CGA - glycoprotein hormones, alpha polypeptide Gene

Homo sapiens

Also known as HCG; LHA; FSHA; GPA1; GPHa; TSHA; GPHA1; CG-ALPHA

Gene ID: 1081 | Gene type: protein coding

About CGA

Cytogenetic location: 6q14.3 Genomic coordinates (GRCh38): 6:87,085,498-87,095,106 (from NCBI)

This gene has 6 transcripts (splice variants) and 214 orthologues. Restricted expression toward placenta (RPKM 388.3).

Summary

The four human glycoprotein Hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these Hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein Hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

CGA Products(2)

mRNA	Protein	Name
NM_000735.4	NP_000726.1	glycoprotein hormones alpha chain isoform 2 precursor
NM_001252383.2	NP_001239312.1	glycoprotein hormones alpha chain isoform 1 precursor

CGA Protein Structure

Hormone_6

0
100
116 a.a.

Protein Preferred Names

Protein Names

glycoprotein hormones alpha chain

FSH-alpha

Recombinant CGA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7869	CG alpha Protein, Human (HEK293, His)	P01215 (A25-S116)	≥95%
HY-P7870	CGA-CGB3 Heterodimer Protein, Human (HEK293, His)	P01215 (A25-S116)&P0DN86 (S21-Q165)	≥95%
HY-P70237	FSH Protein, Human (HEK293, Flag-His)	P01215 (A25-S116) & P01225 (N19-E129)	≥95%
HY-P74133	FSH Protein, Human (HEK293, Fc)	P01215 (A25-S116)&P01225 (N19-E129)	≥95%
HY-P75341	CG alpha Protein, Human (HEK293, mFc)	P01215 (A25-S116)	≥95%
HY-P75342	CG alpha Protein, Human (HEK293)	NP_000726.1 (A25-S116)	≥95%

Related Diseases

Diseases

Alias

Ectopic Pregnancy

Eccyesis	Pregnancy Ectopic
Pregnancy, Ectopic	Ectopic Pregnancies
Extrauterine Gestation Or Pregnancy	Extrauterine Pregnancy
Ep - [Ectopic Pregnancy]	Ectopic Mole
Aborted Ectopic Pregnancy	Ruptured Ectopic Pregnancy

Ovarian Hyperstimulation Syndrome

OHSS	Ovarian Hyperstimulation Syndrome, Familial Gestational Spontaneous
Secondary Meig'S Syndrome	Ohss - [Ovarian Hyperstimulation Syndrome]
Hyperstimulation Of Ovaries Nos	Hyperstimulation Of Ovaries Associated With Induced Ovulation

Ovarian Disease

Ovarian Dysfunction	Ovarian Diseases
Ovarian Disorders	Disorder Of Endocrine Ovary

Germ Cell Cancer

Malignant Germ Cell Tumor	Neoplasms, Germ Cell And Embryonal
Germ Cell Neoplasm	Germ Cell Tumour
Malignant Tumor Of The Germ Cell	Neoplasms Germ Cell
Malignant Germ Cell Neoplasm

Germinoma

Anovulation

Choriocarcinoma

Chorioepithelioma

Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole	Gestational Trophoblastic Disease
Complete Hydatidiform Mole	Hydm
HYDM1	Chm
Molar Pregnancy	Hydatidiform Mole, Complete
Hydatid Mole	Complete Molar Pregnancy
Mole, Hydatidiform, Recurrent, Type 1	Gestational Trophoblastic Neoplasms
Hydatidiform Mole, Recurrent, 2	Classical Hydatidiform Mole

Polycystic Ovary Syndrome

Polycystic Ovarian Syndrome	Pcos
Polycystic Ovarian Disease	Polycystic Ovaries
Stein-Leventhal Syndrome	Multicystic Ovaries
Polycystic Ovary	Sclerocystic Ovaries
Sclerocystic Ovary Syndrome	Stein-Leventhal Synd.
Cystic Disease Of Ovaries	Cystic Disease Of Ovary
Pco	Pcod
Sclerocystic Ovarian Degeneration	Polycystic Ovary Syndrome, Susceptibility To
Pcos - [Polycystic Ovary Syndrome]	Polycystic Ovary Nos
Pco - [Polycystic Ovary]

Ovarian Mixed Germ Cell Neoplasm

Mixed Germ Cell Tumor Of Ovary

Ovarian Mixed Germ Cell Tumor

Orofaciodigital Syndrome Viii

Edwards Syndrome	Trisomy 18
Complete Trisomy 18 Syndrome	OFD8
Orofaciodigital Syndrome 8	Trisomy 18 Syndrome
Oral-Facial-Digital Syndrome With Hypoplastic Epiglottis	E3 Trisomy
Oral-Facial-Digital Syndrome Type 8	Orofaciodigital Syndrome Type 8
Ofds Viii	Oral-Facial-Digital Syndrome, Type Viii
Ofd Syndrome 8	Ofds 8
Oral Facial Digital Syndrome 8	Oral Facial Digital Syndrome Type 8
18 Trisomy	Chromosome 18 Trisomy
Trisomy 16-18	Trisomy E
Trisomy E Syndrome	Chromosome 18 Duplication
Oral-Facial-Digital Syndrome, Edwards Type	Orofaciodigital Syndrome, Edwards Type
Chromosome 18, Trisomy	Cleft Lip/Palate With Abnormal Thumbs And Microcephaly
Trisomy 18 Chromosome	Abnormal Autosomes 18

Teratoma

Teratomas

Hyperthyroidism

Overactive Thyroid

Gestational Trophoblastic Neoplasm

Hydatidiform Mole	Molar Pregnancy
Gestational Trophoblastic Neoplasia	Gestational Trophoblastic Tumor
Gtn	Gestational Trophoblastic Disease
Gestational Trophoblastic Neoplasms	Hydatidiform Mole, Recurrent, 1
Hydatidiform Mole Benign	Trophoblastic Disease
Trophoblastic Disease Nos	Trophoblastic Disorder
Vesicular Mole Nos	Vesicular Mole
Hydatidiform Mole Nos

Trophoblastic Neoplasm

Trophoblastic Tumor

Trophoblastic Neoplasms

Gynecomastia

Androgen Insensitivity Syndrome

Androgen Resistance Syndrome	AIS
Testicular Feminization Syndrome	Androgen Receptor Deficiency
Dhtr Deficiency	Dihydrotestosterone Receptor Deficiency
Ar Deficiency	Testicular Feminization
Tfm	Androgen Insensitivity
Androgen-Insensitivity Syndrome	Goldberg-Maxwell Syndrome
Complete Androgen Insensitivity Syndrome	Cais
Feminisation - Testicular	Goldberg - Maxwell Syndrome
Androgen Insensitivity Syndrome, Complete	Morris Syndrome
Ary	AR
Insensitivity Syndrome, Androgen	Androgen Insensitivity Nos

Seminoma

Seminoma, Pure

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Hypothyroidism

Thyroid Diseases	Thyroid Disease
Thyroid Deficiency	Thyroid Insufficiency
Dysfunction Thyroid	Thyroid Dysfunction

Hyperprolactinemia

Chiari-Frommel Syndrome	Hyperprolactinaemia
Familial Hyperprolactinemia	HPRL
Pregnancy-Related A-G Syndrome	Familial Isolated Prolactin Receptor Deficiency

Infertility

Varicocele

Scrotal Varices	Varicoceles
Varicocele Of Scrotum	Scrotal Varicocele

Complete Androgen Insensitivity Syndrome

Cais	Complete Androgen Resistance Syndrome
Androgen Insensitivity Syndrome Complete	Androgen Insensitivity, Complete
Androgen-Insensitivity Syndrome	Testicular Feminization

Luteoma

Leuteoma Of Pregnancy

Luteoma Of Pregnancy

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Placenta Disease

Placenta Diseases	Placenta Disorder
Pregnancy Complications	Placenta Disorders

Cataract 4, Multiple Types

Cataract 4 Multiple Types	CTRCT4
Cca3	Pcc
Aculeiform Cataract	Cataract 4, Multiple Types, With Or Without Microcornea
Cataract, Crystalline Aculeiform	Caca
Cataract, Congenital, Cerulean Type, 3	Congenital Cataract Cerulean Type 3
Cataract Congenital Dominant Non Nuclear	Ccp
Cataract, Nonnuclear Polymorphic Congenital	Cataract, Punctate, Progressive Juvenile-Onset
Cataract 4 Multiple Types With Or Without Microcornea	Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract
Cataract, Polymorphic Congenital	Congenital Cataract Blue Dot Type 3
Congenital Non-Nuclear Polymorphic Cataract	Crystalline Aculeiform Cataract
Punctate, Progressive Juvenile-Onset, Cataract	Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant

Hydrocele

Testicular Hydrocele

Endometriosis

Endometriosis, Site Unspecified

Endometrial Ectopia

Placental Insufficiency

Uteroplacental Vascular Insufficiency

Oligohydramnios

Oligohydramnios - Delivered	Antepartum Oligohydramnios
Delivered Oligohydramnios	Oligohydramnios, Antepartum Condition Or Complication
Deficient Liquor	Oligohydramnios, Unspecified Trimester
Reduced Liquor Volume

Patellofemoral Pain Syndrome

Glutaric Aciduria Iii

Glutaryl-Coa Oxidase Deficiency	Ga Iii
Glutaric Acidemia Type 3	GA3
Glutaric Aciduria Type 3	Glutaric Aciduria 3
Glutaric Acidemia Type Iii	Glutaric Aciduria Type Iii

Penis Agenesis

Micropenis	Agenesis Of The Penis
Penis Agenesia

Neuroendocrine Tumor

Neuroendocrine Neoplasm	Neuroendocrine Tumors
Carcinoma, Neuroendocrine

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Ovarian Cyst

Ovarian Cysts

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Pituitary Gland Disease

Pituitary Diseases	Pituitary Dysfunction
Pituitary Disease	Pituitary Deficiency
Pituitary Disorders

Cystinosis

Cystine Storage Disease	Cystine Diathesis
Cystine Disease	Cystinoses
Protein Defect Of Cystin Transport	Cystin Transport, Protein Defect Of
Nephropathic Cystinosis	Protein Defect Of Cystine Transport

Hemophagocytic Lymphohistiocytosis, Familial, 3

Familial Hemophagocytic Lymphohistiocytosis 3	FHL3
Hplh3	Hlh3
Lymphohistiocytosis, Hemophagocytic, Familial, Type 3

Placental Site Trophoblastic Tumor

Trophoblastic Tumor Placental Site	Trophoblastic Tumor, Placental Site
Placental Site Trophoblastic Tumour	Placental-Site Gestational Trophoblastic Neoplasm
Placenta Neoplasm	Psst
Deciduoma	Placental Cancer
Primary Malignant Neoplasm Of Placenta

Placental Abruption

Abruptio Placentae	Abruptio Placenta
Abortion, Threatened	Threatened Miscarriage
Haemorrhage Specified As Due To Threatened Abortion	Spontaneous Threatened Abortion

Asperger Syndrome

Asperger Disorder

Asperger Syndrome, Susceptibility To

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0621	Triclabendazole	Inhibitor	98.72%	Yes

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-148511	Vidutolimod	Agonist	/	Phase 3
HY-150724	ODN 1018	Agonist	96.23%	Phase 2
HY-160406	SNX281	Agonist	99.08%	Phase 1

Pre-clinical Phase

Bioactive Molecules (56)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114180	RU.521	Inhibitor	99.89%	Unkown
HY-131454	SR-717	Agonist	99.89%	Unkown
HY-133916	G140	Inhibitor	98.11%	Unkown
HY-128583	G150	Inhibitor	98.61%	Unkown
HY-150741	ODN 2216		97.88%	Unkown
HY-150751	ODN TTAGGG	Antagonist	99.87%	Unkown
HY-114182	PF-06928215	Inhibitor	99.69%	Unkown
HY-139056	SU0268	Inhibitor	99.96%	Unkown
HY-W021040	Fludioxonil	Inhibitor	99.94%	Unkown
HY-123230	Trifloxystrobin	Inhibitor	99.49%	Unkown
HY-150750	ODN M362		/	Unkown
HY-114181	IRAK4-IN-4	Inhibitor	99.85%	Unkown
HY-150742	ODN 2336	Agonist	90.74%	Unkown
HY-150748	ODN D-SL01	Agonist	99.94%	Unkown
HY-B0821	Pymetrozine	Inhibitor	99.78%	Unkown
HY-149526	cGAS-IN-1	Inhibitor	98.29%	Unkown
HY-160546	cGAS-IN-2	Inhibitor	99.67%	Unkown
HY-150747	ODN 6016	Inducer	/	Unkown
HY-150751C	ODN TTAGGG sodium	Antagonist	99.87%	Unkown
HY-B1331	Cyromazine		99.75%	Unkown
HY-138646	Poly(deoxyadenylic-thymidylic) acid sodium	Activator	/	Unkown
HY-158045	PROTAC PARP1 degrader-1	Inhibitor	/	Unkown
HY-164288	TDI-6570	Inhibitor	99.64%	Unkown
HY-131454A	SR-717 free acid	Agonist	/	Unkown
HY-115763	3-Aminopropylphosphinic acid	Agonist	/	Unkown
HY-118578	Furalaxyl	Inhibitor	/	Unkown
HY-123230R	Trifloxystrobin (Standard)	Inhibitor	/	Unkown
HY-123230S	Trifloxystrobin-d6	Inhibitor	/	Unkown
HY-123230S1	Trifloxystrobin-d3		/	Unkown
HY-12464	Butafenacil		/	Unkown
HY-144328	STING agonist-10	Activator	/	Unkown
HY-144329	STING agonist-11	Activator	/	Unkown
HY-148412	Monarsen	Inhibitor	/	Unkown
HY-150213	ODN BW001	Inhibitor	/	Unkown
HY-150751A	Biotin-labeled ODN TTAGGG sodium		/	Unkown
HY-150751B	FITC-labeled ODN TTAGGG sodium	Antagonist	/	Unkown
HY-158126	G-quadruplex ligand 2	Inhibitor	/	Unkown
HY-162133	MSA-2-Pt	Agonist	/	Unkown
HY-162459	cGAS-IN-3	Inhibitor	/	Unkown
HY-162944	NA-Ir		/	Unkown
HY-162967	MS8588		/	Unkown
HY-163461	4F-DDC	Inhibitor	/	Unkown
HY-B0621S	Triclabendazole-d3		/	Unkown
HY-B0621S1	Triclabendazole-13C,d3	Inhibitor	/	Unkown
HY-B1331S1	Cyromazine-13C3		/	Unkown
HY-N12507	Eupenicisirenin C	Inhibitor	/	Unkown
HY-P3041	Chromostatin (bovine)	Inhibitor	/	Unkown
HY-RS02575	CGA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02576	CGAS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02577	Cgas Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS02578	Cgas Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-114730	CGA-JK3	Inhibitor	/	Unkown
HY-121165	Cymiazole		/	Unkown
HY-132221	CU-32	Inhibitor	/	Unkown
HY-79648S	Fmoc-Methylalanine-d3		/	Unkown
HY-W020788	Benoxacor	Agonist	99.39%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CGA	MGD	MGI:88390
Macaca mulatta	CGA	VGNC	VGNC:71021
Canis familiaris	CGA	VGNC	VGNC:39181
Rattus norvegicus	CGA	RGD	RGD:620436
Bos taurus	CGA	VGNC	VGNC:27257
Others	CGA	NCBI