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  2. Il17a - interleukin 17A Gene

Il17a - interleukin 17A Gene

Rattus norvegicus

Also known as Il17; IL-17; CTLA-8; IL-17A

Gene ID: 301289 | Gene type: protein coding

About Il17a

Primary_assembly 9: 23,144,402-23,147,889 forward strand.mRatBN7.2:CM026982.1

This gene has 1 transcript (splice variant), 97 orthologues, 4 paralogues and is associated with 105 phenotypes. Low expression observed in reference dataset.

Summary

Predicted to enable protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of necrotic cell death; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and extracellular space. Used to study anti-basement membrane glomerulonephritis; congestive heart failure; myocarditis; pleurisy; and uveitis. Biomarker of several diseases, including acute necrotizing pancreatitis; inflammatory bowel disease (multiple); lipoid nephrosis; lung disease (multiple); and periodontal disease (multiple). Human ortholog(s) of this gene implicated in Mycobacterium avium complex disease; autoimmune disease (multiple); bronchial disease (multiple); macular degeneration; and rhinitis (multiple). Orthologous to human IL17A (interleukin 17A). [provided by Alliance of Genome Resources, Apr 2022]

Il17a Products(1)

mRNA Protein Name
NM_001106897.1 NP_001100367.1 interleukin-17A precursor

Il17a Protein Structure

IL17

IL17: pfam06083 (71 - 149)

  • 0
  • 100
  • 158 a.a.
Protein Preferred Names Protein Names

interleukin-17A

Interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)

cytotoxic T-lymphocyte-associated antigen 8

Recombinant Il17a Proteins

Cat. No. Product Name Accession Purity
HY-P79326 IL-17A Protein, Rat (CHO) G3V7M4/NP_001100367 (A26-S158) ≥95%
HY-P78556 IL-17A Protein, Rat (His) NP_001100367 (A26-S158) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Il17a NCBI NCBI:3605
Canis familiaris Il17a NCBI NCBI:481837
Macaca fascicularis Il17a NCBI NCBI:102119976
Mus musculus Il17a NCBI NCBI:16171
Susscrofa domestica Il17a NCBI
Leporidae Il17a NCBI
Macaca mulatta Il17a NCBI NCBI:708123