2. Gene
  3. Smo - smoothened, frizzled class receptor Gene

Smo - smoothened, frizzled class receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as bnb; Smoh; smoothened; E130215L21Rik

Gene ID: 319757 | Gene type: protein coding

About Smo

Chromosome 6: 29,735,502-29,761,364 forward strand.GRCm39:CM000999.3

This gene has 2 transcripts (splice variants), 204 orthologues, 15 paralogues and is associated with 40 phenotypes. Broad expression in ovary adult (RPKM 53.2), limb E14.5 (RPKM 37.8) and 25 other tissues.

Summary

Predicted to enable patched binding activity. Involved in several processes, including animal organ development; regulation of animal organ morphogenesis; and regulation of gene expression. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regionalization. Located in 9+0 non-motile cilium; ciliary membrane; and cytoplasm. Is expressed in several structures, including 1st branchial arch; 4-cell stage embryo; alimentary system; central nervous system; and genitourinary system. Used to study medulloblastoma and pulmonary emphysema. Human ortholog(s) of this gene implicated in basal cell carcinoma; hepatocellular carcinoma; pancreatic cancer; and pancreatic ductal carcinoma. Orthologous to human Smo (smoothened, Frizzled class receptor). [provided by Alliance of Genome Resources, Apr 2022]

Smo Products(1)

mRNA Protein Name
NM_176996.5 NP_795970.3 smoothened homolog precursor

Smo Protein Structure

CRD_SMO

CRD_SMO: cd07451 (69 - 199)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (223 - 553)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (232 - 257)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (267 - 288)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (318 - 344)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (362 - 378)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (400 - 429)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (451 - 478)

7tmF_SMO_homolog

7tmF_SMO_homolog: cd15030 (514 - 539)

  • 0
  • 200
  • 400
  • 600
  • 793 a.a.
Protein Preferred Names Protein Names

smoothened homolog

bent body

Related Agents

Approval
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16582A Sonidegib Antagonist 99.94% Yes
HY-16391 Glasdegib Inhibitor 99.31% Yes
HY-16582 Sonidegib diphosphate Antagonist 99.73% Yes
HY-B0877 Halcinonide Agonist 99.56% Unkown
HY-B0603 Fluticasone Agonist / Unkown
HY-16391A Glasdegib maleate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-16587 Saridegib Inhibitor 99.87% Phase 3
HY-13242 Taladegib Inhibitor 99.57% Phase 2
HY-13809 BMS-833923 Inhibitor 98.11% Phase 2
Pre-clinical Phase
Bioactive Molecules (48)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12848 SAG Agonist 99.79% Unkown
HY-17024 Cyclopamine Inhibitor 99.97% Unkown
HY-15108 Purmorphamine Activator 99.89% Unkown
HY-12848B SAG hydrochloride Agonist 99.63% Unkown
HY-100224 SANT-1 Antagonist 99.87% Unkown
HY-15483 DY131 Inhibitor 99.72% Unkown
HY-12848C SAG dihydrochloride Agonist 99.56% Unkown
HY-12316 20(S)-Hydroxycholesterol Activator 98.70% Unkown
HY-100535 KAAD-Cyclopamine Antagonist ≥96.0% Unkown
HY-12317 GSA-10 Agonist 98.01% Unkown
HY-18636 LEQ506 Inhibitor 98.15% Unkown
HY-15412 HhAntag 99.40% Unkown
HY-N0836 Jervine Inhibitor 98.03% Unkown
HY-145387 MRT-81 Antagonist 99.85% Unkown
HY-13459 PF-5274857 Antagonist 98.89% Unkown
HY-100036 MK-4101 Antagonist 98.31% Unkown
HY-117407 ALLO-2 Antagonist 99.72% Unkown
HY-113965 CUR61414 Inhibitor 99.04% Unkown
HY-18287 MRT-83 Antagonist 99.27% Unkown
HY-108508 SMANT hydrochloride Inhibitor 99.90% Unkown
HY-18287A MRT-83 hydrochloride Antagonist 99.60% Unkown
HY-108507 MRT-10 Antagonist 98.99% Unkown
HY-N0247 Saikosaponin B1 Inhibitor 99.42% Unkown
HY-12848R SAG (Standard) Agonist / Unkown
HY-15108G Purmorphamine (GMP) Agonist / Unkown
HY-150567 SMO-IN-3 Inhibitor / Unkown
HY-137115 BODIPY-Cyclopamine / Unkown
HY-16391B Glasdegib hydrochloride Inhibitor / Unkown
HY-147744 AZD7254 Inhibitor / Unkown
HY-162372 Hedgehog IN-6 Inhibitor / Unkown
HY-145918 MRT-14 Antagonist 98.91% Unkown
HY-131016 IHR-Cy3 Antagonist / Unkown
HY-12848A (Rac)-SAG Agonist / Unkown
HY-110240 IHR-1 Antagonist 98.05% Unkown
HY-147743 SMO-IN-1 Inhibitor / Unkown
HY-150564 SMO-IN-2 Inhibitor 98.12% Unkown
HY-115566 S1PL-IN-1 Antagonist / Unkown
HY-153499 SMO-IN-4 Antagonist / Unkown
HY-12848S SAG-d3 Inhibitor 99.85% Unkown
HY-147670 TPB15 Inhibitor / Unkown
HY-13459A PF-5274857 hydrochloride Antagonist / Unkown
HY-148440 RL-0070933 Modulator / Unkown
HY-120499 AZD8542 Antagonist / Unkown
HY-12316R 20(S)-Hydroxycholesterol (Standard) Activator / Unkown
HY-162273 Antibacterial agent 189 / Unkown
HY-123752 MS-0022 Antagonist / Unkown
HY-117903A MRT-92 Antagonist / Unkown
HY-16587A Saridegib hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smo NCBI NCBI:6608
Rattus norvegicus Smo NCBI NCBI:25273