BAHD1 - bromo adjacent homology domain containing 1 Gene

Homo sapiens

Gene ID: 22893 | Gene type: protein coding

About BAHD1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,437,452-40,468,236 (from NCBI)

This gene has 4 transcripts (splice variants), 269 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 12.0), ovary (RPKM 8.8) and 25 other tissues.

Summary

Enables chromatin binding activity. Involved in heterochromatin assembly and negative regulation of transcription, DNA-templated. Located in nucleoplasm. Part of chromatin silencing complex. [provided by Alliance of Genome Resources, Apr 2022]

BAHD1 Products(3)

mRNA	Protein	Name
NM_001301132.2	NP_001288061.1	bromo adjacent homology domain-containing 1 protein isoform b
NM_001411044.1	NP_001397973.1	bromo adjacent homology domain-containing 1 protein isoform c
NM_014952.5	NP_055767.3	bromo adjacent homology domain-containing 1 protein isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	19666599	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in heterochromatin formation	IMP IMP: Inferred from mutant phenotype	19666599	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19666599	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of chromatin silencing complex	IDA IDA: Inferred from direct assay	19666599	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BAHD1 Protein Structure

BAH

0
200
400
600
780 a.a.

Protein Preferred Names

Protein Names

bromo adjacent homology domain-containing 1 protein

BAH domain-containing protein 1

BAHD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BAHD1	Q8TBE0	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	BAHD1	Q8TBE0	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	BAHD1	Q8TBE0	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	BAHD1	Q8TBE0	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	FKBP1A	Homo sapiens	Q0VDC6	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	FKBP1A	Homo sapiens	Q0VDC6	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	FKBP1A	Homo sapiens	Q0VDC6	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	EIF2S3	Homo sapiens	P41091	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	EIF2S3	Homo sapiens	P41091	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	EIF2S3	Homo sapiens	P41091	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	ZNF526	Homo sapiens	Q8TF50	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	ZNF526	Homo sapiens	Q8TF50	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	ZNF526	Homo sapiens	Q8TF50	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	ZNF837	Homo sapiens	Q96EG3	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	ZNF837	Homo sapiens	Q96EG3	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	ZNF837	Homo sapiens	Q96EG3	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	ZNF317	Homo sapiens	Q96PQ6	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	ZNF317	Homo sapiens	Q96PQ6	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	ZNF317	Homo sapiens	Q96PQ6	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	KRTAP19-1	Homo sapiens	Q8IUB9	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	KRTAP2-4	Homo sapiens	Q9BYR9	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	BACH2	Homo sapiens	Q9BYV9	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	BACH2	Homo sapiens	Q9BYV9	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	BACH2	Homo sapiens	Q9BYV9	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	ZNF275	Homo sapiens	Q9NSD4	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	ZNF275	Homo sapiens	Q9NSD4	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	ZNF275	Homo sapiens	Q9NSD4	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	COL26A1	Homo sapiens	Q96A83-2	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	COL26A1	Homo sapiens	Q96A83-2	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	COL26A1	Homo sapiens	Q96A83-2	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	ERN1	Homo sapiens	O75460-2	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	ERN1	Homo sapiens	O75460-2	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	ERN1	Homo sapiens	O75460-2	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	GIPC1	Homo sapiens	O14908-2	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	GIPC1	Homo sapiens	O14908-2	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	GIPC1	Homo sapiens	O14908-2	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	NUP58	Homo sapiens	Q9BVL2	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	NUP58	Homo sapiens	Q9BVL2	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	ZNF408	Homo sapiens	Q9H9D4	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	ZNF408	Homo sapiens	Q9H9D4	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	ZNF408	Homo sapiens	Q9H9D4	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	SERPINH1	Homo sapiens	P50454	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	SERPINH1	Homo sapiens	P50454	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	SERPINH1	Homo sapiens	P50454	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	KPNA3	Homo sapiens	O00505	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	25416956
Intra	BAHD1	Q8TBE0	TRAF4	Homo sapiens	Q9BUZ4	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	TRAF4	Homo sapiens	Q9BUZ4	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	25416956
Intra	BAHD1	Q8TBE0	TRAF4	Homo sapiens	Q9BUZ4	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	PRDM14	Homo sapiens	Q9GZV8	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	PRDM14	Homo sapiens	Q9GZV8	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	BAHD1	Q8TBE0	KHDRBS3	Homo sapiens	O75525	Y2H Array	25416956
Intra	BAHD1	Q8TBE0	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	BAHD1	Q8TBE0	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	BAHD1	Q8TBE0	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	BAHD1	Q8TBE0	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	LZTS2	Homo sapiens	Q9BRK4	Y2H	21516116
Intra	BAHD1	Q8TBE0	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	BAHD1	Q8TBE0	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	M1AP	Homo sapiens	Q8TC57	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	DR1	Homo sapiens	Q01658	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	DR1	Homo sapiens	Q01658	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	DR1	Homo sapiens	Q01658	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	CBX1	Homo sapiens	P83916	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	CBX1	Homo sapiens	P83916	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	CBX5	Homo sapiens	P45973	Y2H Pooling	32814053
Intra	BAHD1	Q8TBE0	CBX5	Homo sapiens	P45973	Validated Y2H	32814053
Intra	BAHD1	Q8TBE0	CBX5	Homo sapiens	P45973	Y2H Array	32814053
Intra	BAHD1	Q8TBE0	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	BAHD1	Q8TBE0	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	LASP1	Homo sapiens	Q14847-2	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	LASP1	Homo sapiens	Q14847-2	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	ARID5A	Homo sapiens	Q03989	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	ARID5A	Homo sapiens	Q03989	Y2H Array	32296183
Intra	BAHD1	Q8TBE0	TNS2	Homo sapiens	Q63HR2	Y2H Prey Pooling	32296183
Intra	BAHD1	Q8TBE0	TNS2	Homo sapiens	Q63HR2	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Human Granulocytic Anaplasmosis

Human Granulocytic Ehrlichiosis	Hge
Human Ehrlichial Infection, Human Granulocytic Type	Human Anaplasmosis Due To Anaplasma Phagocytophilum

Listeriosis

Listeria Infection	Infection By Listeria Monocytogenes
Listeria Monocytogenes Infection	Listeria Infections
Listerial Foodborne Infection	Circling Disease
Infection Due To Listeria Monocytogenes	Listerellosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01352	BAHD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	BAHD1	VGNC	VGNC:70150
Bos taurus	BAHD1	VGNC	VGNC:26411
Felis catus	BAHD1	VGNC	VGNC:60070
Rattus norvegicus	BAHD1	RGD	RGD:1563127
Mus musculus	BAHD1	MGD	MGI:2139371
Canis familiaris	BAHD1	VGNC	VGNC:38370

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