Smo - smoothened, frizzled class receptor Gene

Rattus norvegicus

Also known as Smoh

Gene ID: 25273 | Gene type: protein coding

About Smo

Primary_assembly 4: 58,343,529-58,373,829 forward strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 204 orthologues, 15 paralogues and is associated with 46 phenotypes. Biased expression in Uterus (RPKM 82.7), Kidney (RPKM 58.7) and 9 other tissues.

Summary

Predicted to enable patched binding activity. Involved in several processes, including neuron projection development; osteoblast proliferation; and positive regulation of vascular associated smooth muscle cell migration. Located in several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Used to study Barrett's esophagus; esophagus adenocarcinoma; and middle cerebral artery infarction. Biomarker of ocular hypertension; pancreatitis; pre-malignant neoplasm; and visual epilepsy. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human Smo (smoothened, Frizzled class receptor). [provided by Alliance of Genome Resources, Apr 2022]

Smo Products(1)

mRNA	Protein	Name
NM_012807.2	NP_036939.2	smoothened homolog precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon extension involved in axon guidance	IMP IMP: Inferred from mutant phenotype	19447091	RGD
involved in commissural neuron axon guidance	IMP IMP: Inferred from mutant phenotype	19946319	RGD
involved in facial nerve development	IEP IEP: Inferred from expression pattern	15356205	RGD
involved in mesenchymal to epithelial transition	IMP IMP: Inferred from mutant phenotype	22994359	RGD
involved in negative regulation of hepatocyte proliferation	IMP IMP: Inferred from mutant phenotype	22994359	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	20848190	RGD
involved in neuron projection regeneration	IEP IEP: Inferred from expression pattern	15356205	RGD
involved in osteoblast differentiation	IEP IEP: Inferred from expression pattern	19649528	RGD
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	31221056	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	20600593	RGD
involved in positive regulation of hepatic stellate cell activation	IMP IMP: Inferred from mutant phenotype	22994359	RGD
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	23696546	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	24472833	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	19484749	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axonal growth cone	IDA IDA: Inferred from direct assay	21618238	RGD
located in dendrite	IDA IDA: Inferred from direct assay	21618238	RGD
located in dendritic growth cone	IDA IDA: Inferred from direct assay	21618238	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15356205	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	21618238	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

smoothened homolog

smoothened protein

smoothened, frizzled family receptor

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16582A	Sonidegib	Antagonist	99.94%	Yes
HY-16391	Glasdegib	Inhibitor	99.34%	Yes
HY-16582	Sonidegib diphosphate	Antagonist	99.73%	Yes
HY-B0877	Halcinonide	Agonist	99.56%	Unkown
HY-B0603	Fluticasone	Agonist	98.70%	Unkown
HY-16391A	Glasdegib maleate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16587	Saridegib	Inhibitor	99.87%	Phase 3
HY-13242	Taladegib	Inhibitor	99.92%	Phase 2
HY-13809	BMS-833923	Inhibitor	99.82%	Phase 2
HY-18636	LEQ506	Inhibitor	98.92%	Phase 1

Pre-clinical Phase

Bioactive Molecules (52)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12848	SAG	Agonist	99.79%	Unkown
HY-17024	Cyclopamine	Inhibitor	99.97%	Unkown
HY-15108	Purmorphamine	Activator	99.9%	Unkown
HY-12848B	SAG hydrochloride	Agonist	99.63%	Unkown
HY-100224	SANT-1	Antagonist	99.87%	Unkown
HY-15483	DY131	Inhibitor	99.72%	Unkown
HY-12848C	SAG dihydrochloride	Agonist	99.56%	Unkown
HY-12316	20(S)-Hydroxycholesterol	Activator	99.29%	Unkown
HY-100535	KAAD-Cyclopamine	Antagonist	≥96.0%	Unkown
HY-12317	GSA-10	Agonist	98.01%	Unkown
HY-N0836	Jervine	Inhibitor	98.86%	Unkown
HY-15412	HhAntag		99.40%	Unkown
HY-13459	PF-5274857	Antagonist	99.31%	Unkown
HY-15108G	Purmorphamine (GMP)	Agonist	/	Unkown
HY-145387	MRT-81	Antagonist	99.85%	Unkown
HY-N0247	Saikosaponin B1	Inhibitor	99.42%	Unkown
HY-100036	MK-4101	Antagonist	99.16%	Unkown
HY-117407	ALLO-2	Antagonist	99.72%	Unkown
HY-113965	CUR61414	Inhibitor	99.04%	Unkown
HY-18287A	MRT-83 hydrochloride	Antagonist	99.60%	Unkown
HY-108507	MRT-10	Antagonist	98.99%	Unkown
HY-151115	JNJ-1289	Inhibitor	98.06%	Unkown
HY-108508	SMANT hydrochloride	Inhibitor	99.90%	Unkown
HY-18287	MRT-83	Antagonist	99.27%	Unkown
HY-12848R	SAG (Standard)	Agonist	/	Unkown
HY-16391B	Glasdegib hydrochloride	Inhibitor	/	Unkown
HY-148440	RL-0070933	Modulator	/	Unkown
HY-162273	Antibacterial agent 189		/	Unkown
HY-115566	S1PL-IN-1	Antagonist	/	Unkown
HY-13459A	PF-5274857 hydrochloride	Antagonist	/	Unkown
HY-150567	SMO-IN-3	Inhibitor	/	Unkown
HY-150564	SMO-IN-2	Inhibitor	98.12%	Unkown
HY-137115	BODIPY-Cyclopamine		/	Unkown
HY-16391S1	Glasdegib-d4	Inhibitor	/	Unkown
HY-12316R	20(S)-Hydroxycholesterol (Standard)	Activator	/	Unkown
HY-145918	MRT-14	Antagonist	98.91%	Unkown
HY-147744	AZD7254	Inhibitor	/	Unkown
HY-110240	IHR-1	Antagonist	98.05%	Unkown
HY-12848A	(Rac)-SAG	Agonist	/	Unkown
HY-12848S	SAG-d3	Inhibitor	99.85%	Unkown
HY-147743	SMO-IN-1	Inhibitor	/	Unkown
HY-147670	TPB15	Inhibitor	/	Unkown
HY-131016	IHR-Cy3	Antagonist	/	Unkown
HY-120499	AZD8542	Antagonist	/	Unkown
HY-159893	SMO-IN-5	Inhibitor	/	Unkown
HY-162372	Hedgehog IN-6	Inhibitor	/	Unkown
HY-153499	SMO-IN-4	Antagonist	/	Unkown
HY-133974	7-keto-25-Hydroxycholesterol	Activator	/	Unkown
HY-117903A	MRT-92	Antagonist	/	Unkown
HY-16587A	Saridegib hydrochloride	Inhibitor	/	Unkown
HY-123752	MS-0022	Antagonist	/	Unkown
HY-100224G	SANT-1 (GMP)	Antagonist	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990418	Anti-FZD7 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smo	NCBI	NCBI:6608
Mus musculus	Smo	NCBI	NCBI:319757

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