2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. AT 1001

AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) (Ki=2.64 nM). AT 1001 reversibly blocks inward currents induced by Epibatidine (HY-101078) in HEK cells transfected with α3β4 nAChR. AT-1001 dose-dependently inhibits nicotine self-administration behavior in rats without affecting food-reinforced responding. AT 1001 can be utilized in the research of nicotine addiction and smoking cessation therapies.

For research use only. We do not sell to patients.

AT 1001 Chemical Structure

AT 1001 Chemical Structure

CAS No. : 1314801-63-2

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10 mg USD 400 In-stock
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Description

AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) (Ki=2.64 nM). AT 1001 reversibly blocks inward currents induced by Epibatidine (HY-101078) in HEK cells transfected with α3β4 nAChR. AT-1001 dose-dependently inhibits nicotine self-administration behavior in rats without affecting food-reinforced responding. AT 1001 can be utilized in the research of nicotine addiction and smoking cessation therapies[1].

Molecular Weight

309.24

Formula

C15H21BrN2
CAS No.
SMILES

BrC(C=CC=C1)=C1N[C@H]2C[C@@H]3N(C)[C@@H](CCC3)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (161.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2337 mL 16.1687 mL 32.3373 mL
5 mM 0.6467 mL 3.2337 mL 6.4675 mL
View the Complete Stock Solution Preparation Table

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2337 mL 16.1687 mL 32.3373 mL 80.8434 mL
5 mM 0.6467 mL 3.2337 mL 6.4675 mL 16.1687 mL
10 mM 0.3234 mL 1.6169 mL 3.2337 mL 8.0843 mL
15 mM 0.2156 mL 1.0779 mL 2.1558 mL 5.3896 mL
20 mM 0.1617 mL 0.8084 mL 1.6169 mL 4.0422 mL
25 mM 0.1293 mL 0.6467 mL 1.2935 mL 3.2337 mL
30 mM 0.1078 mL 0.5390 mL 1.0779 mL 2.6948 mL
40 mM 0.0808 mL 0.4042 mL 0.8084 mL 2.0211 mL
50 mM 0.0647 mL 0.3234 mL 0.6467 mL 1.6169 mL
60 mM 0.0539 mL 0.2695 mL 0.5390 mL 1.3474 mL
80 mM 0.0404 mL 0.2021 mL 0.4042 mL 1.0105 mL
100 mM 0.0323 mL 0.1617 mL 0.3234 mL 0.8084 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AT 10011314801-63-2AT1001AT-1001nAChRNicotinic acetylcholine receptorsSelective antagonistacetylcholineHEK cellsNicotineself-administrationInhibitorinhibitorinhibit

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