1. Gene
  2. Ret - ret proto-oncogene Gene

Ret - ret proto-oncogene Gene

Mus musculus

Also known as PTC; RET9; RET51; c-Ret

Gene ID: 19713 | Gene type: protein coding

About Ret

Chromosome 6: 118,128,706-118,174,679 reverse strand.GRCm39:CM000999.3

This gene has 2 transcripts (splice variants), 205 orthologues, 53 paralogues and is associated with 115 phenotypes. Broad expression in cerebellum adult (RPKM 5.3), subcutaneous fat pad adult (RPKM 4.5) and 18 other tissues.

Summary

Enables transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including Peyer's patch morphogenesis; neuron cell-cell adhesion; and positive regulation of metanephric glomerulus development. Acts upstream of or within several processes, including animal organ development; nervous system development; and positive regulation of macromolecule metabolic process. Predicted to be located in several cellular components, including endosome; membrane raft; and neuronal cell body. Predicted to be part of plasma membrane protein complex and receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in several structures, including branchial arch; genitourinary system; gut; nervous system; and sensory organ. Used to study Hirschsprung's disease; clubfoot; multiple endocrine neoplasia type 2B; and pheochromocytoma. Human ortholog(s) of this gene implicated in Hirschsprung's disease; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; multiple endocrine neoplasia type 2B; and pheochromocytoma. Orthologous to human RET (RET proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]

Ret Products(2)

mRNA Protein Name
NM_009050.2 NP_033076.2 proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor
NM_001080780.1 NP_001074249.1 proto-oncogene tyrosine-protein kinase receptor Ret isoform c precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9452475 MGI
enables transmembrane receptor protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
28846099 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within MAPK cascade IGI
IGI: Inferred from genetic interaction
15569713 MGI
involved in Peyer's patch morphogenesis IMP
IMP: Inferred from mutant phenotype
17322904 MGI
acts upstream of or within cell surface receptor protein tyrosine kinase signaling pathway IGI
IGI: Inferred from genetic interaction
9576965 MGI
acts upstream of or within embryonic epithelial tube formation IGI
IGI: Inferred from genetic interaction
15569713 MGI
acts upstream of or within enteric nervous system development IMP
IMP: Inferred from mutant phenotype
9834195 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
11069590 MGI
acts upstream of or within neural crest cell migration IMP
IMP: Inferred from mutant phenotype
15242795 MGI
involved in neuron cell-cell adhesion IDA
IDA: Inferred from direct assay
21357690 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
17553423 MGI
acts upstream of or within neuron maturation IMP
IMP: Inferred from mutant phenotype
15233745 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
17047028 MGI
acts upstream of or within positive regulation of cell size IMP
IMP: Inferred from mutant phenotype
17553423 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22897442 MGI
involved in positive regulation of metanephric glomerulus development IMP
IMP: Inferred from mutant phenotype
17047028 MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
23872421 MGI
acts upstream of or within regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
17553423 MGI
involved in response to pain IMP
IMP: Inferred from mutant phenotype
20237269 MGI
acts upstream of or within ureter maturation IMP
IMP: Inferred from mutant phenotype
21521737 MGI
acts upstream of or within ureteric bud development IMP
IMP: Inferred from mutant phenotype
12195422 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ret Protein Structure

RET_CLD1

RET_CLD1: pfam17756 (28 - 153)

Cadherin

Cadherin: pfam00028 (172 - 261)

RET_CLD3

RET_CLD3: pfam17812 (265 - 379)

RET_CLD4

RET_CLD4: pfam17813 (408 - 507)

PTKc_RET

PTKc_RET: cd05045 (723 - 1012)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1073 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase receptor Ret

proto-oncogene c-Ret

Orthologs Information

Species Symbol Source ID
Homo sapiens Ret NCBI NCBI:5979
Canis familiaris Ret NCBI NCBI:403494
Macaca fascicularis Ret NCBI NCBI:102135879
Susscrofa domestica Ret NCBI
Rattus norvegicus Ret NCBI NCBI:24716
Macaca mulatta Ret NCBI NCBI:703466