Faah - fatty acid amide hydrolase Gene

Rattus norvegicus

Gene ID: 100911581 | Gene type: protein coding

About Faah

Primary_assembly 5: 129,479,824-129,498,677 reverse strand.mRatBN7.2:CM026978.1

This gene has 2 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 6 phenotypes. Biased expression in Liver (RPKM 24.3), Brain (RPKM 57.9) and 6 other tissues.

Summary

Enables several functions, including acylglycerol Lipase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; and identical protein binding activity. Involved in fatty acid catabolic process; monoacylglycerol catabolic process; and positive regulation of vasoconstriction. Located in organelle membrane. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Apr 2022]

Faah Products(1)

mRNA	Protein	Name
NM_001369126.1	NP_001356055.1	fatty-acid amide hydrolase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amidase activity	IDA IDA: Inferred from direct assay	12734197	RGD
enables fatty acid amide hydrolase activity	IDA IDA: Inferred from direct assay	9122178	RGD
enables fatty acid amide hydrolase activity	IMP IMP: Inferred from mutant phenotype	17545313	RGD
enables hydrolase activity, acting on ester bonds	IDA IDA: Inferred from direct assay	12734197	RGD
enables identical protein binding	IMP IMP: Inferred from mutant phenotype	17158103	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	12459591	RGD
enables lipid binding	IDA IDA: Inferred from direct assay	12734197	RGD
enables monoacylglycerol lipase activity	IDA IDA: Inferred from direct assay	17649977	RGD
enables phospholipid binding	IMP IMP: Inferred from mutant phenotype	17158103	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	27191843	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid catabolic process	IDA IDA: Inferred from direct assay	9122178	RGD
involved in fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	17545313	RGD
involved in monoacylglycerol catabolic process	IDA IDA: Inferred from direct assay	17649977	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	17245358	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in organelle membrane	IDA IDA: Inferred from direct assay	9122178	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	15233753	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	15233753	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Faah Protein Structure

Amidase

0
100
200
300
400
500
579 a.a.

Protein Preferred Names

Protein Names

fatty-acid amide hydrolase 1

anandamide amidase	anandamide amidohydrolase 1
fatty acid ester hydrolase	oleamide hydrolase 1

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1227	Carprofen	Inhibitor	99.83%	Unkown
HY-B0182	Carmofur	Inhibitor	99.95%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14376	Redafamdastat	Inhibitor	99.89%	Phase 2
HY-19636	JNJ-42165279	Inhibitor	99.87%	Phase 2
HY-10864	URB-597	Inhibitor	99.15%	Phase 1

Pre-clinical Phase

Bioactive Molecules (78)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14595	Biochanin A	Inhibitor	99.29%	Unkown
HY-119283	MAGL-IN-5	Inhibitor	99.58%	Unkown
HY-14380	PF-3845	Inhibitor	99.95%	Unkown
HY-15250	JZL195	Inhibitor	99.75%	Unkown
HY-19740	BIA 10-2474	Inhibitor	99.39%	Unkown
HY-N7062	JNJ-1661010	Inhibitor	99.77%	Unkown
HY-116477	URB937	Inhibitor	99.85%	Unkown
HY-136924	FP-Biotin		99.84%	Unkown
HY-N2512	1-Monomyristin	Inhibitor	≥98.0%	Unkown
HY-10865	LY2183240	Inhibitor	98.01%	Unkown
HY-125967	AM 374	Inhibitor	≥97.0%	Unkown
HY-155773	VU534	Inhibitor	98.53%	Unkown
HY-103462	TC-F2	Inhibitor	99.75%	Unkown
HY-103337	N-Arachidonoylserotonin	Inhibitor	≥98.0%	Unkown
HY-103461	FAAH-IN-6	Inhibitor	99.70%	Unkown
HY-79511	FAAH-IN-2	Inhibitor	98.21%	Unkown
HY-18081	PF 750	Inhibitor	99.29%	Unkown
HY-N2365	Macamide B	Inhibitor	98.64%	Unkown
HY-127023	Eicosapentaenoyl serotonin	Inhibitor	≥99.0%	Unkown
HY-123863	SSR411298	Inhibitor	99.75%	Unkown
HY-152254	CB2R/FAAH modulator-3	Inhibitor	99.71%	Unkown
HY-18544	AA38-3	Inhibitor	99.89%	Unkown
HY-118158	FAAH/MAGL-IN-4	Inhibitor	99.83%	Unkown
HY-18080	SA 47	Inhibitor	≥99.0%	Unkown
HY-164495	Sob-AM2		/	Unkown
HY-N3033	N-Benzyllinolenamide	Inhibitor	99.70%	Unkown
HY-18013	JNJ-40355003	Inhibitor	99.81%	Unkown
HY-10862	FAAH inhibitor 1	Inhibitor	98.91%	Unkown
HY-W751418	N-Nervonoyl taurine		/	Unkown
HY-111199	JP83	Inhibitor	≥99.0%	Unkown
HY-111389	FAAH-IN-1	Inhibitor	99.93%	Unkown
HY-10867	PF-622	Inhibitor	/	Unkown
HY-146342	FAAH/MAGL-IN-3	Inhibitor	/	Unkown
HY-148909	Isopropyl dodec-11-enylfluorophosphonate	Inhibitor	/	Unkown
HY-157766	FAAH/TRPV1 blocker-1	Inhibitor	/	Unkown
HY-120961	Oleoyl ethyl amide	Inhibitor	/	Unkown
HY-14595R	Biochanin A (Standard)	Inhibitor	/	Unkown
HY-116710	3-Decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone	Inhibitor	/	Unkown
HY-B1227S1	Carprofen-13C,d3		/	Unkown
HY-144738	Dual FAAH/sEH-IN-1	Inhibitor	/	Unkown
HY-149654	FAAH/cPLA2α-IN-1	Inhibitor	/	Unkown
HY-102054	Acetylhydrolase-IN-1	Inhibitor	/	Unkown
HY-115004	MM-433593		/	Unkown
HY-143263	FAAH/MAGL-IN-1	Inhibitor	/	Unkown
HY-103463	SA57	Inhibitor	≥99.0%	Unkown
HY-B1227S	Carprofen-d3	Inhibitor	/	Unkown
HY-103338	AM1172	Inhibitor	/	Unkown
HY-143264	FAAH/MAGL-IN-2	Inhibitor	/	Unkown
HY-152253	CB2R/FAAH modulator-2	Inhibitor	/	Unkown
HY-151919	FAAH-IN-7	Inhibitor	/	Unkown
HY-120369	URB532	Inhibitor	/	Unkown
HY-N2428	N-(3-Methoxybenzyl)Palmitamide	Inhibitor	99.96%	Unkown
HY-146341	FAAH-IN-5	Inhibitor	/	Unkown
HY-152251	CB2R/FAAH modulator-1	Inhibitor	/	Unkown
HY-139143	WWL154	Inhibitor	/	Unkown
HY-W728451	URB694	Inhibitor	/	Unkown
HY-121558	JP104	Inhibitor	/	Unkown
HY-163733	AKU-005	Inhibitor	/	Unkown
HY-147910	Carpro-AM1	Inhibitor	/	Unkown
HY-122159	MDPD	Activator	/	Unkown
HY-12909	MK-4409	Inhibitor	/	Unkown
HY-168563	BuChE-IN-15	Inhibitor	/	Unkown
HY-164506	NRMA-8	Modulator	/	Unkown
HY-10869	OL-135	Inhibitor	/	Unkown
HY-157132	FAAH-IN-8	Inhibitor	/	Unkown
HY-103339	VDM11	Inhibitor	/	Unkown
HY-139384	FAAH inhibitor 2	Inhibitor	/	Unkown
HY-120481	JNJ-40413269	Inhibitor	/	Unkown
HY-111293	Arachidonamide		/	Unkown
HY-121090	FAAH-IN-9	Inhibitor	/	Unkown
HY-77491	FAAH/MAGL-IN-5	Inhibitor	99.17%	Unkown
HY-158784	Arachidonoyl m-nitroaniline		/	Unkown
HY-161965	MK-3168 (12C)	Inhibitor	/	Unkown
HY-120650	CAY10435	Inhibitor	/	Unkown
HY-19636A	JNJ-42165279 dihydrochloride	Inhibitor	/	Unkown
HY-124744	ASP 8477	Inhibitor	/	Unkown
HY-118210	PHOP	Inhibitor	/	Unkown
HY-U00240	SA72	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Faah	NCBI	NCBI:2166

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