Csf1 - colony stimulating factor 1 (macrophage) Gene

Mus musculus

Also known as op; Csfm; MCSF; BAP025; Mhdabap25

Gene ID: 12977 | Gene type: protein coding

About Csf1

Summary

Enables macrophage colony-stimulating factor receptor binding activity and protein homodimerization activity. Involved in several processes, including macrophage colony-stimulating factor signaling pathway; microglial cell proliferation; and positive regulation of gene expression. Acts upstream of or within several processes, including mammary gland development; osteoclast proliferation; and positive regulation of myeloid leukocyte differentiation. Located in extracellular space. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and hindlimb long bone. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Csf1 Products(3)

mRNA	Protein	Name
NM_001113529.1	NP_001107001.1	macrophage colony-stimulating factor 1 isoform 2 precursor
NM_001113530.1	NP_001107002.1	macrophage colony-stimulating factor 1 isoform 1 precursor
NM_007778.4	NP_031804.3	macrophage colony-stimulating factor 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22902366	MGI
enables macrophage colony-stimulating factor receptor binding	IPI IPI: Inferred from physical interaction	2408759	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16267818	MGI
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19017797	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of Ras protein signal transduction	IDA IDA: Inferred from direct assay	17053831	MGI
acts upstream of or within branching involved in mammary gland duct morphogenesis	IMP IMP: Inferred from mutant phenotype	10804170	MGI
involved in developmental process involved in reproduction	IMP IMP: Inferred from mutant phenotype	16237150	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	9215625	MGI
involved in macrophage colony-stimulating factor signaling pathway	IDA IDA: Inferred from direct assay	19017797	MGI
acts upstream of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	9215625	MGI
acts upstream of or within macrophage homeostasis	IMP IMP: Inferred from mutant phenotype	9215625	MGI
acts upstream of or within mammary duct terminal end bud growth	IMP IMP: Inferred from mutant phenotype	10804170	MGI
acts upstream of or within mammary gland fat development	IMP IMP: Inferred from mutant phenotype	10804170	MGI
involved in microglial cell proliferation	IGI IGI: Inferred from genetic interaction	23392676	MGI
acts upstream of monocyte differentiation	IMP IMP: Inferred from mutant phenotype	9215625	MGI
acts upstream of or within monocyte homeostasis	IMP IMP: Inferred from mutant phenotype	9215625	MGI
acts upstream of myeloid leukocyte migration	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within neutrophil homeostasis	IMP IMP: Inferred from mutant phenotype	9215625	MGI
acts upstream of or within osteoclast differentiation	IDA IDA: Inferred from direct assay	17442941	MGI
acts upstream of osteoclast differentiation	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	9215625	MGI
acts upstream of or within osteoclast proliferation	IDA IDA: Inferred from direct assay	22451653	MGI
acts upstream of or within positive regulation of Ras protein signal transduction	IDA IDA: Inferred from direct assay	17053831	MGI
acts upstream of or within positive regulation of cell-matrix adhesion	IGI IGI: Inferred from genetic interaction	17053831	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	30687013	MGI
acts upstream of or within positive regulation of leukocyte migration	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within positive regulation of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	9215625	MGI
acts upstream of or within positive regulation of monocyte differentiation	IMP IMP: Inferred from mutant phenotype	9215625	MGI
acts upstream of or within positive regulation of multicellular organism growth	IMP IMP: Inferred from mutant phenotype	12865350	MGI
acts upstream of or within positive regulation of odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	12865350	MGI
acts upstream of or within positive regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	15657444	MGI
acts upstream of or within positive regulation of osteoclast differentiation	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	9215625	MGI
acts upstream of or within positive regulation of protein kinase activity	IGI IGI: Inferred from genetic interaction	17053831	MGI
acts upstream of or within regulation of ossification	IMP IMP: Inferred from mutant phenotype	12865350	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of CSF1-CSF1R complex	IDA IDA: Inferred from direct assay	19017797	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

macrophage colony-stimulating factor 1

osteopetrosis

Recombinant Csf1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7085	M-CSF Protein, Mouse	P07141 (K33-P187)	≥95%
HY-P7085A	M-CSF Protein, Mouse (CHO)	P07141 (K33-P187)	≥95%
HY-P70553	M-CSF Protein, Mouse (HEK293)	P07141-1 (K33-E262)	≥95%
HY-P700222AF	Animal-Free M-CSF Protein, Mouse (His)	P07141 (K33-P187)	≥95%
HY-P70263A	M-CSF Protein, Mouse (HEK293, C-His)	P07141-1 (K33-E262)	≥95%

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16749	Pexidartinib		99.64%	Yes
HY-16749A	Pexidartinib hydrochloride		99.86%	Yes
HY-12297	Sulfatinib	Inhibitor	98.65%	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-50905	Dovitinib	Inhibitor	99.88%	Phase 3
HY-124526	Chiauranib	Inhibitor	99.28%	Phase 3
HY-12768	Sotuletinib	Inhibitor	99.80%	Phase 2
HY-109086	Edicotinib	Inhibitor	98.78%	Phase 2
HY-111787	Elzovantinib	Inhibitor	99.93%	Phase 2
HY-12768A	Sotuletinib hydrochloride	Inhibitor	98.84%	Phase 2
HY-109190	Seralutinib	Inhibitor	99.94%	Phase 2
HY-114153	PLX5622	Inhibitor	99.95%	Phase 1
HY-114153A	PLX5622 hemifumarate	Inhibitor	99.88%	Phase 1
HY-101768	PRN1371	Inhibitor	99.43%	Phase 1
HY-10204	OSI-930		98.57%	Phase 1

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99245	Emactuzumab	Inhibitor	97.60%	Phase 3
HY-P99259	Cabiralizumab	Inhibitor	99.59%	Phase 2
HY-P99452	Axatilimab	Inhibitor	99.59%	Phase 2
HY-P99368	Lacnotuzumab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (54)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10408	Ki20227	Inhibitor	99.17%	Unkown
HY-132935	BPR1R024	Inhibitor	99.06%	Unkown
HY-101774	CSF1R-IN-1	Inhibitor	98.11%	Unkown
HY-117244	AZD7507	Inhibitor	99.45%	Unkown
HY-122906	JTE-952	Inhibitor	99.95%	Unkown
HY-153920	Pimicotinib	Inhibitor	99.69%	Unkown
HY-117273	AZ304	Inhibitor	99.96%	Unkown
HY-136362	ARRY-382	Inhibitor	99.63%	Unkown
HY-126297	c-Fms-IN-10	Inhibitor	98.63%	Unkown
HY-139990	CSF1R-IN-3	Inhibitor	98.26%	Unkown
HY-147615	CSF1R-IN-12		98.75%	Unkown
HY-161025	SYHA1813	Inhibitor	99.46%	Unkown
HY-13493	AC710	Inhibitor	98.56%	Unkown
HY-112451	cFMS Receptor Inhibitor II	Inhibitor	99.88%	Unkown
HY-119942	c-Fms-IN-8	Inhibitor	99.47%	Unkown
HY-101526	GENZ-882706	Inhibitor	/	Unkown
HY-159108	AZ683	Inhibitor	/	Unkown
HY-160842	CSF1R-IN-24	Inhibitor	98.10%	Unkown
HY-132935A	BPR1R024 mesylate	Inhibitor	/	Unkown
HY-145809	FASN-IN-5	Inhibitor	99.81%	Unkown
HY-101034	CHMFL-ABL/KIT-155		/	Unkown
HY-12768B	Sotuletinib dihydrochloride	Inhibitor	/	Unkown
HY-109086A	Edicotinib hydrochloride	Inhibitor	/	Unkown
HY-144040	CSF1R-IN-4		/	Unkown
HY-144041	CSF1R-IN-5	Inhibitor	/	Unkown
HY-144042	CSF1R-IN-6		/	Unkown
HY-147608	CSF1R-IN-7	Inhibitor	/	Unkown
HY-147609	CSF1R-IN-8	Inhibitor	/	Unkown
HY-147610	CSF1R-IN-9	Inhibitor	/	Unkown
HY-147611	CSF1R-IN-10	Inhibitor	/	Unkown
HY-147616	CSF1R-IN-13		/	Unkown
HY-147617	CSF1R-IN-14		/	Unkown
HY-153012	Axl/Mer/CSF1R-IN-1	Inhibitor	/	Unkown
HY-153243	IACS-9439	Inhibitor	/	Unkown
HY-153277	Axl/Mer/CSF1R-IN-2	Inhibitor	/	Unkown
HY-155001	CSF1R-IN-15	Inhibitor	/	Unkown
HY-155550	CSF1R-IN-17	Antagonist	/	Unkown
HY-157422	CSF1R-IN-19	Inhibitor	/	Unkown
HY-157996	CSF1R-IN-21	Inhibitor	/	Unkown
HY-158050	PXB17	Inhibitor	/	Unkown
HY-158148	CSF1R-IN-23	Inhibitor	/	Unkown
HY-158363	CSF1R-IN-25	Inhibitor	/	Unkown
HY-159838	Enrupatinib	Inhibitor	/	Unkown
HY-161084	CSF1R-IN-18	Inhibitor	/	Unkown
HY-162309	CSF1R-IN-20	Inhibitor	/	Unkown
HY-162415	CSF1R-IN-22		/	Unkown
HY-RS03227	CSF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03228	CSF1R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03229	Csf1r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03230	Csf1r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-13493A	AC710 Mesylate	Inhibitor	/	Unkown
HY-13496	JNJ-28312141	Inhibitor	/	Unkown
HY-159503A	Segigratinib hydrochloride	Inhibitor	/	Unkown
HY-164529	SJ-C1044	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Csf1	NCBI	NCBI:1435
Macaca fascicularis	Csf1	NCBI	NCBI:102141631
Rattus norvegicus	Csf1	NCBI	NCBI:78965
Macaca mulatta	Csf1	NCBI	NCBI:702532

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