2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. ROR
  4. MRL-871

MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells.

For research use only. We do not sell to patients.

MRL-871 Chemical Structure

MRL-871 Chemical Structure

CAS No. : 1392809-08-3

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5 mg USD 290 In-stock
10 mg USD 480 In-stock
25 mg USD 960 In-stock
50 mg USD 1550 In-stock
100 mg USD 2480 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

MRL-871 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE MRL-871

View All ROR Isoform Specific Products:

View All Isoforms
RORγ RORα RORβ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

MRL-871 (compound 3) is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 12.7 nM. MRL-871 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells[1].

Cellular Effect
Cell Line Type Value Description References
PBMC IC50
39.6 nM
Compound: 39; PDB 4YPQ, MRL-871
Inhibition of IL17 production in human PBMC cells measured after 4 days by enzyme-linked immunosorbent assay
Inhibition of IL17 production in human PBMC cells measured after 4 days by enzyme-linked immunosorbent assay
[PMID: 30010338]
In Vitro

MRL-871 (compound 3; 10 μM, 24h) significantly reduces IL-17a mRNA expression 48-fold in EL4 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MRL-871 Related Antibodies
Molecular Weight

444.79

Formula

C22H12ClF3N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C=C1)C2=NN(C3=C2C=CC=C3)C(C4=C(C=CC=C4Cl)C(F)(F)F)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (56.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2483 mL 11.2413 mL 22.4825 mL
5 mM 0.4497 mL 2.2483 mL 4.4965 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.18%

SDS (251 KB)

COA (255 KB) HNMR (283 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2483 mL 11.2413 mL 22.4825 mL 56.2063 mL
5 mM 0.4497 mL 2.2483 mL 4.4965 mL 11.2413 mL
10 mM 0.2248 mL 1.1241 mL 2.2483 mL 5.6206 mL
15 mM 0.1499 mL 0.7494 mL 1.4988 mL 3.7471 mL
20 mM 0.1124 mL 0.5621 mL 1.1241 mL 2.8103 mL
25 mM 0.0899 mL 0.4497 mL 0.8993 mL 2.2483 mL
30 mM 0.0749 mL 0.3747 mL 0.7494 mL 1.8735 mL
40 mM 0.0562 mL 0.2810 mL 0.5621 mL 1.4052 mL
50 mM 0.0450 mL 0.2248 mL 0.4497 mL 1.1241 mL
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MRL-871 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRL-8711392809-08-3MRL871MRL 871RORRAR-related orphan receptorallostericRORγtinverseisoxazolechemotypeIL-17amRNAEL4cellsInhibitorinhibitorinhibit

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