part from oxidative stress-induced apoptosis[1][2][3].

HY-162234

PKCTheta-IN-1	Inhibitor
PKCTheta-IN-1 (Compound 19) is a selective macrocyclic PKCTheta inhibitor with IC₅₀ value of 0.1 nM.

HY-P3879

Protein Kinase C (660-673)
Protein Kinase C (660-673) (PKC βII (660-673)) is the PKC βII V5 peptide with RACK1-binding affinity.

HY-N8475

6-Deoxyisojacareubin	Inhibitor
6-Deoxyisojacareubin is a PKC inhibitor that inhibits the proliferation of QGY-7703 cells in a concentration-dependent manner. 6-Deoxyisojacareubin is also a natural product that can be obtained from Garcinia nervosa. 6-Deoxyisojacareubin can be used in cancer research.

HY-RS11126

Prkce Mouse Pre-designed siRNA Set A	Inhibitor
Prkce Mouse Pre-designed siRNA Set A contains three designed siRNAs for Prkce gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Prkce Mouse Pre-designed siRNA Set A Prkce Mouse Pre-designed siRNA Set A

HY-N4322R

Decursinol angelate (Standard)	Activator
Decursinol angelate (Standard) is the analytical standard of Decursinol angelate. This product is intended for research and analytical applications. Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities.

HY-P1289

[Ala113]MBP(104-118)	Inhibitor
[Ala113]MBP(104-118) is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC₅₀s ranging from 28-62 μM.

HY-P4856

pTH-Related Protein (1-40) (human, mouse, rat)	Activator
pTH-Related Protein (1-40) (human, mouse, rat) stimulates calcium uptake in rat intestinal cells through PTHR1 receptor and PKCα/β signaling pathways. pTH-Related Protein (1-40) up-regulates parathyroid hormone 1 receptor (PTHR1) protein, four transcellular calcium transporters, potential vanillin member 6 (TRPV6), calcium-binding protein-D9K (CaBP-D9k), sodium-calcium Exchanger 1 (NCX1) and plasma membrane calcium ATPase 1 (PMCA1).

HY-164041

Staurosporine-Boc	Inhibitor
Staurosporine-Boc, a natural product isolated from the actinomyces Streptomyces staurosporeus, is a potent non-selective inhibitor of protein kinase. Staurosporine-Boc inhibits a variety of protein kinases, including protein kinase C (PKC), tyrosine kinase, and serine/threonine kinase. Because of its broad inhibition profile, Staurosporine-Boc is widely used as a tool compound in biological research, especially when studying cell signaling pathways.

HY-RS11125

PRKCE Human Pre-designed siRNA Set A	Inhibitor
PRKCE Human Pre-designed siRNA Set A contains three designed siRNAs for PRKCE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRKCE Human Pre-designed siRNA Set A PRKCE Human Pre-designed siRNA Set A

HY-P3842

Protein Kinase C (661-671)
Protein Kinase C (661-671) is a fragment peptide of β1 subspecies of protein kinase C (PKC). PKC plays a role in cellular growth control and tumor promotion.

HY-120485

Raxofelast	Inhibitor
Raxofelast (IRFI-016) is an antioxidant agent in various models of ischemia-reperfusion injury. Raxofelast has antiproliferative activity in H₂O₂-stimulated rat aortic smooth muscle cells. Raxofelast attenuates the activation of mitogen-activating protein kinase (MAPK), ERK kinase 1, 2 (MEK1,2) and protein kinase C (PKC) without affecting Ras expression.

HY-P10218

MANS peptide	Inhibitor	99.85%
MANS peptide is an inhibitor for myristoylated alanine-rich C kinase substrate (MARCKS), which competes with MARCKS in cells for membrane binding, and thus inhibits the stimulation of mucin secretion and tumor metastasis.

PKC Isoform Comparison

PKC

PKCα

PKCβ

PKCγ

PKCδ

PKCε

PKCη

PKCζ

PKCθ

PKCμ

PKC-ι ℩

PKCι

PKC Inhibitors, Antagonists, Activators & Modulators

Product Name	PKC	PKCα	PKCβ	PKCγ	PKCδ	PKCε	PKCη	PKCζ	PKCθ	PKCμ	PKC-ι ℩	PKCι	Purity

Phorbol 12-myristate 13-acetate

PKC, EC₅₀: 11.7 nM

99.80%

Staurosporine

PKC, IC₅₀: 6 nM

99.98%

Go 6983

PKCα, IC₅₀: 7 nM

PKCβ, IC₅₀: 7 nM

PKCγ, IC₅₀: 6 nM

PKCδ, IC₅₀: 10 nM

PKCζ, IC₅₀: 60 nM

PKCμ, IC₅₀: 20000 nM

99.32%

PKC-IN-6

PKC-α, IC₅₀: 240 μM

PKCδ, IC₅₀: >500 μM

99.63%

Mitoxantrone

PKC, IC₅₀: 8.5 μM

99.58%

Midostaurin

cPKC-α, IC₅₀: 22 nM

cPKC-β1, IC₅₀: 30 nM
cPKC-β2, IC₅₀: 31 nM

cPKC-γ, IC₅₀: 24 nM

nPKC-δ, IC₅₀: 33 nM

nPKC-ε, IC₅₀: 1250 nM

nPKC-η, IC₅₀: 160 nM

aPKC-ζ, IC₅₀: 465000 nM

99.91%

Fasudil Hydrochloride

PKC, IC₅₀: 12.30 μM

99.97%

Bisindolylmaleimide I

Bovine brain PKC, IC₅₀: 10 nM

PKCα, IC₅₀: 20 nM

PKCβII, IC₅₀: 16 nM
PKCβI, IC₅₀: 17 nM

PKCγ, IC₅₀: 20 nM

98.15%

Rottlerin

PKCα, IC₅₀: 30 μM (baculovirus-infected Sf9 insect cells)

PKCβ, IC₅₀: 42 μM (baculovirus-infected Sf9 insect cells)

PKCγ, IC₅₀: 40 μM (baculovirus-infected Sf9 insect cells)

PKCδ, IC₅₀: 3 μM (Porcine spleen)

PKCε, IC₅₀: 100 μM (baculovirus-infected Sf9 insect cells)

PKCη, IC₅₀: 82 μM (baculovirus-infected Sf9 insect cells)

PKCζ, IC₅₀: 100 μM (baculovirus-infected Sf9 insect cells)

98.45%

Verbascoside

PKC, IC₅₀: 25 μM

99.83%

Sotrastaurin

PKCα, Ki: 0.95 nM

PKCβI, Ki: 0.64 nM

PKCδ, Ki: 2.1 nM

PKCε, Ki: 3.2 nM

PKCη, Ki: 1.8 nM

PKCθ, Ki: 0.22 nM

99.79%

Mitoxantrone dihydrochloride

PKC, IC₅₀: 8.5 μM

99.55%

D-erythro-Sphingosine

PKC

≥98.0%

Ingenol Mebutate

PKC-α, Ki: 0.3 nM

PKC-β, Ki: 0.105 nM

PKC-γ, Ki: 0.162 nM

PKC-δ, Ki: 0.376 nM

PKC-ε, Ki: 0.171 nM

99.65%

Chelerythrine chloride

PKC, IC₅₀: 660 nM

99.42%

Enzastaurin

PKCα, IC₅₀: 39 nM

PKCβ, IC₅₀: 6 nM

PKCγ, IC₅₀: 83 nM

PKCε, IC₅₀: 110 nM

99.92%

Afuresertib

PKC-βI, IC₅₀: 430 nM

PKCη, IC₅₀: 210 nM

PKCθ, IC₅₀: 510 nM

99.53%

TPPB

PKC, Ki: 11.9 nM

99.92%

Darovasertib

PKCα, IC₅₀: 1.9 nM

PKCθ, IC₅₀: 0.4 nM

99.42%

DCP-LA

PKCε

≥98.0%

Ro 31-8220 mesylate

Rat Brain PKC, IC₅₀: 23 nM

PKC-α, IC₅₀: 5 nM

PKC-βI, IC₅₀: 24 nM
PKC-βII, IC₅₀: 14 nM

PKC-γ, IC₅₀: 27 nM

PKC-ε, IC₅₀: 24 nM

99.57%

Daphnetin

PKC, IC₅₀: 25.01 μM

99.86%

CGP60474

PKC

99.23%

KT5823

PKC, Ki: 4 μM

99.90%

CMPD101

PKCα, IC₅₀: 8.1 μM

98.95%

Prostratin

PKC, Ki: 12.5 nM

99.80%

BJE6-106

PKCα, IC₅₀: 50 μM

PKCδ, IC₅₀: 0.05 μM

99.93%

Ruboxistaurin

PKCα, IC₅₀: 360 nM

PKC-βI, IC₅₀: 4.7 nM
PKC-βII, IC₅₀: 5.9 nM

PKCγ, IC₅₀: 300 nM

PKCδ, IC₅₀: 250 nM

PKCε, IC₅₀: 600 nM

PKCη, IC₅₀: 52 nM

99.48%

R 59-022

PKC

99.82%

Ingenol

PKC, Ki: 30 μM

99.51%

(-)-Indolactam V

PKCα-C1A-long, Kd: 20.8 nM
PKCα-C1B-long, Kd: 4000 nM

PKCβ-C1A-long, Kd: 18.9 nM
PKCβ-C1B, Kd: 137 nM

PKCγ-C1A, Kd: 138 nM
PKCγ-C1B, Kd: 213 nM
PKCγ-CRD2, Ki: 1030 nM

PKCδ-C1B, Kd: 8.3 nM
PKCδ-C1A, Kd: 1900 nM

PKCε-C1B, Kd: 7.7 nM
PKCε-C1A, Kd: 4110 nM

PKCη-CRD2, Ki: 3.36 nM
PKCη-C1B, Kd: 5.5 nM
PKCη-C1A, Kd: 3770 nM

PKCθ-C1B, Kd: 8.7 nM

98.75%

CC-90005

PKCθ, IC₅₀: 8 nM

99.67%

Valrubicin

TPA-activated PKC, IC₅₀: 0.85 μM
PDBu-activated PKC, IC₅₀: 1.25 μM

99.60%

PKCβ inhibitor 1

PKCα, IC₅₀: 331 nM

human PKCβ1, IC₅₀: 21 nM
human PKCβ2, IC₅₀: 5 nM

99.40%

PKC-theta inhibitor 2

PKCθ, IC₅₀: 18 nM

99.37%

Epsilon-V1-2

PKCε

VTX-27

PKCα, Ki: 356 nM

PKCδ, Ki: 16 nM

PKCθ, Ki: 0.08 nM

99.02%

PKC-IN-1

Human PKCα, IC₅₀: 2.3 nM
Human PKCα, Ki: 10.4 nM

Human PKCβII, IC₅₀: 7.6 nM
Human PKCβI, IC₅₀: 8.1 nM
Human PKCβ, Ki: 5.3 nM

Human PKCγ, IC₅₀: 57.5 nM

Human PKCε, IC₅₀: 808 nM

Human PKCθ, IC₅₀: 25.6 nM

Human PKC mu, IC₅₀: 314 nM

99.79%

Delcasertib hydrochloride

δPKC

99.86%

HA-100

PKC, IC₅₀: 12 μM
PKC, Ki: 6.5 μM

99.80%

Bisindolylmaleimide X hydrochloride

PKC

98.90%

CRT0066854

PKCζ, IC₅₀: 639 nM

99.54%

Afuresertib hydrochloride

PKC-βI, IC₅₀: 430 nM

PKCη, IC₅₀: 210 nM

PKCθ, IC₅₀: 510 nM

99.95%

Aurothiomalate sodium

PKCι

≥98.0%

Ruboxistaurin hydrochloride

PKCα, IC₅₀: 360 nM

PKCβI, IC₅₀: 4.7 nM
PKCβII, IC₅₀: 5.9 nM

PKCγ, IC₅₀: 300 nM

PKCδ, IC₅₀: 250 nM

PKCε, IC₅₀: 600 nM

PKCη, IC₅₀: 52 nM

99.94%

TCS 21311

PKCα, IC₅₀: 13 nM

PKCθ, IC₅₀: 68 nM

99.18%

SB-218078

PKC, IC₅₀: 1000 nM

98.30%

ζ-Stat

aPKC-ζ, IC₅₀: 5 μM

Psychosine

PKC

≥99.0%

N-Desmethyltamoxifen hydrochloride

PKC

99.93%

PKCiota-IN-2 formic

PKCα, IC₅₀: 71 nM

PKCε, IC₅₀: 350 nM

PKCι, IC₅₀: 2.8 nM

99.04%

PKC-theta inhibitor 1

PKCα, Ki: 1020 μM

PKCδ, Ki: 392 μM

PKCθ, Ki: 6 nM

99.73%

Reproxalap

PKCα

98.85%

PS432

PKCζ, IC₅₀: 18.5 μM

PKCι, IC₅₀: 16.9 μM

≥99.0%

C8-Ceramide

PKC

≥98.0%

Bisindolylmaleimide IV

PKC, IC₅₀: 0.1-0.55 μM

99.62%

Bisindolylmaleimide VIII acetate

Rat Brain PKC, IC₅₀: 158 nM

PKC-α, IC₅₀: 53 nM

PKC-βI, IC₅₀: 195 nM
PKC-βII, IC₅₀: 163 nM

PKC-γ, IC₅₀: 213 nM

PKC-ε, IC₅₀: 175 nM

99.68%

Bisindolylmaleimide I hydrochloride

Bovine brain PKC, IC₅₀: 10 nM

PKCα, IC₅₀: 20 nM

PKC-βII, IC₅₀: 16 nM
PKC-βI, IC₅₀: 17 nM

PKCγ, IC₅₀: 20 nM

99.18%

Spisulosine

PKCζ

99.00%

R 59-022 hydrochloride

PKC

98.88%

Bisindolylmaleimide III

PKCα

98.95%

Protein kinase inhibitor H-7

PKC, Ki: 6 μM

99.96%

ML192

PKCβII

Ruboxistaurin mesylate

PKCα, IC₅₀: 360 nM

PKC-βI, IC₅₀: 4.7 nM
PKC-βII, IC₅₀: 5.9 nM

PKCγ, IC₅₀: 300 nM

PKCδ, IC₅₀: 250 nM

PKCε, IC₅₀: 600 nM

PKCη, IC₅₀: 52 nM

99.87%

Sphingosine (d14:1)

PKC

≥99.0%

CRT0066854 hydrochloride

PKCζ, IC₅₀: 639 nM

99.29%

Bisindolylmaleimide XI hydrochloride

PKC-α, IC₅₀: 9 nM

PKC-βI, IC₅₀: 28 nM
PKC-βII, IC₅₀: 31 nM

PKC-γ, IC₅₀: 37 nM

PKC-ε, IC₅₀: 108 nM

≥98.0%

SB 220025

PKC, IC₅₀: 2.89 μM

99.90%

A-3 hydrochloride

PKC, Ki: 47 μM

99.75%

PF-4950834

PKCη, IC₅₀: 756 nM

99.60%

Hu7691

PKCη, IC₅₀: 629 nM

99.91%

ζ-Stat trisodium

aPKC-ζ, IC₅₀: 5 μM

Chelerythrine

PKC, IC₅₀: 0.7 μM

CDK8-IN-12

PKCθ, Ki: 109 nM

99.74%

CGP-53353

PKCβII, IC₅₀: 0.41 mM
PKCβI, IC₅₀: 3.8 mM

98.87%

OSU-2S

PKCδ

TAS-301

PKC

99.61%

Delcasertib

δPKC

98.21%

(S)-Ro 32-0432

PKCα, IC₅₀: 9.3 nM

PKC-βI, IC₅₀: 28 nM
PKC-βII, IC₅₀: 30 nM

PKCγ, IC₅₀: 36.5 nM

PKCε, IC₅₀: 108.3 nM

DCPLA-ME

PKCε

≥98.0%

Fasudil

PKC, IC₅₀: 12.3 μM

Ro 31-8220

Rat Brain PKC, IC₅₀: 23 nM

PKC-α, IC₅₀: 5 nM

PKC-βII, IC₅₀: 14 nM
PKC-βI, IC₅₀: 24 nM

PKC-γ, IC₅₀: 27 nM

PKC-ε, IC₅₀: 24 nM

PKCTheta-IN-2

PKCθ, IC₅₀: 0.25 nM

99.49%

Hu7691 free base

PKCη, IC₅₀: 629 nM

Fasudil dihydrochloride

PKC, IC₅₀: 12.3 μM

Mitoxantrone diacetate

PKC, IC₅₀: 8.5 μM

Fasudil hydrochloride semihydrate

PKC, IC₅₀: 12.3 μM

PKC-IN-4

PKC, IC₅₀: 0.52 μM

PKCiota-IN-2

PKCα, IC₅₀: 71 nM

PKCε, IC₅₀: 350 nM

PKCι, IC₅₀: 2.8 nM

N-Desmethyltamoxifen

PKC

HBDDE

PKCα, IC₅₀: 43 μM

PKCγ, IC₅₀: 50 μM

98.03%

PKC β pseudosubstrate

PKC-β

98.98%

Evo312

PKC-βI, IC₅₀: 117.34 nM

PS315

PKCη, IC₅₀: 30 μM

PKCζ, IC₅₀: 10 μM

PKCTheta-IN-1

PKCθ, IC₅₀: 0.1 nM

[Ala113]MBP(104-118)

PKC, IC₅₀: 28-62 μM

PF-04577806

PKCα, IC₅₀: 2.4 nM

PKCβI, IC₅₀: 8.1 nM
PKCβII, IC₅₀: 6.9 nM

PKCγ, IC₅₀: 45.9 nM

PKCδ, IC₅₀: 586 nM

PKCε, IC₅₀: 522 nM

PKCθ, IC₅₀: 29.5 nM

Leucosceptoside A

PKCα, IC₅₀: 19 μM

PKCδ Peptide Substrate

PKCδ

AS2521780

PKCα, IC₅₀: 160 nM

PKCδ, IC₅₀: 160 nM

PKCε, IC₅₀: 18 nM

PKCθ, IC₅₀: 0.48 nM

Aurora A/PKC-IN-1

PKCα, IC₅₀: 16.9 nM

HA-100 hydrochloride

PKC, IC₅₀: 12 μM

PF-03622905

PKCα, IC₅₀: 5.6 nM

PKCβI, IC₅₀: 14.5 nM
PKCβII, IC₅₀: 13 nM

PKCγ, IC₅₀: 37.7 nM

PKCθ, IC₅₀: 74.1 nM

[Ala107]MBP(104-118)

PKC, IC₅₀: 46-145 μM

HA-100 dihydrochloride

PKC, IC₅₀: 12 μM
PKC, Ki: 6.5 μM

PKC β pseudosubstrate TFA

PKCβ

[Ala113]MBP(104-118) TFA

PKC, IC₅₀: 28-62 μM

PKCiota-IN-1

PKCα, IC₅₀: 45 nM

PKCε, IC₅₀: 450 nM

PKCι, IC₅₀: 2.7 nM

CIDD-0072424

PKCε, Ki: 54 nM

GSK-3β inhibitor 13

PKCθ, IC₅₀: 0.36 μM

[Ala107]MBP(104-118) TFA

PKC, IC₅₀: 46-145 μM

Dioleyl phosphatidylserine

PKCγ

(Rac)-Aurora A/PKC-IN-1

PKCα, IC₅₀: 16.9 nM

PKCβI, IC₅₀: 12.1 nM
PKCβII, IC₅₀: 11.3 nM

PKCθ, IC₅₀: 4.2 nM

Bisindolylmaleimide VIII

Rat Brain PKC, IC₅₀: 158 nM

PKCα, IC₅₀: 53 nM

PKC-βI, IC₅₀: 195 nM
PKC-βII, IC₅₀: 163 nM

PKCγ, IC₅₀: 213 nM

PKCε, IC₅₀: 175 nM

Balanol

Human PKCα, : 4-9 nM

PKC-βI, : 4-9 nM
PKC-βII, : 4-9 nM

Human PKCγ, : 4-9 nM

Human PKCδ, : 4-9 nM

Human PKCε, : 4-9 nM

human PKCη, : 150 nM

CMPD101 hydrochloride

PKCα, IC₅₀: 8.1 μM

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PKC

PKC

PKC Isoform Specific Products:

PKC Isoform Specific Products:

PKC Related Products (384)

Antibodies (21)

PKC Isoform Comparison

PKC Related Products (384):