2. Gene
  3. Hras - Harvey rat sarcoma virus oncogene Gene

Hras - Harvey rat sarcoma virus oncogene Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ras; H-ras; Hras1; Kras2; Ha-ras; Hras-1; c-H-ras; c-rasHa; c-Ha-ras; Harvey-ras

Gene ID: 15461 | Gene type: protein coding

About Hras

Chromosome 7: 140,769,018-140,773,918 reverse strand.GRCm39:CM001000.3

This gene has 7 transcripts (splice variants), 225 orthologues, 35 paralogues and is associated with 33 phenotypes. Ubiquitous expression in CNS E18 (RPKM 31.5), cortex adult (RPKM 31.3) and 28 other tissues.

Summary

Enables GTP binding activity. Involved in Ras protein signal transduction. Acts upstream of or within several processes, including defense response to protozoan; intracellular signal transduction; and positive regulation of interferon-gamma production. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome; high grade glioma; and malignant astrocytoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Hras Products(7)

mRNA Protein Name
NM_001130443.2 NP_001123915.1 GTPase HRas isoform 1
NM_001412480.1 NP_001399409.1 GTPase HRas isoform 1
NM_008284.3 NP_032310.2 GTPase HRas isoform 1
NM_001412481.1 NP_001399410.1 GTPase HRas isoform 1
NM_001412478.1 NP_001399407.1 GTPase HRas isoform 1
NM_001130444.2 NP_001123916.1 GTPase HRas isoform 2
NM_001412479.1 NP_001399408.1 GTPase HRas isoform 1

Hras Protein Structure

H_N_K_Ras_like

H_N_K_Ras_like: cd04138 (2 - 163)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

GTPase HRas

H-Ras-1

H-ras 1 protein

Harvey rat sarcoma virus oncogene 1

c-Ha-ras p21 protein

c-Ha-ras transgene

p21ras

transforming protein P21

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0660 Eicosapentaenoic Acid Activator 98.70% Yes
HY-15136 Lonafarnib 99.87% Yes
HY-W011269 Eicosapentaenoic Acid sodium Activator / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16373 CP-609754 Inhibitor 99.21% Phase 1
Pre-clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-156498 RMC-7977 Inhibitor 99.48% Unkown
HY-100002 ML162 99.45% Unkown
HY-122862 RAS inhibitor Abd-7 Inhibitor 99.16% Unkown
HY-18674 K-Ras-IN-1 Inhibitor 98.00% Unkown
HY-113849 MLS-573151 Inhibitor 99.74% Unkown
HY-145962A MRTX-EX185 formic Inhibitor 97.32% Unkown
HY-123242 FTI-2153 Inhibitor 99.11% Unkown
HY-125904 4-Hydroxyretinoic acid Activator 95.11% Unkown
HY-15879 LB42708 ≥99.0% Unkown
HY-123242A FTI-2153 TFA Inhibitor 99.11% Unkown
HY-115489 GGTI-286 Inhibitor / Unkown
HY-115489A GGTI-286 TFA Inhibitor / Unkown
HY-145962 MRTX-EX185 Inhibitor / Unkown
HY-117935 GGTI-286 hydrochloride Inhibitor / Unkown
HY-117807 A-176120 Inhibitor / Unkown
HY-120763 LB42908 Inhibitor / Unkown
HY-120828 Albenatide Agonist / Unkown
HY-151263 G4/HDAC-IN-1 / Unkown
HY-15136B (Rac)-Lonafarnib / Unkown
HY-RS06354 HRAS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06355 Hras Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06356 Hras Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-120271 GGTI-297 Inhibitor / Unkown
HY-B0660A Eicosapentaenoic acid (metformin) Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hras NCBI NCBI:3265