Dihydrocucurbitacin B

Cat. No.: HY-N4171 Purity: 96.76%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Dihydrocucurbitacin B, a triterpene isolated from Cayaponia tayuya roots, inhibits nuclear factor of activated T cells (NFAT), induces cell cycle arrested in the G0 phase, and inhibits delayed type hypersensitivity.

For research use only. We do not sell to patients.

Dihydrocucurbitacin B Chemical Structure

CAS No. : 13201-14-4

Size	Price	Stock	Quantity
5 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	12.09 μM Compound: 1, DHB	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 22472043]
A549	IC₅₀	19.91 μM Compound: 1, DHB	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 22472043]
C8166	CC₅₀	25.5 μg/mL Compound: 5	Cytotoxicity against human C8166 cells by MTT method Cytotoxicity against human C8166 cells by MTT method	[PMID: 18088099]
C8166	EC₅₀	4.2 μg/mL Compound: 5	Antiviral activity against HIV1 in C8166 cells after 72 hrs Antiviral activity against HIV1 in C8166 cells after 72 hrs	[PMID: 18088099]
MCF7	IC₅₀	46.3 μM Compound: 10	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by MTS/PMS assay	[PMID: 25756299]

Molecular Weight

560.72

Formula

C₃₂H₄₈O₈

CAS No.

13201-14-4

Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@]([C@]([C@@](C)(O)C(CCC(C)(C)OC(C)=O)=O)([H])[C@H](O)C1)(CC([C@]3(C)[C@@]2([H])CC=C(C4(C)C)[C@@]3([H])C[C@H](O)C4=O)=O)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (178.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7834 mL	8.9171 mL	17.8342 mL
5 mM	0.3567 mL	1.7834 mL	3.5668 mL
10 mM	0.1783 mL	0.8917 mL	1.7834 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.76%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (252 KB) HNMR (284 KB) LCMS (276 KB)

Handling Instructions (2659 KB)

References

[1]. Escandell JM, et al. Dihydrocucurbitacin B inhibits delayed type hypersensitivity reactions by suppressing lymphocyte proliferation. J Pharmacol Exp Ther. 2007 Sep;322(3):1261-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7834 mL	8.9171 mL	17.8342 mL	44.5855 mL
	5 mM	0.3567 mL	1.7834 mL	3.5668 mL	8.9171 mL
	10 mM	0.1783 mL	0.8917 mL	1.7834 mL	4.4586 mL
	15 mM	0.1189 mL	0.5945 mL	1.1889 mL	2.9724 mL
	20 mM	0.0892 mL	0.4459 mL	0.8917 mL	2.2293 mL
	25 mM	0.0713 mL	0.3567 mL	0.7134 mL	1.7834 mL
	30 mM	0.0594 mL	0.2972 mL	0.5945 mL	1.4862 mL
	40 mM	0.0446 mL	0.2229 mL	0.4459 mL	1.1146 mL
	50 mM	0.0357 mL	0.1783 mL	0.3567 mL	0.8917 mL
	60 mM	0.0297 mL	0.1486 mL	0.2972 mL	0.7431 mL
	80 mM	0.0223 mL	0.1115 mL	0.2229 mL	0.5573 mL
	100 mM	0.0178 mL	0.0892 mL	0.1783 mL	0.4459 mL