STIM1 - stromal interaction molecule 1 Gene

Homo sapiens

Also known as GOK; TAM; TAM1; IMD10; STRMK; D11S4896E

Gene ID: 6786 | Gene type: protein coding

About STIM1

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:3,854,604-4,093,210 (from NCBI)

This gene has 32 transcripts (splice variants), 271 orthologues, 1 paralogue and is associated with 7 phenotypes. Ubiquitous expression in thyroid (RPKM 23.4), esophagus (RPKM 23.1) and 25 other tissues.

Summary

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast Cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

STIM1 Products(19)

mRNA	Protein	Name
NM_001277961.3	NP_001264890.1	stromal interaction molecule 1 isoform 1 precursor
NM_001277962.2	NP_001264891.1	stromal interaction molecule 1 isoform 3 precursor
NM_001382566.1	NP_001369495.1	stromal interaction molecule 1 isoform 4
NM_001382567.1	NP_001369496.1	stromal interaction molecule 1 isoform 5 precursor
NM_001382568.1	NP_001369497.1	stromal interaction molecule 1 isoform 6 precursor
NM_001382569.1	NP_001369498.1	stromal interaction molecule 1 isoform 7
NM_001382570.1	NP_001369499.1	stromal interaction molecule 1 isoform 8 precursor
NM_001382571.1	NP_001369500.1	stromal interaction molecule 1 isoform 9
NM_001382572.1	NP_001369501.1	stromal interaction molecule 1 isoform 10 precursor
NM_001382573.1	NP_001369502.1	stromal interaction molecule 1 isoform 11
NM_001382574.1	NP_001369503.1	stromal interaction molecule 1 isoform 12
NM_001382575.1	NP_001369504.1	stromal interaction molecule 1 isoform 13
NM_001382576.1	NP_001369505.1	stromal interaction molecule 1 isoform 13
NM_001382577.1	NP_001369506.1	stromal interaction molecule 1 isoform 13
NM_001382578.1	NP_001369507.1	stromal interaction molecule 1 isoform 14
NM_001382579.1	NP_001369508.1	stromal interaction molecule 1 isoform 14
NM_001382580.1	NP_001369509.1	stromal interaction molecule 1 isoform 15
NM_001382581.1	NP_001369510.1	stromal interaction molecule 1 isoform 16
NM_003156.4	NP_003147.2	stromal interaction molecule 1 isoform 2 precursor

STIM1 Protein Structure

SAM_2

0
200
400
600
685 a.a.

Protein Preferred Names

Protein Names

stromal interaction molecule 1

Recombinant STIM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74536	STIM1 Protein, Human (HEK293, His)	Q13586/NP_003147.2(L23-D213)	≥95%

Related Diseases

Diseases

Alias

Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis	Stormorken-Sjaastad-Langslet Syndrome
STRMK	York Platelet Syndrome
Yps	Thrombocytopathy, Asplenia And Miosis
Thrombocytopathy Asplenia Miosis	Thrombocytopathy-Asplenia-Miosis Syndrome
Miosis Disorder

Immunodeficiency 10

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2	Combined Immunodeficiency Due To Stim1 Deficiency
IMD10	Stim1 Deficiency
Cid Due To Stim1 Deficiency	Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2
Immunodeficiency, Type 10

Myopathy, Tubular Aggregate, 1

Tubular Aggregate Myopathy	Tam
Myopathy With Tubular Aggregates	TAM1
Myopathy, Tubular Aggregate	Tubular Aggregate Myopathy 1

Kaposi Sarcoma

Kaposi'S Sarcoma	Kaposi Sarcoma, Susceptibility To
Kaposi'S Sarcoma Of Lung	Kaposi'S Sarcoma Of Palate
Kaposi'S Sarcoma Of Soft Tissue	Kaposi'S Sarcoma-Associated Herpesvirus
Multiple Idiopathic Pigmented Hemangiosarcoma	Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To
African Lymphadenopathic Kaposi'S Sarcoma	Anal Kaposi'S Sarcoma
Cardiac Kaposi'S Sarcoma	Central Nervous System Kaposi'S Sarcoma
Conjunctival Kaposi'S Sarcoma	Corneal Kaposi'S Sarcoma
Cutaneous Kaposi'S Sarcoma	Esophageal Kaposi'S Sarcoma
Gallbladder Kaposi'S Sarcoma	Gastric Kaposi'S Sarcoma
Intestinal Kaposi'S Sarcoma	Kaposi'S Sarcoma Of Anus
Kaposi'S Sarcoma Of Central Nervous System	Kaposi'S Sarcoma Of Conjunctiva
Kaposi'S Sarcoma Of Cornea	Kaposi'S Sarcoma Of Esophagus
Kaposi'S Sarcoma Of Gastrointestinal Sites	Kaposi'S Sarcoma Of Heart
Kaposi'S Sarcoma Of Lymph Nodes	Kaposi'S Sarcoma Of Penis
Kaposi'S Sarcoma Of Skin	Kaposi'S Sarcoma Of Soft Tissues
Kaposi'S Sarcoma Of The Cns	Kaposi'S Sarcoma Of The Gallbladder
Kaposi'S Sarcoma Of The Prostate	Kaposi'S Sarcoma, Lung
Kaposi'S Sarcoma, Skin	Lymph Node Kaposi'S Sarcoma
Lymphadenopathic Kaposi'S Sarcoma	Palate Kaposi'S Sarcoma
Penis Kaposi'S Sarcoma	Prostate Kaposi'S Sarcoma
Pulmonary Kaposi'S Sarcoma	Soft Tissue Kaposi'S Sarcoma
Hhv8	Human Herpesvirus 8
Kshv	Kaposi Sarcoma Herpesvirus
Mediterranean Kaposi Sarcoma	Non Aids Related Kaposi Sarcoma
Sarcoma, Kaposi	Sarcoma, Kaposi, Susceptibility To
Non-Aids-Related Kaposi Sarcoma	Angiolymphoid Hyperplasia
Angiofollicular Ganglionic Hyperplasia	Multi-Centric Castleman'S Disease

Rhabdomyosarcoma

T Cell And Nk Cell Immunodeficiency

Rhabdoid Cancer

Rhabdoid Tumor	Malignant Rhabdoid Tumor
Malignant Rhabdoid Tumour	Rhabdoid Sarcoma
Rhabdoid Tumor Predisposition Syndrome 1	Rhabdoid Tumor Predisposition Syndrome 2
Atypical Teratoid Rhabdoid Tumor	Brain Tumor, Posterior Fossa, Of Infancy, Familial
Atypical Teratoid/Rhabdoid Tumor

Myopathy

Muscular Diseases

Myopathies

Breast Fibrosarcoma

Fibrosarcoma Of The Breast

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Immunodeficiency 9

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 1	Combined Immunodeficiency Due To Orai1 Deficiency
IMD9	Cid Due To Orai1 Deficiency
Severe Combined Immunodeficiency Due To Crac Channel Dysfunction	Immunodeficiency, Type 9

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

Anhidrosis

Hypohidrosis	Absence Of Sweating
Adiaphoresis	Impaired Sweating
Oligohidrosis

Brugada Syndrome 4

BRGDA4

Brugada Syndrome, Type 4

Anemia, Autoimmune Hemolytic

Autoimmune Hemolytic Anemia	Idiopathic Autoimmune Hemolytic Anemia
Immuno-Hemolytic Anemia	Anemia, Hemolytic, Autoimmune
Autoimmune Haemolytic Anaemia	Autoimmune Hemolytic Anaemia
Acquired Autoimmune Hemolytic Anemia	Anemia Hemolytic Autoimmune
Familial Auto-Immune Hemolytic Anemia	Aha
Aiha

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Malignant Hyperthermia

Anesthesia Related Hyperthermia	Malignant Hyperpyrexia Due To Anesthesia
Hyperpyrexia, Malignant	Hyperthermia, Malignant
Malignant Hyperpyrexia	Mhs
Malignant Fever

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Congenital Myasthenic Syndrome

Congenital Myasthenia	Congenital Myasthenic Syndromes
Cms	Myasthenic Syndromes, Congenital
Myasthenic Syndromes Congenital	Myasthenic Syndrome, Congenital
Congenital Myasthenic Syndrome Ib	Congenital And Developmental Myasthenia
Developmental Myasthenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101942	Zegocractin	Inhibitor	99.96%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19408	Pyr10	Inhibitor	99.42%	Unkown
HY-100932	ML-9	Inhibitor	99.86%	Unkown
HY-113618B	RO2959 monohydrochloride	Inhibitor	98.21%	Unkown
HY-113618A	RO2959 hydrochloride	Inhibitor	/	Unkown
HY-RS13913	STIM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-100932A	ML-9 Free Base	Inhibitor	/	Unkown
HY-103071	GSK-5503A	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STIM1	MGD	MGI:107476
Canis familiaris	STIM1	VGNC	VGNC:46901
Bos taurus	STIM1	VGNC	VGNC:35383
Macaca mulatta	STIM1	VGNC	VGNC:77911
Rattus norvegicus	STIM1	RGD	RGD:1306831
Felis catus	STIM1	VGNC	VGNC:65772
Others	STIM1	NCBI

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