2. Gene
  3. ASGR1 - asialoglycoprotein receptor 1 Gene

ASGR1 - asialoglycoprotein receptor 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HL-1; ASGPR; ASGPR1; CLEC4H1

Gene ID: 432 | Gene type: protein coding

About ASGR1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,173,431-7,179,370 (from NCBI)

This gene has 9 transcripts (splice variants), 155 orthologues and 14 paralogues. Biased expression in liver (RPKM 145.0) and testis (RPKM 4.7).

Summary

This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic Infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

ASGR1 Products(2)

mRNA Protein Name
NM_001197216.3 NP_001184145.1 asialoglycoprotein receptor 1 isoform b
NM_001671.5 NP_001662.1 asialoglycoprotein receptor 1 isoform a
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASGR1 Protein Structure

Lectin_N

Lectin_N: Hepatic lectin, N-terminal domain (6 - 144)

Lectin_C

Lectin_C: Lectin C-type domain (172 - 279)

  • 0
  • 100
  • 200
  • 291 a.a.
Protein Preferred Names Protein Names

asialoglycoprotein receptor 1

C-type lectin domain family 4 member H1

ASGR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ASGR1 P07306 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
ASGR1 P07306 CERS2 Homo sapiens Q96G23
Y2H
21988832
Intra
ASGR1 P07306 SPAG4 Homo sapiens Q9NPE6
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
Intra
ASGR1 P07306 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
Intra
ASGR1 P07306 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
Intra
ASGR1 P07306 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 HIBADH Homo sapiens P31937
Validated Y2H
32296183
Intra
ASGR1 P07306 HIBADH Homo sapiens P31937
Y2H Array
32296183
Intra
ASGR1 P07306 HIBADH Homo sapiens P31937
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
ASGR1 P07306 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
ASGR1 P07306 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Array
32296183
Intra
ASGR1 P07306 AHNAK2 Homo sapiens Q8IVF2-3
Validated Y2H
32296183
Intra
ASGR1 P07306 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
ASGR1 P07306 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
ASGR1 P07306 ATP1B4 Homo sapiens Q9UN42
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 ATP1B4 Homo sapiens Q9UN42
Validated Y2H
32296183
Intra
ASGR1 P07306 ATP1B4 Homo sapiens Q9UN42
Y2H Array
32296183
Intra
ASGR1 P07306 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra
ASGR1 P07306 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra
ASGR1 P07306 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra
ASGR1 P07306 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
ASGR1 P07306 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
ASGR1 P07306 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 SUSD3 Homo sapiens Q96L08
Y2H Array
32296183
Intra
ASGR1 P07306 SUSD3 Homo sapiens Q96L08
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 SUSD3 Homo sapiens Q96L08
Validated Y2H
32296183
Intra
ASGR1 P07306 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
ASGR1 P07306 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
ASGR1 P07306 AMIGO1 Homo sapiens Q86WK6
Validated Y2H
32296183
Intra
ASGR1 P07306 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
ASGR1 P07306 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 RNF19B Homo sapiens Q6ZMZ0
Validated Y2H
32296183
Intra
ASGR1 P07306 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
Intra
ASGR1 P07306 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 APH1A Homo sapiens Q96BI3
Validated Y2H
32296183
Intra
ASGR1 P07306 APH1A Homo sapiens Q96BI3
Y2H Array
32296183
Intra
ASGR1 P07306 APH1A Homo sapiens Q96BI3
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 MCEMP1 Homo sapiens Q8IX19
Validated Y2H
32296183
Intra
ASGR1 P07306 MCEMP1 Homo sapiens Q8IX19
Y2H Array
32296183
Intra
ASGR1 P07306 MCEMP1 Homo sapiens Q8IX19
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 FCGR1A Homo sapiens P12314
Y2H Array
32296183
Intra
ASGR1 P07306 FCGR1A Homo sapiens P12314
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 FCGR1A Homo sapiens P12314
Validated Y2H
32296183
Intra
ASGR1 P07306 BLCAP Homo sapiens P62952
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 BLCAP Homo sapiens P62952
Validated Y2H
32296183
Intra
ASGR1 P07306 BLCAP Homo sapiens P62952
Y2H Array
32296183
Intra
ASGR1 P07306 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
ASGR1 P07306 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
ASGR1 P07306 SLC10A1 Homo sapiens Q14973
Validated Y2H
32296183
Intra
ASGR1 P07306 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
ASGR1 P07306 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
ASGR1 P07306 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
ASGR1 P07306 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
ASGR1 P07306 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
ASGR1 P07306 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
ASGR1 P07306 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
Intra
ASGR1 P07306 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 IGFBP5 Homo sapiens P24593
Validated Y2H
32296183
Intra
ASGR1 P07306 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
ASGR1 P07306 VSIR Homo sapiens Q9H7M9
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 VSIR Homo sapiens Q9H7M9
Validated Y2H
32296183
Intra
ASGR1 P07306 VSIR Homo sapiens Q9H7M9
Y2H Array
32296183
Intra
ASGR1 P07306 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
ASGR1 P07306 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
ASGR1 P07306 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
ASGR1 P07306 KIR2DL3 Homo sapiens P43628
Validated Y2H
32296183
Intra
ASGR1 P07306 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ASGR1 Proteins

Cat. No. Product Name Accession Purity
HY-P7610 ASGR1/ASGPR1 Protein, Human (HEK293, His) P07306 (Q62-L291) ≥95%

Related Diseases

Diseases Alias
Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec
Hepatitis B

Chronic Hepatitis B

Hepatitis B Infection

Serum Hepatitis

HBV

Hepatitis B Chronic

Hbv, Susceptibility To

Hepatitis B, Chronic

Chronic Hepatitis B Without Delta Agent

Chronic Hbv - [Hepatitis B Virus] Infection

Hepatitis B Nos

Chronic Type B Viral Hepatitis

Hep B Nos
Hepatitis E
Autoimmune Hepatitis

Aih

Hepatitis, Autoimmune

Autoimmune Chronic Active Hepatitis

Autoimmune Hepatitis With Centrilobular Necrosis

Autoimmune Chronic Hepatitis

Hepatitis Autoimmune
Acute Gonococcal Cervicitis

Gonococcal Cervicitis

Acute Gonorrhea Of Cervix
Amelogenesis Imperfecta, Type Ib

AI1B

Aih2

Amelogenesis Imperfecta Type 1b

Amelogenesis Imperfecta Type Ib

Hereditary Localized Enamel Hypoplasia

Amelogenesis Imperfecta - Hypoplastic Autosomal Dominant - Local

Amelogenesis Imperfecta, Hypoplastic Local, Autosomal Dominant

Enamel Hypoplasia, Hereditary Localized

Autosomal Dominant Hypoplastic Local Amelogenesis Imperfecta

Amelogenesis Imperfecta 1b

Amelogenesis Imperfecta Hypoplastic 2

Amelogenesis Imperfecta Hypoplastic Local Autosomal Dominant
Amelogenesis Imperfecta, Type Ie

Aih1

Amelogenesis Imperfecta Type 1e

AI1E

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1

Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth

Enamel Hypoplasia, X-Linked

Amelogenesis Imperfecta Type Ie

Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1

Enamel Hypoplasia X-Linked

Amelogenesis Imperfecta, X-Linked 1

Amelogenesis Imperfecta, Type 1e

Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth

X-Linked Amelogenesis Imperfecta 1

X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1

X-Linked Enamel Hypoplasia

Amelogenesis Imperfecta X-Linked 1

Amelogenesis Imperfecta 1e

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e

Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth

Xai

X-Linked Amelogenesis Imperfecta

Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2
Acute Cervicitis
Amyloidosis, Hereditary, Transthyretin-Related

Transthyretin Amyloidosis

Familial Amyloid Polyneuropathy

Ttr Amyloid Neuropathy

Transthyretin Amyloid Neuropathy

Transthyretin Amyloid Polyneuropathy

Fap

Familial Transthyretin Amyloidosis

Amyloidosis Transthyretin Related

Type I Familial Amyloid Polyneuropathy

Familial Amyloid Polyneuropathy Type I

Attrv122i Amyloidosis

Hereditary Amyloidosis, Transthyretin-Related

Amyloid Polyneuropathy, Familial

Attr Amyloidosis

Attrm Amyloidosis

Corino De Andrade'S Disease

Paramyloidosis

Transthyretin-Related Hereditary Amyloidosis

Ttr Amyloidosis

Hereditary Attr Amyloidosis

Portuguese Polyneuritic Amyloidosis

Portuguese Type Familial Amyloid Neuropathy

Swiss Type Amyloid Polyneuropathy

Type Ii Familial Amyloid Polyneuropathy

Attrv30m Amyloidosis

Attrv30m-Related Amyloidosis

Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type

Attr Cardiomyopathy

Attrv122i-Related Amyloidosis

Ttr-Related Amyloid Cardiomyopathy

Ttr-Related Cardiac Amyloidosis

Transthyretin Amyloid Cardiopathy

Transthyretin-Related Familial Amyloid Cardiomyopathy

Amyloidosis, Transthyretin-Related

AMYL-TTR

Amyloidosis I

Amyloidosis Ohio Type

Amyloidosis Type 7

Amyloidosis Vii

Amyloid Polyneuropathy

Attr

Familial Amyloid Polyneuropathy Type Ii

Hereditary Amyloidosis Transthyretin-Related

Leptomeningeal Amyloidosis

Meningocerebrovascular Amyloidosis

Oculoleptomeningeal Amyloidosis

Familial Amyloid Polyneuropathies

Amyloidosis, Leptomeningeal

Senile Cardiac Amyloidosis

Amyloid Neuropathies, Familial

Danish Type Familial Amyloid Cardiomyopathy

Familial Amyloid Neuropathy, Portuguese Type

Amyloid Polyneuropathy, Swiss Type

Hereditary Oculoleptomeningeal Amyloid Angiopathy

Amyloid Neuropathies
Crigler-Najjar Syndrome, Type I

Crigler-Najjar Syndrome

Crigler-Najjar Syndrome Type 1

Bilirubin Udp Glucuronyl Transferase Deficiency

Crigler Najjar Syndrome

Crigler Najjar Syndrome, Type 1

Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency

Bilirubin-Ugt Deficiency

Hyperbilirubinemia, Crigler-Najjar Type I

Hblrcn1

Familial Nonhemolytic Unconjugated Hyperbilirubinemia

Hereditary Unconjugated Hyperbilirubinemia

Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1

Bilirubin-Ugt Deficiency Type 1

Crigler-Najjar Syndrome 1

CN1

Cn-I

Crigler-Najjar Syndrome Type I

Hereditary Unconjugated Hyperbilirubinaemia

Ugt Deficiency

Bilirubin Glucuronosyltransferase Deficiency

Crigler-Najjar Disease Or Syndrome

Deficiency Of Glucuronosyltransferase

Glucuronyl Transferase Deficiency

Glucuronyltransferase Deficiency

Udp Glucuronyl Transferase Deficiency

Cns - [Crigler-Najjar Syndrome]

Congenital Familial Nonhemolytic Jaundice
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01085 ASGR1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ASGR1 RGD RGD:2160
Mus musculus ASGR1 MGD MGI:88081
Bos taurus ASGR1 VGNC VGNC:26209
Macaca mulatta ASGR1 VGNC VGNC:99120
Macaca fascicularis ASGR1 NCBI NCBI:102139430
Others ASGR1 NCBI