2. Gene
  3. Csf1 - colony stimulating factor 1 Gene

Csf1 - colony stimulating factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 78965 | Gene type: protein coding

About Csf1

Summary

Enables identical protein binding activity. Involved in several processes, including myeloid leukocyte differentiation; odontogenesis; and ossification. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; high grade glioma; and osteopetrosis. Biomarker of systemic scleroderma. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Csf1 Products(1)

mRNA Protein Name
NM_023981.4 NP_076471.3 macrophage colony-stimulating factor 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
8357831 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
8304053 RGD
involved in macrophage differentiation IDA
IDA: Inferred from direct assay
20628067 RGD
involved in macrophage differentiation IEP
IEP: Inferred from expression pattern
12379742 RGD
involved in ossification IMP
IMP: Inferred from mutant phenotype
12379742 RGD
involved in osteoclast differentiation IMP
IMP: Inferred from mutant phenotype
12379742 RGD
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
8304053 RGD
involved in positive regulation of macrophage proliferation IMP
IMP: Inferred from mutant phenotype
8304053 RGD
involved in positive regulation of mononuclear cell migration IMP
IMP: Inferred from mutant phenotype
11499013 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
24882100 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
20833686 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19219684 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular region IDA
IDA: Inferred from direct assay
16673407 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
22846308 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

macrophage colony-stimulating factor 1

CSF-1

MCSF

colony stimulating factor 1 (macrophage)

Recombinant Csf1 Proteins

Cat. No. Product Name Accession Purity
HY-P7247 M-CSF Protein, Rat (CHO) Q8JZQ0-1 (E33-P186) ≥95%
HY-P7386 M-CSF Protein, Rat Q8JZQ0-1 (E33-P186) ≥95%
HY-P70493 M-CSF Protein, Rat (HEK293) Q8JZQ0 (E33-R254) ≥95%

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16749 Pexidartinib 99.64% Yes
HY-16749A Pexidartinib hydrochloride 99.86% Yes
HY-12297 Sulfatinib Inhibitor 99.52% Unkown
Clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Phase
HY-50905 Dovitinib Inhibitor 99.88% Phase 3
HY-124526 Chiauranib Inhibitor 99.28% Phase 3
HY-12768 Sotuletinib Inhibitor 99.80% Phase 2
HY-109086 Edicotinib Inhibitor 98.78% Phase 2
HY-111787 Elzovantinib Inhibitor 99.93% Phase 2
HY-12768A Sotuletinib hydrochloride Inhibitor 98.84% Phase 2
HY-109190 Seralutinib Inhibitor 99.94% Phase 2
HY-152830A Adrixetinib TFA Inhibitor 99.82% Phase 2
HY-12768B Sotuletinib dihydrochloride Inhibitor / Phase 2
HY-152830 Adrixetinib Inhibitor 99.51% Phase 2
HY-114153 PLX5622 Inhibitor 99.95% Phase 1
HY-114153A PLX5622 hemifumarate Inhibitor 99.88% Phase 1
HY-101768 PRN1371 Inhibitor 99.43% Phase 1
HY-10204 OSI-930 98.57% Phase 1
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P99245 Emactuzumab Inhibitor 97.60% Phase 3
HY-P99259 Cabiralizumab Inhibitor 99.59% Phase 2
HY-P99452 Axatilimab Inhibitor 99.59% Phase 2
HY-P99368 Lacnotuzumab Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (53)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10408 Ki20227 Inhibitor 99.17% Unkown
HY-101774 CSF1R-IN-1 Inhibitor 98.11% Unkown
HY-117244 AZD7507 Inhibitor 99.45% Unkown
HY-153920 Pimicotinib Inhibitor 99.69% Unkown
HY-132935 BPR1R024 Inhibitor 99.06% Unkown
HY-122906 JTE-952 Inhibitor 99.95% Unkown
HY-117273 AZ304 Inhibitor 99.96% Unkown
HY-136362 ARRY-382 Inhibitor 99.63% Unkown
HY-126297 c-Fms-IN-10 Inhibitor 98.63% Unkown
HY-139990 CSF1R-IN-3 Inhibitor 98.26% Unkown
HY-147615 CSF1R-IN-12 98.75% Unkown
HY-161025 SYHA1813 Inhibitor 99.46% Unkown
HY-112451 cFMS Receptor Inhibitor II Inhibitor 99.88% Unkown
HY-159108 AZ683 Inhibitor / Unkown
HY-13493 AC710 Inhibitor 98.56% Unkown
HY-119942 c-Fms-IN-8 Inhibitor 99.47% Unkown
HY-101526 GENZ-882706 Inhibitor / Unkown
HY-160842 CSF1R-IN-24 Inhibitor 98.10% Unkown
HY-132935A BPR1R024 mesylate Inhibitor / Unkown
HY-145809 FASN-IN-5 Inhibitor 99.81% Unkown
HY-159838 Enrupatinib Inhibitor / Unkown
HY-101034 CHMFL-ABL/KIT-155 / Unkown
HY-109086A Edicotinib hydrochloride Inhibitor / Unkown
HY-144040 CSF1R-IN-4 / Unkown
HY-144041 CSF1R-IN-5 Inhibitor / Unkown
HY-144042 CSF1R-IN-6 / Unkown
HY-147608 CSF1R-IN-7 Inhibitor / Unkown
HY-147609 CSF1R-IN-8 Inhibitor / Unkown
HY-147610 CSF1R-IN-9 Inhibitor / Unkown
HY-147611 CSF1R-IN-10 Inhibitor / Unkown
HY-147616 CSF1R-IN-13 / Unkown
HY-147617 CSF1R-IN-14 / Unkown
HY-153012 Axl/Mer/CSF1R-IN-1 Inhibitor / Unkown
HY-153243 IACS-9439 Inhibitor / Unkown
HY-153277 Axl/Mer/CSF1R-IN-2 Inhibitor / Unkown
HY-155001 CSF1R-IN-15 Inhibitor / Unkown
HY-155550 CSF1R-IN-17 Antagonist / Unkown
HY-157422 CSF1R-IN-19 Inhibitor / Unkown
HY-157996 CSF1R-IN-21 Inhibitor / Unkown
HY-158050 PXB17 Inhibitor / Unkown
HY-158148 CSF1R-IN-23 Inhibitor / Unkown
HY-158363 CSF1R-IN-25 Inhibitor / Unkown
HY-161084 CSF1R-IN-18 Inhibitor / Unkown
HY-162309 CSF1R-IN-20 Inhibitor / Unkown
HY-162415 CSF1R-IN-22 / Unkown
HY-RS03227 CSF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03228 CSF1R Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03229 Csf1r Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03230 Csf1r Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-13493A AC710 Mesylate Inhibitor / Unkown
HY-13496 JNJ-28312141 Inhibitor / Unkown
HY-159503A Segigratinib hydrochloride Inhibitor / Unkown
HY-164529 SJ-C1044 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Csf1 NCBI NCBI:1435
Macaca fascicularis Csf1 NCBI NCBI:102141631
Mus musculus Csf1 NCBI NCBI:12977
Macaca mulatta Csf1 NCBI NCBI:702532