Hras - Harvey rat sarcoma virus oncogene Gene

Mus musculus

Also known as ras; H-ras; Hras1; Kras2; Ha-ras; Hras-1; c-H-ras; c-rasHa; c-Ha-ras; Harvey-ras

Gene ID: 15461 | Gene type: protein coding

About Hras

Chromosome 7: 140,769,018-140,773,918 reverse strand.GRCm39:CM001000.3

This gene has 7 transcripts (splice variants), 225 orthologues, 35 paralogues and is associated with 33 phenotypes. Ubiquitous expression in CNS E18 (RPKM 31.5), cortex adult (RPKM 31.3) and 28 other tissues.

Summary

Enables GTP binding activity. Involved in Ras protein signal transduction. Acts upstream of or within several processes, including defense response to protozoan; intracellular signal transduction; and positive regulation of interferon-gamma production. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome; high grade glioma; and malignant astrocytoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Hras Products(7)

mRNA	Protein	Name
NM_001130443.2	NP_001123915.1	GTPase HRas isoform 1
NM_001412480.1	NP_001399409.1	GTPase HRas isoform 1
NM_008284.3	NP_032310.2	GTPase HRas isoform 1
NM_001412481.1	NP_001399410.1	GTPase HRas isoform 1
NM_001412478.1	NP_001399407.1	GTPase HRas isoform 1
NM_001130444.2	NP_001123916.1	GTPase HRas isoform 2
NM_001412479.1	NP_001399408.1	GTPase HRas isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	18604197	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8939998	MGI
enables protein-membrane adaptor activity	IDA IDA: Inferred from direct assay	16405865	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Ras protein signal transduction	IGI IGI: Inferred from genetic interaction	11877426	MGI
involved in Schwann cell development	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21444916	MGI
acts upstream of or within T-helper 1 type immune response	IMP IMP: Inferred from mutant phenotype	21444916	MGI
involved in adipose tissue development	IMP IMP: Inferred from mutant phenotype	31408278	MGI
acts upstream of or within cellular senescence	IDA IDA: Inferred from direct assay	12878730	MGI
acts upstream of or within defense response to protozoan	IMP IMP: Inferred from mutant phenotype	21444916	MGI
acts upstream of or within endocytosis	IDA IDA: Inferred from direct assay	12446704	MGI
acts upstream of fibroblast proliferation	IDA IDA: Inferred from direct assay	16478791	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	7829473	MGI
acts upstream of or within intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	16954213	MGI
acts upstream of or within intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16954213	MGI
involved in myelination	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	10845775	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10845775	MGI
acts upstream of neuron apoptotic process	IDA IDA: Inferred from direct assay	10845775	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	10845775	MGI
acts upstream of or within oncogene-induced cell senescence	IDA IDA: Inferred from direct assay	11551927	MGI
acts upstream of or within positive regulation of cell population proliferation	IPI IPI: Inferred from physical interaction	14712229	MGI
acts upstream of or within positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	16478791	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	21357543	MGI
acts upstream of or within positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	21444916	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	12427827	MGI
acts upstream of or within small GTPase-mediated signal transduction	IDA IDA: Inferred from direct assay	14712229	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hras Protein Structure

H_N_K_Ras_like

0
100
189 a.a.

Protein Preferred Names

Protein Names

GTPase HRas

H-Ras-1	H-ras 1 protein
Harvey rat sarcoma virus oncogene 1	c-Ha-ras p21 protein
c-Ha-ras transgene	p21ras
transforming protein P21

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0660	Eicosapentaenoic Acid	Activator	98.70%	Yes
HY-15136	Lonafarnib		99.87%	Yes
HY-W011269	Eicosapentaenoic Acid sodium	Activator	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16373	CP-609754	Inhibitor	99.21%	Phase 1

Pre-clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156498	RMC-7977	Inhibitor	99.48%	Unkown
HY-100002	ML162		99.45%	Unkown
HY-122862	RAS inhibitor Abd-7	Inhibitor	99.16%	Unkown
HY-18674	K-Ras-IN-1	Inhibitor	98.00%	Unkown
HY-113849	MLS-573151	Inhibitor	99.74%	Unkown
HY-145962A	MRTX-EX185 formic	Inhibitor	97.32%	Unkown
HY-123242	FTI-2153	Inhibitor	99.11%	Unkown
HY-125904	4-Hydroxyretinoic acid	Activator	95.11%	Unkown
HY-15879	LB42708		≥99.0%	Unkown
HY-123242A	FTI-2153 TFA	Inhibitor	99.11%	Unkown
HY-115489	GGTI-286	Inhibitor	/	Unkown
HY-115489A	GGTI-286 TFA	Inhibitor	/	Unkown
HY-145962	MRTX-EX185	Inhibitor	/	Unkown
HY-117935	GGTI-286 hydrochloride	Inhibitor	/	Unkown
HY-117807	A-176120	Inhibitor	/	Unkown
HY-120763	LB42908	Inhibitor	/	Unkown
HY-120828	Albenatide	Agonist	/	Unkown
HY-151263	G4/HDAC-IN-1		/	Unkown
HY-15136B	(Rac)-Lonafarnib		/	Unkown
HY-RS06354	HRAS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06355	Hras Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06356	Hras Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-120271	GGTI-297	Inhibitor	/	Unkown
HY-B0660A	Eicosapentaenoic acid (metformin)	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hras	NCBI	NCBI:3265

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