Cxcr4 - chemokine (C-X-C motif) receptor 4 Gene

Mus musculus

Also known as CD184; LESTR; Sdf1r; CXC-R4; CXCR-4; Cmkar4; PB-CKR; b2b220Clo; PBSF/SDF-1

Gene ID: 12767 | Gene type: protein coding

About Cxcr4

Chromosome 1: 128,515,936-128,520,030 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 285 orthologues, 25 paralogues and is associated with 88 phenotypes. Biased expression in thymus adult (RPKM 23.6), spleen adult (RPKM 93.9) and 1 other tissues.

Summary

Predicted to enable several functions, including Chemokine Receptor activity; cytoskeletal protein binding activity; and ubiquitin protein Ligase binding activity. Involved in myelin maintenance; positive regulation of cold-induced thermogenesis; and positive regulation of oligodendrocyte differentiation. Acts upstream of or within several processes, including circulatory system development; gamete generation; and nervous system development. Located in cell-cell junction; external side of plasma membrane; and growth cone. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; extraembryonic component; and nervous system. Used to study WHIM syndrome. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic Cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Orthologous to human CXCR4 (C-X-C motif Chemokine Receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr4 Products(2)

mRNA	Protein	Name
NM_001356509.1	NP_001343438.1	C-X-C chemokine receptor type 4 isoform 2
NM_009911.3	NP_034041.2	C-X-C chemokine receptor type 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18227060	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within CXCL12-activated CXCR4 signaling pathway	IDA IDA: Inferred from direct assay	31845480	MGI
acts upstream of or within T cell proliferation	IMP IMP: Inferred from mutant phenotype	12707343	MGI
acts upstream of or within ameboidal-type cell migration	IMP IMP: Inferred from mutant phenotype	15626744	MGI
acts upstream of or within aorta development	IMP IMP: Inferred from mutant phenotype	25807483	MGI
acts upstream of or within blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	15626744	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	12183377	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15626744	MGI
acts upstream of or within cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	8962122	MGI
involved in generation of neurons	IEP IEP: Inferred from expression pattern	20882566	MGI
acts upstream of or within germ cell development	IMP IMP: Inferred from mutant phenotype	12900445	MGI
acts upstream of or within germ cell migration	IMP IMP: Inferred from mutant phenotype	12900445	MGI
acts upstream of or within hematopoietic stem cell migration	IMP IMP: Inferred from mutant phenotype	20847314	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	27002738	MGI
acts upstream of or within motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	16129397	MGI
involved in myelin maintenance	IMP IMP: Inferred from mutant phenotype	20534485	MGI
involved in neural precursor cell proliferation	IEP IEP: Inferred from expression pattern	20882566	MGI
acts upstream of or within neuron migration	IDA IDA: Inferred from direct assay	12900445	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	20376365	MGI
acts upstream of or within positive regulation of calcium ion import	IDA IDA: Inferred from direct assay	8962122	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	25016030	MGI
involved in positive regulation of oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	20534485	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20847314	MGI
acts upstream of or within regulation of cell migration	IGI IGI: Inferred from genetic interaction	16166380	MGI
acts upstream of or within regulation of cell migration	IMP IMP: Inferred from mutant phenotype	12900445	MGI
acts upstream of or within regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	12183377	MGI
acts upstream of or within ventricular septum development	IMP IMP: Inferred from mutant phenotype	25807483	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	22265737	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23793062	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	19008373	MGI
located in growth cone	IDA IDA: Inferred from direct assay	16129397	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	20376365	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cxcr4 Protein Structure

CXCR4_N

7tmA_CXCR4

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

C-X-C chemokine receptor type 4

SDF-1 receptor	chemokine (C-X-C) receptor 4
chemokine receptor 4	fusin
leukocyte-derived seven transmembrane domain receptor	leukocyte-expressed seven-transmembrane-domain
pre-B-cell-derived chemokine receptor	stromal cell-derived factor 1 receptor

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10046	Plerixafor	Antagonist	99.90%	Yes
HY-50912	Plerixafor octahydrochloride	Antagonist	99.09%	Yes
HY-50101A	Mavorixafor trihydrochloride	Antagonist	99.75%	Yes
HY-50101C	Mavorixafor hydrochloride	Antagonist	/	Unkown
HY-50101	Mavorixafor	Antagonist	/	Unkown

Clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P0171	Motixafortide	Antagonist	99.88%	Phase 3
HY-P1682A	Balixafortide TFA	Antagonist	99.78%	Phase 3
HY-P1682	Balixafortide	Antagonist	/	Phase 3
HY-12488	LY2510924	Inhibitor	99.73%	Phase 2
HY-19867A	Burixafor hydrobromide	Antagonist	≥98.0%	Phase 2
HY-114244	USL311	Antagonist	99.97%	Phase 2
HY-13696	MSX-122	Antagonist	98.92%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99272	Ulocuplumab	Antagonist	99.90%	Phase 3

Pre-clinical Phase

Bioactive Molecules (43)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0011	Baohuoside I	Inhibitor	99.96%	Unkown
HY-111793A	NUCC-390 dihydrochloride	Agonist	99.05%	Unkown
HY-101458A	IT1t dihydrochloride	Antagonist	99.77%	Unkown
HY-15478	WZ811	Antagonist	99.80%	Unkown
HY-P1102	TC14012	Modulator	98.92%	Unkown
HY-15971	AMD 3465 hexahydrobromide	Antagonist	≥98.0%	Unkown
HY-P3612	CTCE-0214	Agonist	98.94%	Unkown
HY-P1104A	FC131 TFA	Antagonist	99.89%	Unkown
HY-P1103	CTCE-9908	Antagonist	99.47%	Unkown
HY-P7061A	ALX 40-4C Trifluoroacetate	Inhibitor	96.65%	Unkown
HY-15971A	AMD 3465	Antagonist	99.59%	Unkown
HY-112709	LIT-927		99.86%	Unkown
HY-103009	MSX-127	Antagonist	99.68%	Unkown
HY-111793	NUCC-390	Agonist	98.40%	Unkown
HY-P4111A	Peptide R TFA	Antagonist	98.34%	Unkown
HY-P4111	Peptide R	Antagonist	/	Unkown
HY-P7061	ALX 40-4C	Inhibitor	/	Unkown
HY-101458	IT1t	Antagonist	/	Unkown
HY-103010	MSX-130	Antagonist	98.00%	Unkown
HY-P1104	FC131	Antagonist	/	Unkown
HY-122058A	KRH-3955 hydrochloride	Antagonist	/	Unkown
HY-147978	CXCR4 antagonist 8	Antagonist	/	Unkown
HY-162632	Hit 14	Inhibitor	/	Unkown
HY-P10429	RCP168	Antagonist	/	Unkown
HY-146054	CXCR4 modulator-2	Modulator	/	Unkown
HY-161735	CXCR4-IN-3	Inhibitor	/	Unkown
HY-P0172	ATI-2341	Agonist	/	Unkown
HY-P10415	EPI-X4	Antagonist	98.80%	Unkown
HY-144285	CXCR4 antagonist 4	Antagonist	/	Unkown
HY-144286	CXCR4 antagonist 3	Inhibitor	/	Unkown
HY-168095	CXCR4 antagonist 10	Inhibitor	/	Unkown
HY-146401	CXCR4 antagonist 6	Antagonist	/	Unkown
HY-P1102A	TC14012 TFA	Modulator	/	Unkown
HY-136437	CXCR4 antagonist 1	Antagonist	/	Unkown
HY-P1103A	CTCE-9908 TFA	Antagonist	/	Unkown
HY-129094	ICT5040	Antagonist	/	Unkown
HY-115493	TIQ-15	Antagonist	/	Unkown
HY-146413	HF50731	Antagonist	/	Unkown
HY-147979	CXCR4 antagonist 9	Antagonist	/	Unkown
HY-146372	CXCR4 antagonist 5	Antagonist	/	Unkown
HY-147808	CXCR4 antagonist 7	Antagonist	/	Unkown
HY-146053	CXCR4 modulator-1	Modulator	/	Unkown
HY-123819	KRH-1636	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cxcr4	NCBI	NCBI:7852

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