Il17a - interleukin 17A Gene

Mus musculus

Also known as Il17; Ctla8; IL-17; Ctla-8; IL-17A

Gene ID: 16171 | Gene type: protein coding

About Il17a

Chromosome 1: 20,801,129-20,804,720 forward strand.GRCm39:CM000994.3

This gene has 1 transcript (splice variant), 97 orthologues, 5 paralogues and is associated with 39 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a pro-inflammatory cytokine that is a member of the interleukin-17 family. The encoded protein plays a central role in host defense against diverse pathogens. The encoded protein is produced by activated T-cells and certain cell types of innate immune system. The active protein functions as either a homodimer with Other interleukin-17 family members and signals through the interleukin-17 receptor to induce inflammatory cytokine production. Aberrant expression of this gene is associated with autoinflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Sep 2015]

Il17a Products(1)

mRNA	Protein	Name
NM_010552.3	NP_034682.1	interleukin-17A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	22727489	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18025225	MGI
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	18025225	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18025225	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Notch signaling pathway	IDA IDA: Inferred from direct assay	28561022	MGI
acts upstream of or within cellular response to interleukin-1	IDA IDA: Inferred from direct assay	19666510	MGI
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	19144317	MGI
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	20364087	MGI
involved in defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	19144317	MGI
involved in defense response to fungus	IMP IMP: Inferred from mutant phenotype	20554964	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	31164412	MGI
involved in granulocyte migration	IGI IGI: Inferred from genetic interaction	24026300	MGI
involved in intestinal epithelial structure maintenance	IMP IMP: Inferred from mutant phenotype	26431948	MGI
involved in keratinocyte differentiation	IDA IDA: Inferred from direct assay	31164412	MGI
involved in keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	31164412	MGI
involved in negative regulation of inflammatory response to wounding	IDA IDA: Inferred from direct assay	27830702	MGI
involved in positive regulation of antimicrobial peptide production	IDA IDA: Inferred from direct assay	19144317	MGI
involved in positive regulation of bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	26431948	MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 1 production	IDA IDA: Inferred from direct assay	18025225	MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response	IDA IDA: Inferred from direct assay	17982105	MGI
acts upstream of or within positive regulation of cytokine production involved in inflammatory response	IGI IGI: Inferred from genetic interaction	16785495	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	20554964	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16982811	MGI
involved in response to wounding	IDA IDA: Inferred from direct assay	22727489	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	18792410	MGI
is active in extracellular space	IDA IDA: Inferred from direct assay	22727489	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	16239543	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il17a Protein Structure

IL17

0
100
158 a.a.

Protein Preferred Names

Protein Names

interleukin-17A

cytotoxic T-lymphocyte-associated antigen 8

Recombinant Il17a Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7372	IL-17A Protein, Mouse (CHO)	Q62386 (A26-A158)	≥95%
HY-P70753	IL-17A Protein, Mouse (HEK293, His)	Q62386 (T22-A158)	≥95%
HY-P73174	IL-17A Protein, Mouse	Q62386 (T22-A158)	≥95%
HY-P77707	IL-17A/F Heterodimer Protein, Mouse (HEK293, His-Avi)	Q62386 (A26-A158)&Q7TNI7 (R29-A161)	≥95%
HY-P77708	IL-17A/F Heterodimer Protein, Mouse (Biotinylated, HEK293, His-Avi)	Q62386 (A26-A158)&Q7TNI7-1 (R29-A161)	≥95%
HY-P78158	IL-17A Protein, Mouse (Biotinylated, HEK293, His-Avi)	Q62386 (A26-A158)	≥95%
HY-P78320	IL-17A Protein, Mouse (HEK293, His-Avi)	Q62386 (A26-A158)	≥95%
HY-P700194AF	Animal-Free IL-17A Protein, Mouse (His)	Q62386 (A26-A158)	≥95%

Related Agents

Approval

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9927	Secukinumab	Inhibitor	≥99.20%	Unkown
HY-P9924	Ixekizumab	Inhibitor	98.90%	Unkown
HY-P99280	Bimekizumab	Antagonist	95.00%	Unkown

Clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Phase
HY-103637A	Vimirogant hydrochloride	Inhibitor	98.39%	Phase 2
HY-103637	Vimirogant	Inhibitor	/	Phase 2
HY-107390	AX-024	Inhibitor	99.29%	Phase 1
HY-107390A	AX-024 hydrochloride	Inhibitor	99.75%	Phase 1
HY-152851	Izumerogant	Agonist	99.95%	Phase 1

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99652	Gumokimab	Inhibitor	/	Phase 3
HY-P99515	Xeligekimab	Inhibitor	95.00%	Phase 3
HY-P99563	Tibulizumab	Inhibitor	/	Phase 3
HY-P99940	Remtolumab	Inhibitor	99.24%	Phase 2

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15826	SGC-CBP30	Inhibitor	99.83%	Unkown
HY-139206	LY3509754	Inhibitor	99.65%	Unkown
HY-101913	IL-17A antagonist 1	Antagonist	99.74%	Unkown
HY-141692	IL-17 modulator 4	Modulator	99.00%	Unkown
HY-145430	IL-17A modulator-1	Modulator	99.01%	Unkown
HY-101915	IL-17A antagonist 3	Antagonist	98.55%	Unkown
HY-139780	JNJ-61803534	Inhibitor	99.88%	Unkown
HY-145429	IL-17A modulator-2	Modulator	99.07%	Unkown
HY-P3450	Erepdekinra	Antagonist	98.60%	Unkown
HY-119464	MRL-871	Agonist	98.18%	Unkown
HY-133552	RORγt Inverse agonist 10	Antagonist	99.13%	Unkown
HY-128353	ROR agonist-1	Antagonist	/	Unkown
HY-126252	A-9758	Inhibitor	/	Unkown
HY-130243	RORγt Inverse agonist 6	Antagonist	98.97%	Unkown
HY-133128	FM26	Antagonist	/	Unkown
HY-139686	IL-17A inhibitor 2	Inhibitor	/	Unkown
HY-142939	RORγt modulator 4	Modulator	/	Unkown
HY-148272	IL-17A modulator-3	Modulator	/	Unkown
HY-153276	Androgen receptor-IN-5	Inhibitor	/	Unkown
HY-153780	Navepdekinra	Inhibitor	/	Unkown
HY-155243	12R-LOX-IN-1	Inhibitor	/	Unkown
HY-158159	IL17A-IN-1	Inhibitor	/	Unkown
HY-162490	TF-S14	Inhibitor	/	Unkown
HY-168084	IL-17-IN-1	Inhibitor	/	Unkown
HY-169007	STAT3-IN-34	Inhibitor	/	Unkown
HY-169305	IL-17A inhibitor 3	Inhibitor	/	Unkown
HY-169306	IL-17A inhibitor 4	Inhibitor	/	Unkown
HY-N0976	1,11b-Dihydro-11b-hydroxymedicarpin		/	Unkown
HY-N11768	4-Methoxylonchocarpin	Inhibitor	/	Unkown
HY-RS06695	IL17A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06696	Il17a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06697	Il17a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-155244	12R-LOX-IN-2	Inhibitor	99.85%	Unkown
HY-164826	Acetyl zingerone	Inhibitor	/	Unkown
HY-N12481	Cephalandole B		/	Unkown
HY-N13251	Verbena Extract		/	Unkown

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9927A	Secukinumab (Anti-Human IL-17A)	Antagonist	/	Unkown
HY-P99310	Perakizumab	Inhibitor	99.79%	Unkown
HY-P99335	Vunakizumab		95.00%	Unkown
HY-P990741	Galvokimig		/	Unkown
HY-P990761	Roconkibart		/	Unkown
HY-P99424	Afasevikumab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il17a	NCBI	NCBI:3605
Canis familiaris	Il17a	NCBI	NCBI:481837
Macaca fascicularis	Il17a	NCBI	NCBI:102119976
Susscrofa domestica	Il17a	NCBI
Leporidae	Il17a	NCBI
Rattus norvegicus	Il17a	NCBI	NCBI:301289
Macaca mulatta	Il17a	NCBI	NCBI:708123

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