STX7 - syntaxin 7 Gene

Homo sapiens

Gene ID: 8417 | Gene type: protein coding

About STX7

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:132,445,867-132,513,472 (from NCBI)

This gene has 4 transcripts (splice variants), 210 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 31.8), spleen (RPKM 19.7) and 24 other tissues.

Summary

The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]

STX7 Products(4)

mRNA	Protein	Name
NM_001326578.2	NP_001313507.1	syntaxin-7 isoform a
NM_001326579.2	NP_001313508.1	syntaxin-7 isoform a
NM_001326580.2	NP_001313509.1	syntaxin-7 isoform b
NM_003569.3	NP_003560.2	syntaxin-7 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	24550300	GOA
enables chloride channel inhibitor activity	IDA IDA: Inferred from direct assay	18570918	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11382755	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	10564279	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in organelle assembly	IDA IDA: Inferred from direct assay	21438968	GOA
involved in organelle localization	IDA IDA: Inferred from direct assay	21438968	GOA
involved in positive regulation of T cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	21438968	GOA
involved in positive regulation of receptor localization to synapse	IMP IMP: Inferred from mutant phenotype	21438968	GOA
involved in regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	18570918	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in azurophil granule	IDA IDA: Inferred from direct assay	20170677	GOA
located in early endosome	IDA IDA: Inferred from direct assay	10564279	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	10564279	GOA
located in endosome	IDA IDA: Inferred from direct assay	10564279	GOA
located in immunological synapse	IDA IDA: Inferred from direct assay	21438968	GOA
located in late endosome	IDA IDA: Inferred from direct assay	18980942	GOA
located in lysosome	IDA IDA: Inferred from direct assay	18980942	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18570918	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18980942	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	18570918	GOA
located in tertiary granule	IDA IDA: Inferred from direct assay	20170677	GOA
located in vesicle	IDA IDA: Inferred from direct assay	18570918	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX7 Protein Structure

Syntaxin_2

SNARE

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

syntaxin-7

Recombinant STX7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71024	STX7 Protein, Human (HEK293, His)	O15400 (S2-L238)	≥95%

Related Diseases

Diseases

Alias

Neuronal Migration Disorders

Abnormality Of Neuronal Migration	Malformations Of Cortical Development, Group Ii
Neuronal Dysmigration Syndromes

Hemophagocytic Lymphohistiocytosis, Familial, 4

Familial Hemophagocytic Lymphohistiocytosis 4	FHL4
Hplh4	Hlh4
Lymphohistiocytosis, Hemophagocytic, Familial, Type 4

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13987	STX7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	STX7	VGNC	VGNC:46958
Macaca mulatta	STX7	VGNC	VGNC:78047
Bos taurus	STX7	VGNC	VGNC:35443
Rattus norvegicus	STX7	RGD	RGD:619747
Mus musculus	STX7	MGD	MGI:1858210
Felis catus	STX7	VGNC	VGNC:102526
Others	STX7	NCBI

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