2. Gene
  3. Faah - fatty acid amide hydrolase Gene

Faah - fatty acid amide hydrolase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 14073 | Gene type: protein coding

About Faah

Chromosome 4: 115,824,342-115,875,123 reverse strand.GRCm39:CM000997.3

This gene has 8 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 17 phenotypes. Broad expression in liver adult (RPKM 3.1), duodenum adult (RPKM 29.3) and 22 other tissues.

Summary

Enables acylglycerol Lipase activity. Predicted to be involved in fatty acid catabolic process; monoacylglycerol catabolic process; and positive regulation of vasoconstriction. Predicted to act upstream of or within lipid catabolic process. Predicted to be located in organelle membrane. Is expressed in several structures, including alimentary system; brain; ganglia; olfactory epithelium; and renal calyx. Human ortholog(s) of this gene implicated in obesity and substance-related disorder. Orthologous to human FAAH (fatty acid amide hydrolase). [provided by Alliance of Genome Resources, Apr 2022]

Faah Products(1)

mRNA Protein Name
NM_010173.5 NP_034303.3 fatty-acid amide hydrolase 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables monoacylglycerol lipase activity IMP
IMP: Inferred from mutant phenotype
20657592 MGI
Biological Process GO Annotation Evidence Reference Source
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission EXP
EXP: Inferred from Experiment
30532004 MGI
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IDA
IDA: Inferred from direct assay
30532004 MGI
involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
30532004 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
30532004 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
30532004 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
30532004 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Faah Protein Structure

Amidase

Amidase: pfam01425 (94 - 561)

  • 0
  • 100
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  • 500
  • 579 a.a.
Protein Preferred Names Protein Names

fatty-acid amide hydrolase 1

amide hydrolase

anandamide amidohydrolase 1

fatty acid amide hydrolase protein

fatty acid ester hydrolase

oleamide hydrolase 1

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1227 Carprofen Inhibitor 99.79% Unkown
HY-B0182 Carmofur Inhibitor 99.95% Unkown
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-14376 Redafamdastat Inhibitor 99.89% Phase 2
HY-19636 JNJ-42165279 Inhibitor 99.87% Phase 2
HY-10864 URB-597 Inhibitor 99.15% Phase 1
Pre-clinical Phase
Bioactive Molecules (76)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14595 Biochanin A Inhibitor 99.29% Unkown
HY-119283 MAGL-IN-5 Inhibitor 99.58% Unkown
HY-14380 PF-3845 Inhibitor 99.95% Unkown
HY-15250 JZL195 Inhibitor 99.75% Unkown
HY-19740 BIA 10-2474 Inhibitor 99.39% Unkown
HY-N7062 JNJ-1661010 Inhibitor 99.77% Unkown
HY-136924 FP-Biotin 99.84% Unkown
HY-N2512 1-Monomyristin Inhibitor ≥98.0% Unkown
HY-116477 URB937 Inhibitor 99.85% Unkown
HY-10865 LY2183240 Inhibitor 98.01% Unkown
HY-125967 AM 374 Inhibitor ≥97.0% Unkown
HY-155773 VU534 Inhibitor 98.53% Unkown
HY-103337 N-Arachidonoylserotonin Inhibitor ≥98.0% Unkown
HY-79511 FAAH-IN-2 Inhibitor 98.21% Unkown
HY-18081 PF 750 Inhibitor 99.29% Unkown
HY-N2365 Macamide B Inhibitor 98.64% Unkown
HY-103462 TC-F2 Inhibitor 99.75% Unkown
HY-127023 Eicosapentaenoyl serotonin Inhibitor ≥99.0% Unkown
HY-123863 SSR411298 Inhibitor 99.75% Unkown
HY-103461 FAAH-IN-6 Inhibitor 99.70% Unkown
HY-152254 CB2R/FAAH modulator-3 Inhibitor 99.71% Unkown
HY-18544 AA38-3 Inhibitor 99.89% Unkown
HY-118158 FAAH/MAGL-IN-4 Inhibitor 99.83% Unkown
HY-18080 SA 47 Inhibitor ≥99.0% Unkown
HY-164495 Sob-AM2 / Unkown
HY-N3033 N-​Benzyllinolenamide Inhibitor 99.70% Unkown
HY-18013 JNJ-40355003 Inhibitor 99.81% Unkown
HY-10862 FAAH inhibitor 1 Inhibitor 98.91% Unkown
HY-111199 JP83 Inhibitor ≥99.0% Unkown
HY-111389 FAAH-IN-1 Inhibitor 99.93% Unkown
HY-10867 PF-622 Inhibitor / Unkown
HY-146342 FAAH/MAGL-IN-3 Inhibitor / Unkown
HY-148909 Isopropyl dodec-11-enylfluorophosphonate Inhibitor / Unkown
HY-157766 FAAH/TRPV1 blocker-1 Inhibitor / Unkown
HY-120961 Oleoyl ethyl amide Inhibitor / Unkown
HY-14595R Biochanin A (Standard) Inhibitor / Unkown
HY-116710 3-Decyl-5,5'-diphenyl-2-thioxo-4-imidazolidinone Inhibitor / Unkown
HY-B1227S1 Carprofen-13C,d3 / Unkown
HY-144738 Dual FAAH/sEH-IN-1 Inhibitor / Unkown
HY-149654 FAAH/cPLA2α-IN-1 Inhibitor / Unkown
HY-102054 Acetylhydrolase-IN-1 Inhibitor / Unkown
HY-143263 FAAH/MAGL-IN-1 Inhibitor / Unkown
HY-103463 SA57 Inhibitor ≥99.0% Unkown
HY-B1227S Carprofen-d3 Inhibitor / Unkown
HY-103338 AM1172 Inhibitor ≥99.0% Unkown
HY-143264 FAAH/MAGL-IN-2 Inhibitor / Unkown
HY-152253 CB2R/FAAH modulator-2 Inhibitor / Unkown
HY-151919 FAAH-IN-7 Inhibitor / Unkown
HY-120369 URB532 Inhibitor / Unkown
HY-N2428 N-(3-Methoxybenzyl)Palmitamide Inhibitor 99.96% Unkown
HY-146341 FAAH-IN-5 Inhibitor / Unkown
HY-152251 CB2R/FAAH modulator-1 Inhibitor / Unkown
HY-139143 WWL154 Inhibitor / Unkown
HY-W728451 URB694 Inhibitor / Unkown
HY-121558 JP104 Inhibitor / Unkown
HY-163733 AKU-005 Inhibitor / Unkown
HY-147910 Carpro-AM1 Inhibitor / Unkown
HY-122159 MDPD Activator / Unkown
HY-12909 MK-4409 Inhibitor / Unkown
HY-168563 BuChE-IN-15 Inhibitor / Unkown
HY-164506 NRMA-8 Modulator / Unkown
HY-10869 OL-135 Inhibitor / Unkown
HY-157132 FAAH-IN-8 Inhibitor / Unkown
HY-103339 VDM11 Inhibitor / Unkown
HY-139384 FAAH inhibitor 2 Inhibitor / Unkown
HY-W751418 N-Nervonoyl taurine / Unkown
HY-120481 JNJ-40413269 Inhibitor / Unkown
HY-111293 Arachidonamide / Unkown
HY-121090 FAAH-IN-9 Inhibitor / Unkown
HY-77491 FAAH/MAGL-IN-5 Inhibitor 99.17% Unkown
HY-158784 Arachidonoyl m-nitroaniline / Unkown
HY-161965 MK-3168 (12C) Inhibitor / Unkown
HY-120650 CAY10435 Inhibitor / Unkown
HY-19636A JNJ-42165279 dihydrochloride Inhibitor / Unkown
HY-118210 PHOP Inhibitor / Unkown
HY-U00240 SA72 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Faah NCBI NCBI:2166