COX5B - cytochrome c oxidase subunit 5B Gene

Homo sapiens

Also known as COXVB

Gene ID: 1329 | Gene type: protein coding

About COX5B

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:97,646,062-97,648,383 (from NCBI)

This gene has 4 transcripts (splice variants) and 284 orthologues. Broad expression in colon (RPKM 200.2), kidney (RPKM 188.7) and 24 other tissues.

Summary

Cytochrome C oxidase (COX) is the terminal Enzyme of the mitochondrial respiratory chain. It is a multi-subunit Enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain Enzyme. [provided by RefSeq, Jul 2008]

COX5B Products(1)

mRNA	Protein	Name
NM_001862.3	NP_001853.2	cytochrome c oxidase subunit 5B, mitochondrial precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	30030519	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COX5B Protein Structure

COX5B

0
100
129 a.a.

Protein Preferred Names

Protein Names

cytochrome c oxidase subunit 5B, mitochondrial

cytochrome c oxidase polypeptide VB, mitochondrial

COX5B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COX5B	P10606	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	COX5B	P10606	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	COX5B	P10606	SLAIN1	Homo sapiens	Q8ND83	Y2H Array	32296183
Intra	COX5B	P10606	SLAIN1	Homo sapiens	Q8ND83	Validated Y2H	32296183
Intra	COX5B	P10606	SLAIN1	Homo sapiens	Q8ND83	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	KRT33B	Homo sapiens	Q14525	Validated Y2H	32296183
Intra	COX5B	P10606	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	COX5B	P10606	DOK3	Homo sapiens	Q7L591-3	Validated Y2H	32296183
Intra	COX5B	P10606	DOK3	Homo sapiens	Q7L591-3	Y2H Array	32296183
Intra	COX5B	P10606	DOK3	Homo sapiens	Q7L591-3	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	COX5B	P10606	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	COX5B	P10606	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	COX5B	P10606	CDR2L	Homo sapiens	Q86X02	Y2H Array	32296183
Intra	COX5B	P10606	CDR2L	Homo sapiens	Q86X02	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	CDR2L	Homo sapiens	Q86X02	Validated Y2H	32296183
Intra	COX5B	P10606	PRDM6	Homo sapiens	Q9NQX0	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	PRDM6	Homo sapiens	Q9NQX0	Validated Y2H	32296183
Intra	COX5B	P10606	PRDM6	Homo sapiens	Q9NQX0	Y2H Array	32296183
Intra	COX5B	P10606	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
Intra	COX5B	P10606	CDR2	Homo sapiens	Q01850	Validated Y2H	25416956
Intra	COX5B	P10606	CDR2	Homo sapiens	Q01850	Validated Y2H	32296183
Intra	COX5B	P10606	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	25416956
Intra	COX5B	P10606	MCCD1	Homo sapiens	P59942	Validated Y2H	32296183
Intra	COX5B	P10606	MCCD1	Homo sapiens	P59942	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	MCCD1	Homo sapiens	P59942	Y2H Array	32296183
Intra	COX5B	P10606	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	SAXO4	Homo sapiens	Q7Z5V6-2	Validated Y2H	32296183
Intra	COX5B	P10606	SAXO4	Homo sapiens	Q7Z5V6-2	Y2H Array	32296183
Intra	COX5B	P10606	TEX12	Homo sapiens	Q9BXU0	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	TEX12	Homo sapiens	Q9BXU0	Validated Y2H	32296183
Intra	COX5B	P10606	TEX12	Homo sapiens	Q9BXU0	Y2H Array	32296183
Intra	COX5B	P10606	VPS28	Homo sapiens	Q9UK41-2	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	VPS28	Homo sapiens	Q9UK41-2	Validated Y2H	32296183
Intra	COX5B	P10606	VPS28	Homo sapiens	Q9UK41-2	Y2H Array	32296183
Intra	COX5B	P10606	FAM228A	Homo sapiens	Q86W67	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	FAM228A	Homo sapiens	Q86W67	Validated Y2H	32296183
Intra	COX5B	P10606	FAM228A	Homo sapiens	Q86W67	Y2H Array	32296183
Intra	COX5B	P10606	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	PRKAR1B	Homo sapiens	P31321	Validated Y2H	32296183
Intra	COX5B	P10606	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	COX5B	P10606	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	COX5B	P10606	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	COX5B	P10606	PNMA1	Homo sapiens	Q8ND90	Y2H Array	25416956
Intra	COX5B	P10606	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	COX5B	P10606	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	COX5B	P10606	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	CDC42EP2	Homo sapiens	O14613	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	CDC42EP2	Homo sapiens	O14613	Y2H Array	32296183
Intra	COX5B	P10606	TRAF1	Homo sapiens	Q13077	Validated Y2H	25416956
Intra	COX5B	P10606	TRAF1	Homo sapiens	Q13077	Y2H Array	25416956
Intra	COX5B	P10606	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	COX5B	P10606	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	COX5B	P10606	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	COX5B	P10606	RBM48	Homo sapiens	Q5RL73	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	RBM48	Homo sapiens	Q5RL73	Validated Y2H	32296183
Intra	COX5B	P10606	RBM48	Homo sapiens	Q5RL73	Y2H Array	32296183
Intra	COX5B	P10606	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	COX5B	P10606	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	FLOT1	Homo sapiens	O75955	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	FLOT1	Homo sapiens	O75955	Y2H Array	32296183
Intra	COX5B	P10606	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	COX5B	P10606	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	GOLGA2	Homo sapiens	Q08379	Validated Y2H	32296183
Intra	COX5B	P10606	BHLHE40	Homo sapiens	O14503	Validated Y2H	25416956
Intra	COX5B	P10606	BHLHE40	Homo sapiens	O14503	Y2H Array	25416956
Intra	COX5B	P10606	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	TRIM27	Homo sapiens	P14373	Validated Y2H	32296183
Intra	COX5B	P10606	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	COX5B	P10606	NUDT5	Homo sapiens	Q9UKK9	Validated Y2H	32296183
Intra	COX5B	P10606	NUDT5	Homo sapiens	Q9UKK9	Y2H Array	32296183
Intra	COX5B	P10606	NUDT5	Homo sapiens	Q9UKK9	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	COX5B	P10606	KRT15	Homo sapiens	P19012	Y2H Array	25416956
Intra	COX5B	P10606	TRIM23	Homo sapiens	P36406	Y2H	21516116
Intra	COX5B	P10606	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	COX5B	P10606	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	COX5B	P10606	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	COX5B	P10606	TASOR2	Homo sapiens	Q5VWN6	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	TASOR2	Homo sapiens	Q5VWN6	Validated Y2H	32296183
Intra	COX5B	P10606	TASOR2	Homo sapiens	Q5VWN6	Y2H Array	32296183
Intra	COX5B	P10606	TASOR2	Homo sapiens	Q5VWN6	Y2H	21516116
Intra	COX5B	P10606	IHO1	Homo sapiens	Q8IYA8	Validated Y2H	25416956
Intra	COX5B	P10606	IHO1	Homo sapiens	Q8IYA8	Y2H Array	25416956
Intra	COX5B	P10606	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	25416956
Intra	COX5B	P10606	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	COX5B	P10606	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	COX5B	P10606	ARID5A	Homo sapiens	Q03989	Validated Y2H	32296183
Intra	COX5B	P10606	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant COX5B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75686	COX5B Protein, Human (His)	P10606 (A32-H129)	≥95%

COX5B Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82805	COX5B Antibody (YA2550)	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03067	COX5B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-169281	Antiviral agent 61	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	COX5B	VGNC	VGNC:39540
Rattus norvegicus	COX5B	RGD	RGD:620608
Mus musculus	COX5B	MGD	MGI:88475
Felis catus	COX5B	VGNC	VGNC:103730
Others	COX5B	NCBI

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