STX7 - syntaxin 7 Gene

Homo sapiens

Gene ID: 8417 | Gene type: protein coding

About STX7

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:132,445,867-132,513,472 (from NCBI)

This gene has 4 transcripts (splice variants), 210 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 31.8), spleen (RPKM 19.7) and 24 other tissues.

Summary

The protein encoded by this gene is a syntaxin family membrane receptor involved in vesicle transport. The encoded protein binds alpha-SNAP, an important regulator of transport vesicle fusion. Along with syntaxin 13, this protein plays a role in the ordered fusion of endosomes and lysosomes with the phagosome. [provided by RefSeq, May 2016]

STX7 Products(4)

mRNA	Protein	Name
NM_001326578.2	NP_001313507.1	syntaxin-7 isoform a
NM_001326579.2	NP_001313508.1	syntaxin-7 isoform a
NM_001326580.2	NP_001313509.1	syntaxin-7 isoform b
NM_003569.3	NP_003560.2	syntaxin-7 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	24550300	GOA
enables chloride channel inhibitor activity	IDA IDA: Inferred from direct assay	18570918	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11382755	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	10564279	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in organelle assembly	IDA IDA: Inferred from direct assay	21438968	GOA
involved in organelle localization	IDA IDA: Inferred from direct assay	21438968	GOA
involved in positive regulation of T cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	21438968	GOA
involved in positive regulation of receptor localization to synapse	IMP IMP: Inferred from mutant phenotype	21438968	GOA
involved in regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	18570918	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in azurophil granule	IDA IDA: Inferred from direct assay	20170677	GOA
located in early endosome	IDA IDA: Inferred from direct assay	10564279	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	10564279	GOA
located in endosome	IDA IDA: Inferred from direct assay	10564279	GOA
located in immunological synapse	IDA IDA: Inferred from direct assay	21438968	GOA
located in late endosome	IDA IDA: Inferred from direct assay	18980942	GOA
located in lysosome	IDA IDA: Inferred from direct assay	18980942	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18570918	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18980942	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	18570918	GOA
located in tertiary granule	IDA IDA: Inferred from direct assay	20170677	GOA
located in vesicle	IDA IDA: Inferred from direct assay	18570918	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX7 Protein Structure

Syntaxin_2

SNARE

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

syntaxin-7

STX7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STX7	O15400	RETREG3	Homo sapiens	Q86VR2	Validated Y2H	32296183
Intra	STX7	O15400	RETREG3	Homo sapiens	Q86VR2	Y2H Prey Pooling	32296183
Intra	STX7	O15400	RETREG3	Homo sapiens	Q86VR2	Y2H Array	32296183
Intra	STX7	O15400	LSMEM2	Homo sapiens	Q8N112	Validated Y2H	32296183
Intra	STX7	O15400	LSMEM2	Homo sapiens	Q8N112	Y2H Array	32296183
Intra	STX7	O15400	LSMEM2	Homo sapiens	Q8N112	Y2H Prey Pooling	32296183
Intra	STX7	O15400	JAGN1	Homo sapiens	Q8N5M9	Y2H Array	32296183
Intra	STX7	O15400	JAGN1	Homo sapiens	Q8N5M9	Y2H Prey Pooling	32296183
Intra	STX7	O15400	JAGN1	Homo sapiens	Q8N5M9	Validated Y2H	32296183
Intra	STX7	O15400	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	STX7	O15400	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	STX7	O15400	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	STX7	O15400	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	STX7	O15400	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	STX7	O15400	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	STX7	O15400	VPS18	Homo sapiens	Q9P253	Anti Tag CoIP	11382755
Intra	STX7	O15400	VPS18	Homo sapiens	Q9P253	Anti Bait CoIP	11382755
Intra	STX7	O15400	ELOVL5	Homo sapiens	Q9NYP7	Y2H Prey Pooling	32296183
Intra	STX7	O15400	ELOVL5	Homo sapiens	Q9NYP7	Y2H Array	32296183
Intra	STX7	O15400	ELOVL5	Homo sapiens	Q9NYP7	Validated Y2H	32296183
Intra	STX7	O15400	ARL13B	Homo sapiens	Q3SXY8	Validated Y2H	32296183
Intra	STX7	O15400	ARL13B	Homo sapiens	Q3SXY8	Y2H Array	32296183
Intra	STX7	O15400	ARL13B	Homo sapiens	Q3SXY8	Y2H Prey Pooling	32296183
Intra	STX7	O15400	TMEM80	Homo sapiens	Q96HE8	Y2H Prey Pooling	32296183
Intra	STX7	O15400	TMEM80	Homo sapiens	Q96HE8	Validated Y2H	32296183
Intra	STX7	O15400	TMEM80	Homo sapiens	Q96HE8	Y2H Array	32296183
Intra	STX7	O15400	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	STX7	O15400	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	STX7	O15400	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	STX7	O15400	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	STX7	O15400	STX2	Homo sapiens	P32856-2	Validated Y2H	32296183
Intra	STX7	O15400	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	STX7	O15400	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	STX7	O15400	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	STX7	O15400	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Prey Pooling	32296183
Intra	STX7	O15400	RIC3	Homo sapiens	Q7Z5B4-5	Validated Y2H	32296183
Intra	STX7	O15400	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Array	32296183
Intra	STX7	O15400	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	STX7	O15400	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	STX7	O15400	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	STX7	O15400	REEP1	Homo sapiens	Q9H902	Y2H Prey Pooling	32296183
Intra	STX7	O15400	REEP1	Homo sapiens	Q9H902	Validated Y2H	32296183
Intra	STX7	O15400	REEP1	Homo sapiens	Q9H902	Y2H Array	32296183
Intra	STX7	O15400	TMEM267	Homo sapiens	Q0VDI3	Y2H Prey Pooling	32296183
Intra	STX7	O15400	TMEM267	Homo sapiens	Q0VDI3	Validated Y2H	32296183
Intra	STX7	O15400	TMEM267	Homo sapiens	Q0VDI3	Y2H Array	32296183
Intra	STX7	O15400	MTUS1	Homo sapiens	Q9ULD2-3	Validated Y2H	32296183
Intra	STX7	O15400	MTUS1	Homo sapiens	Q9ULD2-3	Y2H Array	32296183
Intra	STX7	O15400	MTUS1	Homo sapiens	Q9ULD2-3	Y2H Prey Pooling	32296183
Intra	STX7	O15400	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	STX7	O15400	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	STX7	O15400	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	STX7	O15400	SLC10A6	Homo sapiens	Q3KNW5	Validated Y2H	32296183
Intra	STX7	O15400	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	STX7	O15400	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	STX7	O15400	TMEM241	Homo sapiens	Q24JQ0	Y2H Array	32296183
Intra	STX7	O15400	TMEM241	Homo sapiens	Q24JQ0	Y2H Prey Pooling	32296183
Intra	STX7	O15400	TMEM241	Homo sapiens	Q24JQ0	Validated Y2H	32296183
Intra	STX7	O15400	FAM174A	Homo sapiens	Q8TBP5	Y2H Array	32296183
Intra	STX7	O15400	FAM174A	Homo sapiens	Q8TBP5	Y2H Prey Pooling	32296183
Intra	STX7	O15400	FAM174A	Homo sapiens	Q8TBP5	Validated Y2H	32296183
Intra	STX7	O15400	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Intra	STX7	O15400	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	STX7	O15400	FAM210B	Homo sapiens	Q96KR6	Validated Y2H	32296183
Intra	STX7	O15400	GJC3	Homo sapiens	Q8NFK1	Y2H Prey Pooling	32296183
Intra	STX7	O15400	GJC3	Homo sapiens	Q8NFK1	Validated Y2H	32296183
Intra	STX7	O15400	GJC3	Homo sapiens	Q8NFK1	Y2H Array	32296183
Intra	STX7	O15400	CERS4	Homo sapiens	Q9HA82	Validated Y2H	32296183
Intra	STX7	O15400	CERS4	Homo sapiens	Q9HA82	Y2H Prey Pooling	32296183
Intra	STX7	O15400	CERS4	Homo sapiens	Q9HA82	Y2H Array	32296183
Intra	STX7	O15400	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	STX7	O15400	LIME1	Homo sapiens	Q9H400	Validated Y2H	32296183
Intra	STX7	O15400	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	STX7	O15400	ZFYVE27	Homo sapiens	Q5T4F4	Validated Y2H	32296183
Intra	STX7	O15400	ZFYVE27	Homo sapiens	Q5T4F4	Y2H Prey Pooling	32296183
Intra	STX7	O15400	ZFYVE27	Homo sapiens	Q5T4F4	Y2H Array	32296183
Intra	STX7	O15400	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	STX7	O15400	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	STX7	O15400	EBP	Homo sapiens	Q15125	Validated Y2H	32296183
Intra	STX7	O15400	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	STX7	O15400	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	STX7	O15400	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	STX7	O15400	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	STX7	O15400	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	STX7	O15400	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	STX7	O15400	SLC10A1	Homo sapiens	Q14973	Validated Y2H	32296183
Intra	STX7	O15400	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	STX7	O15400	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	STX7	O15400	YKT6	Homo sapiens	O15498	Anti Tag CoIP	33961781
Intra	STX7	O15400	MRM1	Homo sapiens	Q6IN84	Validated Y2H	32296183
Intra	STX7	O15400	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	STX7	O15400	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	STX7	O15400	TMEM205	Homo sapiens	Q6UW68	Validated Y2H	32296183
Intra	STX7	O15400	TMEM205	Homo sapiens	Q6UW68	Y2H Array	32296183
Intra	STX7	O15400	TMEM205	Homo sapiens	Q6UW68	Y2H Prey Pooling	32296183
Intra	STX7	O15400	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	STX7	O15400	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	STX7	O15400	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	STX7	O15400	TM4SF19	Homo sapiens	Q96DZ7	Validated Y2H	32296183
Intra	STX7	O15400	TM4SF19	Homo sapiens	Q96DZ7	Y2H Prey Pooling	32296183
Intra	STX7	O15400	TM4SF19	Homo sapiens	Q96DZ7	Y2H Array	32296183
Intra	STX7	O15400	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	STX7	O15400	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	STX7	O15400	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	STX7	O15400	ANKS6	Homo sapiens	Q68DC2	Y2H Array	32296183
Intra	STX7	O15400	ANKS6	Homo sapiens	Q68DC2	Y2H Prey Pooling	32296183
Intra	STX7	O15400	ANKS6	Homo sapiens	Q68DC2	Validated Y2H	32296183
Intra	STX7	O15400	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	STX7	O15400	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	STX7	O15400	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	STX7	O15400	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	STX7	O15400	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	STX7	O15400	VAMP8	Homo sapiens	Q9BV40	Anti Tag CoIP	33961781
Intra	STX7	O15400	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	25416956
Intra	STX7	O15400	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	STX7	O15400	STX4	Homo sapiens	Q12846	Validated Y2H	32296183
Intra	STX7	O15400	STX4	Homo sapiens	Q12846	Y2H Array	25416956
Intra	STX7	O15400	STX4	Homo sapiens	Q12846	Anti Tag CoIP	33961781
Intra	STX7	O15400	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	STX7	O15400	CYBRD1	Homo sapiens	Q53TN4	Y2H Array	32296183
Intra	STX7	O15400	CYBRD1	Homo sapiens	Q53TN4	Y2H Prey Pooling	32296183
Intra	STX7	O15400	CYBRD1	Homo sapiens	Q53TN4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STX7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71024	STX7 Protein, Human (HEK293, His)	O15400 (S2-L238)	≥95%

Related Diseases

Diseases

Alias

Neuronal Migration Disorders

Abnormality Of Neuronal Migration	Malformations Of Cortical Development, Group Ii
Neuronal Dysmigration Syndromes

Hemophagocytic Lymphohistiocytosis, Familial, 4

Familial Hemophagocytic Lymphohistiocytosis 4	FHL4
Hplh4	Hlh4
Lymphohistiocytosis, Hemophagocytic, Familial, Type 4

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13987	STX7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	STX7	VGNC	VGNC:46958
Macaca mulatta	STX7	VGNC	VGNC:78047
Bos taurus	STX7	VGNC	VGNC:35443
Rattus norvegicus	STX7	RGD	RGD:619747
Mus musculus	STX7	MGD	MGI:1858210
Felis catus	STX7	VGNC	VGNC:102526
Others	STX7	NCBI

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