Sos1 - SOS Ras/Rac guanine nucleotide exchange factor 1 Gene

Mus musculus

Also known as 9630010N06; 4430401P03Rik

Gene ID: 20662 | Gene type: protein coding

About Sos1

Summary

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including animal organ development; regulation of T cell activation; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in several cellular components, including neuronal cell body; plasma membrane; and postsynaptic density. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and retina. Used to study Noonan syndrome 4. Human ortholog(s) of this gene implicated in Noonan syndrome; Noonan syndrome 4; and gingival fibromatosis. Orthologous to human SOS1 (SOS Ras/Rac guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sos1 Products(1)

mRNA	Protein	Name
NM_009231.2	NP_033257.2	son of sevenless homolog 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	EXP EXP: Inferred from Experiment	15644420	MGI
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	7799946	MGI
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	7799946	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8479540	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15661907	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell homeostasis	IGI IGI: Inferred from genetic interaction	24043312	MGI
involved in B cell receptor signaling pathway	IGI IGI: Inferred from genetic interaction	24043312	MGI
involved in Schwann cell development	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	9030684	MGI
acts upstream of or within cardiac atrium morphogenesis	IMP IMP: Inferred from mutant phenotype	9030684	MGI
acts upstream of or within epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9030684	MGI
acts upstream of or within eyelid development in camera-type eye	IGI IGI: Inferred from genetic interaction	9030684	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	11585837	MGI
acts upstream of or within hair follicle development	IGI IGI: Inferred from genetic interaction	9030684	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	9030684	MGI
acts upstream of or within heart trabecula morphogenesis	IMP IMP: Inferred from mutant phenotype	9030684	MGI
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	7829473	MGI
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	33567274	MGI
acts upstream of or within lymphocyte homeostasis	IGI IGI: Inferred from genetic interaction	24043312	MGI
acts upstream of or within midbrain morphogenesis	IMP IMP: Inferred from mutant phenotype	9030684	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	9030684	MGI
involved in myelination	IMP IMP: Inferred from mutant phenotype	10704452	MGI
acts upstream of or within pericardium morphogenesis	IMP IMP: Inferred from mutant phenotype	9030684	MGI
acts upstream of or within regulation of T cell differentiation in thymus	IGI IGI: Inferred from genetic interaction	24043312	MGI
acts upstream of or within regulation of T cell proliferation	IGI IGI: Inferred from genetic interaction	24043312	MGI
acts upstream of or within regulation of pro-B cell differentiation	IGI IGI: Inferred from genetic interaction	24043312	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	9030684	MGI
acts upstream of or within small GTPase-mediated signal transduction	IMP IMP: Inferred from mutant phenotype	15728722	MGI
acts upstream of or within vitellogenesis	IMP IMP: Inferred from mutant phenotype	9030684	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

son of sevenless homolog 1

guanine nucleotide releasing factor	ras guanine exchange factor
son-of-sevenless 1

Sos1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sos1	Q62245	Grb2	Mus musculus	Q60631	Anti Bait CoIP	9569023
Intra	Sos1	Q62245	Grb2	Mus musculus	Q60631	Anti Bait CoIP	8479540
Cross	Sos1	Q62245	polg_hcvbk	Hepatitis C virus	P26663	Fluorescence Spectr	15767257
Cross	Sos1	Q62245	polg_hcvbk	Hepatitis C virus	P26663	NMR	15767257

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-134813	MRTX1133	Inhibitor	99.97%	Phase 2

Pre-clinical Phase

Bioactive Molecules (73)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125817	BI-3406	Inhibitor	99.95%	Unkown
HY-114398	BAY-293	Inhibitor	98.97%	Unkown
HY-145926	MRTX0902	Inhibitor	99.75%	Unkown
HY-134885	RMC-0331	Inhibitor	98.96%	Unkown
HY-P2265A	SAH-SOS1A TFA	Inhibitor	99.16%	Unkown
HY-151881	SOS1-IN-15	Inhibitor	99.51%	Unkown
HY-111671	SOS1 activator 1	Activator	98.01%	Unkown
HY-151517	SOS1-IN-14	Inhibitor	99.60%	Unkown
HY-148278	BI-0474	Inhibitor	99.83%	Unkown
HY-153606	SOS1 agonist-1	Activator	97.24%	Unkown
HY-145737A	PROTAC SOS1 degrader-1 TFA	Agonist	99.38%	Unkown
HY-144962	SOS1-IN-11	Inhibitor	98.22%	Unkown
HY-W056267	3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde		≥98.0%	Unkown
HY-101796	NSC-70220	Inhibitor	99.42%	Unkown
HY-161235	BTX-7312	Degrader	98.35%	Unkown
HY-134813A	MRTX1133 formic	Inhibitor	98.23%	Unkown
HY-161233	BTX-6654	Inhibitor	/	Unkown
HY-114398A	(S)-BAY-293	Control	/	Unkown
HY-158310	SOS1/EGFR-IN-1	Inhibitor	99.54%	Unkown
HY-144212	SOS1-IN-8	Inhibitor	/	Unkown
HY-124514	UC-857993	Inhibitor	/	Unkown
HY-144207	SOS1-IN-9	Inhibitor	/	Unkown
HY-144210	SOS1-IN-6	Inhibitor	/	Unkown
HY-144211	SOS1-IN-7	Inhibitor	/	Unkown
HY-144213	SOS1-IN-10	Inhibitor	/	Unkown
HY-144657	(4S)-PROTAC SOS1 degrader-1	Inhibitor	/	Unkown
HY-144657A	(4S)-PROTAC SOS1 degrader-1 diTFA	Inhibitor	98.09%	Unkown
HY-144965	SOS1-IN-12	Inhibitor	/	Unkown
HY-144967	SOS1-IN-13	Inhibitor	/	Unkown
HY-145046	SOS1-IN-3	Inhibitor	/	Unkown
HY-145047	SOS1-IN-4	Inhibitor	/	Unkown
HY-145048	SOS1-IN-5	Inhibitor	/	Unkown
HY-145737	PROTAC SOS1 degrader-1	Agonist	/	Unkown
HY-148261	KRAS G12C inhibitor 56	Inhibitor	/	Unkown
HY-151968	KRAS G12C inhibitor 57	Inhibitor	/	Unkown
HY-152145	PROTAC SOS1 degrader-3		/	Unkown
HY-153674	PROTAC SOS1 degrader-4	Degrader	/	Unkown
HY-153940	SOS1/KRAS-IN-1	Inhibitor	/	Unkown
HY-153989	SOS1-IN-16	Inhibitor	/	Unkown
HY-161173	PROTAC SOS1 degrader-5		/	Unkown
HY-161236	KRAS ligand 4	Inhibitor	/	Unkown
HY-161450	LHF418	Inhibitor	/	Unkown
HY-161452	SOS1 Ligand intermediate-3		/	Unkown
HY-161634	PROTAC SOS1 degrader-8	Degrader	/	Unkown
HY-161635	SOS1 Ligand intermediate-4	Inhibitor	/	Unkown
HY-161636	PROTAC SOS1 degrader-9	Degrader	/	Unkown
HY-161637	E3 ligase Ligand 25		/	Unkown
HY-161639	E3 ligase Ligand 26		/	Unkown
HY-161654	PROTAC SOS1 degrader-10	Degrader	/	Unkown
HY-161714	HH0043	Inhibitor	/	Unkown
HY-162281	PROTAC SOS1 degrader-6	Degrader	/	Unkown
HY-163582	PROTAC SOS1 degrader-7		/	Unkown
HY-163939	RGT-018	Inhibitor	/	Unkown
HY-167768	SOS1 activator 2	Modulator	/	Unkown
HY-168514	SOS1/EGFR-IN-2	Inhibitor	/	Unkown
HY-168637	SIAIS562055	Inhibitor	/	Unkown
HY-168638	PROTAC SOS1 ligand 1		/	Unkown
HY-168716	SOS1-IN-17	Inhibitor	/	Unkown
HY-169371	SOS1 Ligand intermediate-7		/	Unkown
HY-172221	SOS1-IN-18	Inhibitor	/	Unkown
HY-173047	KRASG12C IN-15	Inhibitor	/	Unkown
HY-19539	NSC-658497	Inhibitor	/	Unkown
HY-49515	SOS1 Ligand intermediate-2		/	Unkown
HY-P2265	SAH-SOS1A	Inhibitor	/	Unkown
HY-RS13576	SOS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-132129	SOS1-IN-2	Inhibitor	/	Unkown
HY-161638	E3 Ligase Ligand-linker Conjugate 108		/	Unkown
HY-161640	E3 Ligase Ligand-linker Conjugate 109		/	Unkown
HY-161655	SOS1 Ligand intermediate-5		/	Unkown
HY-161656	PIP-C-3-Azaspiro[5.5]undecane-boc		/	Unkown
HY-161657	2-Methoxyphenyl dihydrouracil-azaspiro[5.5]undecane-C-PIP		/	Unkown
HY-163583	SOS1 Ligand intermediate-6		/	Unkown
HY-49514	SOS1 Ligand intermediate-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sos1	NCBI	NCBI:6654

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