2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. AT 1001

AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) (Ki=2.64 nM). AT 1001 reversibly blocks inward currents induced by Epibatidine (HY-101078) in HEK cells transfected with α3β4 nAChR. AT-1001 dose-dependently inhibits nicotine self-administration behavior in rats without affecting food-reinforced responding. AT 1001 can be utilized in the research of nicotine addiction and smoking cessation therapies.

For research use only. We do not sell to patients.

AT 1001 Chemical Structure

AT 1001 Chemical Structure

CAS No. : 1314801-63-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 261 In-stock
Solution
10 mM * 1 mL in DMSO USD 275 In-stock
Solid
5 mg USD 250 In-stock
10 mg USD 400 In-stock
25 mg USD 700 In-stock
50 mg USD 980 In-stock
100 mg USD 1380 In-stock
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Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE AT 1001

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Description

AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) (Ki=2.64 nM). AT 1001 reversibly blocks inward currents induced by Epibatidine (HY-101078) in HEK cells transfected with α3β4 nAChR. AT-1001 dose-dependently inhibits nicotine self-administration behavior in rats without affecting food-reinforced responding. AT 1001 can be utilized in the research of nicotine addiction and smoking cessation therapies[1].

Molecular Weight

309.24

Formula

C15H21BrN2
CAS No.
Appearance

Solid

Color

Brown to dark brown

SMILES

BrC(C=CC=C1)=C1N[C@H]2C[C@@H]3N(C)[C@@H](CCC3)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (161.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2337 mL 16.1687 mL 32.3373 mL
5 mM 0.6467 mL 3.2337 mL 6.4675 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation

Purity: 99.94%

Data Sheet (273 KB) SDS (393 KB)

COA (250 KB) HNMR (132 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2337 mL 16.1687 mL 32.3373 mL 80.8434 mL
5 mM 0.6467 mL 3.2337 mL 6.4675 mL 16.1687 mL
10 mM 0.3234 mL 1.6169 mL 3.2337 mL 8.0843 mL
15 mM 0.2156 mL 1.0779 mL 2.1558 mL 5.3896 mL
20 mM 0.1617 mL 0.8084 mL 1.6169 mL 4.0422 mL
25 mM 0.1293 mL 0.6467 mL 1.2935 mL 3.2337 mL
30 mM 0.1078 mL 0.5390 mL 1.0779 mL 2.6948 mL
40 mM 0.0808 mL 0.4042 mL 0.8084 mL 2.0211 mL
50 mM 0.0647 mL 0.3234 mL 0.6467 mL 1.6169 mL
60 mM 0.0539 mL 0.2695 mL 0.5390 mL 1.3474 mL
80 mM 0.0404 mL 0.2021 mL 0.4042 mL 1.0105 mL
100 mM 0.0323 mL 0.1617 mL 0.3234 mL 0.8084 mL
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AT 1001 Related Classifications

Keywords:

AT 10011314801-63-2AT1001AT-1001nAChRNicotinic acetylcholine receptorsSelective antagonistacetylcholineHEK cellsNicotineself-administrationInhibitorinhibitorinhibit

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SAFETY DATA SHEET (SDS)

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